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Article ; Online: Genotoxic effects of electromagnetic field radiations from mobile phones.

Jagetia, Ganesh Chandra

2022 Volume 212, Issue Pt D, Page(s) 113321

Abstract: The use of wireless communication technology in mobile phones has revolutionized modern telecommunication and mobile phones have become so popular that their number exceeds the global population. Electromagnetic field radiations (EMR) are an integral ... ...

Abstract	The use of wireless communication technology in mobile phones has revolutionized modern telecommunication and mobile phones have become so popular that their number exceeds the global population. Electromagnetic field radiations (EMR) are an integral part of wireless technology, which are emitted by mobile phones, mobile tower antennas, electric power stations, transmission lines, radars, microwave ovens, television sets, refrigerators, diagnostic, therapeutic, and other electronic devices. Manmade EMR sources have added to the existing burden of natural EMR human exposure arising from the Sun, cosmos, atmospheric discharges, and thunder storms. EMR including radiofrequency waves (RF) and extremely low-frequency radiation (ELF) has generated great interest as their short-term exposure causes headache, fatigue, tinnitus, concentration problems, depression, memory loss, skin irritation, sleep disorders, nausea, cardiovascular effects, chest pain, immunity, and hormonal disorders in humans, whereas long-term exposure to EMR leads to the development of cancer. The review has been written by collecting the information using various search engines including google scholar, PubMed, SciFinder, Science direct, EMF-portal, saferemr, and other websites from the internet. The main focus of this review is to delineate the mutagenic and genotoxic effects of EMR in humans and mammals. Numerous investigations revealed that exposure in the range of 0-300 GHz EMR is harmless as it did not increase micronuclei and chromosome aberrations. On the contrary, several other studies have demonstrated that exposure to EMR is genotoxic and mutagenic as it increases the frequency of micronuclei, chromosome aberrations, DNA adducts, DNA single and double strand breaks at the molecular level in vitro and in vivo. The EMR exposure induces reactive oxygen species and changes the fidelity of genes involved in signal transduction, cytoskeleton formation, and cellular metabolism.
MeSH term(s)	Animals ; Cell Phone ; Chromosome Aberrations ; DNA Damage ; Electromagnetic Fields/adverse effects ; Humans ; Mammals ; Radio Waves/adverse effects
Language	English
Publishing date	2022-05-01
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2022.113321
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Article ; Online: Antioxidant activity of curcumin protects against the radiation-induced micronuclei formation in cultured human peripheral blood lymphocytes exposed to various doses of γ-Radiation.

Jagetia, Ganesh Chandra

International journal of radiation biology

2021 Volume 97, Issue 4, Page(s) 485–493

Abstract: Purpose: Ionizing radiations trigger the formation of free radicals that damage DNA and cause cell death. DNA damage may be simply evaluated by micronucleus assay and the pharmacophores that impede free radicals could effectively reduce the DNA damage ... ...

Abstract	Purpose: Ionizing radiations trigger the formation of free radicals that damage DNA and cause cell death. DNA damage may be simply evaluated by micronucleus assay and the pharmacophores that impede free radicals could effectively reduce the DNA damage initiated by irradiation. Therefore, it was desired to determine the capacity of curcumin to alleviate micronuclei formation in human peripheral blood lymphocytes (HPBLs) exposed to 0-4 Gy of γ-radiation. Materials and methods: HPBLs were exposed to 3 Gy after 30 minutes of 0.125, 0.25, 0.5, 1, 2, 5, 10, 20 or 50 µg/mL curcumin treatment or with 0.5 μg/mL curcumin 30 minutes early to 0, 0.5, 1, 2, 3 or 4 Gy Results: HPBLs treated with different concentrations of curcumin before 3 Gy irradiation alleviated the micronuclei formation depending on curcumin concentration and the lowest micronuclei were detected at 0.5 µg/mL curcumin when compared to 3 Gy irradiation alone. Increasing curcumin concentration caused a gradual rise in micronuclei, and the significant increases were detected at 10-50 µg/mL curcumin than 3 Gy irradiation alone. Irradiation of HPBLs to different doses of γ-rays caused a significant rise in micronuclei depending on radiation dose, whereas HPBLs treated with 0.5 µg/mL curcumin 30 minutes before irradiation to different doses of γ-rays significantly reduced frequencies of HPBLs with one, two, or more micronuclei. Curcumin treatment inhibited the formation of hydroxyl (OH), 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), 2,2'-diphenyl-1-picrylhydrazyl (DPPH), and (nitric oxide) NO free radicals in a concentration-related way. Conclusions: Curcumin when treated at a dose of 0.5 μg/mL attenuated micronuclei formation after γ-irradiation by inhibiting the formation of radiation-induced free radicals.
MeSH term(s)	Antioxidants/pharmacology ; Cells, Cultured ; Curcumin/pharmacology ; DNA Damage ; Dose-Response Relationship, Radiation ; Gamma Rays/adverse effects ; Humans ; Lipid Peroxidation/radiation effects ; Lymphocytes/drug effects ; Lymphocytes/metabolism ; Lymphocytes/radiation effects ; Micronucleus Tests ; Radiation-Protective Agents/pharmacology
Chemical Substances	Antioxidants ; Radiation-Protective Agents ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2021-02-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3065-x
ISSN	1362-3095 ; 0020-7616 ; 0955-3002
ISSN (online)	1362-3095
ISSN	0020-7616 ; 0955-3002
DOI	10.1080/09553002.2021.1876948
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Article: Genotoxic effects of electromagnetic field radiations from mobile phones

Jagetia, Ganesh Chandra

Environmental research. 2022 Apr. 12,

2022

Abstract	The use of wireless communication technology in mobile phones has revolutionized modern telecommunication and mobile phones have become so popular that their number exceeds the global population. Electromagnetic field radiations (EMR) are an integral part of wireless technology, which are emitted by mobile phones, mobile towers, electric power stations, transmission lines, radars, microwave ovens, television sets, refrigerators, diagnostic/therapeutic and other electronic devices. The manmade EMR sources have added to the existing burden of natural EMR human exposure arising from the Sun, cosmos, atmospheric discharges, and thunderstorms. EMR including radiofrequency waves (RF) and extremely low frequency radiation (ELF) has generated great interest as their human exposure causes headache, fatigue, tinnitus, concentration problems, depression, memory loss, skin irritation, sleep disorders, nausea, cardiovascular effects, chest pain, immunity and hormonal disorders as the short-term effects and cancer as the late effect. The review has been written by collecting the information using various search engines including google scholar, PubMed SciFinder, Science direct, EMF-portal, saferemr, and other websites on the internet and its main focus is on the mutagenic and genotoxic effects of EMR in humans and mammals. Numerous investigations revealed that exposure in the range of 0–300 GHz EMR is harmless as this did not increase micronuclei and chromosome aberrations. On the contrary, several other studies have demonstrated that exposure to EMR increases the frequency of micronuclei, chromosome aberrations, DNA adducts, DNA single and double strand breaks at the molecular level in vitro and in vivo. The EMR exposure induces reactive oxygen species and changes the fidelity of genes involved in signal transduction, cytoskeleton formation, and cellular metabolism.
Keywords	DNA adducts ; Internet ; chest ; chromosomes ; cytoskeleton ; electric power ; electromagnetic field ; headache ; humans ; immunity ; memory disorders ; metabolism ; mutagens ; nausea ; radio waves ; reactive oxygen species ; research ; signal transduction ; skin irritation ; sleep ; television ; therapeutics ; wireless technology
Language	English
Dates of publication	2022-0412
Publishing place	Elsevier Inc.
Document type	Article
Note	Pre-press version
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2022.113321
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Article ; Online: A clinico-pathological study of thyroid nodules and correlation among ultrasonographic, cytologic, and histologic findings

Rajarshi Sannigrahi / Ganesh Chandra Gayen / Ritam Ray

Asian Journal of Medical Sciences, Vol 14, Iss 3, Pp 186-

2023 Volume 193

Abstract: Background: Nodular thyroid is a common occurrence affecting 5% of the population. Aims and Objectives: To find the prevalence of thyroid nodules, to study the clinico-biochemical profile of the patients with thyroid nodules and to establish a ... ...

Abstract	Background: Nodular thyroid is a common occurrence affecting 5% of the population. Aims and Objectives: To find the prevalence of thyroid nodules, to study the clinico-biochemical profile of the patients with thyroid nodules and to establish a correlation between pre-operative ultrasonography and fine-needle aspiration cytology (FNAC) with post-operative histopathologic findings. Materials and Methods: A prospective observational study was conducted in a tertiary care hospital in Kolkata over 1.5 years. Patients with clinically detectable nodules posted for surgery were evaluated clinically, biochemically, ultrasonographically (USG), and cytologically with FNAC. Histopathologic examination (HPE) was done post-surgery. Comparison was done between those with benign and malignant nodules. Correlation was done between pre-operative USG, FNA, and post-operative HPE of the nodules. Results: Out of 322 cases during the study period, the prevalence of clinically detectable thyroid nodule posted for surgery was 39 (12.58%). Most of the patients were euthyroid (94.9%), had nodules in left lobe (41.5%). Most of the nodules were heteroechoic (56.5%) and majority were THY3 nodules (48.7%) on FNAC. On HPE, malignancy was found in 20.5% of the nodules. Compared to benign nodules, malignant nodules were more commonly larger, on the left lobe, solid, hypoechoic, with spiculated margins, punctate calcification, and having associated neck nodes (pall < 0.03). Out of 11 cases, which were radiologically predicted to be malignant, 10 had THY ≥3 on FNA, and 8 were malignant on HPE. USG had a sensitivity, specificity, positive, and negative predictive value of 87.5%, 87.1%, 63.63%, and 96.43% in predicting malignancy. Conclusion: Pre-operative ultrasonography for thyroid nodules can predict malignancy with sufficient sensitivity and specificity and can obviate the need for unnecessary FNAC in many cases and also suggest imminent need for surgery rather than FNAC in very high risk cases.
Keywords	thyroid nodule ; ultrasonographically ; fine-needle aspiration cytology ; malignancy ; thyroid cancer ; histopathology ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of hearing outcome following canal wall up and canal wall down mastoidectomy in squamosal type of chronic suppurative otitis media

Mainak Samanta / Ganesh Chandra Gayen / Ritam Ray

Asian Journal of Medical Sciences, Vol 14, Iss 5, Pp 102-

A comparative study

2023 Volume 107

Abstract: Background: Chronic suppurative otitis media (CSOM) is a major health issue in developing countries causing persistent problem and may lead to life-threatening complications. This major health issue and its complications can be best avoided by early and ... ...

Abstract	Background: Chronic suppurative otitis media (CSOM) is a major health issue in developing countries causing persistent problem and may lead to life-threatening complications. This major health issue and its complications can be best avoided by early and effective treatment. Aims and Objectives: The aim is to compare the outcome in terms of hearing improvement following canal wall up and canal wall down mastoid surgery. Materials and Methods: This prospective study was conducted in Otorhinolaryngology Department of a Burdwan Medical College and Hospital, Burdwan, a tertiary care hospital in Burdwan from April 2019 to August 2020 and 50 clinically diagnosed cases of COM (Squamous type) were included in this study after through history taking and meticulous clinical examination. Patients were divided in two Groups (Group-A and Group-B) with 25 patients in each group randomly and Group-A patients undergone canal wall up mastoidectomy and Group-B patients undergone canal wall down mastoidectomy (CWDM). Now, before performing surgery, a pre-operative pure tone audiometry was performed for each of the patients and a follow-up pure tone audiometry was done again, 2-month post-operative period. These results were compared to assess the degree of hearing improvement in the two different operative procedures, namely, canal wall up and CWDM. Results: In Group-A, the mean hearing gain (mean±SD) of patients was 12.5700±0.9856. In Group-B, the mean hearing gain (mean±SD) of patients was 8.4200±5.0051. Difference of mean hearing gain with both groups was statistically significant (P=0.0002). Chi-square value: 0.1678; P=0.9195. Conclusion: Hearing gain was more with canal wall up compared to CWDM in CSOM which was statistically significant.
Keywords	canal wall up mastoidectomy ; canal wall down mastoidectomy ; hearing outcome ; Medicine ; R
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Complications of neck dissection

Debabrata Das / Ashis Kumar Ghosh / Subhadip Sardar / Ganesh Chandra Gayen

Bengal Journal of Otolaryngology and Head Neck Surgery, Vol 30, Iss 3, Pp 298-

Our initial experience

2023 Volume 304

Abstract: Abstract: Introduction: Neck dissection is an important surgical procedure to treat head-neck cancers. It also helps to stage the disease as well as denotes further treatment plan. Materials and Methods: A retrospective analytical study is done between ... ...

Abstract	Abstract: Introduction: Neck dissection is an important surgical procedure to treat head-neck cancers. It also helps to stage the disease as well as denotes further treatment plan. Materials and Methods: A retrospective analytical study is done between August 2017-July 2021 in tertiary care hospital to identify methods and practices to reduce complications of neck dissection. 104 patients who met the selection criteria were reviewed. Any intraoperative as well as post-operative complication was carefully assessed and managed as per protocol. Results: 62.5% were in the age group of 49-59 years. 66.35% were male. Maximum patient (65.38%) presented with oral cavity squamous call carcinoma. 51.92% had N1 neck node while 44.23% had N0 neck node. Internal jugular vein injury, spinal accessory nerve and marginal mandibular nerve injury, post-operative hematoma, seroma formation, chyle leak were found as significant complications in initial days. They were less in number or managed well with experience. Conclusion: Detailed knowledge of head-neck anatomy, meticulous dissection technique, early detection of any complication and its management can decrease the long-term morbidity and improve patient’s quality of life. Keywords: Neck dissection, head-neck cancer, complication, meticulous haemostasis.
Keywords	neck dissection ; head-neck cancer ; complication ; meticulous haemostasis ; Medicine ; R ; Otorhinolaryngology ; RF1-547
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	The Association of Otolaryngologists of India, West Bengal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Query expansion based on term selection for Hindi – English cross lingual IR

Ganesh Chandra / Sanjay K. Dwivedi

Journal of King Saud University: Computer and Information Sciences, Vol 32, Iss 3, Pp 310-

2020 Volume 319

Abstract: Retrieving accurate information from collection of information available on web in a cross-lingual communication environment is a very difficult task in our world. In order to retrieve information, user specifies the needed information in the form of ... ...

Abstract	Retrieving accurate information from collection of information available on web in a cross-lingual communication environment is a very difficult task in our world. In order to retrieve information, user specifies the needed information in the form of query. Sometimes query may not be able to express the needed information in specific way due to ambiguity or un-translated query words. This problem can be minimized by expanding the query with other suitable words that make it more specific. Purpose of query expansion is to improve the performance and quality of retrieved information in CLIR. In this paper, Q.E. has been explored for a Hindi-English CLIR in which Hindi queries are used to search English documents. We used Okapi BM25 for documents ranking and then by using Term Selection Value (TSV) translated queries have been expanded. All experiments have been performed on FIRE 2012 dataset by analysing the impact of occurrence of terms in top @3 ranked documents. Our result shows that the relevancy of retrieved results of Hindi-English CLIR using Q.E. which is performed by adding a lowest frequency term from the corpus of top @3 ranked documents is 51.33%, which is higher than before and after Q.E. (i.e. Case1, Case2). Keywords: Okapi BM25, Term selection value (TSV), Query expansion, Information retrieval, Cross language information retrieval
Keywords	Electronic computers. Computer science ; QA75.5-76.95
Subject code	006
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Production of pregelatinized sweet potato flour and its effect on batter and cake properties

Chittrakorn, Sasivimon / Ganesh Chandra Bora

Journal of food processing and preservation. 2021 Dec., v. 45, no. 12

2021

Abstract: Production of pregelatinized sweet potato flour by drum drying and the effect of pregelatinized flour addition on the properties of cake and frozen cake were evaluated. Drum drying temperature was varied at 110, 120, and 130°C. The water absorption index ...

Abstract	Production of pregelatinized sweet potato flour by drum drying and the effect of pregelatinized flour addition on the properties of cake and frozen cake were evaluated. Drum drying temperature was varied at 110, 120, and 130°C. The water absorption index of pregelatinized flour was significantly higher and the water solubility index was lower than native sweet potato flour. Loss of birefringence in starch granules was observed in all pregelatinized flour. The addition of pregelatinized flour to wheat flour at 5%–15% showed a decrease in peak viscosity, breakdown, and setback values. Low enthalpy of gelatinization and retrogradation was observed in wheat flour substituted with pregelatinized flour. Cake batter viscosity and density increased with increasing pregelatinized flour substitution. Volumes of cake made from wheat flour and wheat flour substituted with pregelatinized flour at 5% were similar. The addition of pregelatinized to wheat flour increased hardness and decreased the enthalpy of fresh and frozen cake. PRACTICAL APPLICATIONS: Enhanced utilization of white flesh sweet potato flour in the baking industry was studied. Pregelatinized sweet potato flour was produced by economical drum drying. Results revealed the addition of pregelatinized sweet potato flour to wheat flour increased the viscosity and density of cake batter and hardness of cakes. The reduction of retrogradation rate was observed in a cake made from wheat flour substituted with pregelatinized sweet potato flour.
Keywords	batters ; cakes ; enthalpy ; gelatinization ; hardness ; retrogradation ; sweet potato flour ; viscosity ; water solubility ; water uptake ; wheat flour
Language	English
Dates of publication	2021-12
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	243448-9
ISSN	1745-4549 ; 0145-8892
ISSN (online)	1745-4549
ISSN	0145-8892
DOI	10.1111/jfpp.16019
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Photocatalytic, α-Aminoalkyl Radical-Mediated, Methylene-Extrusive Ring-Closing Transformation of

Upreti, Ganesh Chandra / Singh, Tavinder / Khanna, Kirti / Sahoo, Debasish / Singh, Anand

Organic letters

2024 Volume 26, Issue 17, Page(s) 3652–3656

Abstract: Herein we report a visible-light-induced, α-aminoalkyl radical-mediated cascade reaction of 1,7-enynes that establishes a unique ring-closing enyne transformation pathway which occurs with concomitant loss of a methylene moiety. The α-aminoalkyl radical ... ...

Abstract	Herein we report a visible-light-induced, α-aminoalkyl radical-mediated cascade reaction of 1,7-enynes that establishes a unique ring-closing enyne transformation pathway which occurs with concomitant loss of a methylene moiety. The α-aminoalkyl radical derived from
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.4c01165
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Article: Synthesis of Tritylones via Cascade Reaction of Arynes with 5-Ethoxyoxazoles

Garg, Parul / Upreti, Ganesh Chandra / Singh, Anand

Journal of organic chemistry. 2022 May 17, v. 87, no. 11

2022

Abstract: A cascade reaction involving arynes and 5-ethoxyoxazoles has been developed toward the synthesis of 9-alkyl/aryl tritylones. 5-Ethoxyoxazoles undergo a [4 + 2] cycloaddition reaction with arynes followed by retro-[4 + 2] cycloaddition, a second ... ...

Abstract	A cascade reaction involving arynes and 5-ethoxyoxazoles has been developed toward the synthesis of 9-alkyl/aryl tritylones. 5-Ethoxyoxazoles undergo a [4 + 2] cycloaddition reaction with arynes followed by retro-[4 + 2] cycloaddition, a second intermolecular [4 + 2] cycloaddition reaction, and hydrolytic ring cleavage to generate substituted tritylones in good yields. The conversion of tritylone products to a series of spirocyclic anthrone derivatives has been demonstrated. The reaction is expeditious, exhibits wide scope, and employs readily available starting materials.
Keywords	cycloaddition reactions ; journals ; organic chemistry
Language	English
Dates of publication	2022-0517
Size	p. 7219-7228.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.2c00437
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