Article ; Online: Methanolic Extract of Leathery Murdah, Terminalia coriacea (Roxb.) Wight and Arn. Leaves Exhibits Anti-Inflammatory Activity in Acute and Chronic Models.
2018 Volume 27, Issue 3, Page(s) 267–271
Abstract: Objective: The aim of the present study was to evaluate anti-inflammatory activity of methanolic extract of Terminalia coriacea.: Materials and methods: A methanolic extract of T. coriacea leaves was studied in albino Wistar rats with carrageenan- ... ...
| Abstract | Objective: The aim of the present study was to evaluate anti-inflammatory activity of methanolic extract of Terminalia coriacea. Materials and methods: A methanolic extract of T. coriacea leaves was studied in albino Wistar rats with carrageenan-induced paw edema, an acute model, and cotton pellet-induced granuloma, a chronic model, at 3 oral test doses (125, 250, and 500 mg/kg). Aspirin 100 mg/kg was used as a positive control. Paw volume and wet and dry weights of cotton pellets were determined. The data were analyzed by one-way ANOVA followed by Dunnett's multiple comparison test. Results: The test extract at doses of 125 and 250 mg/kg decreased paw volume and wet and dry weights of cotton pellets. The highest test dose (500 mg/kg) displayed a response comparable to that of the standard drug (p < 0.01) on paw volume. The extract produced similar (p < 0.05) decrease in wet weight of the cotton pellet at 125 and 250 mg/kg, whereas the effect of 500 mg/kg of the extract was comparable to that of aspirin 100 mg/kg (p < 0.01). The extract of T. coriacea at 500 mg/kg induced the most significant (p < 0.01) effect on wet weight of granulomatous tissue. Conclusion: The methanolic extract of T. coriacea leaves successfully decreased paw edema as well as dry and wet weights of granulomatous tissue in both acute and chronic inflammatory models thus confirming the anti- edematogenic, antitransudative, and antiproliferative properties of T. coriacea. |
|---|---|
| MeSH term(s) | Animals ; Anti-Inflammatory Agents/pharmacology ; Aspirin/pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Edema/chemically induced ; Edema/drug therapy ; Granuloma/chemically induced ; Granuloma/drug therapy ; Male ; Phytotherapy/methods ; Plant Extracts/pharmacology ; Rats ; Rats, Wistar ; Terminalia |
| Chemical Substances | Anti-Inflammatory Agents ; Plant Extracts ; Aspirin (R16CO5Y76E) |
| Language | English |
| Publishing date | 2018-03-07 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 645108-1 |
| ISSN | 1423-0151 ; 1011-7571 |
| ISSN (online) | 1423-0151 |
| ISSN | 1011-7571 |
| DOI | 10.1159/000488199 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 2486: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.