LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 876

Search options

  1. Book ; Online: Commercial Banking

    Gan, Christopher

    2021  

    Keywords Coins, banknotes, medals, seals (numismatics) ; deposit insurance ; capital adequacy ; bank risk ; foreign bank entry ; bank competition ; H-statistics ; pooled regression ; dynamic panel models ; risk-taking behavior ; banks ; efficiency ; data envelopment analysis ; Asia-Pacific ; regulations ; bank capital ; meta-analysis ; Bayesian model-averaging ; capital regulation ; competition ; Indian banking sector ; panel data ; revenue diversification ; bank risks ; bank performance ; net interest income ; non-interest income ; risks ; capital
    Size 1 electronic resource (142 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021291436
    ISBN 9783036509419 ; 3036509410
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

  2. Article ; Online: Solution-Focused Brief Therapy (SFBT) with individuals with brain injury and their families.

    Gan, Caron

    NeuroRehabilitation

    2020  Volume 46, Issue 2, Page(s) 143–155

    Abstract: Background: Brain injury is considered a chronic condition and the medical model has long been the traditional paradigm underlying rehabilitation programs for people after acquired brain injury (ABI). In recent years, strengths-based approaches have ... ...

    Abstract Background: Brain injury is considered a chronic condition and the medical model has long been the traditional paradigm underlying rehabilitation programs for people after acquired brain injury (ABI). In recent years, strengths-based approaches have been increasingly proposed, but little has been written about specific psychotherapeutic application in ABI rehabilitation.
    Objective: To describe a strengths-based model, Solution-Focused Brief Therapy (SFBT) and its clinical application to individuals with ABI and their families.
    Methods: The author describes the assumptions, tenets, and principles of SFBT, a competency-based and resource-based model that orients to the future and focuses on strengths and successes. A direct comparison is made between the traditional medical paradigm and the solution-focused paradigm.
    Results: Key ingredients of SFBT are described, including specific strategies, techniques, and its clinical application with individuals with ABI and their families. Limitations around using SFBT and the need for further research with ABI populations are reported.
    Conclusions: SFBT is a welcome shift away from the problem-saturated stories that underlie traditional rehabilitation approaches. The strengths-based underpinning of SFBT is a promising psychotherapeutic intervention that merits further investigation with ABI populations.
    MeSH term(s) Brain Injuries/psychology ; Brain Injuries/therapy ; Family Therapy/methods ; Humans ; Psychotherapy, Brief/methods ; Writing
    Language English
    Publishing date 2020-02-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1087912-2
    ISSN 1878-6448 ; 1053-8135
    ISSN (online) 1878-6448
    ISSN 1053-8135
    DOI 10.3233/NRE-192967
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Using the "Frontalis-Free Orbital Septum-Complex Flap" in the Correction of Unilateral Congenital Ptosis.

    Yan, Yucheng / Gan, Cheng

    The Journal of craniofacial surgery

    2023  Volume 34, Issue 6, Page(s) e602–e604

    Abstract: Congenital ptosis has deleterious effects on the appearance and vision-related function. Patients need timely and effective treatments. A new surgical practice was performed using the discarded fibrous and thickened orbital septum to prolong the advanced ...

    Abstract Congenital ptosis has deleterious effects on the appearance and vision-related function. Patients need timely and effective treatments. A new surgical practice was performed using the discarded fibrous and thickened orbital septum to prolong the advanced frontalis muscular flap and reduce iatrogenic injuries in the frontalis. A 5-year-old boy with severe unilateral congenital ptosis was enrolled and got satisfactory surgical effects without complication. The "frontalis-free orbital septum-complex flap" is a new and relatively ideal method. The purpose of this paper is to demonstrate this surgical practice and provide a new idea for correcting congenital ptosis with the thickened and fibrotic orbital septum.
    MeSH term(s) Male ; Humans ; Child, Preschool ; Blepharoptosis ; Blepharoplasty/methods ; Free Tissue Flaps/surgery ; Treatment Outcome ; Fascia ; Fibrosis ; Oculomotor Muscles/surgery
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000009533
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Left distal ureter leiomyosarcoma: a case report.

    Gan, C / Attwell-Heap, A / Clarke, A

    Journal of surgical case reports

    2022  Volume 2022, Issue 11, Page(s) rjac501

    Abstract: Primary leiomyosarcoma of the ureter is an extremely rare, aggressive malignancy of the urinary tract. This report describes a case of primary leiomyosarcoma of the distal left ureter in a middle-aged male, with no tumor recurrence achieved following ... ...

    Abstract Primary leiomyosarcoma of the ureter is an extremely rare, aggressive malignancy of the urinary tract. This report describes a case of primary leiomyosarcoma of the distal left ureter in a middle-aged male, with no tumor recurrence achieved following resection and end-to-end ureteroureterostomy.
    Language English
    Publishing date 2022-11-09
    Publishing country England
    Document type Case Reports
    ZDB-ID 2580919-2
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjac501
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Can green finance reduce carbon emission intensity? Mechanism and threshold effect

    Gan, Chang / Voda, Mihai

    Environ Sci Pollut Res. 2023 Jan., v. 30, no. 1 p.640-653

    2023  

    Abstract: Against the background of carbon emission reduction, green finance (GF) has become a crucial financial instrument that promotes industrial transformation and low-carbon development. Although some scholars have explored the driving factors affecting the ... ...

    Abstract Against the background of carbon emission reduction, green finance (GF) has become a crucial financial instrument that promotes industrial transformation and low-carbon development. Although some scholars have explored the driving factors affecting the carbon emission intensity (CEI), there is a dearth of literature on the mediation and threshold effects of GF on CEI. Based on the panel data of 30 provinces in China during the period of 2004~2019, this study examined the direct, indirect, and threshold effects of GF on CEI by adopting the panel ordinary least squares, mediation effect, and threshold regression models, respectively. This study draws the following conclusions: GF can directly reduce the CEI. In addition, the scale economics effect and green technology innovation caused by GF have an inhibiting effect on the CEI. However, GF can promote the CEI through structural transformation. What’s more, this study interestingly found that the effect of GF reducing CEI is dynamic and nonlinear. These findings can provide references for policy-makers who hope to accelerate carbon emission reduction and achieve low-carbon development.
    Keywords carbon ; emissions factor ; finance ; sustainable technology ; technology ; China
    Language English
    Dates of publication 2023-01
    Size p. 640-653.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-22176-9
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  6. Article ; Online: Exosomes Released from Bone-Marrow Stem Cells Ameliorate Hippocampal Neuronal Injury Through transferring miR-455-3p.

    Gan, Chao / Ouyang, Feng

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2022  Volume 31, Issue 8, Page(s) 106142

    Abstract: Background: The neuroprotective roles of mesenchymal stem cells (MSCs) in brain injury are elicited at least partially through the secretion exosomes containing microRNAs (miRNAs). We herein investigate the protective function of bone marrow MSCs (BMSCs) ...

    Abstract Background: The neuroprotective roles of mesenchymal stem cells (MSCs) in brain injury are elicited at least partially through the secretion exosomes containing microRNAs (miRNAs). We herein investigate the protective function of bone marrow MSCs (BMSCs)-derived exosomes harboring miR-455-3p against hippocampal neuronal injury in mouse and N2a cell damage model.
    Methods: First, BMSC surface markers were detected by flow cytometry, followed by extraction of BMSCs-derived exosomes (BMSCs-Exos). A mouse model of neuronal injury was induced by middle cerebral artery occlusion/reperfusion (MCAO/R), and N2a cells were exposed to oxygen-glucose deprivation/reoxygenation (OGD/R) for in vitro experiments. BMSCs-Exos were administrated in mice and N2a cells. We subsequently determined viability- and apoptosis-features using EdU staining, CCK-8, flow cytometry and Caspase-3 kits. Subsequently, we used RT-qPCR to assess miR-455-3p expression in brain tissues as well as N2a cells, and bioinformatic tools to predict the targeting mRNA of miR-455-3p, which was validated by dual-luciferase assays.
    Results: BMSCs-Exos improved hippocampal neuronal injury in MCAO/R-treated mice and OGD/R-induced injury to N2a cells. BMSCs-Exos upregulated miR-455-3p expression in brain tissues of mice and OGD/R-treated N2a cells. miR-455-3p targeted and conversely regulated PDCD7 expression. The protective effect of BMSCs-Exos on OGD/R-treated N2a cells was markedly mitigated following miR-455-3p downregulation. Moreover, overexpression of miR-455-3p contributed to increased N2a cell activity and decreased apoptosis, while the rescue experiment results were opposite.
    Conclusion: MSCs-derived exosomal miR-455-3p targeted PDCD7 to alleviate hippocampal neuronal injury in MCAO/R-treated mice and injury of OGD/R-treated N2a cells.
    MeSH term(s) Apoptosis ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Bone Marrow/metabolism ; Exosomes/genetics ; Exosomes/metabolism ; Hippocampus/metabolism ; Humans ; Infarction, Middle Cerebral Artery/genetics ; Infarction, Middle Cerebral Artery/metabolism ; Infarction, Middle Cerebral Artery/therapy ; Mesenchymal Stem Cells/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Reperfusion Injury/metabolism ; Transcription Factors/metabolism
    Chemical Substances Apoptosis Regulatory Proteins ; MIRN455 microRNA, human ; MicroRNAs ; PDCD7 protein, human ; Transcription Factors
    Language English
    Publishing date 2022-05-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2021.106142
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Can green finance reduce carbon emission intensity? Mechanism and threshold effect.

    Gan, Chang / Voda, Mihai

    Environmental science and pollution research international

    2022  

    Abstract: Against the background of carbon emission reduction, green finance (GF) has become a crucial financial instrument that promotes industrial transformation and low-carbon development. Although some scholars have explored the driving factors affecting the ... ...

    Abstract Against the background of carbon emission reduction, green finance (GF) has become a crucial financial instrument that promotes industrial transformation and low-carbon development. Although some scholars have explored the driving factors affecting the carbon emission intensity (CEI), there is a dearth of literature on the mediation and threshold effects of GF on CEI. Based on the panel data of 30 provinces in China during the period of 2004~2019, this study examined the direct, indirect, and threshold effects of GF on CEI by adopting the panel ordinary least squares, mediation effect, and threshold regression models, respectively. This study draws the following conclusions: GF can directly reduce the CEI. In addition, the scale economics effect and green technology innovation caused by GF have an inhibiting effect on the CEI. However, GF can promote the CEI through structural transformation. What's more, this study interestingly found that the effect of GF reducing CEI is dynamic and nonlinear. These findings can provide references for policy-makers who hope to accelerate carbon emission reduction and achieve low-carbon development.
    Language English
    Publishing date 2022-07-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-22176-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: [Eriocitrin suppresses proliferation and migration of hepatocellular carcinoma SMMC-7721 cells by promoting ROS production and activating the MAPK pathway].

    Zhou, H / Zhang, Y / Gan, C / Fan, X / Qi, Z / Qi, S

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

    2023  Volume 43, Issue 3, Page(s) 412–419

    Abstract: Objective: To investigate the role of the ROS/MAPK signaling axis in mediating the inhibitory effect of eriocitrin on proliferation and migration of hepatocellular carcinoma SMMC-7721 cells.: Methods: SMMC-7721 cells were treated with different ... ...

    Abstract Objective: To investigate the role of the ROS/MAPK signaling axis in mediating the inhibitory effect of eriocitrin on proliferation and migration of hepatocellular carcinoma SMMC-7721 cells.
    Methods: SMMC-7721 cells were treated with different concentrations of eriocitrin for 24 h, and the changes in cell viability were detected with CCK-8 assay. The migration and invasion abilities of the treated cells were evaluated using Transwell and scratch healing assays, the cell proliferation was assessed with colony-forming assay, and changes in nuclear morphology were observed with DAPI staining. Western blotting was performed to examine the changes in the expressions of E-cadherin, N-cadherin, MMP-2, MMP-9, PARP, Pro-caspase 3, pJNK, p-P38, and p-ERK. The effect of eriocitrin on PARP cleavage in SMMC-7721 cells pretreated with ERK, JNK and P38 inhibitors (U0126, SB203580 and SP600125, respectively) was detected using Western blotting. The effect of treatment with Nacetyl-cysteine (NAC, 30 μmol/L) and eriocitrin (100, 200, and 300 μg/mL), alone or in combination, on reactive oxygen species (ROS) levels in the cells was examined using a DCFH-DA fluorescent probe.
    Results: Eriocitrin below 50 μg/mL did not produce significant effect on the viability of SMMC-7721 cells (
    Conclusion: Eriocitrin can suppress the proliferation and migration and promote apoptosis of hepatocellular carcinoma SMMC-7721 cells by promoting ROS production and activating the MAPKs signaling pathway.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Reactive Oxygen Species/metabolism ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9 ; Cell Line, Tumor ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Cell Proliferation ; Apoptosis
    Chemical Substances U 0126 ; pyrazolanthrone (1TW30Y2766) ; Reactive Oxygen Species ; eriocitrin (AS293HR5XQ) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Poly(ADP-ribose) Polymerase Inhibitors
    Language Chinese
    Publishing date 2023-04-22
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2250951-3
    ISSN 1673-4254
    ISSN 1673-4254
    DOI 10.12122/j.issn.1673-4254.2023.03.11
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Is routine gastrointestinal endoscopy required in every woman with mucinous ovarian cancer? An analysis of survival rates and metastatic tumours in a cancer centre.

    Katsanevakis, E / Addo-Yobo, W / Bharathan, B / Loona, A / Gan, C / Nunns, D / Gajjar, K

    European journal of obstetrics, gynecology, and reproductive biology

    2024  Volume 294, Page(s) 105–110

    Abstract: Introduction: Mucinous ovarian cancer (MOC) represents a rare entity of ovarian malignant neoplasms. The true incidence could be as low as 3% of all ovarian cancers. The aim of this study is to compare and understand the clinicopathological ... ...

    Abstract Introduction: Mucinous ovarian cancer (MOC) represents a rare entity of ovarian malignant neoplasms. The true incidence could be as low as 3% of all ovarian cancers. The aim of this study is to compare and understand the clinicopathological characteristics of patients with mucinous ovarian cancer, report on the survival rates and evaluate the role of gastrointestinal (GI) endoscopy as part of the peri-operative investigations and the impact it has on the survival rates.
    Methodology: This is a retrospective data collection on patients with MOC operated in Nottingham gynaecological oncology centre over a 10-year period. Data were analysed using SPSS software.
    Results: 43 cases were included in the final analysis. The median maximal tumour diameter was 180 mm. 32 (74.5 %) and 11 (25.5 %) women presented with unilateral and bilateral tumours respectively. 30 patients (69.7 %) presented with stage 1 disease, 1 (2.3 %) presented with stage 2 disease, 7 women (16.4 %) had stage 3 disease and 1 woman (11.6 %) had stage 4 disease. 41 women had staging surgical procedures and 2 women had limited surgery due to poor performance status. After final histology, 5 cases found to have metastatic disease to the ovary rather than primary MOC. 14 women had GI endoscopy as part of their investigation. The total estimated cost of the endoscopies that have been performed is £5635. Primary GI cancer was diagnosed in 1 case during the endoscopy (1 case of gastric cancer). The 5-year overall survival of the women included in this study is 62.8 %. The 5-year overall survival of the women in the endoscopy and non-endoscopy groups was 60 % and 64.3 % respectively (p-value: 0.767).
    Conclusion: The findings of this study show that the survival rates of patients treated for mucinous ovarian cancer in our centre are similar to other published studies. Our findings do not support the routine use of GI endoscopy in the peri-operative investigations of every patient with MOC due to the non-statistically significant difference in the overall survival.
    MeSH term(s) Humans ; Female ; Male ; Retrospective Studies ; Survival Rate ; Carcinoma, Ovarian Epithelial/pathology ; Ovarian Neoplasms/pathology ; Adenocarcinoma, Mucinous/pathology ; Endoscopy, Gastrointestinal ; Neoplasm Staging
    Language English
    Publishing date 2024-01-14
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2024.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Active substance and mechanisms of Actinidia chinensis Planch for the treatment of breast cancer was explored based on network pharmacology and in silico study.

    Xu, Yujing / Yang, Jinrong / Han, Xiaoyu / Gan, Chunchun / Wei, Xiaopeng

    Medicine

    2024  Volume 103, Issue 15, Page(s) e37829

    Abstract: In this paper, our objective was to investigate the potential mechanisms of Actinidia chinensis Planch (ACP) for breast cancer treatment with the application of network pharmacology, molecular docking, and molecular dynamics. "Mihoutaogen" was used as a ... ...

    Abstract In this paper, our objective was to investigate the potential mechanisms of Actinidia chinensis Planch (ACP) for breast cancer treatment with the application of network pharmacology, molecular docking, and molecular dynamics. "Mihoutaogen" was used as a key word to query the Traditional Chinese Medicine Systems Pharmacology database for putative ingredients of ACP and its related targets. DrugBank, GeneCards, Online Mendelian Inheritance in Man, and therapeutic target databases were used to search for genes associated with "breast cancer." Using Cytoscape 3.9.0 we then constructed the protein-protein interaction and drug-ingredient-target-disease networks. An enrichment analysis of Kyoto encyclopedia of genes and genomes pathway and gene ontology were performed to exploration of the signaling pathways associated with ACP for breast cancer treatment. Discovery Studio software was applied to molecular docking. Finally, the ligand-receptor complex was subjected to a 50-ns molecular dynamics simulation using the Desmond_2020.4 tools. Six main active ingredients and 176 targets of ACP and 2243 targets of breast cancer were screened. There were 118 intersections of targets for both active ingredients and diseases. Tumor protein P53 (TP53), AKT serine/threonine kinase 1 (AKT1), estrogen receptor 1 (ESR1), Erb-B2 receptor tyrosine kinase 2 (ERBB2), epidermal growth factor receptor (EGFR), Jun Proto-Oncogene (JUN), and Heat Shock Protein 90 Alpha Family Class A Member 1 (HSP90AA1) selected as the most important genes were used for verification by molecular docking and molecular dynamics simulation. The primary active compounds of ACP against breast cancer were predicted preliminarily, and its mechanism was studied, thereby providing a theoretical basis for future clinical studies.
    MeSH term(s) Humans ; Female ; Actinidia ; Network Pharmacology ; Breast Neoplasms/drug therapy ; Molecular Docking Simulation ; Databases, Genetic
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037829
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top