LIVIVO - Search results -

Search results

Result 1 - 10 of total 59

Search options

Article: The senescence-associated secretory phenotype as a driver of tumor growth: does G3BP1 hold the key?

Omer, Amr / Di Marco, Sergio / Gallouzi, Imed-Eddine

Molecular & cellular oncology

2021 Volume 8, Issue 1, Page(s) 1850161

Abstract: Cellular senescence is a double-edged sword that, depending on the context, acts as either a potent tumor protective mechanism or an age-related driver of diseases such as cancer. Our recent findings show that the rasGAP SH3-binding protein 1 (G3BP1) ... ...

Abstract	Cellular senescence is a double-edged sword that, depending on the context, acts as either a potent tumor protective mechanism or an age-related driver of diseases such as cancer. Our recent findings show that the rasGAP SH3-binding protein 1 (G3BP1) activates the senescent-associated secretory phenotype (SASP) that, in turn, mediates cancer growth/progression.
Language	English
Publishing date	2021-01-11
Publishing country	United States
Document type	Journal Article
ISSN	2372-3556
ISSN	2372-3556
DOI	10.1080/23723556.2020.1850161
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: pADP-ribosylation regulates the cytoplasmic localization, cleavage, and pro-apoptotic function of HuR.

Ashour, Kholoud / Sali, Sujitha / Aldoukhi, Ali H / Hall, Derek / Mubaid, Souad / Busque, Sandrine / Lian, Xian Jin / Gagné, Jean-Philippe / Khattak, Shahryar / Di Marco, Sergio / Poirier, Guy G / Gallouzi, Imed-Eddine

Life science alliance

2024 Volume 7, Issue 6

Abstract: HuR (ElavL1) is one of the main post-transcriptional regulators that determines cell fate. Although the role of HuR in apoptosis is well established, the post-translational modifications that govern this function remain elusive. In this study, we show ... ...

Abstract	HuR (ElavL1) is one of the main post-transcriptional regulators that determines cell fate. Although the role of HuR in apoptosis is well established, the post-translational modifications that govern this function remain elusive. In this study, we show that PARP1/2-mediated poly(ADP)-ribosylation (PARylation) is instrumental in the pro-apoptotic function of HuR. During apoptosis, a substantial reduction in HuR PARylation is observed. This results in the cytoplasmic accumulation and the cleavage of HuR, both of which are essential events for apoptosis. These effects are mediated by a pADP-ribose-binding motif within the HuR-HNS region (HuR PAR-binding site). Under normal conditions, the association of the HuR PAR-binding site with pADP-ribose is responsible for the nuclear retention of HuR. Mutations within this motif prevent the binding of HuR to its import factor TRN2, leading to its cytoplasmic accumulation and cleavage. Collectively, our findings underscore the role of PARylation in controlling the pro-apoptotic function of HuR, offering insight into the mechanism by which PARP1/2 enzymes regulate cell fate and adaptation to various assaults.
MeSH term(s)	Ribose ; Protein Processing, Post-Translational ; Mutation ; Cell Differentiation ; Protein Domains
Chemical Substances	Ribose (681HV46001)
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ISSN	2575-1077
ISSN (online)	2575-1077
DOI	10.26508/lsa.202302316
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Could stress granules be involved in age-related diseases?

Gallouzi, Imed-Eddine

Aging

2009 Volume 1, Issue 9, Page(s) 753–757

MeSH term(s)	Aging/physiology ; Animals ; Cellular Senescence/physiology ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Cytoplasmic Granules/physiology ; Disease/etiology ; Eukaryotic Initiation Factor-2/metabolism ; HSP70 Heat-Shock Proteins/metabolism ; Humans ; Models, Biological ; Neoplasms/etiology ; Neoplasms/pathology ; Neoplasms/physiopathology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Stress, Physiological/physiology
Chemical Substances	Cyclin-Dependent Kinase Inhibitor p21 ; Eukaryotic Initiation Factor-2 ; HSP70 Heat-Shock Proteins ; RNA, Messenger
Language	English
Publishing date	2009-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.100090
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The formation of HuR/YB1 complex is required for the stabilization of target mRNA to promote myogenesis.

Sánchez, Brenda Janice / Mubaid, Souad / Busque, Sandrine / de Los Santos, Yossef Lopez / Ashour, Kholoud / Sadek, Jason / Lian, Xian Jin / Khattak, Shahryar / Di Marco, Sergio / Gallouzi, Imed-Eddine

Nucleic acids research

2023 Volume 51, Issue 3, Page(s) 1375–1392

Abstract: mRNA stability is the mechanism by which cells protect transcripts allowing their expression to execute various functions that affect cell metabolism and fate. It is well-established that RNA binding proteins (RBPs) such as HuR use their ability to ... ...

Abstract	mRNA stability is the mechanism by which cells protect transcripts allowing their expression to execute various functions that affect cell metabolism and fate. It is well-established that RNA binding proteins (RBPs) such as HuR use their ability to stabilize mRNA targets to modulate vital processes such as muscle fiber formation (myogenesis). However, the machinery and the mechanisms regulating mRNA stabilization are still elusive. Here, we identified Y-Box binding protein 1 (YB1) as an indispensable HuR binding partner for mRNA stabilization and promotion of myogenesis. Both HuR and YB1 bind to 409 common mRNA targets, 147 of which contain a U-rich consensus motif in their 3' untranslated region (3'UTR) that can also be found in mRNA targets in other cell systems. YB1 and HuR form a heterodimer that associates with the U-rich consensus motif to stabilize key promyogenic mRNAs. The formation of this complex involves a small domain in HuR (227-234) that if mutated prevents HuR from reestablishing myogenesis in siHuR-treated muscle cells. Together our data uncover that YB1 is a key player in HuR-mediated stabilization of pro-myogenic mRNAs and provide the first indication that the mRNA stability mechanism is as complex as other key cellular processes such as mRNA decay and translation.
MeSH term(s)	3' Untranslated Regions ; ELAV Proteins/genetics ; ELAV Proteins/metabolism ; ELAV-Like Protein 1/metabolism ; Muscle Development ; Muscle Fibers, Skeletal/metabolism ; RNA Stability ; RNA, Messenger/metabolism ; Cell Line ; Animals ; Mice ; Transcription Factors/metabolism
Chemical Substances	3' Untranslated Regions ; ELAV Proteins ; ELAV-Like Protein 1 ; RNA, Messenger ; Elavl1 protein, mouse ; YB-1 protein, mouse ; Transcription Factors
Language	English
Publishing date	2023-01-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkac1245
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1067: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Tankyrase-1 regulates RBP-mediated mRNA turnover to promote muscle fiber formation.

Mubaid, Souad / Sanchez, Brenda Janice / Algehani, Rinad A / Skopenkova, Viktoriia / Adjibade, Pauline / Hall, Derek T / Busque, Sandrine / Lian, Xian Jin / Ashour, Kholoud / Tremblay, Anne-Marie K / Carlile, Graeme / Gagné, Jean-Philippe / Diaz-Gaxiola, Andrea / Khattak, Shahryar / Di Marco, Sergio / Thomas, David Y / Poirier, Guy G / Gallouzi, Imed-Eddine

Nucleic acids research

2024 Volume 52, Issue 7, Page(s) 4002–4020

Abstract: Poly(ADP-ribosylation) (PARylation) is a post-translational modification mediated by a subset of ADP-ribosyl transferases (ARTs). Although PARylation-inhibition based therapies are considered as an avenue to combat debilitating diseases such as cancer ... ...

Abstract	Poly(ADP-ribosylation) (PARylation) is a post-translational modification mediated by a subset of ADP-ribosyl transferases (ARTs). Although PARylation-inhibition based therapies are considered as an avenue to combat debilitating diseases such as cancer and myopathies, the role of this modification in physiological processes such as cell differentiation remains unclear. Here, we show that Tankyrase1 (TNKS1), a PARylating ART, plays a major role in myogenesis, a vital process known to drive muscle fiber formation and regeneration. Although all bona fide PARPs are expressed in muscle cells, experiments using siRNA-mediated knockdown or pharmacological inhibition show that TNKS1 is the enzyme responsible of catalyzing PARylation during myogenesis. Via this activity, TNKS1 controls the turnover of mRNAs encoding myogenic regulatory factors such as nucleophosmin (NPM) and myogenin. TNKS1 mediates these effects by targeting RNA-binding proteins such as Human Antigen R (HuR). HuR harbors a conserved TNKS-binding motif (TBM), the mutation of which not only prevents the association of HuR with TNKS1 and its PARylation, but also precludes HuR from regulating the turnover of NPM and myogenin mRNAs as well as from promoting myogenesis. Therefore, our data uncover a new role for TNKS1 as a key modulator of RBP-mediated post-transcriptional events required for vital processes such as myogenesis.
MeSH term(s)	Tankyrases/metabolism ; Tankyrases/genetics ; Humans ; RNA, Messenger/metabolism ; RNA, Messenger/genetics ; Muscle Development/genetics ; Animals ; Muscle Fibers, Skeletal/metabolism ; Mice ; Myogenin/genetics ; Myogenin/metabolism ; Nucleophosmin ; ELAV-Like Protein 1/metabolism ; ELAV-Like Protein 1/genetics ; RNA Stability/genetics ; Poly ADP Ribosylation/genetics ; Cell Line ; Nuclear Proteins/metabolism ; Nuclear Proteins/genetics ; Cell Differentiation/genetics ; RNA-Binding Proteins/metabolism ; RNA-Binding Proteins/genetics ; HEK293 Cells
Chemical Substances	Tankyrases (EC 2.4.2.30) ; RNA, Messenger ; Myogenin ; Nucleophosmin (117896-08-9) ; ELAV-Like Protein 1 ; TNKS protein, human (EC 2.4.2.30) ; NPM1 protein, human ; ELAVL1 protein, human ; Nuclear Proteins ; RNA-Binding Proteins ; Tnks protein, mouse (EC 2.4.2.30)
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkae059
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1067: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Alternative polyadenylation and the stress response.

Sadek, Jason / Omer, Amr / Hall, Derek / Ashour, Kholoud / Gallouzi, Imed Eddine

Wiley interdisciplinary reviews. RNA

2019 Volume 10, Issue 5, Page(s) e1540

Abstract: The cellular stress response is a universal mechanism necessary for the survival of all organisms. This multifaceted process is primarily driven by regulation of gene expression to produce an intracellular environment suitable for promoting cell survival ...

Abstract	The cellular stress response is a universal mechanism necessary for the survival of all organisms. This multifaceted process is primarily driven by regulation of gene expression to produce an intracellular environment suitable for promoting cell survival and recovery. Posttranscriptional regulatory events are considered as critical mechanisms that modulate core characteristics of mRNA transcripts to promote cell adaptation to various assaults. While the impact of processes such as mRNA splicing, turnover, localization, and translation on the cellular stress response has been extensively studied, recent observations highlight the role of alternative polyadenylation (APA) in response to challenges such as oxidative stress, heat shock, and starvation. The role of APA is comprehensive with far reaching effects on mRNA stability, mRNA localization, and protein coding sequences. Nonetheless, APA remains a relatively unappreciated mode of gene regulation despite its role in regulating key mediators of the stress response. The goal of this review is to provide an overview of the recent advances in our understanding of the various ways by which APA affects cell adaptation to its environment and discuss how a defect in APA could have deleterious consequences on cell survival. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Structure and Dynamics > Influence of RNA Structure in Biological Systems RNA Processing > 3' End Processing.
MeSH term(s)	Humans ; Oxidative Stress/genetics ; Polyadenylation ; RNA, Messenger/chemistry ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Stress, Physiological/genetics
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2019-05-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2634714-3
ISSN	1757-7012 ; 1757-7004
ISSN (online)	1757-7012
ISSN	1757-7004
DOI	10.1002/wrna.1540
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6953: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: G3BP1 controls the senescence-associated secretome and its impact on cancer progression.

Omer, Amr / Barrera, Monica Cruz / Moran, Julian L / Lian, Xian J / Di Marco, Sergio / Beausejour, Christian / Gallouzi, Imed-Eddine

Nature communications

2020 Volume 11, Issue 1, Page(s) 4979

Abstract: Cellular senescence is a known driver of carcinogenesis and age-related diseases, yet senescence is required for various physiological processes. However, the mechanisms and factors that control the negative effects of senescence while retaining its ... ...

Abstract	Cellular senescence is a known driver of carcinogenesis and age-related diseases, yet senescence is required for various physiological processes. However, the mechanisms and factors that control the negative effects of senescence while retaining its benefits are still elusive. Here, we show that the rasGAP SH3-binding protein 1 (G3BP1) is required for the activation of the senescent-associated secretory phenotype (SASP). During senescence, G3BP1 achieves this effect by promoting the association of the cyclic GMP-AMP synthase (cGAS) with cytosolic chromatin fragments. In turn, G3BP1, through cGAS, activates the NF-κB and STAT3 pathways, promoting SASP expression and secretion. G3BP1 depletion or pharmacological inhibition impairs the cGAS-pathway preventing the expression of SASP factors without affecting cell commitment to senescence. These SASPless senescent cells impair senescence-mediated growth of cancer cells in vitro and tumor growth in vivo. Our data reveal that G3BP1 is required for SASP expression and that SASP secretion is a primary mediator of senescence-associated tumor growth.
MeSH term(s)	A549 Cells ; Animals ; Carcinogenesis ; Cell Line ; Cell Movement ; Cellular Senescence/physiology ; Cytokines/metabolism ; DNA Helicases/antagonists & inhibitors ; DNA Helicases/deficiency ; DNA Helicases/metabolism ; Humans ; Inflammation ; Mice ; Neoplasms/metabolism ; Neoplasms/pathology ; Nucleotidyltransferases/metabolism ; Poly-ADP-Ribose Binding Proteins/antagonists & inhibitors ; Poly-ADP-Ribose Binding Proteins/deficiency ; Poly-ADP-Ribose Binding Proteins/metabolism ; RNA Helicases/antagonists & inhibitors ; RNA Helicases/deficiency ; RNA Helicases/metabolism ; RNA Recognition Motif Proteins/antagonists & inhibitors ; RNA Recognition Motif Proteins/deficiency ; RNA Recognition Motif Proteins/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Transcription Factor RelA/metabolism
Chemical Substances	Cytokines ; Poly-ADP-Ribose Binding Proteins ; RELA protein, human ; RNA Recognition Motif Proteins ; STAT3 Transcription Factor ; STAT3 protein, human ; Transcription Factor RelA ; Nucleotidyltransferases (EC 2.7.7.-) ; cGAS protein, human (EC 2.7.7.-) ; DNA Helicases (EC 3.6.4.-) ; G3BP1 protein, human (EC 3.6.4.12) ; RNA Helicases (EC 3.6.4.13)
Language	English
Publishing date	2020-10-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-18734-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Autophagy and heat-shock response impair stress granule assembly during cellular senescence.

Omer, Amr / Patel, Devang / Moran, Julian Lucas / Lian, Xian Jin / Di Marco, Sergio / Gallouzi, Imed-Eddine

Mechanisms of ageing and development

2020 Volume 192, Page(s) 111382

Abstract: Stress granules (SGs) are membraneless organelles formed in response to insult. These granules are related to pathological granules found in age-related neurogenerative diseases such as Parkinson's and Alzheimer's. Previously, we demonstrated that ... ...

Abstract	Stress granules (SGs) are membraneless organelles formed in response to insult. These granules are related to pathological granules found in age-related neurogenerative diseases such as Parkinson's and Alzheimer's. Previously, we demonstrated that senescent cells, which accumulate with age, exposed to chronic oxidative stress, are unable to form SGs. Here, we show that the senescent cells' inability to form SGs correlates with an upregulation in both the heat-shock response and autophagy pathways, both of which are well-established promoters of SG disassembly. Our data also reveals that the knockdown of HSP70 and ATG5, important components of the heat-shock response and autophagy pathways, respectively, restores the number of SGs formed in senescent cells exposed to chronic oxidative stress. Surprisingly, under these conditions, the depletion of HSP70 or ATG5 did not affect the clearance of these SGs during their recovery from chronic stress. These data reveal that senescent cells possess a unique heat-shock and autophagy-dependent ability to impair the formation of SGs in response to chronic stress, thereby expanding the existing understanding of SG dynamics in senescent cells and their potential contribution to age-related neurodegenerative diseases.
MeSH term(s)	Aging/physiology ; Autophagy/physiology ; Autophagy-Related Protein 5/metabolism ; Cell Line ; Cellular Senescence ; Cytoplasmic Granules/physiology ; Gene Expression Regulation ; HSP70 Heat-Shock Proteins/metabolism ; Heat-Shock Response/physiology ; Humans ; Oxidative Stress/physiology ; Ribonucleoproteins/metabolism ; Stress, Physiological
Chemical Substances	Autophagy-Related Protein 5 ; HSP70 Heat-Shock Proteins ; Ribonucleoproteins ; messenger ribonucleoprotein
Language	English
Publishing date	2020-10-10
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	183915-9
ISSN	1872-6216 ; 0047-6374
ISSN (online)	1872-6216
ISSN	0047-6374
DOI	10.1016/j.mad.2020.111382
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1012: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Available for a limited time only: Regulating gene expression through mRNA turnover.

Gallouzi, Imed Eddine / von Roretz, Christopher

Seminars in cell & developmental biology

2014 Volume 34, Page(s) 1

MeSH term(s)	Animals ; Gene Expression Regulation ; Humans ; RNA Stability ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2014-10
Publishing country	England
Document type	Editorial ; Introductory Journal Article
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2014.06.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2918: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Role of Human Antigen R (HuR) in the Regulation of Pulmonary ACE2 Expression.

Aloufi, Noof / Haidar, Zahraa / Ding, Jun / Nair, Parameswaran / Benedetti, Andrea / Eidelman, David H / Gallouzi, Imed-Eddine / Di Marco, Sergio / Hussain, Sabah N / Baglole, Carolyn J

Cells

2021 Volume 11, Issue 1

Abstract: Patients with COPD may be at an increased risk for severe illness from COVID-19 because of ACE2 upregulation, the entry receptor for SARS-CoV-2. Chronic exposure to cigarette smoke, the main risk factor for COPD, increases pulmonary ACE2. How ACE2 ... ...

Abstract	Patients with COPD may be at an increased risk for severe illness from COVID-19 because of ACE2 upregulation, the entry receptor for SARS-CoV-2. Chronic exposure to cigarette smoke, the main risk factor for COPD, increases pulmonary ACE2. How ACE2 expression is controlled is not known but may involve HuR, an RNA binding protein that increases protein expression by stabilizing mRNA. We hypothesized that HuR would increase ACE2 protein expression. We analyzed scRNA-seq data to profile
MeSH term(s)	Aged ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/genetics ; COVID-19/metabolism ; COVID-19/virology ; Cells, Cultured ; ELAV-Like Protein 1/genetics ; ELAV-Like Protein 1/metabolism ; Female ; Fibroblasts/metabolism ; Gene Expression Profiling/methods ; Gene Expression Regulation ; Humans ; Lung/metabolism ; Lung/pathology ; Lung/virology ; Male ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/metabolism ; Pulmonary Disease, Chronic Obstructive/virology ; RNA Interference ; RNA-Seq/methods ; SARS-CoV-2/physiology ; Single-Cell Analysis/methods
Chemical Substances	ELAV-Like Protein 1 ; ELAVL1 protein, human ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-12-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11010022
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

Your last searches

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito