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Article ; Online: Melatonin as a therapeutic agent for alleviating endothelial dysfunction in cardiovascular diseases: Emphasis on oxidative stress.

Zhang, Xiaolu / Zheng, Yujia / Wang, Ziyu / Gan, Jiali / Yu, Bin / Lu, Bin / Jiang, Xijuan

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 167, Page(s) 115475

Abstract: The vascular endothelium is vital in maintaining cardiovascular health by regulating vascular permeability and tone, preventing thrombosis, and controlling vascular inflammation. However, when oxidative stress triggers endothelial dysfunction, it can ... ...

Abstract	The vascular endothelium is vital in maintaining cardiovascular health by regulating vascular permeability and tone, preventing thrombosis, and controlling vascular inflammation. However, when oxidative stress triggers endothelial dysfunction, it can lead to chronic cardiovascular diseases (CVDs). This happens due to oxidative stress-induced mitochondrial dysfunction, inflammatory responses, and reduced levels of nitric oxide. These factors cause damage to endothelial cells, leading to the acceleration of CVD progression. Melatonin, a natural antioxidant, has been shown to inhibit oxidative stress and stabilize endothelial function, providing cardiovascular protection. The clinical application of melatonin in the prevention and treatment of CVDs has received widespread attention. In this review, based on bibliometric studies, we first discussed the relationship between oxidative stress-induced endothelial dysfunction and CVDs, then summarized the role of melatonin in the treatment of atherosclerosis, hypertension, myocardial ischemia-reperfusion injury, and other CVDs. Finally, the potential clinical use of melatonin in the treatment of these diseases is discussed.
Language	English
Publishing date	2023-09-16
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115475
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Article ; Online: Therapeutic Role and Potential Mechanism of Resveratrol in Atherosclerosis: TLR4/NF-

Guo, Lin / Zhang, Xiaolu / Lv, Nuan / Wang, Luming / Gan, Jiali / Jiang, Xijuan / Wang, Yijing

Mediators of inflammation

2023 Volume 2023, Page(s) 1097706

Abstract: Atherosclerosis, the main pathological basis of cardiovascular disease, is a chronic inflammatory disease that severely affects the quality of human life. Resveratrol (Res) is a natural polyphenol that is a major component of many herbs and foods. The ... ...

Abstract	Atherosclerosis, the main pathological basis of cardiovascular disease, is a chronic inflammatory disease that severely affects the quality of human life. Resveratrol (Res) is a natural polyphenol that is a major component of many herbs and foods. The present study analyzed resveratrol from the perspective of visualization and bibliometric analysis and found that resveratrol is closely related to the inflammatory response in cardiovascular diseases (associated with atherosclerosis). To explore the specific molecular mechanism of resveratrol, network pharmacology and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used, in which HIF-1
MeSH term(s)	Humans ; NF-kappa B/metabolism ; Resveratrol/pharmacology ; Resveratrol/therapeutic use ; Toll-Like Receptor 4/metabolism ; Lipopolysaccharides/pharmacology ; Anti-Inflammatory Agents ; Atherosclerosis/drug therapy
Chemical Substances	NF-kappa B ; Resveratrol (Q369O8926L) ; Toll-Like Receptor 4 ; Lipopolysaccharides ; Anti-Inflammatory Agents ; TLR4 protein, human
Language	English
Publishing date	2023-05-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2023/1097706
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Zs.A 3575: Show issues

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Article ; Online: Myocardial Ischemia/Reperfusion Injury: Mechanism and Targeted Treatment for Ferroptosis.

Deng, Yun / Chen, Qiaoling / Wang, Tianyu / Wang, Shuangcui / Li, Ruoyun / Wang, Yuli / Zhang, Jiaqi / Gan, Jiali / Guo, Maojuan

Anatolian journal of cardiology

2024

Abstract: Myocardial ischemia/reperfusion injury (MIRI) is a pathophysiological process connected to the onset of numerous heart disorders. The pathogenesis of MIRI is complex, and it mainly involves calcium overload, classic oxidative stress, mitochondrial ... ...

Abstract	Myocardial ischemia/reperfusion injury (MIRI) is a pathophysiological process connected to the onset of numerous heart disorders. The pathogenesis of MIRI is complex, and it mainly involves calcium overload, classic oxidative stress, mitochondrial disorder, inflammation, microvascular disorder, and cell death. The clinical treatment options for MIRI are presently constrained, making it imperative to develop new treatment modalities. Recent studies have demonstrated that ferroptosis is the main cause of MIRI. Ferroptosis is a new type of regulated iron-dependent cell death whose mechanism and targeted therapy are anticipated to be novel therapeutic techniques for MIRI. Herein, the primary mechanism underlying ferroptosis (the 3 major metabolic routes involving iron, amino acids, and lipids, and in MIRI, the specific mechanism and therapeutic target of ferroptosis) are discussed to determine the potential therapeutic approach for MIRI.
Language	English
Publishing date	2024-02-19
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2278670-3
ISSN	2149-2271 ; 2149-2271
ISSN (online)	2149-2271
ISSN	2149-2271
DOI	10.14744/AnatolJCardiol.2023.3606
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Article ; Online: Enhanced performance in uranium extraction by the synergistic effect of functional groups on chitosan-based adsorbent.

Xin, Qi / Wang, Qingliang / Gan, Jiali / Lei, Zhiwu / Hu, Eming / Wang, Hongqing / Wang, Hongqiang

Carbohydrate polymers

2022 Volume 300, Page(s) 120270

Abstract: In this study, a novel sponge phosphoric acid functionalized porous composite adsorbent (named SPCCHC) was prepared from chitosan and chlorella hydrothermal charcoal. Kinetics and thermodynamics experiments showed that the theoretical maximum adsorption ... ...

Abstract	In this study, a novel sponge phosphoric acid functionalized porous composite adsorbent (named SPCCHC) was prepared from chitosan and chlorella hydrothermal charcoal. Kinetics and thermodynamics experiments showed that the theoretical maximum adsorption capacity of SPCCHC to U(VI) is 579.27 mg/g (288 K, pH = 6.5), indicating a spontaneous exothermic reaction. SPCCHC showed good adsorption selectivity for uranium in the adsorption studies of simulated seawater and a mixed solution of uranium-vanadium. The characterization of SPCCHC before and after U(VI) adsorption proves that the introduction of the phosphate group can greatly improve the adsorption effect of the adsorbent on uranium, particularly the distribution coefficients of uranium and vanadium differ by up to 89.5 times. At the same time, SPCCHC has good recycling performance, which is expected to be used in natural seawater uranium extraction.
MeSH term(s)	Uranium/chemistry ; Chitosan/chemistry ; Vanadium ; Chlorella ; Adsorption ; Kinetics
Chemical Substances	Uranium (4OC371KSTK) ; Chitosan (9012-76-4) ; Vanadium (00J9J9XKDE)
Language	English
Publishing date	2022-10-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2022.120270
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Article ; Online: Polyvinyl alcohol/phytic acid/phosphorylated chitosan hydrogel electrode highly efficient electroadsorption of low concentration uranium from uranium tailings leachate.

Gan, Jiali / Le, Dongdong / Wang, Qingliang / Xin, Qi / Hu, Eming / Lei, Zhiwu / Wang, Hongqing / Wang, Hongqiang

International journal of biological macromolecules

2023 Volume 254, Issue Pt 3, Page(s) 128008

Abstract: In order to improve the removal rate of uranium and reduce the harm of radioactive pollution, a physically crosslinked polyvinyl alcohol/phosphorylated chitosan (PPP) hydrogel electrode was designed by freezing thawing method. The results show that PPP ... ...

Abstract	In order to improve the removal rate of uranium and reduce the harm of radioactive pollution, a physically crosslinked polyvinyl alcohol/phosphorylated chitosan (PPP) hydrogel electrode was designed by freezing thawing method. The results show that PPP hydrogel has a good adsorption effect on uranium, and 200 mL of uranium tailings leachate is absorbed, and the treatment efficiency reaches 100 % within 15 min. PPP hydrogel can adapt to a wide range of pH conditions and exhibit excellent adsorption efficiency in the range of 3-9. At the same time, PPP hydrogel maintains an adsorption efficiency of over 85 % for 950 mg/L uranium solution. This lays the foundation for the practical application of PPP hydrogel. In addition, PPP hydrogel also exhibits good repeatability, after 7 cycles, the material still retains 95 % of its initial performance. The synergistic effect of various functional groups such as phosphate, hydroxyl, and ammonium in the material is the main mechanism of PPP's adsorption capacity for uranium. Furthermore, electrochemical adsorption method significantly enhances the adsorption performance of PPP hydrogel.
MeSH term(s)	Uranium ; Chitosan ; Phytic Acid ; Polyvinyl Alcohol ; Hydrogen-Ion Concentration ; Hydrogels ; Adsorption
Chemical Substances	Uranium (4OC371KSTK) ; Chitosan (9012-76-4) ; Phytic Acid (7IGF0S7R8I) ; polyvinyl alcohol hydrogel ; Polyvinyl Alcohol (9002-89-5) ; Hydrogels
Language	English
Publishing date	2023-11-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.128008
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Zs.B 2374: Show issues

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Article: Does an apple a day keep away diseases? Evidence and mechanism of action.

Zhang, Yue / Zeng, Miao / Zhang, Xiaolu / Yu, Qun / Zeng, Wenyun / Yu, Bin / Gan, Jiali / Zhang, Shiwu / Jiang, Xijuan

Food science & nutrition

2023 Volume 11, Issue 9, Page(s) 4926–4947

Abstract: Apples and their products exemplify the recently reemphasized link between dietary fruit intake and the alleviation of human disease. Their consumption does indeed improve human health due to their high phytochemical content. To identify potentially ... ...

Abstract	Apples and their products exemplify the recently reemphasized link between dietary fruit intake and the alleviation of human disease. Their consumption does indeed improve human health due to their high phytochemical content. To identify potentially relevant articles from clinical trials, some epidemiological studies and meta-analyses, and in vitro and in vivo studies (cell cultures and animal models), PubMed was searched from January 1, 2012, to May 15, 2022. This review summarized the potential effects of apple and apple products (juices, puree, pomace, dried apples, extracts rich in apple bioactives and single apple bioactives) on health. Apples and apple products have protective effects against cardiovascular diseases, cancer, as well as mild cognitive impairment and promote hair growth, healing of burn wounds, improve the oral environment, prevent niacin-induced skin flushing, promote the relief of UV-induced skin pigmentation, and improve the symptoms of atopic dermatitis as well as cedar hay fever among others. These effects are associated with various mechanisms, such as vascular endothelial protection, blood lipids lowering, anti-inflammatory, antioxidant, antiapoptotic, anti-invasion, and antimetastatic effects. Meanwhile, it has provided an important reference for the application and development of medicine, nutrition, and other fields.
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.3487
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Article ; Online: Inflammatory signaling pathways in the treatment of Alzheimer's disease with inhibitors, natural products and metabolites (Review).

Zheng, Yujia / Zhang, Xiaolu / Zhang, Ruifeng / Wang, Ziyu / Gan, Jiali / Gao, Qing / Yang, Lin / Xu, Pengjuan / Jiang, Xijuan

International journal of molecular medicine

2023 Volume 52, Issue 5

Abstract: The intricate nature of Alzheimer's disease (AD) pathogenesis poses a persistent obstacle to drug development. In recent times, neuroinflammation has emerged as a crucial pathogenic mechanism of AD, and the targeting of inflammation has become a viable ... ...

Abstract	The intricate nature of Alzheimer's disease (AD) pathogenesis poses a persistent obstacle to drug development. In recent times, neuroinflammation has emerged as a crucial pathogenic mechanism of AD, and the targeting of inflammation has become a viable approach for the prevention and management of AD. The present study conducted a comprehensive review of the literature between October 2012 and October 2022, identifying a total of 96 references, encompassing 91 distinct pharmaceuticals that have been investigated for their potential impact on AD by inhibiting neuroinflammation. Research has shown that pharmaceuticals have the potential to ameliorate AD by reducing neuroinflammation mainly through regulating inflammatory signaling pathways such as NF‑κB, MAPK, NLRP3, PPARs, STAT3, CREB, PI3K/Akt, Nrf2 and their respective signaling pathways. Among them, tanshinone IIA has been extensively studied for its anti‑inflammatory effects, which have shown significant pharmacological properties and can be applied clinically. Thus, it may hold promise as an effective drug for the treatment of AD. The present review elucidated the inflammatory signaling pathways of pharmaceuticals that have been investigated for their therapeutic efficacy in AD and elucidates their underlying mechanisms. This underscores the auspicious potential of pharmaceuticals in ameliorating AD by impeding neuroinflammation.
MeSH term(s)	Humans ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Neuroinflammatory Diseases ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction ; Pharmaceutical Preparations
Chemical Substances	Amyloid beta-Peptides ; Biological Products ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Pharmaceutical Preparations
Language	English
Publishing date	2023-10-06
Publishing country	Greece
Document type	Review ; Journal Article
ZDB-ID	1444428-8
ISSN	1791-244X ; 1107-3756
ISSN (online)	1791-244X
ISSN	1107-3756
DOI	10.3892/ijmm.2023.5314
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Zs.A 4942: Show issues

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Article ; Online: Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review).

Zhang, Xiaolu / Wang, Ziyu / Zheng, Yujia / Yu, Qun / Zeng, Miao / Bai, Liding / Yang, Lin / Guo, Maojuan / Jiang, Xijuan / Gan, Jiali

International journal of molecular medicine

2023 Volume 51, Issue 4

Abstract: The inflammasome regulates innate immunity by serving as a signaling platform. The Nod‑like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein apoptosis‑associated speck‑like protein (ASC) and pro‑caspase‑1, is by far the ... ...

Abstract	The inflammasome regulates innate immunity by serving as a signaling platform. The Nod‑like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein apoptosis‑associated speck‑like protein (ASC) and pro‑caspase‑1, is by far the most extensively studied and well‑characterized inflammasome. A variety of stimuli can activate the NLRP3 inflammasome. When activated, the NLRP3 protein recruits the adaptor ASC protein and activates pro‑caspase‑1, resulting in inflammatory cytokine maturation and secretion, which is associated with inflammation and pyroptosis. However, the aberrant activation of the NLRP3 inflammasome has been linked to various inflammatory diseases, including atherosclerosis, ischemic stroke, Alzheimer's disease, diabetes mellitus and inflammatory bowel disease. Therefore, the NLRP3 inflammasome has emerged as a promising therapeutic target for inflammatory diseases. In the present review, systematic searches were performed using 'NLRP3 inhibitor(s)' and 'inflammatory disease(s)' as key words. By browsing the literature from 2012 to 2022, 100 articles were retrieved, of which 35 were excluded as they were reviews, editorials, retracted or unavailable online, and 65 articles were included. According to the retrieved literature, the current understanding of NLRP3 inflammasome pathway activation in inflammatory diseases was summarize, and inhibitors of the NLRP3 inflammasome pathway targeting the NLRP3 protein and other inflammasome components or products were highlighted. Additionally, the present review briefly discusses the current novel efforts in clinical research.
MeSH term(s)	Humans ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; NLR Proteins ; Caspase 1 ; Inflammation/drug therapy
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLR Proteins ; Caspase 1 (EC 3.4.22.36)
Language	English
Publishing date	2023-03-24
Publishing country	Greece
Document type	Review ; Journal Article
ZDB-ID	1444428-8
ISSN	1791-244X ; 1107-3756
ISSN (online)	1791-244X
ISSN	1107-3756
DOI	10.3892/ijmm.2023.5238
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Article ; Online: Sodium Danshensu stabilizes atherosclerotic vulnerable plaques by targeting IKKβ mediated inflammation in macrophages.

Zeng, Miao / Zhang, Xiaolu / Lv, Nuan / Wang, Luming / Suo, Yanrong / Gan, Jiali / Yang, Lin / Yu, Bin / Jiang, Xijuan / Zeng, Wenyun

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 165, Page(s) 115153

Abstract: Background: The primary cause of acute cardiovascular events with high mortality is the rupture of atherosclerotic plaque followed by thrombosis. Sodium Danshensu (SDSS) has shown potential in inhibiting the inflammatory response in macrophages and ... ...

Abstract	Background: The primary cause of acute cardiovascular events with high mortality is the rupture of atherosclerotic plaque followed by thrombosis. Sodium Danshensu (SDSS) has shown potential in inhibiting the inflammatory response in macrophages and preventing early plaque formation in atherosclerotic mice. However, the specific targets and detailed mechanism of action of SDSS are still unclear. Objective: This study aims to investigate the efficacy and mechanism of SDSS in inhibiting inflammation in macrophages and stabilizing vulnerable plaques in atherosclerosis (AS). Materials and methods: The efficacy of SDSS in stabilizing vulnerable plaques was demonstrated using various techniques such as ultrasound, Oil Red O staining, HE staining, Masson staining, immunohistochemistry, and lipid analysis in ApoE Results: Initially, the administration of SDSS led to a decrease in the formation and area of aortic plaque, while also stabilizing vulnerable plaques in ApoE Conclusions: SDSS stabilized vulnerable plaques and suppressed inflammatory responses by inhibiting the NF-κB pathway through its targeting of IKKβ.
MeSH term(s)	Animals ; Mice ; Plaque, Atherosclerotic/drug therapy ; Plaque, Atherosclerotic/metabolism ; NF-kappa B/metabolism ; I-kappa B Kinase/metabolism ; Signal Transduction ; Molecular Docking Simulation ; Atherosclerosis/metabolism ; Macrophages/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Apolipoproteins E/metabolism
Chemical Substances	NF-kappa B ; I-kappa B Kinase (EC 2.7.11.10) ; 3,4-dihydroxyphenyllactic acid (4GF33A5PAJ) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Apolipoproteins E
Language	English
Publishing date	2023-07-10
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115153
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Article: Sacubitril/valsartan: research progress of multi-channel therapy for cardiorenal syndrome.

Wang, Shuangcui / Wang, Yuli / Deng, Yun / Zhang, Jiaqi / Jiang, Xijuan / Yu, Jianchun / Gan, Jiali / Zeng, Wenyun / Guo, Maojuan

Frontiers in pharmacology

2023 Volume 14, Page(s) 1167260

Abstract: Cardiorenal syndrome (CRS) results from complex interaction between heart and kidneys, inducing simultaneous acute or chronic dysfunction of these organs. Although its incidence rate is increasing with higher mortality in patients, effective clinical ... ...

Abstract	Cardiorenal syndrome (CRS) results from complex interaction between heart and kidneys, inducing simultaneous acute or chronic dysfunction of these organs. Although its incidence rate is increasing with higher mortality in patients, effective clinical treatment drugs are currently not available. The literature suggests that renin-angiotensin-aldosterone system (RAAS) and diuretic natriuretic peptide (NP) system run through CRS. Drugs only targeting the RAAS and NPs systems are not effective. Sacubitril/valsartan contains two agents (sacubitril and valsartan) that can regulate RAAS and NPs simultaneously. In the 2017 American College of Cardiology/American Heart Association/American Heart Failure (HF) ssociation (ACC/AHA/HFSA) guideline, sacubitril/valsartan was recommended as standard therapy for HF patients. The latest research shows that Combined levosimendan and Sacubitril/Valsartan markets are protected the heart and kidney against cardiovascular syndrome in rat. However, fewer studies have reported its therapeutic efficacy in CRS treatment, and their results are inconclusive. Therefore, based on RAAS and NPs as CRS biomarkers, this paper summarizes possible pathophysiological mechanisms and preliminary clinical application effects of sacubitril/valsartan in the prevention and treatment of CRS. This will provide a pharmacological justification for expanding sacubitril/valsartan use to the treatment of CRS.
Language	English
Publishing date	2023-05-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1167260
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