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  1. AU="Gang Lin"
  2. AU="Oka, T"
  3. AU="Frank-Pearce, Summer G"
  4. AU="Hairi Li"
  5. AU="Park, SungHee"
  6. AU="Pascual-Carreras, Eudald"
  7. AU=Joffe Ari R
  8. AU="Buccafurri, Francesco"
  9. AU="Naomi H. Philip"
  10. AU="P. Naina"
  11. AU="Sigal, Leonard H"
  12. AU="Xu, T" AU="Xu, T"
  13. AU="Mazlout, Adam"
  14. AU="Novak, Cheryl B"
  15. AU="Ren, Zhongmin"
  16. AU="Nadhira Houhou-Fidouh"
  17. AU="Seiffert, Jacqui"
  18. AU=Zhang Zizhen
  19. AU="Bhupender Singh Negi"

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Treffer 1 - 10 von insgesamt 96

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  1. Artikel ; Online: Change characteristics and influencing factors of grassland degradation in adjacent areas of the Qinghai–Tibet Plateau and suggestions for grassland restoration

    Gang Lin / Limin Hua / Yanze Shen / Yajiao Zhao

    PeerJ, Vol 11, p e

    2023  Band 16084

    Abstract: Natural grasslands are being progressively degraded around the world due to climate change and socioeconomic factors. Most of the drivers, processes, and consequences of grassland degradation are studied separately, and it is not yet clear whether the ... ...

    Abstract Natural grasslands are being progressively degraded around the world due to climate change and socioeconomic factors. Most of the drivers, processes, and consequences of grassland degradation are studied separately, and it is not yet clear whether the change characteristics and influence factors of adjacent areas of grassland are identical. We analyzed changes in grassland area and quality, and the influences of climate changes and socioeconomic factors from 1980–2018 in Maqu County, Xiahe County and Luqu County on the eastern Qinghai-Tibet Plateau (QTP). We found that areas with high and medium coverage grassland in Maqu County and Luqu County decreased continuously with time, while low coverage grassland areas increased in three counties. In Xiahe County, the medium coverage grassland area reduced with time (except for 2010), while the high and low coverage grassland areas increased. The actual net primary productivity of the three counties showed a downward trend. In Maqu County, the total grassland area had an extremely significant positive correlation with number of livestock going to market, commodity rate, gross domestic product (GDP), primary industry, tertiary industry, household density, and levels of junior middle school education and university education in the area. In Luqu County, the total grassland area high coverage grassland area were significantly negatively correlated with total number of livestock, secondary industry, levels of primary school education, and temperature. Ecological education was positively correlated with high coverage grassland, and negatively correlated with low coverage grassland in all three areas. The results of this study suggest that the best ways to restore the area and quality of grasslands in these areas would be to reduce the local cultivated land area and slow down the development of the primary and tertiary industries in Maqu County, and to control industry development and the total number of livestock in Luqu County. This study also suggests that improving ...
    Schlagwörter Qinghai–Tibet plateau ; Grassland ; Climate change ; Socioeconomic factor ; Ecological education ; Medicine ; R ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 910
    Sprache Englisch
    Erscheinungsdatum 2023-09-01T00:00:00Z
    Verlag PeerJ Inc.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Microbial proteasomes as drug targets

    Hao Zhang / Gang Lin

    PLoS Pathogens, Vol 17, Iss

    2021  Band 12

    Abstract: Proteasomes are compartmentalized, ATP-dependent, N-terminal nucleophile hydrolases that play essentials roles in intracellular protein turnover. They are present in all 3 kingdoms. Pharmacological inhibition of proteasomes is detrimental to cell ... ...

    Abstract Proteasomes are compartmentalized, ATP-dependent, N-terminal nucleophile hydrolases that play essentials roles in intracellular protein turnover. They are present in all 3 kingdoms. Pharmacological inhibition of proteasomes is detrimental to cell viability. Proteasome inhibitor rugs revolutionize the treatment of multiple myeloma. Proteasomes in pathogenic microbes such as Mycobacterium tuberculosis (Mtb), Plasmodium falciparum (Pf), and other parasites and worms have been validated as therapeutic targets. Starting with Mtb proteasome, efforts in developing inhibitors selective for microbial proteasomes have made great progress lately. In this review, we describe the strategies and pharmacophores that have been used in developing proteasome inhibitors with potency and selectivity that spare human proteasomes and highlight the development of clinical proteasome inhibitor candidates for treatment of leishmaniasis and Chagas disease. Finally, we discuss the future challenges and therapeutical potentials of the microbial proteasome inhibitors.
    Schlagwörter Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Microbial proteasomes as drug targets.

    Hao Zhang / Gang Lin

    PLoS Pathogens, Vol 17, Iss 12, p e

    2021  Band 1010058

    Abstract: Proteasomes are compartmentalized, ATP-dependent, N-terminal nucleophile hydrolases that play essentials roles in intracellular protein turnover. They are present in all 3 kingdoms. Pharmacological inhibition of proteasomes is detrimental to cell ... ...

    Abstract Proteasomes are compartmentalized, ATP-dependent, N-terminal nucleophile hydrolases that play essentials roles in intracellular protein turnover. They are present in all 3 kingdoms. Pharmacological inhibition of proteasomes is detrimental to cell viability. Proteasome inhibitor rugs revolutionize the treatment of multiple myeloma. Proteasomes in pathogenic microbes such as Mycobacterium tuberculosis (Mtb), Plasmodium falciparum (Pf), and other parasites and worms have been validated as therapeutic targets. Starting with Mtb proteasome, efforts in developing inhibitors selective for microbial proteasomes have made great progress lately. In this review, we describe the strategies and pharmacophores that have been used in developing proteasome inhibitors with potency and selectivity that spare human proteasomes and highlight the development of clinical proteasome inhibitor candidates for treatment of leishmaniasis and Chagas disease. Finally, we discuss the future challenges and therapeutical potentials of the microbial proteasome inhibitors.
    Schlagwörter Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Pathways for the carbon peak of resource-based cities under an energy-water coupling relationship

    Gang Lin / Dong Jiang / Jingying Fu / Yitong Yin

    Frontiers in Environmental Science, Vol

    A case study of Taiyuan, Shanxi Province

    2022  Band 10

    Abstract: The “dual carbon” goal proposes new requirements for urban development, and the contradiction between high-speed urban development and environmental problems is becoming increasingly critical. The path of green and low-carbon development urgently needs ... ...

    Abstract The “dual carbon” goal proposes new requirements for urban development, and the contradiction between high-speed urban development and environmental problems is becoming increasingly critical. The path of green and low-carbon development urgently needs to be investigated. In this paper, a simulation system of urban carbon emission based on system dynamics is built from four perspectives of population, economy, water resources and energy, aiming at building a method system for carbon peak path that is universally applicable to resource-based cities from a systematic perspective. This paper designs five scenarios: business as unusual scenario (BAU), adjustment of industrial structure (CPA1), adjustment of energy structure (CPA2), reduce energy consumption per unit of GDP (CPA3) and comprehensive management (CPAcomprehensive). Compared with the other four scenarios, the comprehensive scenario had the best coordination benefit for the coupling system, which took into account economic development, resource consumption and carbon emission reduction and could promote the realization of a carbon peak in Taiyuan city in 2029, and the comprehensive scenario will reduce CO2 by 17.14 million tons, water consumption by 158 million m3, energy consumption by 5.58 million tons of standard coal and economic growth by 175.21 billion yuan in 2029.
    Schlagwörter carbon peak ; water-energy coupling system ; system dynamics ; resource-based city ; Shanxi ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
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  5. Artikel ; Online: A Review on the Overall Optimization of Production–Living–Ecological Space

    Gang Lin / Dong Jiang / Jingying Fu / Yi Zhao

    Land, Vol 11, Iss 345, p

    Theoretical Basis and Conceptual Framework

    2022  Band 345

    Abstract: The 18th National Congress of the Communist Party of China put forward the optimization of territorial space development patterns as the primary measure of ecological civilization construction, and put forward the goal of “promoting intensive and ... ...

    Abstract The 18th National Congress of the Communist Party of China put forward the optimization of territorial space development patterns as the primary measure of ecological civilization construction, and put forward the goal of “promoting intensive and efficient production space, livable and moderate living space, and beautiful (picturesque scenery) ecological space”. Through literature research and summing induction, this paper combs the research progress of the overall optimization of “Production–Living–Ecological” space (PLES) systematically. It is found that the existing work mainly focuses on the overall optimization of PLES from the perspectives of land-use quality, land-use suitability evaluation, resource and environmental carrying capacity, and comparative advantages. However, due to the lack of understanding of the scientific connotation of PLES, and the imperfect construction of quantitative identification methods and classification system, there are many problems in the technical approaches of the overall optimization of PLES, which remain to be clarified. In the future, the technological approach to the overall optimization of PLES should be guided by the vision of building a beautiful China, with the theory of a human–Earth coupling system as the core, and systematically build a theoretical system and technical framework to identify and optimize territorial space.
    Schlagwörter Production–Living–Ecological space ; overall optimization ; beautiful China ; ecological civilization ; Agriculture ; S
    Thema/Rubrik (Code) 720
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Production–Living–Ecological Conflict Identification Using a Multiscale Integration Model Based on Spatial Suitability Analysis and Sustainable Development Evaluation

    Gang Lin / Jingying Fu / Dong Jiang

    Land, Vol 10, Iss 383, p

    A Case Study of Ningbo, China

    2021  Band 383

    Abstract: Production–living–ecological space (PLES) basically covers the scope of spatial activities in people’s material production and spiritual life and is the basic carrier of human social development and economic activities. The coordinated development of ... ...

    Abstract Production–living–ecological space (PLES) basically covers the scope of spatial activities in people’s material production and spiritual life and is the basic carrier of human social development and economic activities. The coordinated development of PLES is an effective method to mitigate land-use conflicts to achieve balanced and coordinated development of the region. However, so far, compared with the single-scale study based on administrative unit, the PLES conflicts between microcosmic grid-scale receives less attention. Considering the important scale problems of the geographical study, this study aims to analyze the synergetic degree of PLES under different scales (administrative-unit, grid, and integrated multiscale) and to scientifically diagnose land use conflicts in Ningbo, China. Results indicated that production land and ecological land in Ningbo were continuously occupied by human activities from 2010 to 2018. The lowest and lower suitability areas of ecological space in Ningbo increased from 2010 to 2018. Land ecological suitability was seriously affected by urban expansion, its ecological value was reduced, and the PLES developed towards the trend of being uncoordinated. Multiscale coupling analysis showed that the PLES in Ningbo was in less conflict on the whole, but with the development of the economy, the coupling coordination degree of PLES was also damaged. This study establishes the different scales of a PLES coupling coordination development degree evaluation index system and enriches the methods of multiscale land use fusion conflict diagnosis and also provides a scientific reference for the optimized and sustainable development of regional territorial space.
    Schlagwörter PLES ; multiscale integration ; coupling coordination ; conflict diagnosis ; Ningbo ; Agriculture ; S
    Thema/Rubrik (Code) 910
    Sprache Englisch
    Erscheinungsdatum 2021-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Dual-channel convolutional neural network for power edge image recognition

    Fangrong Zhou / Yi Ma / Bo Wang / Gang Lin

    Journal of Cloud Computing: Advances, Systems and Applications, Vol 10, Iss 1, Pp 1-

    2021  Band 9

    Abstract: Abstract In view of the low accuracy and poor processing capacity of traditional power equipment image recognition methods, this paper proposes a power equipment image recognition method based on a dual-channel convolutional neural network (DC-CNN) model ...

    Abstract Abstract In view of the low accuracy and poor processing capacity of traditional power equipment image recognition methods, this paper proposes a power equipment image recognition method based on a dual-channel convolutional neural network (DC-CNN) model and random forest (RF) classification. In the aspect of feature extraction, the DC-CNN model extracts the characteristics of power equipment through two independent CNN models. In the aspect of the recognition algorithm, by referring to the advantages of the traditional machine learning method and incorporating the advantages of the RF, an RF classification method incorporating deep learning is proposed. Finally, the proposed DC-CNN model and RF classification method are used to classify images of various types of power equipment. The results show that the proposed methods can be effectively applied to the image recognition of various types of power equipment, and they greatly improve the recognition rate of power equipment images.
    Schlagwörter Dual-channel ; Convolution neural network ; Power equipment ; Random forests ; Image recognition ; Computer engineering. Computer hardware ; TK7885-7895 ; Electronic computers. Computer science ; QA75.5-76.95
    Thema/Rubrik (Code) 006
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag SpringerOpen
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Spatiotemporal Evolution Characteristics and the Climatic Response of Carbon Sources and Sinks in the Chinese Grassland Ecosystem from 2010 to 2020

    Xiang Li / Gang Lin / Dong Jiang / Jingying Fu / Yaxin Wang

    Sustainability, Vol 14, Iss 14, p

    2022  Band 8461

    Abstract: With the increase in global carbon dioxide emissions, China has put forward the goals of a carbon peak and carbon neutrality (double carbon) and formulated an action plan to consolidate and enhance the carbon sink capacity of the ecosystem. The Chinese ... ...

    Abstract With the increase in global carbon dioxide emissions, China has put forward the goals of a carbon peak and carbon neutrality (double carbon) and formulated an action plan to consolidate and enhance the carbon sink capacity of the ecosystem. The Chinese grassland ecosystem (CGE) is widely distributed and is the key link for China to achieve the double carbon objectives. However, there is a relative lack of research on carbon sources and sinks in the CGE, so it is urgent to integrate and analyze the carbon sources and sinks in the grassland ecosystem on the national scale. Based on the refined grid data, the net ecosystem productivity (NEP) of the CGE was estimated by coupling the vegetation production model and soil respiration model. The results showed that the cumulative carbon sequestration of the CGE was 14.46 PgC from 2010 to 2020. In terms of spatial distribution, this shows that the differentiation characteristics are high in the northwest of China and low in the southeast of China, which strongly corresponds with the 400 mm isohyet and 0 °C isotherm of China. The results of the correlation analysis showed that the NEP of the CGE was positively correlated with precipitation and negatively correlated with temperature; that is, precipitation mainly promotes the accumulation of NEP, and temperature mainly inhibits it. The coupling effect of temperature and precipitation jointly affects the spatial change of carbon sources and sinks of the CGE. This study can provide a scientific basis for government departments to formulate targeted policies to deal with climate change, which is of great significance for China to improve ecosystem management, ensure ecological security and promote the realization of China’s double carbon goal.
    Schlagwörter grassland ecosystem ; vegetation production model ; soil respiration model ; net ecosystem productivity ; carbon peak and neutrality ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 550
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: The Complete Mitochondrial Genome and Phylogenetic Analysis of the Freshwater Shellfish Novaculina chinensis (Bivalvia

    Ziquan Zhou / Yuxin Song / Zewen Zheng / Yunguang Liu / Haiyan Yao / Xiaozhen Rao / Gang Lin

    International Journal of Molecular Sciences, Vol 25, Iss 1, p

    Pharidae)

    2023  Band 67

    Abstract: Razor clams, belonging to the Pharidae and Solenidae families, are ecologically and economically important; however, very little research has been conducted on the Pharidae family. The genus Novaculina is a marine-derived freshwater lineage, and ... ...

    Abstract Razor clams, belonging to the Pharidae and Solenidae families, are ecologically and economically important; however, very little research has been conducted on the Pharidae family. The genus Novaculina is a marine-derived freshwater lineage, and Novaculina chinensis is a rare freshwater species of the Pharidae family. In order to understand the phylogenetic relationships of N. chinensis , we sequenced the mitochondrial genome of the genus Novaculina , which is 16,262 bp in length and consists of 12 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs), and 2 ribosomal RNA genes (rRNAs). The phylogenetic relationships of 69 Imparidentian mitochondrial genomes (mitogenomes) indicated that N. chineisis is closely related to Sinonovacula constricta of the order Adapedonta. Our study also found that the Ka/Ks ratios of 12 protein-coding genes in the Pharidae family are lower than one, indicating the occurrence of negative purification selection. Morphological observations of the siphons of N. chinensis , Novaculina myanmarensis , and Novaculina gangetica indicate that N. chinensis may be the ancestral clade of the genus Novaculina , which has not been proposed in previous studies. Our study provides useful molecular information on the phylogenetic and evolutionary relationships of Pharidae and also contributes to the conservation and management of the germplasm resources of N. chinensis .
    Schlagwörter razor clams ; Pharidae ; Novaculina chinensis ; mitogenome ; phylogenetic relationship ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag MDPI AG
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Evaluating Performance of Public Transport Networks by Using Public Transport Criteria Matrix Analytic Hierarchy Process Models—Case Study of Stonnington, Bayswater, and Cockburn Public Transport Network

    Gang Lin / Shaoli Wang / Conghua Lin / Linshan Bu / Honglei Xu

    Sustainability, Vol 13, Iss 6949, p

    2021  Band 6949

    Abstract: To mitigate car traffic problems, the United Nations Human Settlements Programme (UN-Habitat) issued a document that provides guidelines for sustainable development and the promotion of public transport. The efficiency of the policies and strategies ... ...

    Abstract To mitigate car traffic problems, the United Nations Human Settlements Programme (UN-Habitat) issued a document that provides guidelines for sustainable development and the promotion of public transport. The efficiency of the policies and strategies needs to be evaluated to improve the performance of public transportation networks. To assess the performance of a public transport network, it is first necessary to select evaluation criteria. Based on existing indicators, this research proposes a public transport criteria matrix that includes the basic public transport infrastructure level, public transport service level, economic benefit level, and sustainable development level. A public transport criteria matrix AHP model is established to assess the performance of public transport networks. The established model selects appropriate evaluation criteria based on existing performance standards. It is applied to study the Stonnington, Bayswater, and Cockburn public transport network, representing a series of land use and transport policy backgrounds. The local public transport authorities can apply the established transport criteria matrix AHP model to monitor the performance of a public transport network and provide guidance for its improvement.
    Schlagwörter PT network performance criteria ; criteria selection ; case study ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 380
    Sprache Englisch
    Erscheinungsdatum 2021-06-01T00:00:00Z
    Verlag MDPI AG
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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