LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 17

Search options

  1. Article ; Online: Crypto Pharmacy – Digital Medicine

    Ganesan Subramanian / Anand SreekantanThampy / Nnamdi Valbosco Ugwuoke / Baghwan Ramnani

    IEEE Open Journal of the Computer Society, Vol 2, Pp 26-

    A Mobile Application Integrated With Hybrid Blockchain to Tackle the Issues in Pharma Supply Chain

    2021  Volume 37

    Abstract: Mobile application integrated with cryptocurrency would be an innovative solution for making medicine purchase in the future. This research work fixates on the design and implementation of a crypto pharmacy - digital medicine utilizing hybrid blockchain ... ...

    Abstract Mobile application integrated with cryptocurrency would be an innovative solution for making medicine purchase in the future. This research work fixates on the design and implementation of a crypto pharmacy - digital medicine utilizing hybrid blockchain technology. We present the concept of crypto medicine that eliminates third-party presence (buy/sell) in a medicine purchase. The proposed design integrates the mobile application with the NEM blockchain. The manufacturer engenders the digital medicines with NEM blockchain namespace, all the pharma products are assigned with NEM cryptocurrency XEM, labeled with a QR code. Our archetype model (perspicacious detector) executes the astute contract that connects all the stakeholders in a pharma supply chain. The proposed mobile application has been prosperously integrated with NEM cryptocurrency by assigning XEM for the medicines, all the transactions are monitored in a blockchain from manufacturer to culminate-utilizer. The mobile application designed utilizing apple iOS integrated with nem2sdk swift framework. This system evades a few millions worth of substandard medicine integrated in the ecumenical market every year. In additament to crypto medicine, the genuine-time monitoring of liquid medicine has been tested with the IoT platform. It fetches the temperature data into the blockchain and authenticates the reliability of medicine for intensive care unit patients.
    Keywords Blockchain ; Covid-19 ; counterfeit medicine ; distributed ledger ; mobile application ; Internet of Things ; Electronic computers. Computer science ; QA75.5-76.95 ; Information technology ; T58.5-58.64
    Subject code 600
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher IEEE
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Frequency of hereditary hemochromatosis gene mutations and their effects on iron overload among beta thalassemia patients of Chennai residents

    Bhuvana Selvaraj / Sangeetha Soundararajan / Shettu Narayanasamy / Ganesan Subramanian / Senthil Kumar Ramanathan

    AIMS Molecular Science, Vol 8, Iss 4, Pp 233-

    2021  Volume 247

    Abstract: Hereditary Hemochromatosis (HH) is an autosomal recessive disorder of iron metabolism associated with HFE gene mutations, characterized by increased iron absorption and accumulation leading to multi-organ damage caused by iron overload toxicity. Beta ... ...

    Abstract Hereditary Hemochromatosis (HH) is an autosomal recessive disorder of iron metabolism associated with HFE gene mutations, characterized by increased iron absorption and accumulation leading to multi-organ damage caused by iron overload toxicity. Beta thalassemia is caused by a mutation in the human beta globin gene. Imbalanced production of globin chain results in beta thalassemia, where the unpaired alpha chains precipitates in red cell precursors leading to ineffective erythropoiesis and reduced RBC survival. Both HH and beta thalassemia condition results in rapid accumulation of iron lead to iron overload in tissues and organs. The study aims to analyze the frequency of HFE variants among beta thalassemia cases and their effect on iron overload. The frequency of three HFE variants C282Y, H63D, S65C was analyzed by PCR RFLP method among Beta Thalassemia Trait (BTT) (n = 203), Beta Thalassemia Major (BTM) (n = 19) and age and sex-matched control samples (n = 200). The present study furnished allele frequency of H63D variant in BTT, BTM and controls 8.13, 15.8 and 6% respectively. Ten out of 33 heterozygous H63D variants exhibited iron overload with higher ferritin levels indicating HFE variant might aggravate the absorption of iron. The C282Y variant was present in heterozygous state in 1 case among beta thalassemia carriers. The C282Y variant was absent among BTM and control cases. S65C HFE variant was absent in the present study. Iron overload was completely absent in the control cases among all three HFE genotypes. Hence it is inferred from the present investigation, analysis of HFE genes and iron status will remarkably help to reason out the probable reason behind the iron status and support in proper management of beta thalassemia cases.
    Keywords hereditary hemochromatosis ; beta thalassemia ; hfe ; iron overload ; ferritin ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher AIMS Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: MIJ821 (onfasprodil) in healthy volunteers: First-in-human, randomized, placebo-controlled study (single ascending dose and repeated intravenous dose).

    Gomez-Mancilla, Baltazar / Levy, Jeffrey A / Ganesan, Subramanian / Faller, Thomas / Issachar, Gil / Peremen, Ziv / Laufer, Offir / Shani-Hershkovich, Revital / Biliouris, Kostas / Walker, Ela / Healy, Mark P / Sverdlov, Oleksandr / Desai, Sachin / Ghaemi, S Nassir / Cha, Jang-Ho / Shanker, Y Gopi

    Clinical and translational science

    2023  Volume 16, Issue 11, Page(s) 2236–2252

    Abstract: This single-center study administered MIJ821 (onfasprodil) as an intravenous infusion to healthy volunteers and included two parts: a single ascending dose study (Part 1) and a repeated intravenous dose study (Part 2). Primary objective was to evaluate ... ...

    Abstract This single-center study administered MIJ821 (onfasprodil) as an intravenous infusion to healthy volunteers and included two parts: a single ascending dose study (Part 1) and a repeated intravenous dose study (Part 2). Primary objective was to evaluate the safety and tolerability of single ascending intravenous doses infused over a 40-min period and of two repeated doses (1 week apart) of MIJ821 in healthy volunteers. Secondary objectives were to assess the pharmacokinetics of MIJ821 after intravenous infusion in Part 1 and Part 2 of the study. Overall, 43 subjects in Part 1 and 12 subjects in Part 2 were randomized in the study. Median age in Part 1 and Part 2 was 45.0 and 43.5 years, respectively, with the majority being Caucasian (Part 1: 84%; Part 2: 92%). 19 subjects (44.2%) in Part 1 and 8 subjects (66.7%) in Part 2 experienced at least one adverse event (AE). Following single dose in Part 1 and Part 2, the AUC
    MeSH term(s) Humans ; Infusions, Intravenous ; Double-Blind Method ; Area Under Curve ; Healthy Volunteers ; Dose-Response Relationship, Drug
    Language English
    Publishing date 2023-10-10
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2433157-0
    ISSN 1752-8062 ; 1752-8054
    ISSN (online) 1752-8062
    ISSN 1752-8054
    DOI 10.1111/cts.13623
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Question 2 Should phenytoin and carbamazepine be avoided in Asian populations with the HLA-B*1502 positive genetic variant?

    Ganesan, Subramanian / Hussain, Nahin

    Archives of disease in childhood

    2011  Volume 96, Issue 1, Page(s) 104–106

    MeSH term(s) Anticonvulsants ; Asian Continental Ancestry Group/genetics ; Carbamazepine ; Child ; Contraindications ; Drug Eruptions/ethnology ; Drug Eruptions/genetics ; Epilepsy/drug therapy ; Epilepsy/ethnology ; Evidence-Based Medicine ; HLA-B Antigens/genetics ; HLA-B15 Antigen ; Humans ; Phenytoin
    Chemical Substances Anticonvulsants ; HLA-B Antigens ; HLA-B*15:02 antigen ; HLA-B15 Antigen ; Carbamazepine (33CM23913M) ; Phenytoin (6158TKW0C5)
    Language English
    Publishing date 2011-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/adc.2010.190454
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.106: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MA 3: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Mathematical modeling of a carrier-mediated transport process in a liquid membrane.

    Ganesan, Subramanian / Anitha, Shanmugarajan / Subbiah, Alwarappan / Rajendran, Lakshmanan

    The Journal of membrane biology

    2013  Volume 246, Issue 6, Page(s) 435–442

    Abstract: An analysis of the reaction diffusion in a carrier-mediated transport process through a membrane is presented. A simple approximate analytical expression of concentration profiles is derived in terms of all dimensionless parameters. Furthermore, in this ... ...

    Abstract An analysis of the reaction diffusion in a carrier-mediated transport process through a membrane is presented. A simple approximate analytical expression of concentration profiles is derived in terms of all dimensionless parameters. Furthermore, in this work we employ the homotopy perturbation method to solve the nonlinear reaction-diffusion equations. Moreover, the analytical results have been compared to the numerical simulation using the Matlab program. The simulated results are comparable with the appropriate theories. The results obtained in this work are valid for the entire solution domain.
    MeSH term(s) Biological Transport/physiology ; Cell Membrane/physiology ; Models, Biological
    Language English
    Publishing date 2013-05-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3082-x
    ISSN 1432-1424 ; 0022-2631
    ISSN (online) 1432-1424
    ISSN 0022-2631
    DOI 10.1007/s00232-013-9555-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 613: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Vitamin B12 deficiency: a treatable cause of developmental delay in infancy.

    Ganesan, Subramanian / Thanawala, Nehal / Hussain, Nahin

    Journal of paediatrics and child health

    2013  Volume 49, Issue 4, Page(s) E348–9

    MeSH term(s) Atrophy ; Developmental Disabilities/drug therapy ; Developmental Disabilities/etiology ; Female ; Fever/drug therapy ; Fever/etiology ; Homocysteine/blood ; Humans ; Infant ; Muscle Hypotonia/drug therapy ; Muscle Hypotonia/etiology ; Neuroimaging ; Seizures/drug therapy ; Seizures/etiology ; Vitamin B 12/administration & dosage ; Vitamin B 12/therapeutic use ; Vitamin B 12 Deficiency/complications ; Vitamin B 12 Deficiency/drug therapy
    Chemical Substances Homocysteine (0LVT1QZ0BA) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2013-04
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.12158
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Acute disseminated encephalomyelitis presenting as pyrexia of unknown origin.

    Ganesan, Subramanian / Khan, Arif / Hussain, Nahin / Dabydeen, Lyvia

    Journal of pediatric neurosciences

    2012  Volume 7, Issue 2, Page(s) 148–150

    Language English
    Publishing date 2012-11-30
    Publishing country India
    Document type Journal Article
    ISSN 1817-1745
    ISSN 1817-1745
    DOI 10.4103/1817-1745.102584
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Life threatening complication of sore throat: Lemierre's syndrome.

    Khan, Arif / Ganesan, Subramanian / Arora, Manish / Hussain, Nahin

    Indian journal of pediatrics

    2012  Volume 80, Issue 12, Page(s) 1059–1061

    Abstract: The authors report a case of previously healthy toddler who presented with acute sore throat that led to bacteremia, septic shock, disseminated intravascular coagulopathy, encephalopathy and pleural effusion. Magnetic resonance imaging and venogram ... ...

    Abstract The authors report a case of previously healthy toddler who presented with acute sore throat that led to bacteremia, septic shock, disseminated intravascular coagulopathy, encephalopathy and pleural effusion. Magnetic resonance imaging and venogram showed thrombosis of the internal jugular vein. He was successfully treated with antibiotics and low molecular weight heparin. The authors review the literature and explore the presentation, management and the role of anticoagulation in this condition. To the authors' knowledge, this is one of the youngest patient reports with this condition in the literature.
    MeSH term(s) Humans ; Infant ; Lemierre Syndrome/etiology ; Male ; Pharyngitis/complications
    Language English
    Publishing date 2012-12-30
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-012-0938-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 826: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Unusual cause of small bowel obstruction in an autistic child.

    Singh, Aoife / Ganesan, Subramanian / Pande, Suchandra / Sridhar, Arani V

    BMJ case reports

    2012  Volume 2012

    MeSH term(s) Autistic Disorder/complications ; Bezoars/complications ; Bezoars/diagnosis ; Child ; Diagnosis, Differential ; Female ; Humans ; Intestinal Obstruction/diagnosis ; Intestinal Obstruction/etiology ; Intestine, Small ; Radiography, Abdominal ; Tomography, X-Ray Computed
    Language English
    Publishing date 2012-07-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2012-006400
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Unusual immunophenotype of T-cell large granular lymphocytic leukemia

    Nikhil Rabade / Dia Mansukhani / Shanaz Khodaiji / Balkrishna Padte / Abhay Bhave / Prashant Tembhare / Papagudi Ganesan Subramanian / Kunal Sehgal

    Indian Journal of Pathology and Microbiology, Vol 58, Iss 1, Pp 108-

    Report of two cases

    2015  Volume 112

    Abstract: Large granular lymphocytes (LGL) leukemias are commonly of the T-cell or NK-cell type. T-cell LGL leukemia is typically a disorder of mature CD3, CD8 and T-cell receptor TCR (TCR - T cell receptor)-αβ positive cytotoxic T-cells. Rare variants include ... ...

    Abstract Large granular lymphocytes (LGL) leukemias are commonly of the T-cell or NK-cell type. T-cell LGL leukemia is typically a disorder of mature CD3, CD8 and T-cell receptor TCR (TCR - T cell receptor)-αβ positive cytotoxic T-cells. Rare variants include TCRγδ+ variants and CD4 + TCRαβ+ cases. We report a case of each of these rare variants. An 83-year-old female presented with anemia and lymphocytosis with LGLs on peripheral smear. Six-color multiparametric flowcytometric analysis showed expression of CD3, heterogeneous CD7, dim CD2 and TCRγδ and lacked expression of CD5, TCRαβ, CD56, CD4 and CD8. A final diagnosis of TCRγδ+ T-cell LGL leukemia was made. Differentiation between TCRγδ+ T-cell LGL leukemia and other γδ+ T-cell malignancies is of utmost importance due to the indolent nature of the former as compared to the highly aggressive behavior of the latter. An 85-year-old male diagnosed with liposarcoma was identified to have lymphocytosis during preoperative evaluation. Peripheral smear showed presence of LGLs. Flowcytometric immunophenotyping showed expression of TCRαβ, CD3, CD2, CD5, CD4, dim CD8, CD56 with aberrant loss of CD7 expression. Vβ repertoire analysis by flowcytometry showed 97% cells with Vβ14 clonality. A final diagnosis of TCRαβ+ CD4 + T-cell LGL leukemia was made. CD4 + T-cell large granular lymphocytic leukemias have an indolent, less aggressive course when compared to their CD8 + counterparts and are not necessarily associated with cytopenias. However, their association with secondary neoplasia (29% of the cases) warrants a high degree of suspicion in the diagnosis as also noted in the index case. Use of a wide panel of antibodies and newer modalities such as Vβ repertoire analysis helps in accurate subtyping of LGL leukemia.
    Keywords Alpha beta large granular lymphocytes ; CD4 + large granular lymphocytes leukemia ; gamma delta large granular lymphocytes ; large granular lymphocytes ; large granular lymphocytes leukemia ; Pathology ; RB1-214 ; Medicine ; R ; Microbiology ; QR1-502 ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top