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  1. Article ; Online: General population normative values for the EORTC QLQ-C30 by age, sex, and health condition for the French general population.

    Pilz, Micha J / Loth, Fanny L C / Nolte, Sandra / Thurner, Anna M M / Gamper, Eva-Maria / Anota, Amélie / Liegl, Gregor / Giesinger, Johannes M

    Journal of patient-reported outcomes

    2024  Volume 8, Issue 1, Page(s) 48

    Abstract: Background: General population normative values for the widely used health-related quality of life (HRQoL) measure EORTC QLQ-C30 support the interpretation of trial results and HRQoL of patients in clinical practice. Here, we provide sex-, age- and ... ...

    Abstract Background: General population normative values for the widely used health-related quality of life (HRQoL) measure EORTC QLQ-C30 support the interpretation of trial results and HRQoL of patients in clinical practice. Here, we provide sex-, age- and health condition-specific normative values for the EORTC QLQ-C30 in the French general population.
    Methods: French general population data was collected in an international EORTC project. Online panels with quota samples were used to recruit sex and age groups. Number and type of comorbidities were assessed. Descriptive statistics were used to calculate general population values for each QLQ-C30 scale, separately for sex, age, and presence of one- and more chronic health conditions. A multivariate linear regression model has been developed to allow estimating the effect of sex, age, and the presence for one- and more chronic health conditions on EORTC QLQ-C30 scores. Data was weighted according to United Nation statistics adjusting for the proportion of sex and age groups.
    Results: In total, 1001 French respondents were included in our analyses. The weighted mean age was 47.9 years, 514 (51.3%) participants were women, and 497 (52.2%) participants reported at least one health condition. Men reported statistically significant better scores for Emotional Functioning (+9.6 points, p = 0.006) and Fatigue (-7.8 point; p = 0.04); women reported better profiles for Role Functioning (+8.7 points; p = 0.008) and Financial Difficulty (-7.8 points, p = 0.011). According to the regression model, the sex effect was statistically significant in eight scales; the effect of increasing age had a statistically significant effect on seven of the 15 EORTC QLQ-C30 scales. The sex- and age effect varied in its direction across the various scales. The presence of health conditions showed a strong negative effect on all scales.
    Conclusion: This is the first publication of detailed French normative values for the EORTC QLQ-C30. It aims to support the interpretation of HRQoL profiles in French cancer populations. The strong impact of health conditions on QLQ-C30 scores highlights the importance of considering the impact of comorbidities in cancer patients when interpreting HRQoL data.
    MeSH term(s) Humans ; Male ; Female ; Quality of Life/psychology ; France/epidemiology ; Middle Aged ; Adult ; Aged ; Age Factors ; Health Status ; Sex Factors ; Surveys and Questionnaires ; Young Adult ; Reference Values ; Chronic Disease/epidemiology ; Chronic Disease/psychology ; Adolescent ; Aged, 80 and over
    Language English
    Publishing date 2024-05-02
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2509-8020
    ISSN (online) 2509-8020
    DOI 10.1186/s41687-024-00719-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The EORTC QLU-C10D discrete choice experiment for cancer patients: a first step towards patient utility weights.

    Gamper, Eva-Maria / King, Madeleine T / Norman, Richard / Loth, Fanny L C / Holzner, Bernhard / Kemmler, Georg

    Journal of patient-reported outcomes

    2022  Volume 6, Issue 1, Page(s) 42

    Abstract: Background: The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Utility-Core 10 Dimensions (QLU-C10D) is a novel cancer-specific preference-based measure (PBM) for which value sets are being developed for an increasing ...

    Abstract Background: The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Utility-Core 10 Dimensions (QLU-C10D) is a novel cancer-specific preference-based measure (PBM) for which value sets are being developed for an increasing number of countries. This is done by obtaining health preferences from the respective general population. There is an ongoing discussion if instead patients suffering from the disease in question should be asked for their preferences. We used the QLU-C10D valuation survey, originally designed for use in the general population, in a sample of cancer patients in Austria to assess the methodology's acceptability and applicability in this target group before obtaining QLU-C10D patient preferences.
    Methods: The core of the QLU-C10D valuation survey is a discrete choice experiment in which respondents are asked to give preferences for certain health states (described by a relatively large number of 10 quality of life domains) and an associated survival time. They therewith are asked to trade off quality of life against life time. As this might be a very burdensome task for cancer patients undergoing treatment, a cognitive interview was conducted in a pilot sample to assess burden and potential additional needs for explanation in order to be able to use the DCE for the development of QLU-C10D patient preferences. In addition, responses to general feedback questions on the survey were compared against responses from a matched control group from the already completed Austrian general population valuation survey.
    Results: We included 48 patients (mean age 59.9 years; 46% female). In the cognitive interview, the majority indicated that their experience with the survey was positive (85%) and overall clarity as good (90%). In response to the general feedback questions, patients rated the presentation of the health states less clear than matched controls (p = 0.008). There was no difference between patients and the general population concerning the difficulty in choosing between the health states (p = 0.344).
    Conclusion: Despite the relatively large number of DCE domains the survey was manageable for patients and allows going on with the QLU-C10D patient valuation study.
    Language English
    Publishing date 2022-05-04
    Publishing country Germany
    Document type Journal Article
    ISSN 2509-8020
    ISSN (online) 2509-8020
    DOI 10.1186/s41687-022-00430-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cancer-Specific Health Utilities: Evaluation of Core Measurement Properties of the EORTC QLU-C10D in Lung Cancer Patients-Data from Four Multicentre LUX-Lung Trials, Applying Six Country Tariffs.

    Pilz, Micha J / Seyringer, Simone / Al-Naesan, Imad / King, Madeleine T / Bottomley, Andrew / Norman, Richard / Schlosser, Lisa / Hell, Tobias / Gamper, Eva Maria

    PharmacoEconomics - open

    2024  

    Abstract: Background: Cost-utility analysis generally requires valid preference-based measures (PBMs) to assess the utility of patient health. While generic PBMs are widely used, disease-specific PBMs may capture additional aspects of health relevant for certain ... ...

    Abstract Background: Cost-utility analysis generally requires valid preference-based measures (PBMs) to assess the utility of patient health. While generic PBMs are widely used, disease-specific PBMs may capture additional aspects of health relevant for certain patient populations. This study investigates the construct and concurrent criterion validity of the cancer-specific European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Utility-Core 10 dimensions (QLU-C10D) in non-small-cell lung cancer patients.
    Methods: We retrospectively analysed data from four multicentre LUX-Lung trials, all of which had administered the EORTC Quality of Life Questionnaire (QLQ-C30) and the EQ-5D-3L. We applied six country-specific value sets (Australia, Canada, Italy, the Netherlands, Poland, and the United Kingdom) to both instruments. Criterion validity was assessed via correlations between the instruments' utility scores. Correlations of divergent and convergent domains and Bland-Altman plots investigated construct validity. Floor and ceiling effects were assessed.
    Results: The comparison of the EORTC QLU-C10D and EQ-5D-3L produced homogenous results for five of the six country tariffs. High correlations of utilities (r > 0.7) were found for all country tariffs except for the Netherlands. Moderate to high correlations of converging domain pairs (r from 0.472 to 0.718) were found with few exceptions, such as the Social Functioning-Usual Activities domain pair (max. r = 0.376). For all but the Dutch tariff, the EORTC QLU-C10D produced consistently lower utility values compared to the EQ-5D-3L (x̄ difference from - 0.082 to 0.033). Floor and ceiling effects were consistently lower for the EORTC QLU-C10D (max. 4.67% for utilities).
    Conclusions: The six country tariffs showed good psychometric properties for the EORTC QLU-C10D in lung cancer patients. Criterion and construct validity was established. The QLU-C10D showed superior measurement precision towards the upper and lower end of the scale compared to the EQ-5D-3L, which is important when cost-utility analysis seeks to measure health change across the severity spectrum.
    Language English
    Publishing date 2024-05-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2874287-4
    ISSN 2509-4254 ; 2509-4262
    ISSN (online) 2509-4254
    ISSN 2509-4262
    DOI 10.1007/s41669-024-00484-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The EORTC QLU-C10D is a valid cancer-specific preference-based measure for cost-utility and health technology assessment in the Netherlands.

    Pilz, Micha J / Seyringer, Simon / Hallsson, Lára R / Bottomley, Andrew / Jansen, Femke / King, Madeleine T / Norman, Richard / Rutten, Marianne J / Leeuw, Irma M Verdonck-de / Siersema, Peter D / Gamper, Eva Maria

    The European journal of health economics : HEPAC : health economics in prevention and care

    2024  

    Abstract: Background: Cost-utility analysis typically relies on preference-based measures (PBMs). While generic PBMs are widely used, disease-specific PBMs can capture aspects relevant for certain patient populations. Here the EORTC QLU-C10D, a cancer-specific ... ...

    Abstract Background: Cost-utility analysis typically relies on preference-based measures (PBMs). While generic PBMs are widely used, disease-specific PBMs can capture aspects relevant for certain patient populations. Here the EORTC QLU-C10D, a cancer-specific PBM based on the QLQ-C30, is validated using Dutch trial data with the EQ-5D-3L as a generic comparator measure.
    Methods: We retrospectively analysed data from four Dutch randomised controlled trials (RCTs) comprising the EORTC QLQ-C30 and the EQ-5D-3L. Respective Dutch value sets were applied. Correlations between the instruments were calculated for domains and index scores. Bland-Altman plots and intra-class correlations (ICC) displayed agreement between the measures. Independent and paired t-tests, effect sizes and relative validity indices were used to determine the instruments' performance in detecting clinically known-group differences and health changes over time.
    Results: We analysed data from 602 cancer patients from four different trials. In overall, the EORTC QLU-C10D showed good relative validity with the EQ-5D-3L as a comparator (correlations of index scores r = 0.53-0.75, ICCs 0.686-0.808, conceptually similar domains showed higher correlations than dissimilar domains). Most importantly, it detected 63% of expected clinical group differences and 50% of changes over time in patients undergoing treatment. Both instruments showed poor performance in survivors. Detection rate and measurement efficiency were clearly higher for the QLU-C10D than for the EQ-5D-3L.
    Conclusions: The Dutch EORTC QLU-C10D showed good comparative validity in patients undergoing treatment. Our results underline the benefit that can be achieved by using a cancer-specific PBM for generating health utilities for cancer patients from a measurement perspective.
    Language English
    Publishing date 2024-03-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2045253-6
    ISSN 1618-7601 ; 1618-7598
    ISSN (online) 1618-7601
    ISSN 1618-7598
    DOI 10.1007/s10198-024-01670-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: EORTC QLQ-C30 general population normative data for Italy by sex, age and health condition: an analysis of 1,036 individuals.

    Pilz, Micha J / Gamper, Eva-Maria / Efficace, Fabio / Arraras, Juan I / Nolte, Sandra / Liegl, Gregor / Rose, Matthias / Giesinger, Johannes M

    BMC public health

    2022  Volume 22, Issue 1, Page(s) 1040

    Abstract: Background: General population normative values for the widely used health-related quality of life (HRQoL) measure, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 (EORTC QLQ-C30), are available for a ... ...

    Abstract Background: General population normative values for the widely used health-related quality of life (HRQoL) measure, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 (EORTC QLQ-C30), are available for a range of countries. These are mostly countries in northern Europe. However, there is still a lack of such normative values for southern Europe. Therefore, this study aims to provide sex-, age- and health condition-specific normative values for the general Italian population for the EORTC QLQ-C30.
    Material and methods: This study is based on Italian EORTC QLQ-C30 general population data previously collected in an international EORTC project comprising over 15,000 respondents across 15 countries. Recruitment and assessment were carried out via online panels. Quota sampling was used for sex and age groups (18‍-‍39, 40-49, 50-59, 60-69 and ≥ 70 years), separately for each country. We applied weights to match the age and sex distribution in our sample with UN statistics for Italy. Along with descriptive statistics, linear regression models were estimated to describe the associations of sex, age and health condition with the EORTC QLQ-C30 scores.
    Results: A total of 1,036 respondents from Italy were included in our analyses. The weighted mean age was 49.3 years, and 536 (51.7%) participants were female. Having at least one health condition was reported by 60.7% of the participants. Men reported better scores than women on all EORTC QLQ-C30 scales but diarrhoea. While the impact of age differed across scales, older age was overall associated with better HRQoL as shown by the summary score. For all scales, differences were in favour of participants who did not report any health condition, compared to those who reported at least one.
    Conclusion: The Italian normative values for the EORTC QLQ-C30 scales support the interpretation of HRQoL profiles in Italian cancer populations. The strong impact of health conditions on EORTC QLQ-C30 scores highlights the importance of adjusting for the impact of comorbidities in cancer patients when interpreting HRQoL data.
    MeSH term(s) Aged ; Female ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Neoplasms/epidemiology ; Quality of Life ; Sex Distribution ; Surveys and Questionnaires
    Language English
    Publishing date 2022-05-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-022-13211-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Thesis: The development of a computer adaptive test for emotional functioning in cancer patients

    Gamper, Eva-Maria

    2012  

    Abstract: Calibrated a German item bank for the computer-adaptive testing (CAT) of emotional functioning (EF) in cancer patients and tested different CAT versions. The methodology for item bank development was derived from European Organization for Research and ... ...

    Title translation Die Entwicklung eines adaptiven Computer-Tests zur Erfassung des emotionalen Funktionierens bei Krebspatienten
    Abstract Calibrated a German item bank for the computer-adaptive testing (CAT) of emotional functioning (EF) in cancer patients and tested different CAT versions. The methodology for item bank development was derived from European Organization for Research and Treatment of Cancer (EORTC) Guidelines for Module Development. They comprise thorough conceptualization and literature search, a multi-level cross-cultural review process, as well as the field testing of the developed item list in a sample of cancer patients. Data were analyzed using classical psychometric methods and item response theory (IRT) as well as real-data CAT simulations. The development procedure yielded 38 cross-culturally reviewed items assessing aspects of anxiety, depression, and general distress. They were tested in 204 cancer patients (mean age 59.3; 50.5% men). Psychometric analyses resulted in an item bank of 23 items with sufficient fit to a unidimensional model of EF and good content coverage. CAT simulations showed that the item bank is productive for CAT measurement and provides precise estimates with a small number of items. The item bank showed sufficient discriminative power, except for patients with very good EF. A severe floor effect indicated that more items would be required at the lower end of the continuum when aiming at assessing minor impairments.
    Keywords Adaptive Testing ; Adaptives Testen ; Emotional Adjustment ; Emotional Responses ; Emotionale Bewältigung ; Emotionale Reaktionen ; Krebskrankheit ; Measurement ; Messung ; Neoplasms
    Language English
    Size 134 pp.
    Publisher Universität, Fakultät für Psychologie und Sportwissenschaft
    Publishing place Innsbruck
    Document type Book ; Thesis
    Database PSYNDEX

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  7. Article ; Online: Estimation of an EORTC QLU-C10 Value Set for Spain Using a Discrete Choice Experiment.

    Finch, Aureliano Paolo / Gamper, Eva / Norman, Richard / Viney, Rosalie / Holzner, Bernhard / King, Madeleine / Kemmler, Georg

    PharmacoEconomics

    2021  Volume 39, Issue 9, Page(s) 1085–1098

    Abstract: Background: The EORTC QLU-C10D is a preference-based measure derived from the EORTC QLQ-C30. For use in economic evaluations, country-specific value sets are needed. This study aimed to generate an EORTC QLU-C10 value set for Spain.: Methods: A ... ...

    Abstract Background: The EORTC QLU-C10D is a preference-based measure derived from the EORTC QLQ-C30. For use in economic evaluations, country-specific value sets are needed. This study aimed to generate an EORTC QLU-C10 value set for Spain.
    Methods: A sample of the Spanish general population completed an online discrete choice experiment. An attribute-balanced incomplete block design was used to select 960 choice tasks, with a total of 1920 health states. Each participant was randomly assigned 16 choice sets without replacement. Data were modelled using generalized estimating equations and mixed logistic regressions.
    Results: A total of 1625 panel members were invited to participate, 1010 of whom were included in the study. Dimension decrements were generally monotonic with larger disutilities at increased severity levels. Dimensions associated with larger decrements were physical functioning and pain, while the dimension with the smallest decrement was sleep disturbances. The PITS state (i.e. worst attainable health) for the Spanish population is - 0.043.
    Conclusions: This study generated the first Spanish value set for the QLU-C10D. This can facilitate cost-utility analyses when applied to data collected with the EORTC QLQ-C30.
    MeSH term(s) Cost-Benefit Analysis ; Humans ; Logistic Models ; Quality of Life ; Spain ; Surveys and Questionnaires
    Language English
    Publishing date 2021-07-03
    Publishing country New Zealand
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1100273-6
    ISSN 1179-2027 ; 1170-7690
    ISSN (online) 1179-2027
    ISSN 1170-7690
    DOI 10.1007/s40273-021-01058-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dutch utility weights for the EORTC cancer-specific utility instrument: the Dutch EORTC QLU-C10D.

    Jansen, Femke / Verdonck-de Leeuw, Irma M / Gamper, Eva / Norman, Richard / Holzner, Bernhard / King, Madeleine / Kemmler, Georg

    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

    2021  Volume 30, Issue 7, Page(s) 2009–2019

    Abstract: Purpose: To measure utilities among cancer patients, a cancer-specific utility instrument called the European Organization for Research and Treatment of Cancer (EORTC) QLU-C10D has been developed based on EORTC quality of life core module (QLQ-C30). ... ...

    Abstract Purpose: To measure utilities among cancer patients, a cancer-specific utility instrument called the European Organization for Research and Treatment of Cancer (EORTC) QLU-C10D has been developed based on EORTC quality of life core module (QLQ-C30). This study aimed to provide Dutch utility weights for the QLU-C10D.
    Methods: A cross-sectional valuation study was performed in 1017 participants representative in age and gender of the Dutch general population. The valuation method was a discrete choice experiment containing 960 choice sets, i.e. pairs of QLU-C10D health states, each health state described in terms of the 10 QLU-C10D domains and the duration of that health state. Each participant considered 16 choice sets, choosing their preferred health state from each pair. Utility scores were derived using generalized estimation equation models. Non-monotonic levels were combined.
    Results: Utility decrements were generated for all 10 QLU-C10D domains, with largest decrements for pain (- 0.242), physical functioning (- 0.228), and role functioning (- 0.149). Non-monotonic levels of emotional functioning, pain, fatigue, sleep problems, and appetite loss were combined. No decrement in utility was seen in case of a little or quite a bit impairment in emotional functioning or a little pain. The mean QLU-C10D utility score of the participants was 0.85 (median = 0.91, interquartile range = 0.82 to 0.96).
    Conclusion: Dutch utility decrements were generated for the QLU-C10D. These are important for evaluating the cost-utility of new cancer treatments and supportive care interventions. Further insight is warranted into the added value of the QLU-C10D alongside other utility instruments.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Quality of Life/psychology ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2021-01-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1161148-0
    ISSN 1573-2649 ; 0962-9343
    ISSN (online) 1573-2649
    ISSN 0962-9343
    DOI 10.1007/s11136-021-02767-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Past and Current Practice of Patient-Reported Outcome Measurement in Randomized Cancer Clinical Trials: A Systematic Review.

    Giesinger, Johannes M / Efficace, Fabio / Aaronson, Neil / Calvert, Melanie / Kyte, Derek / Cottone, Francesco / Cella, David / Gamper, Eva-Maria

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

    2021  Volume 24, Issue 4, Page(s) 585–591

    Abstract: Objectives: In our systematic review, we assessed past and current practice of patient-reported outcome (PRO) measurement in cancer randomized, controlled trials (RCTs).: Methods: We included RCTs with PRO endpoints evaluating conventional medical ... ...

    Abstract Objectives: In our systematic review, we assessed past and current practice of patient-reported outcome (PRO) measurement in cancer randomized, controlled trials (RCTs).
    Methods: We included RCTs with PRO endpoints evaluating conventional medical treatments, conducted in patients with the most prevalent solid tumor types (breast, lung, colorectal, prostate, bladder, and gynecological cancers) and either published in 2004 to 2018 or registered on clinicaltrials.gov and initiated in 2014 to 2019. Frequency of use of individual PRO measures was assessed overall, over time, and by cancer site.
    Results: Screening of 42 095 database records and 3425 registered trials identified 480 published and 537 registered trials meeting inclusion criteria. Among published trials, the European Organisation for Research and Treatment of Cancer (EORTC) measures were used most often (54.8% of trials), followed by the Functional Assessment of Chronic Illness Therapy (FACIT) measures (35.8%), the EQ-5D (10.2%), the SF-36 (7.3%), and the MD Anderson Symptom Inventory (MDASI; 2.5%). Among registered trials, the EORTC measures were used in 66.1% of the trials, followed by the FACIT measures (25.9%), the EQ-5D (23.1%), the SF-36 (4.8%), the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE; 2.2%), the Patient-Reported Outcomes Measurement Information System (PROMIS) measures (1.7%), and the MDASI measures (1.1%).
    Conclusion: The PRO measures most frequently used in RCTs identified in our review differ substantially in terms of content and domains, reflecting the ongoing debate among the scientific community, healthcare providers, and regulators on the type of PRO to be measured. Current findings may contribute to better informing the development of an internationally agreed core outcome set for future cancer trials.
    MeSH term(s) Humans ; Neoplasms/psychology ; Neoplasms/therapy ; Patient Reported Outcome Measures ; Quality of Life ; Randomized Controlled Trials as Topic ; Surveys and Questionnaires
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Systematic Review
    ZDB-ID 1471745-1
    ISSN 1524-4733 ; 1098-3015
    ISSN (online) 1524-4733
    ISSN 1098-3015
    DOI 10.1016/j.jval.2020.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Correction to: do patients consider computer-adaptive measures more appropriate than static questionnaires?

    Gamper, Eva-Maria / Martini, Caroline / Petersen, Morten Aagaard / Virgolini, Irene / Holzner, Bernhard / Giesinger, Johannes M

    Journal of patient-reported outcomes

    2019  Volume 3, Issue 1, Page(s) 13

    Abstract: Following publication of the original article [1], the authors reported three of their given name have been erroneously tagged as their family names. The correct names are: give name Caroline family name Martini, give name Irene family name Virgolini, ... ...

    Abstract Following publication of the original article [1], the authors reported three of their given name have been erroneously tagged as their family names. The correct names are: give name Caroline family name Martini, give name Irene family name Virgolini, give name Bernhard family name Holzner.
    Language English
    Publishing date 2019-02-19
    Publishing country Germany
    Document type Published Erratum
    ISSN 2509-8020
    ISSN (online) 2509-8020
    DOI 10.1186/s41687-019-0103-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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