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Article ; Online: A Quantum Algorithm from Response Theory: Digital Quantum Simulation of Two-Dimensional Electronic Spectroscopy.

Bruschi, Matteo / Gallina, Federico / Fresch, Barbara

The journal of physical chemistry letters

2024 Volume 15, Issue 5, Page(s) 1484–1492

Abstract: Multidimensional optical spectroscopies are powerful techniques to investigate energy transfer pathways in natural and artificial systems. Because of the high information content of the spectra, numerical simulations of the optical response are of ... ...

Abstract	Multidimensional optical spectroscopies are powerful techniques to investigate energy transfer pathways in natural and artificial systems. Because of the high information content of the spectra, numerical simulations of the optical response are of primary importance to assist the interpretation of spectral features. However, the increasing complexity of the investigated systems and their quantum dynamics call for the development of novel simulation strategies. In this work, we consider using digital quantum computers. By combining quantum dynamical simulation and nonlinear response theory, we present a quantum algorithm for computing the optical response of molecular systems. The quantum advantage stems from the efficient quantum simulation of the dynamics governed by the molecular Hamiltonian, and it is demonstrated by explicitly considering exciton-vibrational coupling. The protocol is tested on a near-term quantum device, providing the digital quantum simulation of the linear and nonlinear response of simple molecular models.
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.3c03499
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Article ; Online: Unifying Nonlinear Response and Incoherent Mixing in Action-2D Electronic Spectroscopy.

Bruschi, Matteo / Bolzonello, Luca / Gallina, Federico / Fresch, Barbara

The journal of physical chemistry letters

2023 Volume 14, Issue 30, Page(s) 6872–6879

Abstract: Action-detection has expanded the scope and applicability of 2D electronic spectroscopy, while posing new challenges for the unambiguous interpretation of spectral features. In this context, identifying the origin of cross-peaks at early waiting times is ...

Abstract	Action-detection has expanded the scope and applicability of 2D electronic spectroscopy, while posing new challenges for the unambiguous interpretation of spectral features. In this context, identifying the origin of cross-peaks at early waiting times is not trivial, and incoherent mixing is often invoked as an unwanted contribution masking the nonlinear signal. In this work, we elaborate on the relation between the nonlinear response and the incoherent mixing contribution by analyzing the action signal in terms of one- and two-particle observables. Considering a weakly interacting molecular dimer, we show how cross-peaks at early waiting times, reflecting exciton-exciton annihilation dynamics, can be equivalently interpreted as arising from incoherent mixing. This equivalence, on the one hand, highlights the information content of spectral features related to incoherent mixing and, on the other hand, provides an efficient numerical scheme to simulate the action response of weakly interacting systems.
Language	English
Publishing date	2023-07-25
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.3c01670
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Article ; Online: Release of Mafia-crime prisoners during the COVID-19 epidemic: imbalance between detainee's health and public safety.

Gallina, Pasquale / Giannicco, G / Gallina, F

BMJ military health

2020 Volume 166, Issue 6, Page(s) 444

MeSH term(s)	COVID-19/prevention & control ; Crime ; Humans ; Italy ; Pandemics ; Prisoners/legislation & jurisprudence ; Prisons ; SARS-CoV-2 ; Safety
Language	English
Publishing date	2020-11-26
Publishing country	England
Document type	Letter
ZDB-ID	3011686-7
ISSN	2633-3775 ; 2633-3767
ISSN (online)	2633-3775
ISSN	2633-3767
DOI	10.1136/bmjmilitary-2020-001689
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Article ; Online: Simulating action-2D electronic spectroscopy of quantum dots: insights on the exciton and biexciton interplay from detection-mode and time-gating.

Bruschi, Matteo / Gallina, Federico / Fresch, Barbara

Physical chemistry chemical physics : PCCP

2022 Volume 24, Issue 45, Page(s) 27645–27659

Abstract: Action-2D electronic spectroscopy is emerging as a powerful technique to investigate exciton dynamics in molecular aggregates and nanostructures. While maintaining the power of highlighting coherent evolution between the laser pulses, action detection is ...

Abstract	Action-2D electronic spectroscopy is emerging as a powerful technique to investigate exciton dynamics in molecular aggregates and nanostructures. While maintaining the power of highlighting coherent evolution between the laser pulses, action detection is based on measuring the incoherent signal proportional to the excited-state populations generated by an additional laser pulse. Numerical simulations of the action signal play a crucial role in aiding the interpretation of the spectral features, which may differ from those of the analog coherent technique in a non-trivial way. We present a numerical investigation of the action response of a model of quantum dot as a case study to unravel the exciton and biexciton contributions in the 2D-spectra of nanostructures. The simulation protocol is based on a non-perturbative treatment of the light-matter interaction by solving the Lindblad quantum master equation and the different contributions to the non-linear response are disentangled using a phase-modulation scheme. We analyze how the relative weights of the exciton and biexciton signals determine the lineshape of the spectrum, how they depend upon the physical nature of the detected signal,
Language	English
Publishing date	2022-11-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d2cp04270c
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Article ; Online: A primarily clinician's responsibility.

Jankovic, Momcilo / Biondi, Andrea / Gallina, Francesca / Cortinovis, Diego

Pediatric blood & cancer

2022 Volume 69, Issue 9, Page(s) e29612

Language	English
Publishing date	2022-02-23
Publishing country	United States
Document type	Letter
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.29612
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Zs.A 1131: Show issues

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Article ; Online: Do we really need fine-needle biopsy needle for an ultrasound-guided biopsy of pancreatic adenocarcinoma? A retrospective study.

Orlando, D / Gallina, F / Forcella, D / Marandino, F / Visca, P / Venti, E / Pierconti, F / Assisi, D

European review for medical and pharmacological sciences

2021 Volume 25, Issue 21, Page(s) 6492–6498

Abstract: Objective: Endoscopic ultrasound (EUS)-guided FNB was not demonstrated to be better than EUS fine-needle aspiration (FNA) to obtain adequate samples for diagnosis of pancreatic tumors. We report our experience using a 22-gauge needle aspiration to ... ...

Abstract	Objective: Endoscopic ultrasound (EUS)-guided FNB was not demonstrated to be better than EUS fine-needle aspiration (FNA) to obtain adequate samples for diagnosis of pancreatic tumors. We report our experience using a 22-gauge needle aspiration to obtain both cytologic and histologic samples. Patients and methods: In a total of 232 patients (51% men), 22-gauge needles (Cook Medical) were used to obtain a cytological sample (between 2008 and 2016, Cohort A) and a cytologic and a histologic sample (between 2016 and 2019, Cohort B) to evaluate the usability of this needle to collect material for cytologic and histologic examination. MOSE was used. Results: Pancreatic adenocarcinoma was diagnosed in 76/113 (68%) patients in Cohort A and in 88/119 (74%) in Cohort B. Non-diagnostic sampling occurred in 30/113 (26%) patients in Cohort A and in 25/119 (21%) in Cohort B. The median number of passages was three in both cohorts. Lesions were in the head/uncinated process 57% vs. 51% and body/tail 43% vs. 49% in Cohorts A and B, respectively; the mean tumor size was 34.5 mm (SD 10.7) in Cohort A and 35.4 mm (SD 14.7) in Cohort B. Conclusions: FNA needle (22-gauge) with adequate passes, MOSE determination and adequate processing of specimens, provided FNA and FNB specimen collection.
MeSH term(s)	Adenocarcinoma/diagnosis ; Adenocarcinoma/pathology ; Aged ; Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Female ; Humans ; Male ; Middle Aged ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/pathology ; Retrospective Studies
Language	English
Publishing date	2021-11-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202111_27093
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Zs.A 1887: Show issues

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Article ; Online: Uniportal thoracoscopic left main bronchus resection with new lobar carina reconstruction.

Mercadante, Edoardo / Alessandrini, Gabriele / Forcella, Daniele / Melis, Enrico / Gallina, Filippo / Facciolo, Francesco

Multimedia manual of cardiothoracic surgery : MMCTS

2020 Volume 2020

Abstract: Isolated endobronchial tumors of the left main bronchus are quite rare. They are treated by surgical resection, preferably using lung-sparing techniques, when possible. These procedures are technically challenging and are usually performed through a ... ...

Abstract	Isolated endobronchial tumors of the left main bronchus are quite rare. They are treated by surgical resection, preferably using lung-sparing techniques, when possible. These procedures are technically challenging and are usually performed through a standard thoracotomy. This video tutorial shows a left main bronchus sleeve resection with distal lobar carina reconstruction, performed through a uniportal thoracoscopic approach, for a typical carcinoid tumor of the distal left main bronchus.
MeSH term(s)	Adult ; Bronchi/pathology ; Bronchi/surgery ; Bronchial Neoplasms/pathology ; Bronchial Neoplasms/surgery ; Carcinoid Tumor/pathology ; Carcinoid Tumor/surgery ; Humans ; Male ; Organ Sparing Treatments/methods ; Pneumonectomy/methods ; Reconstructive Surgical Procedures/methods ; Thoracic Surgery, Video-Assisted/methods ; Treatment Outcome
Language	English
Publishing date	2020-07-06
Publishing country	England
Document type	Case Reports ; Video-Audio Media
ZDB-ID	2280156-X
ISSN	1813-9175 ; 1813-9175
ISSN (online)	1813-9175
ISSN	1813-9175
DOI	10.1510/mmcts.2020.039
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Article ; Online: CD28/PD1 co-expression: dual impact on CD8

Palermo, Belinda / Franzese, Ornella / Frisullo, Giuseppe / D'Ambrosio, Lorenzo / Panetta, Mariangela / Campo, Giulia / D'Andrea, Daniel / Sperduti, Isabella / De Nicola, Francesca / Goeman, Frauke / Gallina, Filippo / Visca, Paolo / Facciolo, Francesco / Nisticò, Paola

Journal of experimental & clinical cancer research : CR

2023 Volume 42, Issue 1, Page(s) 287

Abstract: Background: Immune checkpoint blockade (ICB) has significantly prolonged survival of non-small cell lung cancer (NSCLC) patients, although most patients develop mechanisms of resistance. Recently single-cell RNA-sequencing (scRNA-Seq) revealed a huge T- ... ...

Abstract	Background: Immune checkpoint blockade (ICB) has significantly prolonged survival of non-small cell lung cancer (NSCLC) patients, although most patients develop mechanisms of resistance. Recently single-cell RNA-sequencing (scRNA-Seq) revealed a huge T-cell phenotypic and (dys)functional state variability. Accordingly, T-cell exhaustion is recognized as a functional adaptation, with a dynamic progression from a long-lived "pre-exhausted stem-like progenitor" to a "terminally exhausted" state. In this scenario it is crucial to understand the complex interplay between co-stimulatory and inhibitory molecules in CD8 Methods: To gain a baseline landscape of the composition, functional states, and transcriptomic signatures predictive of prognosis, we analyzed CD8 Results: Despite the increased PD1 levels, an improved PD1 Conclusions: Our findings identify signatures able to stratify survival of LUAD patients and predict ICB response in advanced NSCLC. CD28 is advocated as a key determinant in the signatures identified, in both periphery and tumor site, thus likely providing feasible biomarkers of ICB response.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; CD8-Positive T-Lymphocytes ; CD28 Antigens/genetics ; CD28 Antigens/therapeutic use ; Immune Checkpoint Inhibitors/therapeutic use ; Hepatitis A Virus Cellular Receptor 2/genetics ; Lung Neoplasms/pathology ; Adenocarcinoma of Lung/pathology
Chemical Substances	CD28 Antigens ; Immune Checkpoint Inhibitors ; Hepatitis A Virus Cellular Receptor 2
Language	English
Publishing date	2023-10-28
Publishing country	England
Document type	Journal Article
ZDB-ID	803138-1
ISSN	1756-9966 ; 0392-9078
ISSN (online)	1756-9966
ISSN	0392-9078
DOI	10.1186/s13046-023-02846-3
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Zs.A 2065: Show issues

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Article ; Online: Non-Small Cell Lung Cancer With N1 Involvement or Skip Metastases Presents the Same Survival Outcome: Results From a Multicentric Study.

Chiappetta, Marco / Sassorossi, Carolina / Lococo, Filippo / Sperduti, Isabella / Mucilli, Felice / Lyberis, Paraskevas / Ratto, GiovanniBattista / Spaggiari, Lorenzo / Gallina, Filippo / Facciolo, Francesco / Margaritora, Stefano

Clinical lung cancer

2023 Volume 24, Issue 7, Page(s) e275–e281

Abstract: Background: The prognostic difference among patients affected by NSCLC with hilar metastases only or mediastinal nodes metastases without hilar involvement (skip metastases) is still unclear. Aim of this study is to analyse if prognostic difference are ... ...

Abstract	Background: The prognostic difference among patients affected by NSCLC with hilar metastases only or mediastinal nodes metastases without hilar involvement (skip metastases) is still unclear. Aim of this study is to analyse if prognostic difference are present or if the two groups present the same survival outcome. Materials and methods: Data on NSCLC patients from 7 high volume centres (2004-2014) were collected and retrospectively reviewed. Histology different from adenocarcinoma(ADC) or squamous cell carcinoma(SCC), patients without data on lymphadenectomy, who underwent neoadjuvant treatment, with distant metastases or incomplete resection were excluded, selecting patients with hilar involvement or with skip metastases. Different prognostic factors such as Tstage, histology, pathological stage, nodal characteristics and adjuvant therapy administration were correlated to overall survival (OS) by the Kaplan-Meier product-limit method. The log-rank test was used to assess differences between subgroups. A multivariable Cox proportional hazard model was developed using stepwise regression to compare the prognostic power of different factors. Results: The final analysis was conducted on 480 adenocarcinoma/squamous cell carcinoma patients. Five-year OS (5YOS) resulted 53.9%. No significant differences in OS were detected comparing pN1 vs. pN2 patients or stage IIB vs. stage IIIA-B patients. Univariable confirmed as favourable prognostic factors young age (P<.001), T1-2 tumors (P=.030), number of resected nodes≥10 (P=.040), lymph node ratio (P=.026). Multivariable analysis confirmed as independent negative prognostic factors T≥3 (HR:1.385, 95%CI:1.037-1.851, P=.027) and age≥68 years (HR1.637, 95%CI:1.245-2.152). Conclusion: Patients with N1 involvement or skip metastases present a similar prognosis, suggesting that N2 involvement in these cases may be related to a direct lymphatic drainage to the mediastinal stations.
MeSH term(s)	Humans ; Aged ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/pathology ; Retrospective Studies ; Neoplasm Staging ; Prognosis ; Adenocarcinoma/pathology ; Carcinoma, Squamous Cell/therapy ; Carcinoma, Squamous Cell/pathology ; Lymph Nodes/pathology ; Mediastinal Neoplasms/pathology ; Survival Rate
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	2145146-1
ISSN	1938-0690 ; 1525-7304
ISSN (online)	1938-0690
ISSN	1525-7304
DOI	10.1016/j.cllc.2023.06.007
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Zs.A 5893: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: KRAS G12C mutation and risk of disease recurrence in stage I surgically resected lung adenocarcinoma.

Gallina, F T / Marinelli, D / Melis, E / Forcella, D / Taje, R / Buglioni, S / Visca, P / Torchia, A / Cecere, F L / Botticelli, A / Santini, D / Ciliberto, G / Cappuzzo, F / Facciolo, F

Lung cancer (Amsterdam, Netherlands)

2023 Volume 181, Page(s) 107254

Abstract: KRAS G12C mutations are found in about 12-13% of LUAD samples and it is unclear whether they are associated with worse survival outcomes in resected, stage I LUAD. We assessed whether KRAS-G12C mutated tumours had worse DFS when compared to KRAS-nonG12C ... ...

Abstract	KRAS G12C mutations are found in about 12-13% of LUAD samples and it is unclear whether they are associated with worse survival outcomes in resected, stage I LUAD. We assessed whether KRAS-G12C mutated tumours had worse DFS when compared to KRAS-nonG12C mutated tumours and to KRAS wild-type tumours in a cohort of resected, stage I LUAD (IRE cohort). We then leveraged on publicly available datasets (TCGA-LUAD, MSK-LUAD
MeSH term(s)	Humans ; Proto-Oncogene Proteins p21(ras)/genetics ; Prognosis ; Lung Neoplasms/pathology ; Adenocarcinoma of Lung ; Mutation
Chemical Substances	Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; KRAS protein, human
Language	English
Publishing date	2023-05-24
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632771-0
ISSN	1872-8332 ; 0169-5002
ISSN (online)	1872-8332
ISSN	0169-5002
DOI	10.1016/j.lungcan.2023.107254
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Zs.A 2135: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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