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Article: Un polype colique qui change.

Pizzanelli, Sarah / Cauchin, Estelle / Bossard, Céline / Galmiche, Louise

2022 Volume 42, Issue 6, Page(s) 488–490

Title translation	An uncommun digestive polyp.
MeSH term(s)	Humans ; Polyps/diagnosis
Language	French
Publishing date	2022-09-23
Publishing country	France
Document type	Journal Article
ZDB-ID	225720-8
ISSN	0242-6498
ISSN	0242-6498
DOI	10.1016/j.annpat.2022.07.025
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Article ; Online: Enhanced accuracy and reduced delay in diagnosing bone tumors within an expert sarcoma network: A nationwide study.

Crenn, Vincent / Lataste, François / Galmiche, Louise / Le Nail, Louis-Romée / Ropars, Mickaël / Blay, Jean-Yves / de Pinieux, Gonzague / Gouin, Francois

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2024 Volume 50, Issue 6, Page(s) 108271

Abstract: Introduction: Primary bone tumors encompass a range of rare and diverse lesions. Pathological diagnosis poses significant challenges, with histological discrepancies extensively studied in soft tissue sarcomas but lacking specific investigation in bone ... ...

Abstract	Introduction: Primary bone tumors encompass a range of rare and diverse lesions. Pathological diagnosis poses significant challenges, with histological discrepancies extensively studied in soft tissue sarcomas but lacking specific investigation in bone lesions. This study aimed to determine the rate of major diagnostic discrepancies in primary bone tumors, assessing whether initial histological analysis within an expert referral center network reduces this rate and final diagnostic delay. Additionally, we examined the impact of mandatory systematic re-reading by expert pathologists on diagnostic variation and readjustment. Methods: Our study cohort comprised patients with primary bone tumors, drawn from the national prospective French sarcoma network database. A total of 1075 patients were included from 2018 to 2019. Results: The cohort exhibited a major discrepancy rate of 24%. Within the expert referral centers network, 49 cases (7%) showed major diagnostic discrepancies in the initial analysis, compared to 207 cases (57%) outside the network (p < 0.001). Regarding the final diagnostic delay, a mean of 2.8 weeks (±4.9) was observed within the network, contrasting with 6.5 weeks (±9.1) outside the network (p < 0.001). Systematic re-reading by an expert pathologist facilitated diagnosis readjustment in 75% of the 256 cases, with 68% of all diagnostic variations occurring preoperatively. Conclusion: Early management within the expert network significantly reduced major diagnostic discrepancies and shortened the diagnosis delay by approximately a month. Expert pathologist systematic re-readings were responsible for diagnosis readjustments in three-quarters of cases, with two-thirds of all diagnostic variations occurring preoperatively, thereby mitigating the consequences of mistreatment.
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2024.108271
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Tumeur sacrococcygienne rare.

Khneisser, Pierre / Sarnacki, Sabine / Orbach, Daniel / Brisse, Hervé / Pierron, Gaelle / Galmiche, Louise

Annales de pathologie

2020 Volume 41, Issue 2, Page(s) 232–234

Title translation	A rare sacrococcygeal tumor.
MeSH term(s)	Humans ; Neoplasms ; Sacrococcygeal Region ; Teratoma
Language	French
Publishing date	2020-10-06
Publishing country	France
Document type	Journal Article
ZDB-ID	225720-8
ISSN	0242-6498
ISSN	0242-6498
DOI	10.1016/j.annpat.2020.09.002
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Article ; Online: Impact of percutaneous pulmonary valve implantation procedural steps on leaflets histology and mechanical behaviour: An in vitro study.

Jalal, Zakaria / Galmiche, Louise / Beloin, Christophe / Boudjemline, Younes

Archives of cardiovascular diseases

2016 Volume 109, Issue 8-9, Page(s) 465–475

Abstract: Background: Percutaneous pulmonary valve implantation (PPVI) using the bovine jugular vein Melody(®) valve (Medtronic Inc., Minneapolis, MN, USA) is safe and effective. However, post-procedural complications have been reported, the reasons for which are ...

Abstract	Background: Percutaneous pulmonary valve implantation (PPVI) using the bovine jugular vein Melody(®) valve (Medtronic Inc., Minneapolis, MN, USA) is safe and effective. However, post-procedural complications have been reported, the reasons for which are unclear. Objective: To assess the impact of PPVI procedural steps on valvular histology and leaflet mechanical behaviour. Methods: Three different valved stents (the Melody(®) valve and two homemade stents with bovine and porcine pericardium) were tested in vitro under four conditions: (1) control group; (2) crimping; (3) crimping plus inflation of low-pressure balloon; (4) condition III plus post-dilatation (high-pressure balloon). For each condition, valvular leaflets (and a venous wall sample for Melody(®) stents) were taken for histological analysis and mechanical uniaxial testing of the valve leaflets. Results: Among the Melody(®) valves, the incidence of transverse fractures was significantly higher in traumatized samples compared with the control group (P<0.05), whereas the incidence and depth of transverse fractures were not statistically different between the four conditions for bovine and porcine pericardial leaflets. No significant modification of the mechanical behaviour of in vitro traumatized Melody(®) valvular leaflets was observed. Bovine and porcine pericardia became more elastic and less resilient after balloon expansion and post-dilatation (conditions III and IV), with a significant decrease in elastic modulus and stress at rupture. Conclusion: Valved stent implantation procedural steps induced histological lesions on Melody(®) valve leaflets. Conversely, bovine and porcine pericardial valved stents were not histologically altered by in vitro manipulations, although their mechanical properties were significantly modified. These data could explain some of the long-term complications observed with these substitutes.
MeSH term(s)	Animals ; Bioprosthesis ; Cattle ; Heart Valve Prosthesis ; Materials Testing/methods ; Pericardium/transplantation ; Prosthesis Design ; Pulmonary Valve/pathology ; Pulmonary Valve/surgery ; Pulmonary Valve Insufficiency/surgery ; Pulmonary Valve Stenosis/surgery ; Swine
Language	English
Publishing date	2016-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2408778-6
ISSN	1875-2128 ; 1875-2136
ISSN (online)	1875-2128
ISSN	1875-2136
DOI	10.1016/j.acvd.2016.01.015
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Article ; Online: Giant Cell Tumors With HMGA2::NCOR2 Fusion : Clinicopathologic, Molecular, and Epigenetic Study of a Distinct Entity.

Perret, Raul / Malaka, Zaki / Velasco, Valérie / Llamas-Gutierrez, Francisco / Ropars, Mickael / Linck, Pierre-Antoine / Hostein, Isabelle / Azmani, Rihab / Valo, Isabelle / Galmiche, Louise / Moreau, Anne / de Pinieux, Gonzague / Michot, Audrey / Bochaton, Dorian / Coindre, Jean-Michel / Le Loarer, François

The American journal of surgical pathology

2023 Volume 47, Issue 7, Page(s) 801–811

Abstract: Giant cell tumors (GCTs) with high mobility group AT-Hook 2 ( HMGA2 )::nuclear receptor corepressor 2 ( NCOR2 ) fusion are rare mesenchymal tumors of controversial nosology, which have been anecdotally reported to respond to CSFR1 inhibitors. Here, we ... ...

Abstract	Giant cell tumors (GCTs) with high mobility group AT-Hook 2 ( HMGA2 )::nuclear receptor corepressor 2 ( NCOR2 ) fusion are rare mesenchymal tumors of controversial nosology, which have been anecdotally reported to respond to CSFR1 inhibitors. Here, we performed a comprehensive study of 6 GCTs with HMGA2::NCOR2 fusion and explored their relationship with other giant cell-rich neoplasms. Tumors occurred in 4 females and 2 males ranging in age from 17 to 32 years old (median 24). Three lesions originated in subcutaneous soft tissue and 3 in bone. Tumor size ranged from 20 to 33 mm (median 27 mm). The lesions had a nodular/multinodular architecture and were composed of sheets of mononuclear "histiocytoid" cells with uniform nuclei intermingled with multinucleated giant cells. Mitotic activity was low and nuclear atypia and metaplastic bone were absent. Variable findings included necrosis, cystic degeneration, lymphocytic infiltrate (sometimes forming nodules), and xanthogranulomatous inflammation. On immunohistochemistry, all cases focally expressed pan-keratin and were negative with SATB2 and H3.3G34W. Whole RNA-sequencing was performed in all cases of GCT with HMGA2::NCOR2 fusion and a subset of giant cell-rich tumors (tenosynovial-GCT, n = 19 and "wild-type" GCT of soft tissue, n = 9). Hierarchical clustering of RNA-sequencing data showed that GCT with HMGA2::NCOR2 fusion formed a single cluster, independent of the other 2 entities. Methylome profiling showed similar results, but the distinction from "wild-type" GCT of soft tissue was less flagrant. Gene expression analysis showed similar levels of expression of the CSF1/CSFR1 axis between GCT with HMGA2::NCOR2 fusion and tenosynovial-GCT, supporting their potential sensitivity to CSFR1 inhibitors. Clinical follow-up was available for 5 patients (range: 10 to 64 mo; median 32 mo). Three patients (60%) experienced local recurrences, whereas none had distant metastases or died of disease. Overall, our study confirms and expands previous knowledge on GCT with HMGA2::NCOR2 fusion and supports its inclusion as an independent entity.
MeSH term(s)	Male ; Female ; Humans ; Adolescent ; Young Adult ; Adult ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/analysis ; Giant Cell Tumors/pathology ; Immunohistochemistry ; Bone and Bones/pathology ; Epigenesis, Genetic ; Nuclear Receptor Co-Repressor 2/genetics
Chemical Substances	Biomarkers, Tumor ; NCOR2 protein, human ; Nuclear Receptor Co-Repressor 2
Language	English
Publishing date	2023-05-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752964-8
ISSN	1532-0979 ; 0147-5185
ISSN (online)	1532-0979
ISSN	0147-5185
DOI	10.1097/PAS.0000000000002051
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Article ; Online: Detection and localization of calcium oxalate in kidney using synchrotron deep ultraviolet fluorescence microscopy.

Estève, Emmanuel / Buob, David / Jamme, Frédéric / Jouanneau, Chantal / Kascakova, Slavka / Haymann, Jean Philippe / Letavernier, Emmanuel / Galmiche, Louise / Ronco, Pierre / Daudon, Michel / Bazin, Dominique / Réfrégiers, Matthieu

Journal of synchrotron radiation

2022 Volume 29, Issue Pt 1, Page(s) 214–223

Abstract: Renal oxalosis is a rare cause of renal failure whose diagnosis can be challenging. Synchrotron deep ultraviolet (UV) fluorescence was assayed to improve oxalosis detection on kidney biopsies spatial resolution and sensitivity compared with the Fourier ... ...

Abstract	Renal oxalosis is a rare cause of renal failure whose diagnosis can be challenging. Synchrotron deep ultraviolet (UV) fluorescence was assayed to improve oxalosis detection on kidney biopsies spatial resolution and sensitivity compared with the Fourier transform infrared microspectroscopy gold standard. The fluorescence spectrum of synthetic mono-, di- and tri-hydrated calcium oxalate was investigated using a microspectrometer coupled to the synchrotron UV beamline DISCO, Synchrotron SOLEIL, France. The obtained spectra were used to detect oxalocalcic crystals in a case control study of 42 human kidney biopsies including 19 renal oxalosis due to primary (PHO, n = 11) and secondary hyperoxaluria (SHO, n = 8), seven samples from PHO patients who received combined kidney and liver transplants, and 16 controls. For all oxalocalcic hydrates samples, a fluorescence signal is detected at 420 nm. These spectra were used to identify standard oxalocalcic crystals in patients with PHO or SHO. They also revealed micrometric crystallites as well as non-aggregated oxalate accumulation in tubular cells. A nine-points histological score was established for the diagnosis of renal oxalosis with 100% specificity (76-100) and a 73% sensitivity (43-90). Oxalate tubular accumulation and higher histological score were correlated to lower estimated glomerular filtration rate and higher urinary oxalate over creatinine ratio.
MeSH term(s)	Calcium Oxalate ; Case-Control Studies ; Humans ; Kidney/diagnostic imaging ; Microscopy, Fluorescence ; Synchrotrons
Chemical Substances	Calcium Oxalate (2612HC57YE)
Language	English
Publishing date	2022-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2021413-3
ISSN	1600-5775 ; 0909-0495
ISSN (online)	1600-5775
ISSN	0909-0495
DOI	10.1107/S1600577521011371
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Article: Une tumeur néonatale rare de la sphère cervico-faciale.

Leclerc, Julie / Morice, Anne / Belhous, Kahina / Pierron, Gaëlle / Kadlub, Natacha / Galmiche, Louise

Annales de pathologie

2018 Volume 39, Issue 1, Page(s) 60–63

Title translation	A rare neonatal tumor of the head and neck region.
MeSH term(s)	Head and Neck Neoplasms/pathology ; Humans ; Infant, Newborn ; Male ; Rhabdomyoma/pathology
Language	French
Publishing date	2018-12-13
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	225720-8
ISSN	0242-6498
ISSN	0242-6498
DOI	10.1016/j.annpat.2018.09.004
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Article: Sphingosine Kinase-1 Is Overexpressed and Correlates with Hypoxia in Osteosarcoma: Relationship with Clinicopathological Parameters.

Gomez-Brouchet, Anne / Illac, Claire / Ledoux, Adeline / Fortin, Pierre-Yves / de Barros, Sandra / Vabre, Clémentine / Despas, Fabien / Peries, Sophie / Casaroli, Christelle / Bouvier, Corinne / Aubert, Sébastien / de Pinieux, Gonzague / Larousserie, Frédérique / Galmiche, Louise / Talmont, Franck / Pitson, Stuart / Maddelein, Marie-Lise / Cuvillier, Olivier

Cancers

2022 Volume 14, Issue 3

Abstract: The Sphingosine kinase-1/Sphingosine 1-Phosphate (SphK1/S1P) signaling pathway is overexpressed in various cancers, and is instrumental for the adaptation to hypoxia in a number of solid tumor models, but no data are available in osteosarcoma. Here we ... ...

Abstract	The Sphingosine kinase-1/Sphingosine 1-Phosphate (SphK1/S1P) signaling pathway is overexpressed in various cancers, and is instrumental for the adaptation to hypoxia in a number of solid tumor models, but no data are available in osteosarcoma. Here we report that SphK1 and the S1P
Language	English
Publishing date	2022-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14030499
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Article ; Online: A kidney discard decision strategy based on zero-time histology analysis could lead to an unjustified increase in the organ turndown rate among ECD.

Luque, Yosu / Jamme, Matthieu / Aubert, Olivier / Roux, Arthur / Martinez, Frank / Amrouche, Lucile / Tinel, Claire / Galmiche, Louise / Duong Van Huyen, Jean-Paul / Audenet, François / Legendre, Christophe / Anglicheau, Dany / Rabant, Marion

Transplant international : official journal of the European Society for Organ Transplantation

2021 Volume 34, Issue 8, Page(s) 1506–1516

Abstract: The utility of zero-time kidney biopsies (KB) in deciding to accept expanded criteria donor (ECD) kidneys remains controversial. However, zero-time histology is one of the main causes for discarding kidneys in the United States. In a single-centre study, ...

Abstract	The utility of zero-time kidney biopsies (KB) in deciding to accept expanded criteria donor (ECD) kidneys remains controversial. However, zero-time histology is one of the main causes for discarding kidneys in the United States. In a single-centre study, we examined the utility and impact on outcome of the use of frozen section zero-time KB among ECD. Ninety-two zero-time KB were analysed for accept/discard decision between 2005 and 2015 among ECD. 53% of kidneys were rejected after zero-time KB analysis; there was no difference in individual clinical and biological data between accepted/rejected groups. However, histology of rejected kidneys showed more sclerotic glomeruli (20% vs. 8%; P < 0.001), increased interstitial fibrosis (1.25 ± 0.12 vs. 0.47 ± 0.09; P < 0.0001), more arteriosclerosis (2.14 ± 0.17 vs. 1.71 ± 0.11; P = 0.0032) and arteriolar hyalinosis (2.15 ± 0.12 vs. 1.55 ± 0.11; P = 0.0006). Using propensity score matching, we generated a group of 42 kidney allograft recipients who received a transplant matched for donor zero-time histology and clinical characteristics with donors whose kidneys were rejected. Interestingly, their 1- and 5-year graft survival and function were similar to the global cohort of ECD recipients. In conclusion, when performed, zero-time KB was a decisive element for kidney discard decision. However, adverse zero-time histology was not associated with poorer graft survival and kidney function among ECD.
MeSH term(s)	Graft Survival ; Humans ; Kidney ; Kidney Transplantation ; Nephrectomy ; Retrospective Studies ; Tissue Donors ; United States
Language	English
Publishing date	2021-07-08
Publishing country	England
Document type	Journal Article
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.1111/tri.13933
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Article ; Online: A three-gene expression signature associated with positive surgical margins in tongue squamous cell carcinomas: Predicting surgical resectability from tumour biology?

Saidak, Zuzana / Pascual, Caroline / Bouaoud, Jebrane / Galmiche, Louise / Clatot, Florian / Dakpé, Stéphanie / Page, Cyril / Galmiche, Antoine

Oral oncology

2019 Volume 94, Page(s) 115–120

Abstract: Objectives: Achieving complete tumour resection is one of the main goals of surgery for head and neck squamous cell carcinoma (HNSCC) tumours. Whether biological characteristics of tumours contribute to the surgical resectability and the presence of ... ...

Abstract	Objectives: Achieving complete tumour resection is one of the main goals of surgery for head and neck squamous cell carcinoma (HNSCC) tumours. Whether biological characteristics of tumours contribute to the surgical resectability and the presence of positive surgical margins (SM) after resection of HNSCC is unclear. We aimed to address this issue. Materials and methods: We used data from The Cancer Genome Atlas (TCGA) to relate the SM status of 356 HNSCC tumours covering five major primary locations (tongue, larynx, tonsils, floor of mouth and buccal mucosa) with data from multiple omics approaches (transcriptomic, genomic and proteomic analyses). Results: We identified three differentially expressed genes whose expression was significantly associated with the presence of positive SM in tongue tumours (n = 144). The three genes (CCDC66, ZRANB2 and VCPKMT) displayed significantly higher mRNA levels in tongue tumours with positive SM compared to tumours with negative SM. The corresponding gene expression signature identified tongue tumours with a positive SM with high sensitivity and specificity (85% and 76%, respectively, Area Under the Curve (AUC) = 0.84). Tongue tumours with this signature were characterised by a high grade, elevated proliferation levels and a tumour stroma with fewer fibroblasts and endothelial cells. Conclusion: Positive SM were found to be strikingly associated with tumour biology in tongue tumours. These findings offer interesting perspectives for biomarker identification and precision surgery in these tumours.
MeSH term(s)	Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/surgery ; Female ; Humans ; Male ; Margins of Excision ; Middle Aged ; Tongue Neoplasms/pathology ; Tongue Neoplasms/surgery ; Transcriptome/genetics ; Tumor Microenvironment
Language	English
Publishing date	2019-05-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2019.05.020
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