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Article: Wound analgesia in a patient with hemophilia in a highly traumatic operation.

Levchenko, O K / Polyanskaya, T U / Zorenko, V Y / Galstian, G M

2019 Volume 90, Issue 7, Page(s) 82–85

Abstract: Aim: The aim of the study was to describe the use of the wound analgesia method in a patient with hemophilia in the case of a clinical case.: Materials and methods: A patient with severe hemophilia A underwent postoperative analgesia after total knee ...

Abstract	Aim: The aim of the study was to describe the use of the wound analgesia method in a patient with hemophilia in the case of a clinical case. Materials and methods: A patient with severe hemophilia A underwent postoperative analgesia after total knee replacement (within the first 48 hours) with an extended infusion of local anesthetic (ropivacaine) into the wound. Results: During the first 8 hours, the patient received 20 mg of morphine (with the aid of a device for patient-controlled analgesia), the pain level ranged from 7 to 4 points. Further, there was a sufficient effect (NRS - 2 points), from anesthesia only with ropivacaine, using a system for anesthetizing surgical wounds. Complications and side effects were not noted. Conclusion: The clinical case demonstrates an effective and safe method of prolonged analgesia in patients with hemophilia. Considering encouraging data, further study of wound analgesia in this category of patients is necessary.
MeSH term(s)	Adult ; Analgesia/instrumentation ; Analgesia/methods ; Analgesia, Patient-Controlled/methods ; Analgesics, Opioid/administration & dosage ; Anesthetics, Local/administration & dosage ; Arthroplasty, Replacement, Knee/methods ; Blood Loss, Surgical/prevention & control ; Hemophilia A/surgery ; Humans ; Male ; Morphine/administration & dosage ; Pain, Postoperative/prevention & control ; Postoperative Hemorrhage/prevention & control ; Ropivacaine/administration & dosage ; Treatment Outcome
Chemical Substances	Analgesics, Opioid ; Anesthetics, Local ; Morphine (76I7G6D29C) ; Ropivacaine (7IO5LYA57N)
Language	English
Publishing date	2019-01-30
Publishing country	Russia (Federation)
Document type	Case Reports
ZDB-ID	40718-5
ISSN	2309-5342 ; 0040-3660
ISSN (online)	2309-5342
ISSN	0040-3660
DOI	10.26442/terarkh201890782-85
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Article: [Using recombinant activated blood coagulation factor VII for treatment of hemorrhagic syndrome in patients with thrombocytopenia].

Galstian, G M / Kolosova, I V

Anesteziologiia i reanimatologiia

2014 Volume 59, Issue 6, Page(s) 60–66

Abstract: The review deals with an analysis of the use of recombinant activated factor clotting VII (rFVIIa) for the treatment of hemorrhagic syndrome in patients with thrombocytopenia. The review discusses cases of rFVIIa use during bleeding of different ... ...

Abstract	The review deals with an analysis of the use of recombinant activated factor clotting VII (rFVIIa) for the treatment of hemorrhagic syndrome in patients with thrombocytopenia. The review discusses cases of rFVIIa use during bleeding of different localization and different invasive interventions, a frequency of thrombotic complications and causes of the rFVlIIa insufficiency.
MeSH term(s)	Factor VIIa/administration & dosage ; Factor VIIa/adverse effects ; Factor VIIa/therapeutic use ; Hemorrhage/drug therapy ; Hemorrhage/etiology ; Humans ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/adverse effects ; Recombinant Proteins/therapeutic use ; Syndrome ; Thrombocytopenia/complications ; Thrombocytopenia/drug therapy
Chemical Substances	Recombinant Proteins ; recombinant FVIIa (AC71R787OV) ; Factor VIIa (EC 3.4.21.21)
Language	Russian
Publishing date	2014-11
Publishing country	Russia (Federation)
Document type	Journal Article ; Review
ZDB-ID	754946-5
ISSN	0201-7563
ISSN	0201-7563
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Article: [Lung artery catheterization in patients with blood diseases].

Galstian, G M / Bychinin, M V / Shulutko, E M / Gorodetskiĭ, V M

Anesteziologiia i reanimatologiia

2013 , Issue 5, Page(s) 24–30

Abstract: Unlabelled: Purpose of the study was to analyze complications of the lung artery catheterization in patients with blood disease.: Materials and methods: 93 cases of the lung artery catheterization in patients with blood disease were studied in the ... ...

Abstract	Unlabelled: Purpose of the study was to analyze complications of the lung artery catheterization in patients with blood disease. Materials and methods: 93 cases of the lung artery catheterization in patients with blood disease were studied in the retrospective research. Results: Indications for lung artery catheterization were septic shock (in 78.5% of cases) and acute respiratory failure with different etiology (in 21.5% of cases). In 31 cases (33.3%) lung artery catheterization was performed in patients with agranulocytosis and in 81 cases (87%) in patients with thrombocytopenia (platelets median was 44 10(9)/L, from 7 10(9)/L to 7 150 10(9)/L). If a thrombocytopenia was less than 30 10(9)/L the patients received transfusion of platelets concentrates. Early complications of the lung artery catheterization occurred in 5 patients with thrombocytopenia (5.4%). Character of the complications was hemorrhagic (haematoma, bleeding from place of puncture, lung bleeding) and mechanical (puncture of artery, pneumothorax, haemothorax). Number of attempts of central veins puncture was a risk factor for the complications. Frequency of catheter associated sepsis was 5.89 cases each 1000 catheter-days. Frequency of soft tissues infection in the area of catheterization was 9.78 cases each 1000 catheter-days. Catheter associated infections occurred in cases when catheter was used more than 5 days. 2 of 3 patients with catheter associated sepsis had agranulocytosis. Other complications included intermittent arrhythmias during catheter moving through heart chambers (58), rupture of catheter container during its use (4), thrombosis of the one lumen of catheter (3). Conclusions: Lung artery catheterization can be used in patients with blood disease and first of all in patients with septic shock and acute respiratory failure. In patients with agranulocytosis less invasive methods of monitoring are more advisable.
MeSH term(s)	Catheter-Related Infections/epidemiology ; Catheter-Related Infections/etiology ; Catheterization, Swan-Ganz/adverse effects ; Catheterization, Swan-Ganz/instrumentation ; Catheterization, Swan-Ganz/statistics & numerical data ; Equipment Failure/statistics & numerical data ; Hematologic Diseases/complications ; Hematologic Diseases/therapy ; Humans ; Incidence ; Pulmonary Artery/injuries ; Retrospective Studies ; Risk Factors ; Sepsis/epidemiology ; Sepsis/etiology
Language	Russian
Publishing date	2013-09
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	754946-5
ISSN	0201-7563
ISSN	0201-7563
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Article: [Whether fibrinogen concentrates are necessary in Russia?].

Galstian, G M / Berkovskiĭ, A L / Zhuravlev, V V / Polokhov, D M / Savchenko, V G

Anesteziologiia i reanimatologiia

2014 , Issue 3, Page(s) 49–59

Abstract: Purpose of the study: To analyze an efficiency of hypofibrinogenemia treatment. In the Scientific Center for Hematology (Moscow) significant hypofibrinogenemia occurs in 3% of patients with hemoblastosis. 1000 doses of cryoprecipitate are used for a ... ...

Abstract	Purpose of the study: To analyze an efficiency of hypofibrinogenemia treatment. In the Scientific Center for Hematology (Moscow) significant hypofibrinogenemia occurs in 3% of patients with hemoblastosis. 1000 doses of cryoprecipitate are used for a hypofibrinogenemia treatment every year (21-23 doses for each patient). Containing of fibrinogen in a one cryoprecipitate dose is from 108 mug to 711 mug (M = 276 mug). Volume of one dose is from 8 to 90 ml (M = 24 ml). Hypofibrinogenemia occurred in all patients required a cryoprecipitate transfusion (M = 1 g L(-1), min 0.5 g L(-1), max 2 g L(-1)). We fixed an increasing of fibrinogen level in plasma by 0.7 +/- 0.2 g L(-1) after the cryoprecipitate transfusion. We analyzed a world experience of the use of fibrinogen containing blood components. Conclusions: Fresh frozen plasma transfusion cannot be a choice method of treatment for hypofibrinogenemia. Fibrinogen's concentrate has the same effectiveness as a cryoprecipitate both for congenital and acquired deficit of fibrinogen. The frequency of complications due to fibrinogen's concentrate is low. Currently clinical studies of recombinant fibrinogen are conducted. Ways of implementation of fibrinogen preparations in Russia are discussed.
MeSH term(s)	Afibrinogenemia/blood ; Afibrinogenemia/etiology ; Afibrinogenemia/therapy ; Blood Component Transfusion/methods ; Factor VIII/administration & dosage ; Factor VIII/analysis ; Fibrinogen/administration & dosage ; Fibrinogen/analysis ; Humans ; Practice Guidelines as Topic ; Recombinant Proteins ; Retrospective Studies ; Russia
Chemical Substances	Recombinant Proteins ; cryoprecipitate coagulum ; Factor VIII (9001-27-8) ; Fibrinogen (9001-32-5)
Language	Russian
Publishing date	2014-05
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	754946-5
ISSN	0201-7563
ISSN	0201-7563
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Article: [Assessment of cardiac output and intrathoracic blood volume by means of transpulmonary thermodilution and ultrasound dilution: similarities and differences].

Galstian, G M / Bychinin, M V / Gorodetskiĭ, V M / Aleksanian, M Zh

Anesteziologiia i reanimatologiia

2011 , Issue 3, Page(s) 48–53

Abstract: Unlabelled: The aim of the study is to compare results of the assessment of cardiac output and intrathoracic blood volume by two methods--transpulmonary (TTD) and ultrasound (UTD) thermodilution.: Materials and methods: The prospective study included ...

Abstract	Unlabelled: The aim of the study is to compare results of the assessment of cardiac output and intrathoracic blood volume by two methods--transpulmonary (TTD) and ultrasound (UTD) thermodilution. Materials and methods: The prospective study included 58 patients (sepsis, septic shock, acute respiratory distress syndrome, intracranial haemorrhages), which underwent femoral artery catheterization with "Pulsiocath" 5Fr catheter (PICCO technology). For the means of ultrasound the catheter was connected to the central venous catheter by an arteriovenous loop. Sensors on arterial and venous ends of the loop registered the time and the volume of the indicator, blood properties and the ultrasound curve. Cooled (0 to 8 C) 5% glucose solution was used as an indicator for TTD, while heated (up to 37C) 0.9% NaCl solution was used as an indicator for the ultrasound. The cardiac output (CO) was measured by TTD and UTD, the global end diastolic volume (GEDV) by TTD, its analogue total end diastolic volume (TEDV) by UTD, intrathoracic blood volume (ITBV) by TTD and central blood volume (CBV) by UTD. 218 pairs of measurements were conducted. Oscillations of CO (TTD) were 2.76-16.3 l/min (8.6 +/- 2.48 l/min) and of CO (UTD)--2.92-18.1 l/min (8.72 +/- 2.65 l/min). There was a strong correlation between CO (TTD) and CO (UTD). The systematic mistake was 0.12 l/min, percentage based mistake--20.9%. ITBV correlated with CBV. There was a big systematic mistake found, which measured as much as 323 ml, the percentage based mistake was 36.5%. The correlation between GEDV and TEDV was (r = 0.70, p < 0.01). The TTD ejection fraction (23.2 +/- 5.6%) was lower (p < 0.01), than by UTD (57.8 +/- 15.2%). Results: Both methods demonstrate close values of CO. GEDV was higher than TEDV and physiological heart volume. The absolute values of GEDV and ITBV measured by TTD are higher than the actual ones, although they reflect the changes of blood volume and can be used as dynamic preload parameters.
MeSH term(s)	Adolescent ; Adult ; Aged ; Blood Volume/physiology ; Blood Volume Determination/instrumentation ; Blood Volume Determination/methods ; Cardiac Output/physiology ; Catheterization, Swan-Ganz ; Cerebral Hemorrhage/physiopathology ; Female ; Humans ; Indicator Dilution Techniques/instrumentation ; Male ; Middle Aged ; Monitoring, Physiologic/methods ; Prospective Studies ; Respiratory Distress Syndrome, Adult/physiopathology ; Shock, Septic/physiopathology ; Thermodilution/methods ; Ultrasonography ; Young Adult
Language	Russian
Publishing date	2011-05
Publishing country	Russia (Federation)
Document type	Comparative Study ; English Abstract ; Journal Article
ZDB-ID	754946-5
ISSN	0201-7563
ISSN	0201-7563
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Article: [Antithrombin III in the treatment of sepsis-- new approaches to prescribing the old drug].

Galstian, G M / Shutova, N A / Gorodetskiĭ, V M

Anesteziologiia i reanimatologiia

2007 , Issue 6, Page(s) 66–71

MeSH term(s)	Animals ; Anti-Inflammatory Agents/therapeutic use ; Anticoagulants/administration & dosage ; Anticoagulants/pharmacokinetics ; Anticoagulants/therapeutic use ; Antithrombin III/administration & dosage ; Antithrombin III/pharmacokinetics ; Antithrombin III/therapeutic use ; Blood Coagulation/drug effects ; Clinical Trials as Topic ; Humans ; Sepsis/blood ; Sepsis/drug therapy
Chemical Substances	Anti-Inflammatory Agents ; Anticoagulants ; Antithrombin III (9000-94-6)
Language	Russian
Publishing date	2007-11
Publishing country	Russia (Federation)
Document type	Journal Article ; Review
ZDB-ID	754946-5
ISSN	0201-7563
ISSN	0201-7563
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Article: [The laboratory diagnostic of herpes viral infections under nosocomial pneumonia in oncologic hematologic patients].

Garanja, T A / Tikhomirov, D S / Tupoleva, T A / Troitskaia, V V / Parovichnikova, E M / Galstian, G M / Filatov, F P

Klinicheskaia laboratornaia diagnostika

2015 Volume 60, Issue 3, Page(s) 50–54

Abstract: The study was organized to discover diagnostically valuable clinical material for detection of etiologic agent of pneumonia in oncological hematological patients, rate of association of nosocomial pneumonia with herpes viruses and evaluation of viral ... ...

Abstract	The study was organized to discover diagnostically valuable clinical material for detection of etiologic agent of pneumonia in oncological hematological patients, rate of association of nosocomial pneumonia with herpes viruses and evaluation of viral load in patients with depressed immunity. In oncological hematological patients, half of nosocomial pneumonia cases is associated with herpes virus. In every third patient DNA of Epstein-Barr virus and DNA of type I and II are detected. The most informative material in this case is broncho-alveolar lavage fluid and the most convenient diagnostic technique is polymerase chain reaction in real-time. The low viral load in broncho-alveolar lavage fluid is specfic for Epstein-Barr virus, cytomegalovirus and human herpes virus type VI. The concentration of DNA ofsimple herpes virus type I and type II is located in both high and low values. The paradox phenomena is established concerning more benevolent course of nosocomial pneumonia associated with simple herpes virus type I and II in patients with higher viral load in broncho-alveolar lavage fluid. The further research in this direction is needed.
MeSH term(s)	Cross Infection/blood ; Cross Infection/virology ; Cytomegalovirus/isolation & purification ; Cytomegalovirus/pathogenicity ; Hematologic Neoplasms/blood ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/virology ; Herpesviridae Infections/blood ; Herpesviridae Infections/virology ; Herpesvirus 4, Human/isolation & purification ; Herpesvirus 4, Human/pathogenicity ; Humans ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/virology
Language	Russian
Publishing date	2015-05-28
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	1155086-7
ISSN	0869-2084
ISSN	0869-2084
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Zs.MO 647: Show issues

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Article: [A case of spontaneous chylothorax complicating pregnancy].

Novikov, V A / Galstian, G M / Shavlokhov, V S / Shevelev, A A / Gorodetskiĭ, V M

Terapevticheskii arkhiv

2012 Volume 84, Issue 7, Page(s) 84–88

Abstract: The paper gives a clinical case of left-sided chylothorax developing in a young woman in the second half of pregnancy due to thrombosis of the left internal jugular vein, left subclavian vein, and brachiocephalic trunk. Cesarean section was made. Medical ...

Abstract	The paper gives a clinical case of left-sided chylothorax developing in a young woman in the second half of pregnancy due to thrombosis of the left internal jugular vein, left subclavian vein, and brachiocephalic trunk. Cesarean section was made. Medical treatment thereafter proved to be effective. The possible mechanisms for spontaneous venous thrombosis and chylothorax during pregnancy and the methods of their diagnosis and treatment are discussed.
MeSH term(s)	Adult ; Brachiocephalic Trunk ; Cesarean Section/methods ; Chylothorax/diagnosis ; Chylothorax/etiology ; Chylothorax/pathology ; Female ; Humans ; Jugular Veins ; Pregnancy ; Pregnancy Complications/physiopathology ; Subclavian Vein ; Venous Thrombosis/complications ; Venous Thrombosis/diagnosis ; Venous Thrombosis/therapy
Language	Russian
Publishing date	2012
Publishing country	Russia (Federation)
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	40718-5
ISSN	2309-5342 ; 0040-3660
ISSN (online)	2309-5342
ISSN	0040-3660
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Lechenie antagonistami kal'tsiia pochechnoĭ gipertonii--novyĭ shag po puti optimizatsii gipotenzivnoĭ terapii.

Galstian, G M

Terapevticheskii arkhiv

1989 Volume 61, Issue 8, Page(s) 138–143

Title translation	Calcium antagonist treatment of renal hypertension--a new step on the way to optimizing hypotensive therapy.
MeSH term(s)	Animals ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Calcium Channel Blockers/pharmacology ; Calcium Channel Blockers/therapeutic use ; Drug Therapy, Combination ; Humans ; Hypertension, Renal/drug therapy ; Hypertension, Renal/physiopathology ; Kidney/drug effects ; Kidney/physiopathology
Chemical Substances	Antihypertensive Agents ; Calcium Channel Blockers
Language	Russian
Publishing date	1989
Publishing country	Russia (Federation)
Document type	Journal Article ; Review
ZDB-ID	40718-5
ISSN	2309-5342 ; 0040-3660
ISSN (online)	2309-5342
ISSN	0040-3660
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Article: [Clinical manifestations of Legionella pneumonia in hematology patients].

Galstian, G M / Kostina, I É / Katrysh, S A / Kliasova, G A / Karpova, T I / Tartakovskiĭ, I S

Terapevticheskii arkhiv

2014 Volume 86, Issue 3, Page(s) 45–52

Abstract: Aim: To detect the most common clinical manifestations of Legionella pneumonia (LP) in immunocompromized patients.: Subjects and methods: Clinical manifestations, the results of investigation of bronchoalveolar lavage fluid (BALF) and urine, and the ... ...

Abstract	Aim: To detect the most common clinical manifestations of Legionella pneumonia (LP) in immunocompromized patients. Subjects and methods: Clinical manifestations, the results of investigation of bronchoalveolar lavage fluid (BALF) and urine, and the data of lung computed tomography (CT) were studied in patients with blood system diseases and acute respiratory failure (ARF). Results: The diagnosis of LP was verified in 8 (10.5%) of 76 patients with blood system diseases and ARF. The disease manifested as fever, higher concentrations of inflammatory markers (procalcitonin, fibrinogen), ARF, hypoxemia, and infiltrative lung injury. Six of the 8 patients were switched to mechanical ventilation. Lung CT showed no pathognomonic signs. Five of the 8 patients were observed to have renal dysfunction. The diagnosis of LP was made on the basis of the results of BALF examination in 7 patients and urinary antigen detection in 1. The disease was caused by Legionella pneumophila serogroup 1 in 3 patients and by L. pneumophila of other serogroups in the other patients. Therapy with respiratory fluoroquinolones was performed in 5 patients. Three patients died from progressive ARF and hypoxemia. BALF results were obtained after their death and therapy for legionellosis was not initiated. Conclusion: The incidence of LP is 10.5% in hematology patients. The clinical manifestations of legionellosis are nonspecific; its diagnosis requires bacteriological and/or serological evidence. Due to the high risk of death, it is reasonable to preuse respiratory fluoroquinolones or macrolides in immunocompromized patients with progressive ARF and suspected Legionella pneumonia before diagnosis.
MeSH term(s)	Adult ; Aged ; Anti-Bacterial Agents/therapeutic use ; Antigens, Bacterial/urine ; Bronchoalveolar Lavage/methods ; Female ; Fluoroquinolones/therapeutic use ; Hematologic Diseases/complications ; Hematologic Diseases/immunology ; Humans ; Immunocompromised Host ; Incidence ; Legionella/immunology ; Legionnaires' Disease/diagnosis ; Legionnaires' Disease/drug therapy ; Legionnaires' Disease/epidemiology ; Legionnaires' Disease/etiology ; Legionnaires' Disease/immunology ; Legionnaires' Disease/physiopathology ; Macrolides/therapeutic use ; Male ; Middle Aged ; Outcome Assessment (Health Care) ; Respiratory Insufficiency/drug therapy ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/mortality ; Respiratory Insufficiency/physiopathology ; Russia/epidemiology ; Survival Rate ; Tomography, X-Ray Computed/methods
Chemical Substances	Anti-Bacterial Agents ; Antigens, Bacterial ; Fluoroquinolones ; Macrolides
Language	Russian
Publishing date	2014
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	40718-5
ISSN	2309-5342 ; 0040-3660
ISSN (online)	2309-5342
ISSN	0040-3660
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