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Article ; Online: Current Perspective and Mechanistic Insights on Bioactive Plant Secondary Metabolites for the Prevention and Treatment of Cardiovascular Diseases.

Grewal, Jyotika / Kumar, Vijay / Gandhi, Yashika / Rawat, Hemant / Singh, Ravindra / Singh, Arjun / Narasimhaji, Ch V / Acharya, Rabinarayan / Mishra, Sujeet K

Cardiovascular & hematological disorders drug targets

2023 Volume 23, Issue 3, Page(s) 157–176

Abstract: Cardiovascular diseases (CVDs) are one of the most prevalent medical conditions of modern era and are one of the primary causes of adult mortality in both developing and developed countries. Conventional medications such as use of aspirin, beta-blockers, ...

Abstract	Cardiovascular diseases (CVDs) are one of the most prevalent medical conditions of modern era and are one of the primary causes of adult mortality in both developing and developed countries. Conventional medications such as use of aspirin, beta-blockers, statins and angiotensin- converting enzyme inhibitors involve use of drugs with many antagonistic effects. Hence, alternative therapies which are safe, effective, and relatively cheap are increasingly being investigated for the treatment and prevention of CVDs. The secondary metabolites of medicinal plants contain several bioactive compounds which have emerged as alternatives to toxic modern medicines. The detrimental effects of CVDs can be mitigated via the use of various bioactive phytochemicals such as catechin, isoflavones, quercetin etc. present in medicinal plants. Current review intends to accumulate previously published data over the years using online databases concerning herbal plant based secondary metabolites that can help in inhibition and treatment of CVDs. An in-depth review of various phytochemical constituents with therapeutic actions such as antioxidant, anti-inflammatory, vasorelaxant, anti-hypertensive and cardioprotective properties has been delineated. An attempt has been made to provide a probable mechanistic overview for the pertinent phytoconstituent which will help in achieving a better prognosis and effective treatment for CVDs.
MeSH term(s)	Humans ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/prevention & control ; Plants, Medicinal/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Anti-Inflammatory Agents/therapeutic use
Chemical Substances	Plant Extracts ; Phytochemicals ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-11-02
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	2244164-5
ISSN	2212-4063 ; 1871-529X
ISSN (online)	2212-4063
ISSN	1871-529X
DOI	10.2174/011871529X262371231009132426
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Article ; Online: Probing interactions within liquid media via a model H-bond donor-acceptor mixture.

Kadyan, Anu / Gandhi, Yashika / Pandey, Siddharth

Physical chemistry chemical physics : PCCP

2019 Volume 21, Issue 9, Page(s) 4791–4801

Abstract: Understanding interactions within liquids so as to obtain desired physicochemical properties is of utmost importance in chemistry. Solute-solvent and solvent-solvent interactions within mixtures of hexamethylphosphoramide (HMPA) and 2,2,2- ... ...

Abstract	Understanding interactions within liquids so as to obtain desired physicochemical properties is of utmost importance in chemistry. Solute-solvent and solvent-solvent interactions within mixtures of hexamethylphosphoramide (HMPA) and 2,2,2-trifluoroethanol (TFE) are assessed using various invasive and non-invasive techniques. HMPA and TFE possess similar static dielectric constants. While HMPA has high H-bond accepting basicity (β ∼ 1) and no H-bond donating acidity (α ∼ 0), TFE has high H-bond donating acidity (α ∼ 1) and almost no H-bond accepting basicity (β ∼ 0). Kamlet-Taft parameters obtained using solvatochromic UV-Vis molecular absorbance probes suggest α and β of the (HMPA + TFE) mixture to be higher than those expected from mole-fraction weighted ideal-additive values with α and β exhibiting synergism in TFE-rich and HMPA-rich regions where α > 1 and β > 1, respectively. HMPA has lower dipolarity/polarizability (π) than TFE, however, the addition of TFE to HMPA results in even further lowering of π implying significant non-polar nature of the (HMPA + TFE) mixture as compared to its neat constituents. Photoinduced charge-transfer (neutral and anionic) and ratiometric solvatochromic fluorescence polarity probes also confirm the mixture dipolarity to be significantly lower than that expected. FTIR absorbance and Raman spectroscopic measurements hint at the weakening of the strong H-bonds among TFE and/or HMPA as the two solvents are mixed. Positive excess molar volumes (VE) and excess logarithmic viscosities [(ln η)E] indicate weakened interactions in the (HMPA + TFE) mixtures as compared to the interactions within neat TFE and neat HMPA. Microfluidity of the mixture obtained from an intramolecular excimer-forming fluorescence probe further supports these outcomes. Formation of a low polarity liquid milieu upon mixing of two higher polarity solvents is amply highlighted.
Language	English
Publishing date	2019-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/c8cp07733a
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Article ; Online: Cytotoxic effect of plant extract-based nanoparticles on cancerous cells: a review

Grewal, Jyotika / Kumar, Vijay / Rawat, Hemant / Gandhi, Yashika / Singh, Ravindra / Singh, Arjun / Babu, Gajji / Srikanth, N. / Mishra, Sujeet K.

Environ Chem Lett. 2022 Aug., v. 20, no. 4 p.2487-2507

2022

Abstract: Cancer is one of the most fatal diseases causing deaths of millions of people worldwide. Since actual cancer treatments are rarely efficient and often toxic, there is a demand for innocuous and more effective anticancer drugs. For instance, metal/metal ... ...

Abstract	Cancer is one of the most fatal diseases causing deaths of millions of people worldwide. Since actual cancer treatments are rarely efficient and often toxic, there is a demand for innocuous and more effective anticancer drugs. For instance, metal/metal oxide nanoparticles allow controlled drug release and drug delivery to specific targets. In particular, medicinal plant-based metal nanoparticles appear as safer and more effective. Here, we present the synthesis of metal nanoparticles using medicinal plant extracts, and the toxicity of these nanoparticles for cancerous cells. The anticancer effect is explained by several possible mechanisms such as generation of reactive oxygen species, cell cycle arrest, antioxidant property, apoptosis and autophagy. We present plant compounds that induce cytotoxicity against cancerous cells, and assays for the measurement of cell toxicity.
Keywords	antineoplastic activity ; antioxidant activity ; apoptosis ; autophagy ; cell cycle checkpoints ; cytotoxicity ; drug delivery systems ; drugs ; medicinal plants ; nanoparticles ; reactive oxygen species
Language	English
Dates of publication	2022-08
Size	p. 2487-2507.
Publishing place	Springer International Publishing
Document type	Article ; Online
Note	Review
ZDB-ID	2107984-5
ISSN	1610-3661 ; 1610-3653
ISSN (online)	1610-3661
ISSN	1610-3653
DOI	10.1007/s10311-022-01422-z
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Article: Establishment of the mechanism of purification and levigation of green chemistry-assisted biocomposites of red ochre (Gairika): synthesis, characterization, and antibacterial, prebiotic, antioxidant, and antacid activities of the traditional Ayurvedic medicine Laghu Sutashekhara Rasa.

Charde, Vaibhav / Kumar, Vijay / Dane, Ganesh / Gandhi, Yashika / Soni, Hemant / Jagtap, Chandrashekar / Mishra, Sujeet K / Shakya, Santosh K / Singh, Arjun / Singh, Ravindra / Sharma, Bhagwan S / Khanduri, Shruti / Srikanth, Narayanam / Acharya, Rabinarayan / Webster, Thomas J

Frontiers in chemistry

2023 Volume 11, Page(s) 1271157

Abstract: Gairika (red ochre) has a long history of influencing human civilization. Gairika is a rich source of nutrients used for reproductive and brain health. Gairika is mentioned as an antacid drug in Indian Ayurvedic medicine under Laghu Sutashekhara Rasa ( ... ...

Abstract	Gairika (red ochre) has a long history of influencing human civilization. Gairika is a rich source of nutrients used for reproductive and brain health. Gairika is mentioned as an antacid drug in Indian Ayurvedic medicine under Laghu Sutashekhara Rasa (LSR). However, a detailed study on LSR has not been reported to date. In the present study, LSR was prepared, and a pharmaceutical SOP (standardization procedure) was reported to obtain batch-to-batch reproducibility. LSR was characterized using FTIR, XRD, SEM-EDX, and TGA analyses. LSR was tested
Language	English
Publishing date	2023-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2023.1271157
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Article ; Online: Chemoprofiling and medicinal potential of underutilized leaves of Cyperus scariosus.

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7263

Abstract: Agro-waste is the outcome of the under-utilization of bioresources and a lack of knowledge to re-use this waste in proper ways or a circular economy approach. In the Indian medicinal system, the root of Cyperus scariosus (CS) is used at a large scale due ...

Abstract	Agro-waste is the outcome of the under-utilization of bioresources and a lack of knowledge to re-use this waste in proper ways or a circular economy approach. In the Indian medicinal system, the root of Cyperus scariosus (CS) is used at a large scale due to their vital medicinal properties. Unfortunately, the aerial part of CS is treated as agro-waste and is an under-utilized bioresource. Due to a lack of knowledge, CS is treated as a weed. This present study is the first ever attempt to explore CS leaves as medicinally and a nutrient rich source. To determine the food and nutritional values of the neglected part of Cyperus scariosus R.Br. (CS), i.e. CS leaves, phytochemicals and metal ions of CS were quantified by newly developed HPLC and ICPOES-based methods. The content of the phytochemicals observed in HPLC analysis for caffeic acid, catechin, epicatechin, trans-p-coumaric acid, and trans-ferulic acid was 10.51, 276.15, 279.09, 70.53, and 36.83 µg/g, respectively. In GC-MS/MS analysis, fatty acids including linolenic acid, phytol, palmitic acid, etc. were identified. In ICPOES analysis, the significant content of Na, K, Ca, Cu, Fe, Mg, Mn, and Zn was observed. The TPC and TFC of the CS leaves was 17.933 mg GAE eq./g and 130.767 mg QCE eq./g along with an IC
MeSH term(s)	Cyperus ; Plant Extracts/chemistry ; Tandem Mass Spectrometry ; Antioxidants/analysis ; Phytochemicals/pharmacology ; Phytochemicals/analysis ; Plant Leaves/chemistry
Chemical Substances	Plant Extracts ; Antioxidants ; Phytochemicals
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58041-7
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Article ; Online: Advances in anti-inflammatory medicinal plants and phytochemicals in the management of arthritis: A comprehensive review

Gandhi, Yashika / Kumar, Ravi / Grewal, Jyotika / Rawat, Hemant / Mishra, Sujeet K. / Kumar, Vijay / Shakya, Santosh K. / Jain, Vipin / Babu, Gajji / Sharma, Preeti / Singh, Arjun / Singh, Ravindra / Acharya, Rabinarayan

Food Chemistry Advances. 2022 Oct., v. 1 p.100085-

2022

Abstract: Rheumatoid arthritis (RA) is considered to be an inflammatory disorder whereas OA is not an overtly inflammatory disorder as RA but certain inflammatory cytokines and periodic inflammation are observed to be involved in its progression. The ... ...

Abstract	Rheumatoid arthritis (RA) is considered to be an inflammatory disorder whereas OA is not an overtly inflammatory disorder as RA but certain inflammatory cytokines and periodic inflammation are observed to be involved in its progression. The pathophysiology of arthritis involves a cascade of processes taking place; therefore, arthritis necessitates a multidimensional approach for its management. Numerous conventional anti-arthritic drugs have been employed to relieve arthritis conditions but their efficacy and tolerability can be overshadowed by the reported deleterious effects on human health. Therefore, the pressing priority is to explore the complementary and alternative treatment options i.e., traditional medicine, medicinal plants and their phytochemicals, which exhibit significant anti-inflammatory activities with less deleterious effects on human health. The present review summarizes such potential medicinal plants and natural bio-active compounds against arthritis on the basis of their potent anti-inflammatory activities demonstrated in various in vitro, in vivo studies, other preclinical and clinical studies in order to facilitate researchers to develop phytomedicines against arthritis.
Keywords	cytokines ; food chemistry ; human health ; inflammation ; pathophysiology ; phytochemicals ; rheumatoid arthritis ; traditional medicine ; Arthritis ; Medicinal plants ; COX-2 ; Traditional medicines ; Ayurveda ; RA ; OA ; SAIDs ; NSAIDs ; COX ; NF-?B ; JAK ; MAPK ; STAT ; IL ; TNF-? ; MIP-1? ; MMP ; PGE2 ; LOX ; iNOS ; ROS
Language	English
Dates of publication	2022-10
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ISSN	2772-753X
DOI	10.1016/j.focha.2022.100085
Database	NAL-Catalogue (AGRICOLA)

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Article: Phytomedicines explored under in vitro and in silico studies against coronavirus: An opportunity to develop traditional medicines

Gandhi, Yashika / Mishra, Sujeet K. / Rawat, Hemant / Grewal, Jyotika / Kumar, Ravi / Shakya, Santosh K. / Jain, Vipin Kumar / Babu, G. / Singh, Arjun / Singh, Ravindra / Acharya, Rabinarayan / Kumar, Vijay

SAAB South African journal of botany. 2022 Apr. 29,

2022

Abstract: The widespread COVID-19 pandemic, caused by novel coronavirus SARS-CoV-2, has emanated as one of the most life-threatening transmissible diseases. Currently, the repurposed drugs such as remdesivir, azithromycine, chloroquine, and hydroxychloroquine are ... ...

Abstract	The widespread COVID-19 pandemic, caused by novel coronavirus SARS-CoV-2, has emanated as one of the most life-threatening transmissible diseases. Currently, the repurposed drugs such as remdesivir, azithromycine, chloroquine, and hydroxychloroquine are being employed in the management of COVID-19 but their adverse effects are a matter of concern. In this regard, alternative treatment options i.e., traditional medicine, medicinal plants, and their phytochemicals, which exhibit significant therapeutic efficacy and show a low toxicity profile, are being explored. The current review aims at unraveling the promising medicinal plants, phytochemicals, and traditional medicines against SARS-CoV-2 to discover phytomedicines for the management of COVID-19 on the basis of their potent antiviral activities against coronaviruses, as demonstrated in various biochemical and computational chemical biology studies. The review consists of integrative and updated information on the potential traditional medicines against COVID-19 and will facilitate researchers to develop traditional medicines for the management of COVID-19.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; chloroquine ; computer simulation ; phytochemicals ; therapeutics ; toxicity ; traditional medicine
Language	English
Dates of publication	2022-0429
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	2126918-X
ISSN	0254-6299
ISSN	0254-6299
DOI	10.1016/j.sajb.2022.04.053
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Article: The validated pharmaceutical standard operating procedure and quality control study of the coded polyherbal tablet formulation AYUSH SG-5

Kumar, Vijay / Kushwaha, Vikram / Charde, Vaibhav / Jagtap, Chandrashekar / Gandhi, Yashika / Grewal, Jyotika / Verma, Ravi / Rawat, Hemant / Mishra, Sujeet K. / Thakur, Akanksha / Babu, G. / Singh, Arjun / Singh, Ravindra / Srikanth, Narayanam / Dhiman, K.S.

SAAB South African journal of botany. 2022 Feb. 27,

2022

Abstract: In India, Ayurvedic medicine has its own significance and dominance in the Indian Medicine System. The traditional medicine system of India is not well renowned due to the lack of standardization of herbal drugs. To assess the quality, purity, efficacy, ... ...

Abstract	In India, Ayurvedic medicine has its own significance and dominance in the Indian Medicine System. The traditional medicine system of India is not well renowned due to the lack of standardization of herbal drugs. To assess the quality, purity, efficacy, potency, and safety of herbal drugs, standardization is the major aspect. Recently, World Health Organization (WHO) and European Medicines Agency (EMEA) have issued guidelines for the quality control of herbal drugs. The aim of the present study is the standardization of the coded polyherbal tablet formulation AYUSH SG-5. A scientific methodology was adopted to perform the standardization parameters like organoleptic parameters, microscopic, macroscopic, physico-chemical analysis, and high-performance thin-layer chromatographic (HPTLC) profiling of AYUSH SG-5. The HPTLC study has exhibited the presence of various phytochemicals such as 6-gingerol in Sunthi (Zingiber officinale rhizomes), Epicatechin in Vetas (stem bark of Salix alba), Colchicine in Suranjan (Colchicum luteum corms), Resveratrol in Chopchini (Smilax china tuber), Guggulsterone E & Z in Guggul (Commiphora wightii resin). Based on the results of the present study, a monograph was proposed in the interests of quality control of the AYUSH SG-5. This research will help pharmacists to develop the formulation of AYUSH SG-5 with greater reproducibility and this document could be treated as a pharmaceutical standard operating procedure (SOP) for the production of AYUSH SG-5 in pharmacy.
Keywords	Ayurvedic medicine ; Colchicum ; Commiphora wightii ; Salix alba ; Smilax china ; World Health Organization ; Zingiber officinale ; bark ; colchicine ; corms ; epicatechin ; quality control ; resveratrol ; thin layer chromatography ; India
Language	English
Dates of publication	2022-0227
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	2126918-X
ISSN	0254-6299
ISSN	0254-6299
DOI	10.1016/j.sajb.2022.02.038
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Article ; Online: A Comparative Analysis of Phytochemicals, Metal Ions, Volatile Metabolites in Heart Wood, Stem Bark and Leaves of Salix alba L. along with in Vitro Antioxidant, Antacid, Antimicrobial Activities for Sake of Environment Conservation by Substitution of Stem Bark With Leaf.

Gandhi, Yashika / Rawat, Hemant / Singh Dhanjal, Daljeet / Kumar, Vijay / Charde, Vaibhav / Soni, Hemant / Mishra, Sujeet K / Singh, Gagandeep / Singh, Simranjeet / Sharma, Preeti / Shakya, Santosh K / Narsimhaji, C V / Meena, Ajay K / Singh, Arjun / Singh, Ravindra / Srikanth, Naryanam / Acharya, Rabinarayan

Chemistry & biodiversity

2023 Volume 20, Issue 12, Page(s) e202301234

Abstract: The genus of Salix is used in food, medicine and nutraceuticals, and standardized by using the single marker compound Salicin only. Stem bark is the official part used for the preparation of various drugs, nutraceuticals and food products, which may lead ...

Abstract	The genus of Salix is used in food, medicine and nutraceuticals, and standardized by using the single marker compound Salicin only. Stem bark is the official part used for the preparation of various drugs, nutraceuticals and food products, which may lead to overexploitation and damage of tree. There is need to search substitution of the stem bark with leaf of Salix alba L. (SA), which is yet not reported. Comparative phytochemicals viz. Salicin, Procyanidin B1 and Catechin were quantified in the various parts of SA viz. heart wood (SA-HW), stem bark (SA-SB) and leaves (SA-L) of Salix alba L.by using newly developed HPLC method. It was observed that SA-HW and SA-L contained far better amount of Salicin, Procyanidin B and Catechin as compared to SA-SB (SA-HW~SA-L≫SA-SB). Essential and toxic metal ions of all three parts were analysed using newly developed ICP-OES method, where SA-L were founded as a rich source of micronutrients and essential metal ions as compared to SA-SB and SA-HW. GC-MS analysis has shown the presence of fatty acids and volatile compounds. The observed TPC and TFC values for all three parts were ranged from 2.69 to 32.30 mg GAE/g of wt. and 37.57 to 220.76 mg QCE/g of wt. respectively. In DPPH assay the IC
MeSH term(s)	Catechin/pharmacology ; Antioxidants/analysis ; Antacids/analysis ; Antacids/metabolism ; Salix/chemistry ; Salix/metabolism ; Wood ; Plant Bark/chemistry ; Escherichia coli ; Staphylococcus aureus ; Plant Extracts/chemistry ; Anti-Ulcer Agents ; Phytochemicals/chemistry ; Anti-Bacterial Agents/metabolism ; Plant Leaves ; Anti-Infective Agents/metabolism
Chemical Substances	salicin (4649620TBZ) ; Catechin (8R1V1STN48) ; Antioxidants ; Antacids ; Plant Extracts ; Anti-Ulcer Agents ; Phytochemicals ; Anti-Bacterial Agents ; Anti-Infective Agents
Language	English
Publishing date	2023-11-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202301234
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Article: Phytomedicines explored under

Gandhi, Yashika / Mishra, Sujeet K / Rawat, Hemant / Grewal, Jyotika / Kumar, Ravi / Shakya, Santosh K / Jain, Vipin Kumar / Babu, G / Singh, Arjun / Singh, Ravindra / Acharya, Rabinarayan / Kumar, Vijay

South African journal of botany : official journal of the South African Association of Botanists = Suid-Afrikaanse tydskrif vir plantkunde : amptelike tydskrif van die Suid-Afrikaanse Genootskap van Plantkundiges

2022 Volume 151, Page(s) 451–483

Abstract	The widespread COVID-19 pandemic, caused by novel coronavirus SARS-CoV-2, has emanated as one of the most life-threatening transmissible diseases. Currently, the repurposed drugs such as remdesivir, azithromycine, chloroquine, and hydroxychloroquine are being employed in the management of COVID-19 but their adverse effects are a matter of concern. In this regard, alternative treatment options
Language	English
Publishing date	2022-05-02
Publishing country	South Africa
Document type	Journal Article ; Review
ZDB-ID	2126918-X
ISSN	0254-6299
ISSN	0254-6299
DOI	10.1016/j.sajb.2022.04.053
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