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  1. Article ; Online: The Clinical Study of Kidney Stone Disease and the Value of Specificity.

    Pao, Alan C / Ganesan, Calyani

    Clinical journal of the American Society of Nephrology : CJASN

    2024  Volume 19, Issue 5, Page(s) 551–553

    MeSH term(s) Humans ; Kidney Calculi/therapy ; Kidney Calculi/diagnosis ; Sensitivity and Specificity ; Predictive Value of Tests
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.0000000000000459
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  2. Article ; Online: Medical Treatment and Prevention of Urinary Stone Disease.

    Spradling, Kyle / Ganesan, Calyani / Conti, Simon

    The Urologic clinics of North America

    2024  Volume 49, Issue 2, Page(s) 335–344

    Abstract: The pathophysiology underlying urinary stone formation remains an area of active investigation. There are many pharmacotherapies aimed at optimizing metabolic factors and reducing urinary supersaturation of stone components that play an important role in ...

    Abstract The pathophysiology underlying urinary stone formation remains an area of active investigation. There are many pharmacotherapies aimed at optimizing metabolic factors and reducing urinary supersaturation of stone components that play an important role in urinary stone prevention. In addition, medical expulsive therapy for ureteral stones and medical dissolution therapy for uric acid-based urinary stones are helpful treatment tools and are used alongside surgical treatments in the management of urinary stones.
    MeSH term(s) Female ; Humans ; Male ; Ureteral Calculi/prevention & control ; Urinary Calculi/prevention & control ; Urolithiasis
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 192293-2
    ISSN 1558-318X ; 0094-0143
    ISSN (online) 1558-318X
    ISSN 0094-0143
    DOI 10.1016/j.ucl.2021.12.007
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  3. Article ; Online: Estimated Effect of Parathyroidectomy on Long-Term Kidney Function in Adults With Primary Hyperparathyroidism.

    Seib, Carolyn D / Ganesan, Calyani / Tamura, Manjula Kurella

    Annals of internal medicine

    2023  Volume 176, Issue 11, Page(s) eL230280

    MeSH term(s) Adult ; Humans ; Parathyroidectomy ; Hyperparathyroidism, Primary/complications ; Hyperparathyroidism, Primary/surgery ; Parathyroid Hormone ; Kidney Transplantation ; Kidney ; Retrospective Studies ; Calcium
    Chemical Substances Parathyroid Hormone ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L23-0280
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  4. Article ; Online: The Nephrologist's Role in the Management of Kidney Cancer: A Renaissance.

    Ganesan, Calyani / Pao, Alan C / Leppert, John T

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2023  Volume 82, Issue 6, Page(s) 644–646

    MeSH term(s) Humans ; Nephrologists ; Kidney Neoplasms/therapy
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2023.08.003
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  5. Article ; Online: Urine oxalate and citrate excretion in patients with kidney stone disease: An ab initio clinical prediction.

    Ganesan, Calyani / Pao, Alan C

    Physiological reports

    2021  Volume 9, Issue 15, Page(s) e14966

    MeSH term(s) Citrates/urine ; Citric Acid/urine ; Humans ; Kidney Calculi/urine ; Oxalates
    Chemical Substances Citrates ; Oxalates ; Citric Acid (2968PHW8QP)
    Language English
    Publishing date 2021-08-12
    Publishing country United States
    Document type Editorial ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.14966
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  6. Article ; Online: Clinical Outcomes after a Kidney Stone Event in Kidney Transplant Recipients.

    Ganesan, Calyani / Liu, Sai / Montez-Rath, Maria / Leppert, John T / Pao, Alan C

    Clinical journal of the American Society of Nephrology : CJASN

    2024  

    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.0000000000000451
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  7. Article ; Online: Breaking the Cycle of Recurrent Calcium Stone Disease.

    Malieckal, Deepa A / Ganesan, Calyani / Mendez, Denisse Arellano / Pao, Alan C

    Advances in kidney disease and health

    2023  Volume 30, Issue 2, Page(s) 164–176

    Abstract: Calcium stones are common and recurrent in nature, yet few therapeutic tools are available for secondary prevention. Personalized approaches for stone prevention have been informed by 24-hour urine testing to guide dietary and medical interventions. ... ...

    Abstract Calcium stones are common and recurrent in nature, yet few therapeutic tools are available for secondary prevention. Personalized approaches for stone prevention have been informed by 24-hour urine testing to guide dietary and medical interventions. However, current evidence is conflicting about whether an approach guided by 24-hour urine testing is more effective than a generic one. The available medications for stone prevention, namely thiazide diuretics, alkali, and allopurinol, are not always prescribed consistently, dosed correctly, or tolerated well by patients. New treatments on the horizon hold the promise of preventing calcium oxalate stones by degrading oxalate in the gut, reprogramming the gut microbiome to reduce oxalate absorption, or knocking down expression of enzymes involved in hepatic oxalate production. New treatments are also needed to target Randall's plaque, the root cause of calcium stone formation.
    MeSH term(s) Humans ; Calcium ; Allopurinol ; Alkalies ; Body Fluids ; Chronic Disease ; Oxalates
    Chemical Substances Calcium (SY7Q814VUP) ; Allopurinol (63CZ7GJN5I) ; Alkalies ; Oxalates
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3156601-7
    ISSN 2949-8139
    ISSN (online) 2949-8139
    DOI 10.1053/j.akdh.2022.12.004
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  8. Article ; Online: Spironolactone plus patiromer: proceed with caution.

    Ganesan, Calyani / Pao, Alan C

    Lancet (London, England)

    2019  Volume 394, Issue 10208, Page(s) 1486–1488

    MeSH term(s) Amber ; Double-Blind Method ; Humans ; Hypertension ; Polymers ; Renal Insufficiency, Chronic ; Spironolactone
    Chemical Substances Amber ; Polymers ; patiromer (1FQ2RY5YHH) ; Spironolactone (27O7W4T232)
    Language English
    Publishing date 2019-10-28
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)32485-7
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  9. Article ; Online: Hypocitraturia and Risk of Bone Disease in Patients With Kidney Stone Disease.

    Ganesan, Calyani / Thomas, I-Chun / Montez-Rath, Maria E / Chertow, Glenn M / Leppert, John T / Pao, Alan C

    JBMR plus

    2023  Volume 7, Issue 9, Page(s) e10786

    Abstract: Patients with kidney stone disease are at higher risk for bone disease. Hypocitraturia is common in patients with kidney stone disease and a key risk factor for stone recurrence. In this retrospective cohort study, we sought to determine whether ... ...

    Abstract Patients with kidney stone disease are at higher risk for bone disease. Hypocitraturia is common in patients with kidney stone disease and a key risk factor for stone recurrence. In this retrospective cohort study, we sought to determine whether hypocitraturia is also a risk factor for incident bone disease in patients with kidney stone disease. We used nationwide data from the Veterans Health Administration and identified 9025 patients with kidney stone disease who had a 24-hour urine citrate measurement between 2007 and 2015. We examined clinical characteristics of patients by level of 24-hour urine citrate excretion (<200, 200-400, and >400 mg/d) and the time to osteoporosis or fracture according to 24-hour urine citrate excretion level. Almost one in five veterans with kidney stone disease and a 24-hour urine citrate measurement had severe hypocitraturia, defined as <200 mg/d. Patients with severe hypocitraturia were at risk for osteoporosis or fracture (hazard ratio [HR] = 1.23; confidence interval [CI] 1.03-1.48), but after adjustment for demographic factors, comorbid conditions, and laboratory abnormalities associated with hypocitraturia, the association was no longer statistically significant (HR = 1.18; CI 0.98-1.43). Our results in a predominantly male cohort suggest a modest association between hypocitraturia and osteoporosis or fracture; there are likely to be other explanations for the potent association between kidney stone disease and diminished bone health. © 2023 The Authors.
    Language English
    Publishing date 2023-06-27
    Publishing country England
    Document type Journal Article
    ISSN 2473-4039
    ISSN (online) 2473-4039
    DOI 10.1002/jbm4.10786
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  10. Article ; Online: National Imaging Trends for Suspected Urinary Stone Disease in the Emergency Department.

    Ganesan, Calyani / Stedman, Margaret R / Liu, Sai / Conti, Simon L / Chertow, Glenn M / Leppert, John T / Pao, Alan C

    JAMA internal medicine

    2022  Volume 182, Issue 12, Page(s) 1323–1325

    MeSH term(s) Humans ; Urinary Calculi/diagnostic imaging ; Emergency Service, Hospital ; Diagnostic Imaging
    Language English
    Publishing date 2022-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2022.4939
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