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  1. Article ; Online: The Emerging Role of Tumor Deposits as an Independent Prognostic Factor in Advanced Colorectal Cancer.

    Gallo, Gaetano

    Journal of investigative surgery : the official journal of the Academy of Surgical Research

    2021  Volume 35, Issue 4, Page(s) 860–861

    MeSH term(s) Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Extranodal Extension ; Humans ; Neoplasm Staging ; Prognosis
    Language English
    Publishing date 2021-06-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 639444-9
    ISSN 1521-0553 ; 0894-1939
    ISSN (online) 1521-0553
    ISSN 0894-1939
    DOI 10.1080/08941939.2021.1936304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Grand challenges in colorectal and proctological surgery.

    Gallo, Gaetano / Goglia, Marta

    Frontiers in surgery

    2023  Volume 10, Page(s) 1331877

    Language English
    Publishing date 2023-12-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1331877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Updates on ulcerative colitis and Crohn's disease: from bench to bedside.

    D'Andrea, Vito / Gallo, Gaetano

    Frontiers in medicine

    2023  Volume 10, Page(s) 1285660

    Language English
    Publishing date 2023-09-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1285660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clinical evidence and rationale of mesoglycan to treat chronic venous disease and hemorrhoidal disease: a narrative review.

    Gallo, Gaetano / Picciariello, Arcangelo / Tufano, Antonella / Camporese, Giuseppe

    Updates in surgery

    2024  Volume 76, Issue 2, Page(s) 423–434

    Abstract: Chronic venous disease (CVD) and hemorrhoidal disease (HD) are among the most common vascular diseases in the world, with CVD affecting 22-41% of the population in Europe and HD having a point prevalence of 11-39%. The burden is substantial in terms of ... ...

    Abstract Chronic venous disease (CVD) and hemorrhoidal disease (HD) are among the most common vascular diseases in the world, with CVD affecting 22-41% of the population in Europe and HD having a point prevalence of 11-39%. The burden is substantial in terms of the effect of symptoms on patients' health-related quality of life (HRQoL) and direct/indirect medical costs. Treatment begins with lifestyle changes, compression in CVD and topical therapies in HD, and escalates as needed through oral therapies first and eventually to surgery for severe disease. CVD and HD share etiological features and pathological changes affecting the structure and function of the tissue extracellular matrix. Mesoglycan, a natural glycosaminoglycan (GAG) preparation composed primarily of heparan sulfate and dermatan sulfate, has been demonstrated to positively impact the underlying causes of CVD and HD, regenerating the glycocalyx and restoring endothelial function, in addition to having antithrombotic, profibrinolytic, anti-inflammatory, antiedema and wound-healing effects. In clinical trials, oral mesoglycan reduced the severity of CVD signs and symptoms, improved HRQoL, and accelerated ulcer healing. In patients with HD, mesoglycan significantly reduced the severity of signs and symptoms and the risk of rectal bleeding. In patients undergoing excisional hemorrhoidectomy, adding mesoglycan to standard postoperative care reduced pain, improved HRQoL, reduced incidence of thrombosis, and facilitated an earlier return to normal activities/work, compared with standard postoperative care alone. The clinical effects of mesoglycan in patients with CVD or HD are consistent with the agent's known mechanisms of action.
    MeSH term(s) Humans ; Hemorrhoids/drug therapy ; Quality of Life ; Vascular Diseases/drug therapy ; Glycosaminoglycans/therapeutic use ; Chronic Disease
    Chemical Substances mesoglycan (80455-95-4) ; Glycosaminoglycans
    Language English
    Publishing date 2024-02-14
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-024-01776-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sclerotherapy with 3% polidocanol foam for the treatment of mucocutaneous bridges and/or residual piles after open excisional hemorrhoidectomy.

    Gallo, Gaetano / Laforgia, Rita / Goglia, Marta / Lobascio, Pierluigi

    Updates in surgery

    2024  

    Abstract: Injection sclerotherapy is an effective and safe treatment in selected cases. It might be used as the first treatment for I-III degree hemorrhoidal disease (HD), but also as a bridge therapy for more severe cases not amenable to invasive treatments. ... ...

    Abstract Injection sclerotherapy is an effective and safe treatment in selected cases. It might be used as the first treatment for I-III degree hemorrhoidal disease (HD), but also as a bridge therapy for more severe cases not amenable to invasive treatments. However, concerning the long-term recurrence rate, open excisional hemorrhoidectomy remains the gold standard in cases of III- and IV-degree HD. In this context, it is recommended to perform the excision of no more than three piles and to preserve the muco-cutaneous bridges to avoid post-operative anal stenosis. The aim of this study is to evaluate surgical outcomes and efficacy of the combined treatment of open excisional hemorrhoidectomy and the use of ST on the remnant muco-cutaneous bridges/residual piles. This was a single-center retrospective study and a total of 18 patients with IV-degree HD, aged between 18 and 75 years with symptomatic HD according to the Goligher classification, were enrolled between January 2023 and June 2023 and their follow-up continued until October 2023 after reaching 3 months of follow-up. The Hemorrhoidal Disease Symptom Score (HDSS), the Short Health Scale for HD (SHS-HD) score and the Vaizey Incontinence Score were used to assess symptoms and their impact on quality of life and continence. A total of 77.8% (14/18) of the patients were symptom-free (hemorrhoidal disease symptom score (HDSS) score = 0) after 3 months. Moreover, a statistically significant decrease in the median HDSS and short health scale for HD (SHS-HD) score was registered from 16 preoperatively (T0) to 2 at 3-month follow-up (T3). Neither post-operative bleeding nor any type of complications occurred. The use of sclerotherapy in combination with the traditional open excisional hemorrhoidectomy has shown promising results. Further structured studies are needed and greater dissemination and education of the general surgeon on the subject is necessary.
    Language English
    Publishing date 2024-03-13
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-024-01798-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Preoperative Colorectal-Cancer Detection: Do We Need Anything Else? An Invited Brief Commentary on Is CT Scan More Accurate than Endoscopy in Identifying Distance from the Anal Verge for Left-sided Colon Cancer? A Comparative Cohort Analysis.

    Gallo, Gaetano

    Journal of investigative surgery : the official journal of the Academy of Surgical Research

    2018  Volume 33, Issue 3, Page(s) 281–282

    MeSH term(s) Anal Canal ; Colonic Neoplasms ; Colorectal Neoplasms ; Endoscopy ; Humans ; Tomography, X-Ray Computed
    Language English
    Publishing date 2018-10-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 639444-9
    ISSN 1521-0553 ; 0894-1939
    ISSN (online) 1521-0553
    ISSN 0894-1939
    DOI 10.1080/08941939.2018.1497735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Role of Insulin in Hepatic Regeneration: A New Frontier in Liver Function. An Invited Brief Commentary on "Insulin Metabolism and Assessment of Hepatic Insulin Extraction During Liver Regeneration. A Study in a Rat Model".

    Gallo, Gaetano

    Journal of investigative surgery : the official journal of the Academy of Surgical Research

    2018  Volume 33, Issue 1, Page(s) 77–78

    MeSH term(s) Animals ; Blood Glucose ; Insulin ; Liver ; Liver Regeneration ; Rats
    Chemical Substances Blood Glucose ; Insulin
    Language English
    Publishing date 2018-10-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 639444-9
    ISSN 1521-0553 ; 0894-1939
    ISSN (online) 1521-0553
    ISSN 0894-1939
    DOI 10.1080/08941939.2018.1488020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Postoperative Bleeding Following Minimally Invasive Surgery for Pilonidal Disease.

    Basso, Luigi / Gallo, Gaetano

    Diseases of the colon and rectum

    2022  Volume 65, Issue 4, Page(s) e248

    MeSH term(s) Curettage ; Humans ; Minimally Invasive Surgical Procedures/adverse effects ; Neoplasm Recurrence, Local/surgery ; Phenol ; Pilonidal Sinus/surgery ; Platelet-Rich Plasma
    Chemical Substances Phenol (339NCG44TV)
    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000002404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Sclerotherapy with 3% polidocanol foam in the treatment of hemorrhoidal disease: unveiling the missing pieces for a comprehensive evaluation.

    Gallo, Gaetano / Dezi, Agnese / Grossi, Ugo / Picciariello, Arcangelo

    Frontiers in surgery

    2023  Volume 10, Page(s) 1344724

    Language English
    Publishing date 2023-12-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1344724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Modified Karydakis procedure for sacrococcygeal pilonidal disease under local anaesthesia - a video vignette.

    Grossi, Ugo / Pelizzo, Patrizia / Gallo, Gaetano / Piccino, Marco / Zanus, Giacomo

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2023  Volume 25, Issue 6, Page(s) 1307–1308

    MeSH term(s) Humans ; Anesthesia, Local ; Neoplasm Recurrence, Local ; Surgical Flaps ; Pilonidal Sinus/surgery ; Sacrococcygeal Region/surgery ; Recurrence
    Language English
    Publishing date 2023-03-05
    Publishing country England
    Document type Video-Audio Media ; Letter
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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