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Article ; Online: Pre-gestational diabetes during the COVID-19 pandemic in Bergamo, Italy.

Dodesini, Alessandro Roberto / Galliani, Silvia / Ciriello, Elena / Bellante, Rosalia / Trevisan, Roberto

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2020 Volume 151, Issue 2, Page(s) 295–296

Keywords	covid19
Language	English
Publishing date	2020-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.13306
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Article: Pre-gestational diabetes during the COVID-19 pandemic in Bergamo, Italy

Dodesini, Alessandro Roberto / Galliani, Silvia / Ciriello, Elena / Bellante, Rosalia / Trevisan, Roberto

Int J Gynaecol Obstet

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #643700
Database	COVID19

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Article ; Online: Pre‐gestational diabetes during the COVID‐19 pandemic in Bergamo, Italy

Dodesini, Alessandro Roberto / Galliani, Silvia / Ciriello, Elena / Bellante, Rosalia / Trevisan, Roberto

International Journal of Gynecology & Obstetrics

2020 Volume 151, Issue 2, Page(s) 295–296

Keywords	Obstetrics and Gynaecology ; General Medicine ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.13306
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of a low glycemic index high in fiber diet on blood glucose in women with gestational diabetes.

Dodesini, Alessandro Roberto / Donadoni, Veronica / Ciriello, Elena / Colombo, Ottavia / Patanè, Luisa / Galliani, Silvia / Cortinovis, Fiorenzo / Trevisan, Roberto

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2019 Volume 34, Issue 6, Page(s) 1010–1011

MeSH term(s)	Blood Glucose ; Diabetes Mellitus, Type 2 ; Diabetes, Gestational ; Diet ; Dietary Carbohydrates ; Female ; Glycemic Index ; Humans ; Pregnancy
Chemical Substances	Blood Glucose ; Dietary Carbohydrates
Language	English
Publishing date	2019-06-03
Publishing country	England
Document type	Letter
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2019.1622674
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Article ; Online: Thyroid Autoantibodies and the Clinical Presentation of Moyamoya Disease: A Prospective Study.

Lanterna, Luigi A / Galliani, Silvia / Zangari, Rosalia / Conti, Luciano / Brembilla, Carlo / Gritti, Paolo / Colleoni, Maria Luisa / Bernucci, Claudio

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2018 Volume 27, Issue 5, Page(s) 1194–1199

Abstract: Background: Moyamoya is a rare cerebrovascular disease characterized by the progressive occlusion of the intracranial carotid artery. Thyroid autoantibodies have been found to be associated with the disease, but their clinical significance has never ... ...

Abstract	Background: Moyamoya is a rare cerebrovascular disease characterized by the progressive occlusion of the intracranial carotid artery. Thyroid autoantibodies have been found to be associated with the disease, but their clinical significance has never been studied. The objective of this study was to investigate the relationship between thyroid autoantibodies and the clinical presentation of moyamoya. Methods: This is a prospective study including 37 patients with moyamoya disease (MMD) or unilateral moyamoya (uMM). Thyroid function and thyroid autoantibodies (e.g., antithyroperoxidase and antithyroglobulin) were investigated. We studied the effect of gender, age, type of moyamoya (uMM versus MMD), and thyroid autoantibodies on the clinical presentation, dichotomized into aggressive (hemorrhage, major stroke, or frequent transient ischemic attack [TIA]) and nonaggressive presentation (headache, rare TIAs, and incidental diagnosis) according to the criteria of the Research Committee on Spontaneous Occlusion of the Circle of Willis. Results: Of the 37 patients included in the study, the autoantibodies were elevated in 9 (24.3%). An aggressive presentation occurred in 21 patients (hemorrhage in 11, major stroke in 9, frequent TIAs in 1). The autoantibodies were elevated in 8 of the 21 patients (38.09%) with an aggressive presentation and in 1 of those presenting with minor symptoms (6.2%). The presence of elevated autoantibodies was the only variable associated with an aggressive presentation in the multivariate logistic analysis (P = .048). Conclusions: When the serum concentration of the thyroid autoantibodies is increased, the patients have a higher risk of an aggressive presentation. Our results support the hypothesis that activation of immune-mediated processes affects the moyamoya physiopathology.
MeSH term(s)	Adolescent ; Adult ; Aged ; Autoantibodies/blood ; Biomarkers/blood ; Child ; Child, Preschool ; Female ; Headache/etiology ; Humans ; Infant ; Intracranial Hemorrhages/etiology ; Ischemic Attack, Transient/etiology ; Logistic Models ; Male ; Middle Aged ; Moyamoya Disease/blood ; Moyamoya Disease/complications ; Moyamoya Disease/diagnosis ; Moyamoya Disease/immunology ; Multivariate Analysis ; Prognosis ; Prospective Studies ; Risk Factors ; Stroke/etiology ; Thyroid Function Tests ; Thyroid Gland/immunology ; Thyroid Gland/physiopathology ; Up-Regulation ; Young Adult
Chemical Substances	Autoantibodies ; Biomarkers ; anti-thyroglobulin ; thyroid microsomal antibodies
Language	English
Publishing date	2018-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1131675-5
ISSN	1532-8511 ; 1052-3057
ISSN (online)	1532-8511
ISSN	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2017.11.037
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Article ; Online: Continuous subcutaneous insulin infusion reduces maternal and neonatal risk in pregnant women with type 1 diabetes: An observational cohort study of 122 pregnancies.

Dodesini, Alessandro Roberto / Cavalli, Giorgia / Ciriello, Elena / Lepore, Giuseppe / Corsi, Anna / Scaranna, Cristiana / Bellante, Rosalia / Albizzi, Mascia / Galliani, Silvia / Mangili, Giovanna / Trevisan, Roberto

Journal of diabetes

2020 Volume 12, Issue 11, Page(s) 860–861

MeSH term(s)	Adult ; Aged ; Cohort Studies ; Diabetes Mellitus, Type 1/drug therapy ; Female ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/therapeutic use ; Infant, Newborn ; Infusions, Subcutaneous ; Injections ; Insulin/administration & dosage ; Insulin/therapeutic use ; Insulin Infusion Systems ; Pregnancy ; Treatment Outcome
Chemical Substances	Hypoglycemic Agents ; Insulin
Language	English
Publishing date	2020-07-17
Publishing country	Australia
Document type	Letter ; Observational Study
ZDB-ID	2503337-2
ISSN	1753-0407 ; 1753-0393
ISSN (online)	1753-0407
ISSN	1753-0393
DOI	10.1111/1753-0407.13080
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Article ; Online: Will undocumented migrants contribute to change epidemiology, presentation and pharmacologic treatment of diabetes in Western countries?

Fiorini, Gianfrancesco / Milani, Silvano / Pincelli, Angela I / Calella, Damiano / Galliani, Silvia / Badalamenti, Silvia / Rigamonti, Antonello E / Marazzi, Nicoletta / Sartorio, Alessandro / Cella, Silvano G

Primary care diabetes

2019 Volume 14, Issue 1, Page(s) 21–28

Abstract: Aims: Migrants from countries in which health and social conditions are unsatisfactory, and their offspring, are becoming a growing component of the western population. Available health data show that their morbidity is at least comparable to that of ... ...

Abstract	Aims: Migrants from countries in which health and social conditions are unsatisfactory, and their offspring, are becoming a growing component of the western population. Available health data show that their morbidity is at least comparable to that of the host country population, with a significant contribution of chronic diseases as diabetes. The possibility that diabetes shows different features in undocumented migrants is the hypothesis that we tried to investigate in this study. Methods: We retrospectively analysed the data of 413 patients with type 2 diabetes mellitus (T2DM): 222 patients followed in a diabetes clinic at a University Hospital and 191 undocumented migrants cared for by a Charity in Milan, Italy. Results: We found that the onset of the disease was earlier in migrants; they showed a significant lower body mass index (BMI) and had lower socioeconomic conditions. They had a worse glycaemic control. The pattern of complications was also different between the two groups, with cardiovascular complications more frequent in Italians. Finally, also pharmacologic treatment differed significantly. Conclusions: Age of onset, clinical manifestations and complications of T2DM in undocumented migrants and natives may show significant differences. This is important for both epidemiological and clinical reasons. If these preliminary observations are confirmed by larger studies, we can conclude that undocumented migrants should be screened for T2DM earlier than natives, and that therapies should be tailored to the specific features of their disease.
MeSH term(s)	Adult ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Health Status Disparities ; Healthcare Disparities ; Humans ; Hypoglycemic Agents/therapeutic use ; Italy/epidemiology ; Male ; Middle Aged ; Retrospective Studies ; Social Determinants of Health ; Socioeconomic Factors ; Undocumented Immigrants
Chemical Substances	Hypoglycemic Agents
Language	English
Publishing date	2019-05-04
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	2273997-X
ISSN	1878-0210 ; 1751-9918
ISSN (online)	1878-0210
ISSN	1751-9918
DOI	10.1016/j.pcd.2019.04.004
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Article ; Online: Sitagliptin Treatment at the Time of Hospitalization Was Associated With Reduced Mortality in Patients With Type 2 Diabetes and COVID-19: A Multicenter, Case-Control, Retrospective, Observational Study.

Solerte, Sebastiano Bruno / D'Addio, Francesca / Trevisan, Roberto / Lovati, Elisabetta / Rossi, Antonio / Pastore, Ida / Dell'Acqua, Marco / Ippolito, Elio / Scaranna, Cristiana / Bellante, Rosalia / Galliani, Silvia / Dodesini, Alessandro Roberto / Lepore, Giuseppe / Geni, Francesca / Fiorina, Roberta Maria / Catena, Emanuele / Corsico, Angelo / Colombo, Riccardo / Mirani, Marco /

De Riva, Carlo / Oleandri, Salvatore Endrio / Abdi, Reza / Bonventre, Joseph V / Rusconi, Stefano / Folli, Franco / Di Sabatino, Antonio / Zuccotti, Gianvincenzo / Galli, Massimo / Fiorina, Paolo

Diabetes care

2020 Volume 43, Issue 12, Page(s) 2999–3006

Abstract: Objective: Poor outcomes have been reported in patients with type 2 diabetes and coronavirus disease 2019 (COVID-19); thus, it is mandatory to explore novel therapeutic approaches for this population.: Research design and methods: In a multicenter, ... ...

Abstract	Objective: Poor outcomes have been reported in patients with type 2 diabetes and coronavirus disease 2019 (COVID-19); thus, it is mandatory to explore novel therapeutic approaches for this population. Research design and methods: In a multicenter, case-control, retrospective, observational study, sitagliptin, an oral and highly selective dipeptidyl peptidase 4 inhibitor, was added to standard of care (e.g., insulin administration) at the time of hospitalization in patients with type 2 diabetes who were hospitalized with COVID-19. Every center also recruited at a 1:1 ratio untreated control subjects matched for age and sex. All patients had pneumonia and exhibited oxygen saturation <95% when breathing ambient air or when receiving oxygen support. The primary end points were discharge from the hospital/death and improvement of clinical outcomes, defined as an increase in at least two points on a seven-category modified ordinal scale. Data were collected retrospectively from patients receiving sitagliptin from 1 March through 30 April 2020. Results: Of the 338 consecutive patients with type 2 diabetes and COVID-19 admitted in Northern Italy hospitals included in this study, 169 were on sitagliptin, while 169 were on standard of care. Treatment with sitagliptin at the time of hospitalization was associated with reduced mortality (18% vs. 37% of deceased patients; hazard ratio 0.44 [95% CI 0.29-0.66]; Conclusions: In this multicenter, case-control, retrospective, observational study of patients with type 2 diabetes admitted to the hospital for COVID-19, sitagliptin treatment at the time of hospitalization was associated with reduced mortality and improved clinical outcomes as compared with standard-of-care treatment. The effects of sitagliptin in patients with type 2 diabetes and COVID-19 should be confirmed in an ongoing randomized, placebo-controlled trial.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Diabetes Mellitus, Type 2/drug therapy ; Hospitalization ; Humans ; Italy ; Pandemics ; Pneumonia, Viral ; Retrospective Studies ; SARS-CoV-2 ; Sitagliptin Phosphate/therapeutic use
Chemical Substances	Sitagliptin Phosphate (TS63EW8X6F)
Keywords	covid19
Language	English
Publishing date	2020-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc20-1521
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Article: Sitagliptin Treatment at the Time of Hospitalization Was Associated With Reduced Mortality in Patients With Type 2 Diabetes and COVID-19: A Multicenter, Case-Control, Retrospective, Observational Study

Solerte, Sebastiano Bruno / D039, / Addio, Francesca / Trevisan, Roberto / Lovati, Elisabetta / Rossi, Antonio / Pastore, Ida / Dell039, / Acqua, Marco / Ippolito, Elio / Scaranna, Cristiana / Bellante, Rosalia / Galliani, Silvia / Dodesini, Alessandro Roberto / Lepore, Giuseppe / Geni, Francesca / Fiorina, Roberta Maria / Catena, Emanuele / Corsico, Angelo /

Colombo, Riccardo / Mirani, Marco / De Riva, Carlo / Oleandri, Salvatore Endrio / Abdi, Reza / Bonventre, Joseph V / Rusconi, Stefano / Folli, Franco / Di Sabatino, Antonio / Zuccotti, Gianvincenzo / Galli, Massimo / Fiorina, Paolo

Diabetes care

Abstract: OBJECTIVE: Poor outcomes have been reported in patients with type 2 diabetes and coronavirus disease 2019 (COVID-19); thus, it is mandatory to explore novel therapeutic approaches for this population. RESEARCH DESIGN AND METHODS: In a multicenter, case- ... ...

Abstract	OBJECTIVE: Poor outcomes have been reported in patients with type 2 diabetes and coronavirus disease 2019 (COVID-19); thus, it is mandatory to explore novel therapeutic approaches for this population. RESEARCH DESIGN AND METHODS: In a multicenter, case-control, retrospective, observational study, sitagliptin, an oral and highly selective dipeptidyl peptidase 4 inhibitor, was added to standard of care (e.g., insulin administration) at the time of hospitalization in patients with type 2 diabetes who were hospitalized with COVID-19. Every center also recruited at a 1:1 ratio untreated control subjects matched for age and sex. All patients had pneumonia and exhibited oxygen saturation <95% when breathing ambient air or when receiving oxygen support. The primary end points were discharge from the hospital/death and improvement of clinical outcomes, defined as an increase in at least two points on a seven-category modified ordinal scale. Data were collected retrospectively from patients receiving sitagliptin from 1 March through 30 April 2020. RESULTS: Of the 338 consecutive patients with type 2 diabetes and COVID-19 admitted in Northern Italy hospitals included in this study, 169 were on sitagliptin, while 169 were on standard of care. Treatment with sitagliptin at the time of hospitalization was associated with reduced mortality (18% vs. 37% of deceased patients; hazard ratio 0.44 [95% CI 0.29-0.66]; P = 0.0001), with an improvement in clinical outcomes (60% vs. 38% of improved patients; P = 0.0001) and with a greater number of hospital discharges (120 vs. 89 of discharged patients; P = 0.0008) compared with patients receiving standard of care, respectively. CONCLUSIONS: In this multicenter, case-control, retrospective, observational study of patients with type 2 diabetes admitted to the hospital for COVID-19, sitagliptin treatment at the time of hospitalization was associated with reduced mortality and improved clinical outcomes as compared with standard-of-care treatment. The effects of sitagliptin in patients with type 2 diabetes and COVID-19 should be confirmed in an ongoing randomized, placebo-controlled trial.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #809048
Database	COVID19

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