Article ; Online: Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2
2020 Volume 31, Issue 2, Page(s) 107511
Abstract: Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development. Previously, we demonstrated that the Sonic Hedgehog (SHH) subgroup grows hierarchically, with ... ...
| Abstract | Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development. Previously, we demonstrated that the Sonic Hedgehog (SHH) subgroup grows hierarchically, with Sox2 |
|---|---|
| MeSH term(s) | Animals ; Cell Lineage/genetics ; Cells, Cultured ; Cerebellar Neoplasms/pathology ; Cerebellum/embryology ; Female ; Hedgehog Proteins/metabolism ; Humans ; Male ; Medulloblastoma/etiology ; Medulloblastoma/metabolism ; Mice, Knockout ; Mice, Transgenic ; Neoplasm Recurrence, Local/pathology ; Neural Stem Cells/metabolism ; Neurogenesis ; Neurons/metabolism ; SOXB1 Transcription Factors/metabolism ; SOXB1 Transcription Factors/physiology ; Signal Transduction/physiology ; Single-Cell Analysis/methods |
| Chemical Substances | Hedgehog Proteins ; SOX2 protein, human ; SOXB1 Transcription Factors |
| Language | English |
| Publishing date | 2020-04-15 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2649101-1 |
| ISSN | 2211-1247 ; 2211-1247 |
| ISSN (online) | 2211-1247 |
| ISSN | 2211-1247 |
| DOI | 10.1016/j.celrep.2020.03.075 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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