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  1. Article ; Online: Overview of Facebook Use by Hospitals in Italy: A Nationwide Survey during the COVID-19 Emergency.

    Schiavone, Beniamino / Vitale, Andrea / Gallo, Mena / Russo, Gianlucasalvatore / Ponticelli, Domenico / Borrelli, Mario

    International journal of environmental research and public health

    2021  Volume 18, Issue 14

    Abstract: ... ...

    Abstract Background
    MeSH term(s) COVID-19 ; Communicable Disease Control ; Hospitals ; Humans ; Italy ; SARS-CoV-2 ; Social Media
    Language English
    Publishing date 2021-07-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18147225
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  2. Article ; Online: Comparison between available early antiviral treatments in outpatients with SARS-CoV-2 infection: a real-life study.

    Rinaldi, Matteo / Campoli, Caterina / Gallo, Mena / Marzolla, Domenico / Zuppiroli, Alberto / Riccardi, Riccardo / Casarini, Martina / Riccucci, Daniele / Malosso, Marta / Bonazzetti, Cecilia / Pascale, Renato / Tazza, Beatrice / Pasquini, Zeno / Marconi, Lorenzo / Curti, Stefania / Giannella, Maddalena / Viale, Pierluigi

    BMC infectious diseases

    2023  Volume 23, Issue 1, Page(s) 646

    Abstract: Purpose: To investigate the clinical impact of three available antivirals for early COVID-19 treatment in a large real-life cohort.: Methods: Between January and October 2022 all outpatients tested positive for SARS-CoV-2 referring to IRCCS S. Orsola ...

    Abstract Purpose: To investigate the clinical impact of three available antivirals for early COVID-19 treatment in a large real-life cohort.
    Methods: Between January and October 2022 all outpatients tested positive for SARS-CoV-2 referring to IRCCS S. Orsola hospital treated with an early antiviral therapy were enrolled. A comparison between patients treated with nirmatrelvir/ritonavir (NTV/r), molnupiravir (MPV) and remdesivir (RDV) was conducted in term of indications and outcome. To account for differences between treatment groups a propensity score analysis was performed. After estimating the weights, we fitted a survey-weighted Cox regression model with inverse-probability weighting with hospital admission/death versus clinical recovery as the primary outcome.
    Results: Overall 1342 patients were enrolled, 775 (57.8%), 360 (26.8%) and 207 (15.4%) in MPV, NTV/r and RDV group, respectively. Median age was 73 (59-82) years, male sex was 53.4%. Primary indication was immunosuppression (438, 32.6%), the median time from symptom onset to drug administration was 3 [2-4] days. Overall, clinical recovery was reached in 96.9% of patients, with hospital admission rate of 2.6%. No significant differences were found in clinical recovery nor hospitalization. Cox regression showed a decreased probability of hospital admission/ death among prior vaccinated patients compared with unvaccinated (HR 0.31 [95%CI 0.14-0.70], p = 0.005]). No difference in hospitalization rates in early treatment compared to late treatment were found.
    Conclusions: No differences among MPV, NTV/r and RDV in terms of clinical recovery or hospitalization were found. Patients not vaccinated had a significant increased risk of hospitalization.
    MeSH term(s) Humans ; Male ; Aged ; Outpatients ; COVID-19 Drug Treatment ; COVID-19 ; SARS-CoV-2 ; Antiviral Agents/therapeutic use ; Ritonavir/therapeutic use
    Chemical Substances molnupiravir (YA84KI1VEW) ; Antiviral Agents ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 2023-10-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-023-08538-9
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  3. Article ; Online: Predictive model for bacterial co-infection in patients hospitalized for COVID-19: a multicenter observational cohort study.

    Giannella, Maddalena / Rinaldi, Matteo / Tesini, Giulia / Gallo, Mena / Cipriani, Veronica / Vatamanu, Oana / Campoli, Caterina / Toschi, Alice / Ferraro, Giuseppe / Horna, Clara Solera / Bartoletti, Michele / Ambretti, Simone / Violante, Francesco / Viale, Pierluigi / Curti, Stefania

    Infection

    2022  Volume 50, Issue 5, Page(s) 1243–1253

    Abstract: Objective: The aim of our study was to build a predictive model able to stratify the risk of bacterial co-infection at hospitalization in patients with COVID-19.: Methods: Multicenter observational study of adult patients hospitalized from February ... ...

    Abstract Objective: The aim of our study was to build a predictive model able to stratify the risk of bacterial co-infection at hospitalization in patients with COVID-19.
    Methods: Multicenter observational study of adult patients hospitalized from February to December 2020 with confirmed COVID-19 diagnosis. Endpoint was microbiologically documented bacterial co-infection diagnosed within 72 h from hospitalization. The cohort was randomly split into derivation and validation cohort. To investigate risk factors for co-infection univariable and multivariable logistic regression analyses were performed. Predictive risk score was obtained assigning a point value corresponding to β-coefficients to the variables in the multivariable model. ROC analysis in the validation cohort was used to estimate prediction accuracy.
    Results: Overall, 1733 patients were analyzed: 61.4% males, median age 69 years (IQR 57-80), median Charlson 3 (IQR 2-6). Co-infection was diagnosed in 110 (6.3%) patients. Empirical antibiotics were started in 64.2 and 59.5% of patients with and without co-infection (p = 0.35). At multivariable analysis in the derivation cohort: WBC ≥ 7.7/mm
    Conclusions: Our score may be useful in stratifying bacterial co-infection risk in COVID-19 hospitalized patients, optimizing diagnostic testing and antibiotic use.
    MeSH term(s) Adult ; Aged ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/diagnosis ; Bacterial Infections/epidemiology ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing ; Cohort Studies ; Coinfection/diagnosis ; Coinfection/epidemiology ; Female ; Hospitalization ; Humans ; Male ; Retrospective Studies
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-04-29
    Publishing country Germany
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-022-01801-2
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    Zs.A 881: Show issues Location:
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    Zs.MO 528: Show issues

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  4. Article: Cholangiocarcinoma and Occupational Exposure to Asbestos: Insights From the Italian Pooled Cohort Study.

    Curti, Stefania / Gallo, Mena / Ferrante, Daniela / Bella, Francesca / Boschetti, Lorenza / Casotto, Veronica / Ceppi, Marcello / Cervino, Daniela / Fazzo, Lucia / Fedeli, Ugo / Giorgi Rossi, Paolo / Giovannetti, Lucia / Girardi, Paolo / Lando, Cecilia / Migliore, Enrica / Miligi, Lucia / Oddone, Enrico / Perlangeli, Vincenza / Pernetti, Roberta /
    Piro, Sara / Storchi, Cinzia / Tumino, Rosario / Zona, Amerigo / Zorzi, Manuel / Brandi, Giovanni / Ferretti, Stefano / Magnani, Corrado / Marinaccio, Alessandro / Mattioli, Stefano

    La Medicina del lavoro

    2024  Volume 115, Issue 2, Page(s) e2024016

    Abstract: Background: Recent studies supported the association between occupational exposure to asbestos and risk of cholangiocarcinoma (CC). Aim of the present study is to investigate this association using an update of mortality data from the Italian pooled ... ...

    Abstract Background: Recent studies supported the association between occupational exposure to asbestos and risk of cholangiocarcinoma (CC). Aim of the present study is to investigate this association using an update of mortality data from the Italian pooled asbestos cohort study and to test record linkage to Cancer Registries to distinguish between hepatocellular carcinoma (HCC) and intrahepatic/extrahepatic forms of CC.
    Methods: The update of a large cohort study pooling 52 Italian industrial cohorts of workers formerly exposed to asbestos was carried out. Causes of death were coded according to ICD. Linkage was carried out for those subjects who died for liver or bile duct cancer with data on histological subtype provided by Cancer Registries.
    Results: 47 cohorts took part in the study (57,227 subjects). We identified 639 causes of death for liver and bile duct cancer in the 44 cohorts covered by Cancer Registry. Of these 639, 240 cases were linked to Cancer Registry, namely 14 CC, 83 HCC, 117 cases with unspecified histology, 25 other carcinomas, and one case of cirrhosis (likely precancerous condition). Of the 14 CC, 12 occurred in 2010-2019, two in 2000-2009, and none before 2000.
    Conclusion: Further studies are needed to explore the association between occupational exposure to asbestos and CC. Record linkage was hampered due to incomplete coverage of the study areas and periods by Cancer Registries. The identification of CC among unspecific histology cases is fundamental to establish more effective and targeted liver cancer screening strategies.
    MeSH term(s) Humans ; Cholangiocarcinoma/epidemiology ; Cholangiocarcinoma/etiology ; Occupational Exposure/adverse effects ; Italy/epidemiology ; Bile Duct Neoplasms/epidemiology ; Bile Duct Neoplasms/etiology ; Male ; Asbestos/adverse effects ; Cohort Studies ; Female ; Middle Aged ; Aged ; Occupational Diseases/epidemiology ; Occupational Diseases/etiology ; Liver Neoplasms/epidemiology ; Liver Neoplasms/etiology ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/etiology ; Registries
    Chemical Substances Asbestos (1332-21-4)
    Language English
    Publishing date 2024-04-24
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123678-7
    ISSN 0025-7818
    ISSN 0025-7818
    DOI 10.23749/mdl.v115i2.14649
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    Un I Zs.265: Show issues Location:
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    Zs.MO 395: Show issues

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  5. Article ; Online: Validation of the INCREMENT-SOT-CPE score in a large cohort of liver transplant recipients with carbapenem-resistant Enterobacterales infection.

    Rinaldi, Matteo / Bonazzetti, Cecilia / Gallo, Mena / Ferraro, Giuseppe / Freire, Maristela / Terrabuio, Débora Raquel Benedita / Tandoi, Francesco / Romagnoli, Renato / De Rosa, Francesco Giuseppe / Mularoni, Alessandra / Ferrarese, Alberto / Burra, Patrizia / Halpern, Marcia / Balbi, Elizabeth / Simkins, Jacques / Abbo, Lilian / Morrás, Ignacio / Cantero, Mireia / Alagna, Laura /
    Bandera, Alessandra / Clemente, Wanessa Trinidade / Valerio, Maricela / Fernández, Ainhoa / Muñoz, Patricia / Statlender, Liran / Yahav, Dafna / Camargo, Luis Fernando Aranha / Girão, Evelyne Santana / Grossi, Paolo / Viale, Pierluigi / Curti, Stefania / Giannella, Maddalena

    Transplant infectious disease : an official journal of the Transplantation Society

    2023  Volume 25, Issue 2, Page(s) e14036

    Abstract: Background: Management of infections due to carbapenemase-resistant Enterobacterales (CRE) in solid organ transplant (SOT) recipients remains a difficult challenge. The INCREMENT-SOT-CPE score has been specifically developed from SOT recipients to ... ...

    Abstract Background: Management of infections due to carbapenemase-resistant Enterobacterales (CRE) in solid organ transplant (SOT) recipients remains a difficult challenge. The INCREMENT-SOT-CPE score has been specifically developed from SOT recipients to stratify mortality risk, but an external validation is lacking.
    Methods: Multicenter retrospective cohort study of liver transplant (LT) recipients colonized with CRE infection who developed infection after transplant over 7-year period. Primary endpoint was all-cause 30-day mortality from infection onset. A comparison between INCREMENT-SOT-CPE and other selected scores was performed. A two-level mixed effects logistic regression model with random effects for the center was fitted. Performance characteristics at optimal cut-point were calculated. Multivariable Cox regression analysis of risk factors for all-cause 30-day mortality was carried out.
    Results: Overall, 250 CRE carriers developed infection after LT and were analyzed. The median age was 55 years (interquartile range [IQR]: 46-62) and 157 were males (62.8%). All-cause 30-day mortality was 35.6%. A sequential organ failure assessment (SOFA) score ≥ 11 showed a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of 69.7%, 76.4%, 62.0%, 82.0%, and 74.0%, respectively. An INCREMENT-SOT-CPE ≥ 11 reported a sensitivity, specificity, PPV, NPV, and accuracy of 73.0%, 62.1%, 51.6%, 80.6% and 66.0%, respectively. At multivariable analysis acute renal failure, prolonged mechanical ventilation, INCREMENT-SOT-CPE score ≥ 11 and SOFA score ≥ 11 were independently associated with all-cause 30-day mortality, while a tigecycline-based targeted regimen was found to be protective.
    Conclusions: Both INCREMENT-SOT-CPE ≥ 11 and SOFA ≥ 11 were identified as strong predictors of all-cause 30-day mortality in a large cohort of CRE carriers developing infection after LT.
    MeSH term(s) Male ; Humans ; Middle Aged ; Female ; Organ Transplantation/adverse effects ; Liver Transplantation/adverse effects ; Carbapenems ; Retrospective Studies ; Risk Factors ; Transplant Recipients
    Chemical Substances Carbapenems
    Language English
    Publishing date 2023-03-07
    Publishing country Denmark
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.14036
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