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  1. Book ; Thesis: Antigen-spezifische CD8+-T-Zell-vermittelte limbische Enzephalitis als Ursache einer Temporallappen-Epilepsie mit Hippocampussklerose

    Gallus, Marco

    2021  

    Title variant CDachtplus-T-Zell-vermittelte
    Institution Westfälische Wilhelms-Universität Münster
    Author's details vorgelegt von Gallus, Marco aus Nürnberg
    Language German
    Size 91, XXIV Blätter, Illustrationen, Diagramme
    Publishing place Münster
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Westfälische Wilhelms-Universität Münster, 2021
    Note Plus im Titel höhergestellt
    HBZ-ID HT021188030
    Database Catalogue ZB MED Medicine, Health

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    2022 E 411 order for loan Magazin

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  2. Article: Correction: Gallus et al. Immunotherapy Approaches in Isocitrate-Dehydrogenase-Mutant Low-Grade Glioma.

    Gallus, Marco / Kwok, Darwin / Lakshmanachetty, Senthilnath / Yamamichi, Akane / Okada, Hideho

    Cancers

    2023  Volume 16, Issue 1

    Abstract: It has come to our attention that the previously published manuscript contained an outdated iteration of Table 1 [ ... ]. ...

    Abstract It has come to our attention that the previously published manuscript contained an outdated iteration of Table 1 [...].
    Language English
    Publishing date 2023-12-26
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16010119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Immunotherapy Approaches in Isocitrate-Dehydrogenase-Mutant Low-Grade Glioma.

    Gallus, Marco / Kwok, Darwin / Lakshmanachetty, Senthilnath / Yamamichi, Akane / Okada, Hideho

    Cancers

    2023  Volume 15, Issue 14

    Abstract: Low-grade gliomas (LGGs) are slow-growing tumors in the central nervous system (CNS). Patients characteristically show the onset of seizures or neurological deficits due to the predominant LGG location in high-functional brain areas. As a molecular ... ...

    Abstract Low-grade gliomas (LGGs) are slow-growing tumors in the central nervous system (CNS). Patients characteristically show the onset of seizures or neurological deficits due to the predominant LGG location in high-functional brain areas. As a molecular hallmark, LGGs display mutations in the isocitrate dehydrogenase (IDH) enzymes, resulting in an altered cellular energy metabolism and the production of the oncometabolite D-2-hydroxyglutarate. Despite the remarkable progress in improving the extent of resection and adjuvant radiotherapy and chemotherapy, LGG remains incurable, and secondary malignant transformation is often observed. Therefore, novel therapeutic approaches are urgently needed. In recent years, immunotherapeutic strategies have led to tremendous success in various cancer types, but the effect of immunotherapy against glioma has been limited due to several challenges, such as tumor heterogeneity and the immunologically "cold" tumor microenvironment. Nevertheless, recent preclinical and clinical findings from immunotherapy trials are encouraging and offer a glimmer of hope for treating IDH-mutant LGG patients. Here, we aim to review the lessons learned from trials involving vaccines, T-cell therapies, and IDH-mutant inhibitors and discuss future approaches to enhance the efficacy of immunotherapies in IDH-mutant LGG.
    Language English
    Publishing date 2023-07-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15143726
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  4. Article: How Should We Treat Meningeal Melanocytoma? A Retrospective Analysis of Potential Treatment Strategies.

    Ricchizzi, Sarah / Gallus, Marco / Stummer, Walter / Holling, Markus

    Cancers

    2022  Volume 14, Issue 23

    Abstract: Background: Meningeal melanocytomas (MM) are rare primary melanocytic tumors of the leptomeninges with an incidence of 1:10,000,000. Until now, there has been only sparse information about this tumor entity. Here, we provide a meta-analysis of all cases ...

    Abstract Background: Meningeal melanocytomas (MM) are rare primary melanocytic tumors of the leptomeninges with an incidence of 1:10,000,000. Until now, there has been only sparse information about this tumor entity. Here, we provide a meta-analysis of all cases published in the English language since 1972.
    Methods: A literature review was performed using PubMed and Web of Science. All published cases were evaluated for location, sex, age, therapeutic approach, and outcome. In total, we included 201 patient cases in our meta-analysis.
    Results: The majority of MM was diagnosed more frequently in men between the third and fifth decade of life. Surgery is the preferred therapeutic approach, and total resection is associated with the best outcome. Patients with partial resection or tumor recurrence benefit from adjuvant radiotherapy, whereas chemo- or immunotherapies do not improve the disease course. Malignant transformation was described in 18 patients. Of these, 11 patients developed metastasis.
    Conclusions: We present the first retrospective meta-analysis of all MM cases published in the English language, including an evaluation of different treatment strategies allowing us to suggest a novel treatment guideline highlighting the importance of total resection for recurrence-free survival and characterizing those cases which benefit from adjuvant radiotherapy.
    Language English
    Publishing date 2022-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14235851
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  5. Article ; Online: Does Early Mobilization Following Resection of Spinal Intra-Dural Pathology Increase the Risk of Cerebrospinal Fluid Leaks?-A Dual-Center Comparative Effectiveness Research.

    Schwake, Michael / Krahwinkel, Sophia / Gallus, Marco / Schipmann, Stephanie / Maragno, Emanuele / Neuschmelting, Volker / Perrech, Moritz / Müther, Michael / Lenschow, Moritz

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 1

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Comparative Effectiveness Research ; Early Ambulation ; Plastic Surgery Procedures ; Spinal Neoplasms ; Cerebrospinal Fluid Leak/etiology
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60010171
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  6. Article ; Online: A Retrospective Cohort Study Evaluating the Comparative Effectiveness of Unilateral Hemilaminectomy and Bilateral Laminectomy in the Resection of Spinal Meningiomas.

    Said, Wesam / Maragno, Emanuele / Leibrandt, Lara / Spille, Dorothee / Schipmann, Stephanie / Stummer, Walter / Gallus, Marco / Schwake, Michael

    Operative neurosurgery (Hagerstown, Md.)

    2024  

    Abstract: Background and objectives: The primary treatment modality for spinal meningiomas (SM) is surgical resection. In recent years, minimal invasive spine surgery has gained considerable popularity, attributing its growth to advancements in surgical ... ...

    Abstract Background and objectives: The primary treatment modality for spinal meningiomas (SM) is surgical resection. In recent years, minimal invasive spine surgery has gained considerable popularity, attributing its growth to advancements in surgical technologies and improved training of surgeons. Nonetheless, the suitability and effectiveness of minimal invasive spine surgery for intradural spinal tumor resection remain a subject of debate. In this cohort study, we aimed to compare the extent of resection of the unilateral hemilaminectomy approach, a less invasive technique, with the more traditional and invasive bilateral laminectomy.
    Methods: We performed a retrospective cohort study including patients with SM who underwent surgery at our department between 1996 and 2020. Cohorts included patients who underwent tumor resection through bilateral laminectomy and patients who underwent a unilateral hemilaminectomy. The primary end point was extent of resection according to the Simpson classification.
    Results: Of 131 with SM, 36 had a bilateral laminectomy and 95 were operated through a unilateral hemilaminectomy. In both groups, gross total resection, Simpson grades 1 and 2, was achieved in 94.44% and 94.74%, respectively (P = .999). The neurological outcome was also comparable in both cohorts (P = .356). Both length of hospital stay and estimated blood loss were significantly lower in the unilateral cohort (P < .05).
    Conclusion: The results of this study indicate that the unilateral hemilaminectomy yields comparable results in both oncological and neurological outcome when compared with the bilateral laminectomy. Thus, unilateral hemilaminectomy may serve as a viable and safe alternative for the surgical removal of SM.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1227/ons.0000000000001099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mixed Reality as a Teaching Tool for Medical Students in Neurosurgery.

    Silvero Isidre, Arturo / Friederichs, Hendrik / Müther, Michael / Gallus, Marco / Stummer, Walter / Holling, Markus

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 10

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Augmented Reality ; Neurosurgery ; Students, Medical ; Curriculum ; Educational Measurement
    Language English
    Publishing date 2023-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59101720
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  8. Article ; Online: Resection of Intramedullary Hemangioblastoma: Timing of Surgery and Its Impact on Neurological Outcome and Quality of Life.

    Schwake, Michael / Ricchizzi, Sarah / Krahwinkel, Sophia / Maragno, Emanuele / Schipmann, Stephanie / Stummer, Walter / Gallus, Marco / Holling, Markus

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 9

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Adult ; Humans ; Hemangioblastoma/surgery ; Quality of Life ; Retrospective Studies ; Cross Infection ; Length of Stay
    Language English
    Publishing date 2023-09-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59091611
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  9. Article ; Online: The Role of Prolonged Bed Rest in Postoperative Cerebrospinal Fluid Leakage After Surgery of Intradural Pathology-A Retrospective Cohort Study.

    Krahwinkel, Sophia / Schipmann, Stephanie / Spille, Dorothee / Maragno, Emanuele / Al Barim, Bilal / Warneke, Nils / Stummer, Walter / Gallus, Marco / Schwake, Michael

    Neurosurgery

    2023  Volume 93, Issue 3, Page(s) 563–575

    Abstract: Background: Postoperative cerebrospinal fluid leakage (CSFL) is a feared complication after surgery on intradural pathologies and may cause postoperative complications and subsequently higher treatment costs.: Objective: To assess whether prolonged ... ...

    Abstract Background: Postoperative cerebrospinal fluid leakage (CSFL) is a feared complication after surgery on intradural pathologies and may cause postoperative complications and subsequently higher treatment costs.
    Objective: To assess whether prolonged bed rest may lower the risk of CSFL.
    Methods: We performed a retrospective cohort study including patients with intradural pathologies who underwent surgery at our department between 2013 and 2021. Cohorts included patients who completed 3 days of postoperative bed rest and patients who were mobilized earlier. The primary end point was the occurrence of clinically proven CSFL.
    Results: Four hundred and thirty-three patients were included (female [51.7%], male [48.3%]) with a mean age of 48 years (SD ±20). Bed rest was ordered in 315 cases (72.7%). In 7 cases (N = 7/433, 1.6%), we identified a postoperative CSFL. Four of them (N = 4/118) did not preserve bed rest, showing no significant difference to the bed rest cohort (N = 3/315; P = .091). In univariate analysis, laminectomy (N = 4/61; odds ratio [OR] 8.632, 95% CI 1.883-39.573), expansion duraplasty (N = 6/70; OR 33.938, 95% CI 4.019-286.615), and recurrent surgery (N = 5/66; OR 14.959, 95% CI 2.838-78.838) were significant risk factors for developing CSFL. In multivariate analysis, expansion duraplasty was confirmed as independent risk factor (OR 33.937, 95% CI 4.018-286.615, P = .001). In addition, patients with CSFL had significant higher risk for meningitis (N = 3/7; 42.8%, P = .001).
    Conclusion: Prolonged bed rest did not protect patients from developing CSFL after surgery on intradural pathologies. Avoiding laminectomy, large voids, and minimal invasive approaches may play a role in preventing CSFL. Furthermore, special caution is indicated if expansion duraplasty was done.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Bed Rest/adverse effects ; Retrospective Studies ; Cerebrospinal Fluid Leak/epidemiology ; Cerebrospinal Fluid Leak/etiology ; Laminectomy/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/neu.0000000000002448
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    Zs.MO 539: Show issues

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  10. Article ; Online: Postoperative surveillance in cranial and spinal tumor neurosurgery: when is this warranted?

    Schipmann, Stephanie / Spille, Dorothee Cäcilia / Gallus, Marco / Lohmann, Sebastian / Schwake, Michael / Warneke, Nils / Suero Molina, Eric / Stummer, Walter / Holling, Markus

    Journal of neurosurgery

    2022  Volume 138, Issue 5, Page(s) 1188–1198

    Abstract: Objective: The outbreak of COVID-19 and the sudden increase in the number of patients requiring mechanical ventilation significantly affected the management of neurooncological patients. Hospitals were forced to reallocate already scarce human resources ...

    Abstract Objective: The outbreak of COVID-19 and the sudden increase in the number of patients requiring mechanical ventilation significantly affected the management of neurooncological patients. Hospitals were forced to reallocate already scarce human resources to maximize intensive care unit (ICU) capacities, resulting in a significant postponement of elective procedures for patients with brain and spinal tumors, who traditionally require elective postoperative surveillance on ICU or intermediate care wards. This study aimed to characterize those patients in whom postoperative monitoring is required by analyzing early postoperative complications and associated risk factors.
    Methods: All patients included in the analysis experienced benign or malignant cerebral or intradural tumors and underwent surgery between September 2017 and May 2019 at University Hospital Münster, Germany. Patient data were generated from a semiautomatic, prospectively designed database. The occurrence of adverse events within 24 hours and 30 days postoperatively-including unplanned reoperation, postoperative hemorrhage, CSF leakage, and pulmonary embolism-was chosen as the primary outcome measure. Furthermore, reasons and risk factors that led to a prolonged stay on the ICU were investigated. By performing multivariable logistic regression modeling, a risk score for early postoperative adverse events was calculated by assigning points based on beta coefficients.
    Results: Eight hundred eleven patients were included in the study. Eleven patients (1.4%) had an early adverse event within 24 hours, which was either an unplanned reoperation (0.9%, n = 7) or a pulmonary embolism (0.5%, n = 4) within 24 hours. To predict the incidence of early postoperative complications, a score was developed including the number of secondary diagnoses, BMI, and incision closure time, termed the SOS score. According to this score, 0.3% of the patients were at low risk, 2.5% at intermediate risk, and 12% at high risk (p < 0.001).
    Conclusions: Postoperative surveillance in cranial and spinal tumor neurosurgery might only be required in a distinct patient collective. In this study, the authors present a new score allowing efficient prediction of the likelihood of early adverse events in patients undergoing neurooncological procedures, thus helping to stratify the necessity for ICU or intermediate care unit beds. Nevertheless, validation of the score in a multicenter prospective setting is needed.
    MeSH term(s) Humans ; Spinal Neoplasms/complications ; Neurosurgery ; Prospective Studies ; COVID-19/complications ; Postoperative Complications/epidemiology ; Pulmonary Embolism ; Risk Factors
    Language English
    Publishing date 2022-09-16
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2022.7.JNS22691
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