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  1. Article: Strut and radio-morphometric analysis of mandibular trabecular structure in pre-and post-menopausal women to aid in the diagnosis of osteoporosis.

    Anandan, Ragavendiran / C L, Krithika / Ganesan, Anuradha / Aniyan K, Yesoda

    Journal of oral biology and craniofacial research

    2024  Volume 14, Issue 3, Page(s) 273–279

    Abstract: Purpose: The purpose of the study is to evaluate the mandibular trabecular pattern in pre- and postmenopausal age women. By analysing the strut, fractal, grey level co-occurrence matrix, and radio-morphometric indices in the panoramic radiograph.: ... ...

    Abstract Purpose: The purpose of the study is to evaluate the mandibular trabecular pattern in pre- and postmenopausal age women. By analysing the strut, fractal, grey level co-occurrence matrix, and radio-morphometric indices in the panoramic radiograph.
    Method: Panoramic radiographs from 2019 to 2022 were used to assess pre- and postmenopausal women's bone mineral density. A total of 272 panoramic radiographs, which exhibited clear visibility of the mental foramen on both sides without any blurring, motion artefacts, surgical errors, overlapping hyoid bone, or inferior mandibular cortex, were divided into two groups. Group A (136 premenopausal women) and Group B (136 postmenopausal women). It is a retrospective study that is non-interventional/observational in design. Strut features, fractal dimensions, a grey-level co-occurrence matrix, and radio morphometric indices were used to investigate bone texture in an image processing program. The mean difference between group variables was calculated using an independent sample
    Results: Pre-menopausal women had a mean age of 38.83 ± 6.01 years, while postmenopausal women had a mean age of 68.26 ± 8.31 In the postmenopausal group Four regions of interest exhibited fractal dimensions with a P value of less than 0.01 and GLCM features including contrast (0.812), correlation (0.230), energy (0.215), and homogeneity (0.322). Strut features of the four regions showed that 15 of 19 characteristics were significantly different.
    Conclusion: Orthopantomogram is useful in screening for osteoporosis. Strut, radio-morphometric indices, and fractal analysis can assess bone texture and quality. Future research incorporating artificial intelligence can revolutionize image analysis and support clinical decision-making.
    Language English
    Publishing date 2024-03-22
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2212-4268
    ISSN 2212-4268
    DOI 10.1016/j.jobcr.2024.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Periodic acid-Schiff staining in oral exfoliative cytology of diabetic patients: The odyssey for noninvasive screening - A systematic review and meta-analysis.

    Aniyan, K Yesoda / Lakshmi, Krithika Chandrasekar / Ganesan, Anuradha

    Dental research journal

    2023  Volume 20, Page(s) 73

    Abstract: Background: Diabetes mellitus is a dominant metabolic disorder in the current fast paced culture; its prevalence is escalating worldwide and among all age groups. Guidelines recommend universal screening for diabetes; however, the uptake of these tests ... ...

    Abstract Background: Diabetes mellitus is a dominant metabolic disorder in the current fast paced culture; its prevalence is escalating worldwide and among all age groups. Guidelines recommend universal screening for diabetes; however, the uptake of these tests in individuals suggests challenges owing to invasive nature of blood collection. Thus, there arises the need for a noninvasive investigation for diabetes screening with a minimum paraphilia and for all medical settings.
    Materials and methods: We have thus conducted a systematic review and meta-analysis according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, to quantify the association between diabetes and effectiveness of periodic acid-Schiff staining of exfoliative cytology as a screening method. MEDLINE, EMBASE, Cochrane, Scopus, Web of science, CINAHL, and Google Scholar were searched systematically for publications dated till July 20, 2022. Six studies (case-control cross-sectional) were selected and evaluated in depth. The statistical evaluation was done with a forest plot with odds ratio and weightage examined.
    Results: It was proved that exfoliative cytology with periodic acid-Schiff (PAS) staining can be used as a screening test for diabetic status evaluation. The findings suggest that the aforesaid noninvasive test is a conclusive screening practice for diabetics.
    Conclusion: This systematic review and meta-analysis suggest that PAS staining in exfoliative cytology can be used as a noninvasive screening in diabetic individuals to assess the current level of blood glucose. Given the increased risk of diabetes worldwide, higher quality prospective evidence is suggested in larger sample sizes with other metabolic disorders, ethnicity, and oral disorders to further evaluate the plausibility of the results.
    Language English
    Publishing date 2023-06-27
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2418290-4
    ISSN 2008-0255 ; 1735-3327
    ISSN (online) 2008-0255
    ISSN 1735-3327
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  3. Article ; Online: Challenges in Managing Gonorrhea and New Advances in Prevention.

    Ewers, Evan C / Curtin, John M / Ganesan, Anuradha

    Infectious disease clinics of North America

    2023  Volume 37, Issue 2, Page(s) 223–243

    Abstract: Gonorrhea is the second most common bacterial sexually transmitted infection in the United States. Rates are increasing, and multiple challenges compound management, including worsening antimicrobial resistance. New therapeutics, enhanced screening and ... ...

    Abstract Gonorrhea is the second most common bacterial sexually transmitted infection in the United States. Rates are increasing, and multiple challenges compound management, including worsening antimicrobial resistance. New therapeutics, enhanced screening and partner notification, and treatment through point-of-care testing and expedited partner therapy, as well as primary prevention efforts provide opportunities for success in combating these trends.
    MeSH term(s) Humans ; United States ; Gonorrhea/diagnosis ; Gonorrhea/drug therapy ; Gonorrhea/prevention & control ; Chlamydia Infections ; Sexual Partners ; Contact Tracing ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/prevention & control
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1077676-x
    ISSN 1557-9824 ; 0891-5520
    ISSN (online) 1557-9824
    ISSN 0891-5520
    DOI 10.1016/j.idc.2023.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Exploring the Relationship between Psychoneuroimmunology and Oral Diseases: A Comprehensive Review and Analysis.

    Ganesan, Anuradha / Kumar, Gautham / Gauthaman, Jeevitha / Lakshmi, Krithika Chandrasekar / Kumbalaparambil, Yesoda Aniyan

    Journal of lifestyle medicine

    2024  Volume 14, Issue 1, Page(s) 13–19

    Abstract: The relationship between psychoneuroimmunology (PNI) and oral health has recently garnered increasing attention due to the intricate interaction among psychological factors, the nervous system, immune responses, and oral diseases. This comprehensive ... ...

    Abstract The relationship between psychoneuroimmunology (PNI) and oral health has recently garnered increasing attention due to the intricate interaction among psychological factors, the nervous system, immune responses, and oral diseases. This comprehensive review aims to elucidate the multifaceted connections between PNI and various oral conditions and conduct an in-depth analysis. Psychological factors, such as stress, anxiety, and depression, have been linked to oral microbiome alterations and immune function and the development and progression of oral diseases, such as periodontal disorders, oral ulcers, and temporomandibular disorders. Conversely, oral health conditions, particularly chronic periodontitis, have been associated with systemic inflammation, affecting mental health and overall well-being through neuroendocrine-immune pathways. Moreover, neural mechanisms, including the brain-gut axis and the autonomic nervous system, significantly influenced oral health through immune modulation and inflammatory responses. Understanding these complex interactions has implications for therapeutic interventions that target both psychological well-being and oral health outcomes. This review synthesizes current research findings from various disciplines, including immunology, neuroscience, dentistry, and psychology, to offer a comprehensive understanding of the bidirectional relationship between PNI and oral diseases. The implications of these interactions on treatment strategies, preventive measures, and interdisciplinary approaches underscore the need for integrated healthcare models that address psychological and oral health aspects to improve outcomes and quality of life in patients.
    Language English
    Publishing date 2024-04-10
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 3021714-3
    ISSN 2288-1557 ; 2234-8549
    ISSN (online) 2288-1557
    ISSN 2234-8549
    DOI 10.15280/jlm.2024.14.1.13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Impact of Mindfulness Meditation on the Psychosomatic Spectrum of Oral Diseases: Mapping the Evidence.

    Ganesan, Anuradha / Gauthaman, Jeevitha / Kumar, Gautham

    Journal of lifestyle medicine

    2022  Volume 12, Issue 1, Page(s) 1–8

    Abstract: The psychological aspect of dis-ease, which is indeed a lack of 'ease' is generally overlooked in the management of myriad maladies that affect the human body. The concept of mindfulness meditation, which is an interesting hybrid born from the meditative ...

    Abstract The psychological aspect of dis-ease, which is indeed a lack of 'ease' is generally overlooked in the management of myriad maladies that affect the human body. The concept of mindfulness meditation, which is an interesting hybrid born from the meditative discipline of the east and the intellectual discipline of the west is gaining attention in the past two decades for its benefits in the holistic development of individuals. When individuals with ailments are trained under therapists supervised by the clinicians, significant results can be seen in alleviating symptoms like pain, stress, anxiety and an improvement in the quality of life is observed. This review article focuses on the structure and basics of mindful meditation and the mechanisms of mindfulness and its positive effects on various diseases like lichen planus, urticaria, psoriasis, eczema, myofacial pain dysfunction syndrome, to name a few. There are various arenas within the discipline of oral and maxillofacial medicine where mindfulness-based techniques can be explored for its effectiveness in combating psychosomatic conditions. The article highlights the importance of holistic approach in treating diseases in which mindfulness meditation techniques play an important role.
    Language English
    Publishing date 2022-03-09
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 3021714-3
    ISSN 2288-1557 ; 2234-8549
    ISSN (online) 2288-1557
    ISSN 2234-8549
    DOI 10.15280/jlm.2022.12.1.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Effectiveness of Salivary Glucose in Diagnosing Gestational Diabetes Mellitus.

    Ganesan, Anuradha / Muthukrishnan, Arvind / Veeraraghavan, Vishnupriya

    Contemporary clinical dentistry

    2021  Volume 12, Issue 3, Page(s) 294–300

    Abstract: Context: Frequent monitoring of glucose is important in the management of diabetes. A noninvasive painless technique was used to detect glucose levels with the use of saliva as a diagnostic fluid.: Aims: The aim of our study was to correlate the ... ...

    Abstract Context: Frequent monitoring of glucose is important in the management of diabetes. A noninvasive painless technique was used to detect glucose levels with the use of saliva as a diagnostic fluid.
    Aims: The aim of our study was to correlate the blood glucose levels with stimulated and unstimulated salivary samples and also to assess the reliability of using salivary glucose in diagnosing and monitoring the blood glucose levels in gestational diabetic patients.
    Settings and design: The study was conducted among 100 clinically healthy nondiabetic individuals and 99 individuals suffering from gestational diabetes mellitus (GDM).
    Subjects and methods: Fasting blood glucose estimation and postprandial salivary glucose estimation were done in stimulated and unstimulated salivary samples using glucose oxidase/peroxidase method.
    Statistical analysis used: Data obtained were subjected to normality test, and
    Results: A positive correlation was obtained for stimulated and unstimulated salivary samples in fasting and postprandial conditions. Linear regression analysis and receiver operating characteristic curve were plotted, and the optimal cutoff value for unstimulated and stimulated salivary glucose under fasting conditions was 5.1 mg/dl and 5.4 mg/dl, respectively. The optimal cutoff value for unstimulated and stimulated salivary glucose was 8.8 mg/dl and 9.3 mg/dl, respectively, in postprandial conditions.
    Conclusions: Saliva appears to be a reliable biofluid to assess the blood glucose levels and can definitely be a reliable alternative to blood glucose in GDM patients.
    Language English
    Publishing date 2021-09-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 2582352-8
    ISSN 0976-2361 ; 0976-237X
    ISSN (online) 0976-2361
    ISSN 0976-237X
    DOI 10.4103/ccd.ccd_530_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Evaluation of Salivary Opiorphin, pH and Flow Rate in Oral Submucous Fibrosis - A Case - Control Observational Study.

    Varsha, K S / Lakshmi, Krithika C / Ganesan, Anuradha / Kannan, A / Aniyan, K Yesoda

    Journal of pharmacy & bioallied sciences

    2023  Volume 15, Issue Suppl 1, Page(s) S656–S660

    Abstract: Aim and objectives: The aim of the study was to evaluate the salivary pH, flow rate and opiorphin in Oral submucous fibrosis patients and to compare them with healthy individuals.: Materials and methods: A comparative study was conducted to evaluate ... ...

    Abstract Aim and objectives: The aim of the study was to evaluate the salivary pH, flow rate and opiorphin in Oral submucous fibrosis patients and to compare them with healthy individuals.
    Materials and methods: A comparative study was conducted to evaluate the salivary opiorphin levels, pH and flow rate among 78 patients (39 Oral submucous fibrosis + 39 control). Burning sensation was assessed using VAS score. Opiorphin levels were assessed using Cusabio Human Salivary Opiorphin ELISA kit. Salivary flow rate was assessed using graduated syringes and salivary pH was assessed using Hydrion salivary pH strips. Kolmogorov-Smirnov and Shapiro Wilk test were assessed for normality testing and distribution. Inferential statistics was done by using Unpaired t test/Independent sample t test to compare the mean values of variables included in the study among the OSMF and healthy patients.
    Results: There was statistically significant difference in pH and flow rate with a reduction in the mean pH (p=0.024) and flow rate (p<0.01) among the oral submucous fibrosis patients compared to the control group. A statistically significant increase (p<0.01) in salivary opiorphin levels was noted in the oral submucous fibrosis patients. Majority of the study participants had mild to moderate burning sensation.
    Conclusion: This study was a pilot evaluation of salivary opiorphin in OSMF. Salivary opiorphin could be used as an objective marker for chronic subjective conditions The pre-treatment and post treatment evaluation of salivary opiorphin could provide more insight on its role.
    Language English
    Publishing date 2023-07-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.jpbs_15_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comparison of topical purslane & topical 0.1% triamcinolone acetonide in the management of oral lichen planus - a double blinded clinical trial.

    Murugan, Arul Jothi / Ganesan, Anuradha / Aniyan, Yesoda K / Lakshmi, Krithika Chandrasekar / Asokan, Kannan

    BMC oral health

    2023  Volume 23, Issue 1, Page(s) 678

    Abstract: Aim and background: Oral lichen planus (OLP) is a chronic autoimmune mucocutaneous disorder of unknown etiology and treatment is targeted at alleviating symptoms. At present, corticosteroids are the mainstay treatment, and their side effects hamper ... ...

    Abstract Aim and background: Oral lichen planus (OLP) is a chronic autoimmune mucocutaneous disorder of unknown etiology and treatment is targeted at alleviating symptoms. At present, corticosteroids are the mainstay treatment, and their side effects hamper their long-term use, demanding alternative therapy. This study intended to assess the efficacy of topical purslane (Portulaca oleracea) at two concentrations, 5% and 10%, in OLP and to compare the level of clinical improvement in comparison to topical 0.1% triamcinolone acetonide gel.
    Materials and methods: After sample size determination, thirty-four subjects confirmed histopathologically with OLP were included in the study. They were divided into 3 groups, Group 1(Control) was treated with 0.1% triamcinolone acetonide, and Group 2(Case) and 3 (Case) were treated with topical purslane 5% and 10%, respectively. They were examined at baseline, 14 days, 30 days, 60 days, and 90 days. Clinical improvement was then analyzed at the end of 90 days using a visual analog scale (VAS) and Thongprasom's criteria.
    Results: The study was analyzed statistically and a P value of < 0.05 was considered statistically significant. Intragroup comparison revealed a statistically significant difference between the five time periods (baseline, 14 days, 30 days, 60 days, and 90 days) for the study variables (burning sensation, pain, lesion score, clinical response, symptomatic response) for all three groups (p = 0.001). Alleviation of all symptoms and remission of the lesion were noted for all three groups at the end of three months.
    Conclusion: Purslane is a magical herb with a plethora of rich nutrients, ease in accessibility and devoid of side effects. It was concluded that its preparation is beneficial and can be a safer alternative long-term drug for the management of OLP.
    Clinical significance: With available literature evidence, our present study is the first of its kind to formulate a topical gel with purslane to treat symptomatic OLP. Our study had a longer follow-up of 3 months compared to other studies in the literature.
    MeSH term(s) Humans ; Triamcinolone Acetonide/therapeutic use ; Lichen Planus, Oral/drug therapy ; Portulaca ; Research Design ; Sample Size
    Chemical Substances Triamcinolone Acetonide (F446C597KA)
    Language English
    Publishing date 2023-09-19
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-023-03385-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Effectiveness of Salivary Glucose as a Reliable Alternative in Diagnosis of Type 1 Diabetes Mellitus: A Cross-Sectional Study.

    Ganesan, Anuradha / Muthukrishnan, Arvind / Veeraraghavan, Vishnu Priya / Kumar, N Gautham

    Journal of pharmacy & bioallied sciences

    2022  Volume 14, Issue Suppl 1, Page(s) S557–S562

    Abstract: Aims and objective: The aim of the present study was to ascertain the reliability of using salivary glucose in diagnosing and monitoring the blood glucose levels in type 1 diabetic patients and also to evaluate the salivary glucose in fasting and ... ...

    Abstract Aims and objective: The aim of the present study was to ascertain the reliability of using salivary glucose in diagnosing and monitoring the blood glucose levels in type 1 diabetic patients and also to evaluate the salivary glucose in fasting and postprandial states and correlate with the blood glucose levels and hemoglobin A1c values.
    Materials and methods: The study was conducted on 79 Type 1 diabetic patients and 100 healthy controls. The blood and salivary glucose levels were evaluated in both study and control groups using glucose-oxidase peroxidase method.
    Results: There was significantly higher level of salivary glucose in diabetics than in controls. There was a positive moderate-to-strong correlation between stimulated and unstimulated salivary glucose to blood glucose in both fasting and postprandial states. The cutoff values for stimulated and unstimulated fasting salivary glucose was 5.8 mg/dl and 5.6 mg/dl, respectively. The cutoff value for stimulated and unstimulated salivary glucose in postprandial state was 10.3 mg/dl and 9.5 mg/dl, respectively.
    Conclusion: Salivary glucose appears to be a reliable biofluid to assess the blood glucose levels and can be a reliable alternative to blood glucose in Type 1 diabetes mellitus patients.
    Language English
    Publishing date 2022-07-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.jpbs_666_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Evaluating the expression of microRNA-15a-5p and YAP1 gene in oral squamous cell carcinoma in comparison with normal tissue: A cross-sectional study.

    Saravana Murthy, Padmavathi / Kannan, A / Ganesan, Anuradha / Lakshmi, Krithika Chandrasekar / Aniyan Kumbalaparambil, Yesoda

    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

    2023  Volume 52, Issue 7, Page(s) 593–600

    Abstract: Background: MicroRNAs (miRNAs) play crucial regulatory roles in cancer progression, including oral cancer (OC). However, the biological mechanisms of miRNA-15a-5p in OC remain unclear. This study aimed to evaluate the expression of miRNA-15a-5p and the ... ...

    Abstract Background: MicroRNAs (miRNAs) play crucial regulatory roles in cancer progression, including oral cancer (OC). However, the biological mechanisms of miRNA-15a-5p in OC remain unclear. This study aimed to evaluate the expression of miRNA-15a-5p and the YAP1 gene in OC.
    Methods: A total of 22 clinically and histologically confirmed oral squamous cell carcinoma (OSCC) patients were recruited, and their tissues were stored in a stabilizing solution. Later, RT-PCR was performed to evaluate miRNA-15a-5p and the targeting gene YAP1. The results of OSCC samples were compared with unpaired normal tissues.
    Results: The normality tests, Kolmogorov-Smirnov and Shapiro-Wilk, revealed a normal distribution. Inferential statistics were performed using an independent sample t-test/unpaired t-test among the study intervals to compare the expression of miR-15a and YAP1. SPSS (IBM SPSS Statistics for Windows, Version 26.0, Armonk, NY: IBM Corp. Released 2019) was used to analyse the data. The significance level was set at 5% (α = 0.05), and a p-value <0.05 was considered statistically significant. The expression of miRNA-15a-5p was lower in OSCC than in normal tissue, whereas the opposite was observed for YAP1 levels.
    Conclusion: In conclusion, this study demonstrated that miRNA-15a-5p was downregulated and YAP1 was overexpressed, which had a statistically significant difference between the normal and OSCC groups. Therefore, miRNA-15a-5p may serve as a novel biomarker to better understand the pathology and as a potential target in OSCC therapy.
    MeSH term(s) Humans ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; Cross-Sectional Studies ; Squamous Cell Carcinoma of Head and Neck/genetics ; Mouth Neoplasms/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Head and Neck Neoplasms/genetics ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Cell Proliferation/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-06-07
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1021270-x
    ISSN 1600-0714 ; 0904-2512
    ISSN (online) 1600-0714
    ISSN 0904-2512
    DOI 10.1111/jop.13451
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