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  1. Article ; Online: Health Emergency Preparedness and Response Capacity in Latin America and the Caribbean.

    Gamba, Magda R / LeBlanc, Tanya Telfair / Vázquez, Damián / Dos Santos, Eliane P / Franco, Oscar H

    American journal of public health

    2022  Volume 112, Issue S6, Page(s) S572

    MeSH term(s) Caribbean Region ; Civil Defense ; Ethnicity ; Humans ; Latin America
    Language English
    Publishing date 2022-08-12
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2022.306815
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  2. Article ; Online: Association between dietary phytochemical index, cardiometabolic risk factors and metabolic syndrome in Switzerland. The CoLaus study.

    Gamba, Magda / Roa-Diaz, Zayne M / Raguindin, Peter Francis / Glisic, Marija / Bano, Arjola / Muka, Taulant / Franco, Oscar H / Marques-Vidal, Pedro

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2023  Volume 33, Issue 11, Page(s) 2220–2232

    Abstract: Background and aims: Plant-based diets are associated with reduced cardiometabolic risk factors (CRFs) and lower risk of metabolic syndrome (MetS), probably via phytochemicals acting synergistically. However, dietary phytochemical content estimation is ... ...

    Abstract Background and aims: Plant-based diets are associated with reduced cardiometabolic risk factors (CRFs) and lower risk of metabolic syndrome (MetS), probably via phytochemicals acting synergistically. However, dietary phytochemical content estimation is challenging; therefore, the dietary phytochemical index (DPI) was proposed as a practical way to assess total dietary phytochemical content from phytochemical-rich foods (PRFs). We evaluated the association between DPI with CRFs and MetS and its components.
    Methods and results: Cross-sectional analysis of 2009-2012 data of Colaus cohort study (Lausanne, Switzerland), including 3879 participants (mean age 57.6 ± 10.4 years, 53.5% women). Dietary intake was assessed via a validated food frequency questionnaire. DPI was calculated as the total energy intake percentage obtained from PRFs consumption and assessed as quartiles. Associations were determined using multivariable linear and logistic regression for CRFs and MetS, respectively. Median DPI value was 25.5 (interquartile range: 17.7-34.6). After multivariable-adjusted analyses, significant inverse associations were observed between the last two highest DPI quartiles and waist circumference (WC), body mass index (BMI), insulin, leptin, and hs-CRP. No significant associations were observed for MetS or its components except for central obesity, as subjects in the highest DPI quartile had lower odds (OR: 0.78; 95% CI: 0.62, 0.97) than those in lowest quartile.
    Conclusion: A diet high in PRFs assessed via DPI is associated with lower WC, BMI, insulin, leptin, hs-CRP values, and lower odds of central obesity, indicating a potential protective effect of phytochemical intake on these CRFs and highlighting the importance of high PRFs intake in promoting cardiometabolic health.
    Language English
    Publishing date 2023-07-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2023.07.018
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  3. Article ; Online: Association between Total Dietary Phytochemical Intake and Cardiometabolic Health Outcomes-Results from a 10-Year Follow-Up on a Middle-Aged Cohort Population.

    Gamba, Magda / Pano, Octavio / Raguindin, Peter Francis / Roa-Diaz, Zayne M / Muka, Taulant / Glisic, Marija / Franco, Oscar H / Marques-Vidal, Pedro

    Nutrients

    2023  Volume 15, Issue 22

    Abstract: Dietary phytochemical intake associations with cardiovascular health and mortality remain unknown. We studied the relations between total dietary phytochemical intake and cardiovascular health outcomes in a middle-aged Swiss population. We analyzed data ... ...

    Abstract Dietary phytochemical intake associations with cardiovascular health and mortality remain unknown. We studied the relations between total dietary phytochemical intake and cardiovascular health outcomes in a middle-aged Swiss population. We analyzed data spanning 2009 to 2021 from a prospective cohort study in Lausanne, Switzerland, including 3721 participants (54.8% women, 57.2 ± 10.3 years) without cardiovascular disease (CVD) history. Dietary intake was assessed using a validated self-reported food frequency questionnaire. The Dietary Phytochemical Index (DPI) and the healthy Dietary Phytochemical Index (hDPI) were calculated as the total energy intake percentage obtained from phytochemical-rich food consumption. The Healthy Plant-Based Diet Index (hPBD) was estimated by scoring healthy plant foods positively and less-healthy plant foods negatively. Indices tertiles and cardiometabolic outcome associations were determined using Cox proportional hazard models. Over 30,217 person-years of follow-up, 262 CVD events, and 178 deaths occurred. Unadjusted analyses found 36%, 33%, and 32% lower CVD risk for the highest hDPI, DPI, and hPBD tertiles, respectively. After adjustment, only the second hDPI tertile showed a 30% lower CVD risk (HR 0.70, 95% CI 0.51-0.95; P for trend 0.362). No other associations emerged. In this middle-aged Swiss cohort, no associations between dietary indices reflecting a phytochemical-rich dietary pattern and incident CVD, all-cause, or CVD mortality were observed.
    MeSH term(s) Middle Aged ; Humans ; Female ; Male ; Prospective Studies ; Follow-Up Studies ; Risk Factors ; Diet ; Eating ; Cardiovascular Diseases/epidemiology ; Phytochemicals ; Outcome Assessment, Health Care
    Chemical Substances Phytochemicals
    Language English
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15224793
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  4. Article ; Online: Association between Dietary Phytochemical Index, cardiometabolic risk factors and metabolic syndrome in Switzerland. The CoLaus Study

    Gamba, Magda / Roa-Diaz, Zayne M. / Raguindin, Peter F. / Glisic, Marija / Bano, Arjola / Muka, Taulant / Franco, Oscar H. / Marques-Vidal, Pedro

    Nutrition, Metabolism and Cardiovascular Diseases. 2023 July 17,

    2023  

    Abstract: Plant-based diets are associated with reduced cardiometabolic risk factors (CRFs) and lower risk of metabolic syndrome (MetS), probably via phytochemicals acting synergistically. However, dietary phytochemical content estimation is challenging; therefore, ...

    Abstract Plant-based diets are associated with reduced cardiometabolic risk factors (CRFs) and lower risk of metabolic syndrome (MetS), probably via phytochemicals acting synergistically. However, dietary phytochemical content estimation is challenging; therefore, the dietary phytochemical index (DPI) was proposed as a practical way to assess total dietary phytochemical content from phytochemical-rich foods (PRFs). We evaluated the association between DPI with CRFs and MetS and its components. Cross-sectional analysis of 2009-2012 data of Colaus cohort study (Lausanne, Switzerland), including 3879 participants (mean age 57.6±10.4 years, 53.5% women). Dietary intake was assessed via a validated food frequency questionnaire. DPI was calculated as the total energy intake percentage obtained from PRFs consumption and assessed as quartiles. Associations were determined using multivariable linear and logistic regression for CRFs and MetS, respectively. Median DPI value was 25.5 (interquartile range: 17.7–34.6). After multivariable-adjusted analyses, significant inverse associations were observed between the last two highest DPI quartiles and waist circumference (WC), body mass index (BMI), insulin, leptin, and hs-CRP. No significant associations were observed for MetS or its components except for central obesity, as subjects in the highest DPI quartile had lower odds (OR: 0.78; 95% CI: 0.62, 0.97) than those in lowest quartile. A diet high in PRFs assessed via DPI is associated with lower WC, BMI, insulin, leptin, hs-CRP values, and lower odds of central obesity, indicating a potential protective effect of phytochemical intake on these CRFs and highlighting the importance of high PRFs intake in promoting cardiometabolic health.
    Keywords body mass index ; cohort studies ; cross-sectional studies ; energy intake ; food frequency questionnaires ; food intake ; insulin ; leptin ; metabolic syndrome ; metabolism ; obesity ; phytochemicals ; protective effect ; regression analysis ; risk ; waist circumference ; Switzerland ; Dietary Phytochemical Index ; Phytochemical-rich foods ; Cardiometabolic risk factors
    Language English
    Dates of publication 2023-0717
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 1067704-5
    ISSN 0939-4753
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2023.07.018
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  5. Article ; Online: [No title information]

    Gamba, Magda R / LeBlanc, Tanya Telfair / Vazquez, Damian / Pereira Dos Santos, Eliane / Franco, Oscar H

    Revista panamericana de salud publica = Pan American journal of public health

    2022  Volume 46, Page(s) e99

    Title translation Capacidad de preparación y respuesta de América Latina y el Caribe frente a emergencias sanitarias.
    Language Spanish
    Publishing date 2022-08-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 1376934-0
    ISSN 1680-5348 ; 1020-4989
    ISSN (online) 1680-5348
    ISSN 1020-4989
    DOI 10.26633/RPSP.2022.99
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  6. Article ; Online: Concepts and definitions of healthy ageing: a systematic review and synthesis of theoretical models.

    Menassa, Marilyne / Stronks, Karien / Khatmi, Farnaz / Roa Díaz, Zayne Milena / Espinola, Octavio Pano / Gamba, Magda / Itodo, Oche Adam / Buttia, Chepkoech / Wehrli, Faina / Minder, Beatrice / Velarde, Minerva Rivas / Franco, Oscar H

    EClinicalMedicine

    2023  Volume 56, Page(s) 101821

    Abstract: Background: Healthy ageing (HA) has been defined using multiple approaches. We aim to produce a comprehensive overview and analysis of the theoretical models underpinning this concept and its associated normative terms and definitions.: Methods: We ... ...

    Abstract Background: Healthy ageing (HA) has been defined using multiple approaches. We aim to produce a comprehensive overview and analysis of the theoretical models underpinning this concept and its associated normative terms and definitions.
    Methods: We conducted a systematic review of peer-reviewed HA models in Embase.com, Medline (Ovid), Cochrane CENTRAL, CINAHL, PsycINFO, and Web of Science until August 2022. Original theoretical papers, concept analyses, and reviews that proposed new models were included. Operational models/definitions, development psychology theories and mechanisms of ageing were excluded. We followed an iterative approach to extract the models' characteristics and thematically analyze them based on the approach of Walker and Avant. The protocol was registered in PROSPERO (CRD42021238796).
    Findings: Out of 10,741 records, we included 59 papers comprising 65 models/definitions, published in English (1960-2022) from 16 countries in Europe, Asia, and America. Human ageing was described using 12 normative terms, mainly (models (%)): successful (34 (52%)), healthy (eight (12%)), well (five (8%)), and active (four (6%)). We identified intrinsic/extrinsic factors interacting throughout the life course, adaptive processes as attributes, and outcomes describing ageing patterns across objective and subjective dimensions (number of models/definitions): cognitive (62), psychological (53), physical (49), social (49), environmental (19), spiritual (16), economic (13), cultural (eight), political (six), and demographic (four) dimensions. Three types of models emerged: health-state outcomes (three), adaptations across the life course (31), or a combination of both (31). Two additional sub-classifications emphasized person-environment congruence and health promotion.
    Interpretation: HA conceptualizations highlight its multidimensionality and complexity that renders a monistic model/definition challenging. It has become evident that life long person-environment interactions, adaptations, environments, and health promotion/empowerment are essential for HA. Our model classification provides a basis for harmonizing terms and dimensions that can guide research and comparisons of empirical findings, and inform social and health policies enabling HA for various populations and contexts.
    Funding: MM, ZMRD, and OI are supported by the European Union's Horizon 2020 Marie Skłodowska-Curie grant No 801076, and MM is also supported by the Swiss National Foundation grant No 189235.
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2022.101821
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  7. Article: Bioactive compounds and nutritional composition of Swiss chard (Beta vulgaris L. var. cicla and flavescens): a systematic review

    Gamba, Magda / Raguindin, Peter Francis / Asllanaj, Eralda / Merlo, Francesco / Glisic, Marija / Minder, Beatrice / Bussler, Weston / Metzger, Brandon / Kern, Hua / Muka, Taulant

    Critical reviews in food science and nutrition. 2021 Nov. 13, v. 61, no. 20

    2021  

    Abstract: Swiss chard (Beta vulgaris L. var. cicla or flavescens) is a green leafy vegetable whose bioactive compounds have been studied due to its effects on health. We systematically reviewed the nutritional profile and bioactive composition of Swiss chard and ... ...

    Abstract Swiss chard (Beta vulgaris L. var. cicla or flavescens) is a green leafy vegetable whose bioactive compounds have been studied due to its effects on health. We systematically reviewed the nutritional profile and bioactive composition of Swiss chard and reported their concentrations. Four main databases were searched for studies analyzing the chemical composition of Swiss chard. Screening, selection of articles, and data extraction were carried out by two independent reviewers. Twenty-eight articles of 1102 records identified by bibliographic search met our inclusion criteria for final analysis. We found a total of 192 chemical compounds categorized into 23 groups. The cicla variety was the most studied, and nutrients and phytochemicals were reported mainly on leaves. Betalains with 20% of the reported data, fats (16%), flavonoids (11%), non-flavonoid phenolics (11%), terpenes and derivatives (8%), carbohydrates (7%), and minerals (6%) were among the most reported categories. Swiss chard leaves have the highest content of fiber, sodium, magnesium, flavonoids, and vitamin C, while stems are high in potassium. Swiss chard should be considered a source of nutrients and phytochemicals, and further research is needed on identifying and quantifying other bioactive compounds and understanding their impact on health.
    Keywords Beta vulgaris subsp. vulgaris ; ascorbic acid ; betalains ; flavonoids ; food science ; green leafy vegetables ; magnesium ; nutrient content ; nutrition ; phenolic compounds ; potassium ; sodium ; systematic review ; terpenoids
    Language English
    Dates of publication 2021-1113
    Size p. 3465-3480.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 1037504-1
    ISSN 1549-7852 ; 1040-8398
    ISSN (online) 1549-7852
    ISSN 1040-8398
    DOI 10.1080/10408398.2020.1799326
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  8. Article: Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials

    Llanaj, Erand / Dejanovic, Gordana M. / Valido, Ezra / Bano, Arjola / Gamba, Magda / Kastrati, Lum / Minder, Beatrice / Stojic, Stevan / Voortman, Trudy / Marques-Vidal, Pedro / Stoyanov, Jivko / Metzger, Brandon / Glisic, Marija / Kern, Hua / Muka, Taulant

    European journal of nutrition. 2022 June, v. 61, no. 4

    2022  

    Abstract: PURPOSE: Oat supplementation interventions (OSIs) may have a beneficial effect on cardiovascular disease (CVD) risk. However, dietary background can modulate such effect. This systematic review assesses the effects of OSIs on CVD risk markers among ... ...

    Abstract PURPOSE: Oat supplementation interventions (OSIs) may have a beneficial effect on cardiovascular disease (CVD) risk. However, dietary background can modulate such effect. This systematic review assesses the effects of OSIs on CVD risk markers among adults, accounting for different dietary backgrounds or control arms. METHODS: We included randomized clinical trials (RCTs) that assessed the effect of oat, oat beta-glucan-rich extracts or avenanthramides on CVD risk markers. RESULTS: Seventy-four RCTs, including 4937 predominantly hypercholesterolemic, obese subjects, with mild metabolic disturbances, were included in the systematic review. Of these, 59 RCTs contributed to the meta-analyses. Subjects receiving an OSI, compared to control arms without oats, had improved levels of total cholesterol (TC) [weighted mean difference and (95% CI) − 0.42 mmol/L, (− 0.61; − 0.22)], LDL cholesterol [− 0.29 mmol/L, (− 0.37; − 0.20)], glucose [− 0.25 nmol/L, (− 0.36; − 0.14)], body mass index [− 0.13 kg/m², (− 0.26; − 0.01)], weight [− 0.94 kg, (− 1.84: − 0.05)], and waist circumference [− 1.06 cm, (− 1.85; − 0.27)]. RCTs on inflammation and/or oxidative stress markers were scarce and with inconsistent findings. RCTs comparing an OSI to heterogeneous interventions (e.g., wheat, eggs, rice, etc.), showed lowered levels of glycated haemoglobin, diastolic blood pressure, HDL cholesterol and apolipoprotein B. The majority of included RCTs (81.1%) had some concerns for risk of bias. CONCLUSION: Dietary OSIs resulted in lowered levels of blood lipids and improvements in anthropometric parameters among participants with predominantly mild metabolic disturbances, regardless of dietary background or control. Further high-quality trials are warranted to establish the role of OSIs on blood pressure, glucose homeostasis and inflammation markers.
    Keywords apolipoprotein B ; avenanthramides ; blood ; body mass index ; cardiovascular diseases ; diastolic blood pressure ; glucose ; hemoglobin ; high density lipoprotein cholesterol ; homeostasis ; hypercholesterolemia ; inflammation ; low density lipoprotein cholesterol ; meta-analysis ; nutrition ; oats ; oxidative stress ; rice ; systematic review ; waist circumference ; wheat
    Language English
    Dates of publication 2022-06
    Size p. 1749-1778.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Review
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-021-02763-1
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  9. Article ; Online: Diabetes and Myocardial Fibrosis: A Systematic Review and Meta-Analysis.

    Salvador, Dante B / Gamba, Magda R / Gonzalez-Jaramillo, Nathalia / Gonzalez-Jaramillo, Valentina / Raguindin, Peter Francis N / Minder, Beatrice / Gräni, Christoph / Wilhelm, Matthias / Stettler, Christoph / Doria, Alessandro / Franco, Oscar H / Muka, Taulant / Bano, Arjola

    JACC. Cardiovascular imaging

    2022  Volume 15, Issue 5, Page(s) 796–808

    Abstract: Objectives: This systematic review and meta-analysis investigated the association of diabetes and glycemic control with myocardial fibrosis (MF).: Background: MF is associated with an increased risk of heart failure, coronary artery disease, ... ...

    Abstract Objectives: This systematic review and meta-analysis investigated the association of diabetes and glycemic control with myocardial fibrosis (MF).
    Background: MF is associated with an increased risk of heart failure, coronary artery disease, arrhythmias, and death. Diabetes may influence the development of MF, but evidence is inconsistent.
    Methods: The authors searched EMBASE, Medline Ovid, Cochrane CENTRAL, Web of Science, and Google Scholar for observational and interventional studies investigating the association of diabetes, glycemic control, and antidiabetic medication with MF assessed by histology and cardiac magnetic resonance (ie, extracellular volume fraction [ECV%] and T
    Results: A total of 32 studies (88% exclusively on type 2 diabetes) involving 5,053 participants were included in the systematic review. Meta-analyses showed that diabetes was associated with a higher degree of MF assessed by histological collagen volume fraction (n = 6 studies; mean difference: 5.80; 95% CI: 2.00-9.59) and ECV% (13 studies; mean difference: 2.09; 95% CI: 0.92-3.27), but not by native or postcontrast T
    Conclusions: Diabetes is associated with higher degree of MF assessed by histology and ECV% but not by T
    MeSH term(s) Cardiomyopathies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Fibrosis ; Humans ; Magnetic Resonance Imaging, Cine ; Myocardium/pathology ; Predictive Value of Tests
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2021.12.008
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  10. Article ; Online: Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials.

    Llanaj, Erand / Dejanovic, Gordana M / Valido, Ezra / Bano, Arjola / Gamba, Magda / Kastrati, Lum / Minder, Beatrice / Stojic, Stevan / Voortman, Trudy / Marques-Vidal, Pedro / Stoyanov, Jivko / Metzger, Brandon / Glisic, Marija / Kern, Hua / Muka, Taulant

    European journal of nutrition

    2022  Volume 61, Issue 4, Page(s) 1749–1778

    Abstract: Purpose: Oat supplementation interventions (OSIs) may have a beneficial effect on cardiovascular disease (CVD) risk. However, dietary background can modulate such effect. This systematic review assesses the effects of OSIs on CVD risk markers among ... ...

    Abstract Purpose: Oat supplementation interventions (OSIs) may have a beneficial effect on cardiovascular disease (CVD) risk. However, dietary background can modulate such effect. This systematic review assesses the effects of OSIs on CVD risk markers among adults, accounting for different dietary backgrounds or control arms.
    Methods: We included randomized clinical trials (RCTs) that assessed the effect of oat, oat beta-glucan-rich extracts or avenanthramides on CVD risk markers.
    Results: Seventy-four RCTs, including 4937 predominantly hypercholesterolemic, obese subjects, with mild metabolic disturbances, were included in the systematic review. Of these, 59 RCTs contributed to the meta-analyses. Subjects receiving an OSI, compared to control arms without oats, had improved levels of total cholesterol (TC) [weighted mean difference and (95% CI) - 0.42 mmol/L, (- 0.61; - 0.22)], LDL cholesterol [- 0.29 mmol/L, (- 0.37; - 0.20)], glucose [- 0.25 nmol/L, (- 0.36; - 0.14)], body mass index [- 0.13 kg/m
    Conclusion: Dietary OSIs resulted in lowered levels of blood lipids and improvements in anthropometric parameters among participants with predominantly mild metabolic disturbances, regardless of dietary background or control. Further high-quality trials are warranted to establish the role of OSIs on blood pressure, glucose homeostasis and inflammation markers.
    MeSH term(s) Adult ; Avena ; Biomarkers ; Cardiovascular Diseases/prevention & control ; Cholesterol ; Dietary Supplements ; Glucose ; Humans ; Inflammation ; Randomized Controlled Trials as Topic
    Chemical Substances Biomarkers ; Cholesterol (97C5T2UQ7J) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-01-03
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-021-02763-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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