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Article: MATERNAL RISK FACTORS AS DETERMINANTS OF LOW BIRTH WEIGHT AMONG ARMED FORCES FAMILIES.

Kapilashrami, M C / Virk, R S / Ganguly, S S / Chatterjee, K

2017 Volume 56, Issue 2, Page(s) 113–116

Abstract: Low birth weight (LBW) is responsible for a significant proportion of child morbidity and mortality apart from its possible role in the occurrence of chronic disease in adult life. This study highlights the overall low incidence of LBWs at 13.6% among ... ...

Abstract	Low birth weight (LBW) is responsible for a significant proportion of child morbidity and mortality apart from its possible role in the occurrence of chronic disease in adult life. This study highlights the overall low incidence of LBWs at 13.6% among the Armed Forces families. The Other Ranks had a proportionally higher incidence of LBW at 24.14%. 82.14% of the LBWs occurred in the age group of 20-29 yrs, with only 6.93% of the births being teenage pregnancies. Primiparous women accounted for 54.95% of births but 75% of the LBWs. Smoking was not a significant factor. The findings underscore the need for special attention to other rank families and primiparas. A continued effort at updating the health care facilities provided to the Armed Forces families, and a concerted health and dietary advice by the authorised medical attendants, directed at the primiparous women, will further help lower the incidence of LBWs. The National LBW target of less than 10% by 2000 AD is definitely achievable by the Armed Forces.
Language	English
Publishing date	2017-06-10
Publishing country	India
Document type	Journal Article
ZDB-ID	196342-9
ISSN	0377-1237
ISSN	0377-1237
DOI	10.1016/S0377-1237(17)30124-7
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Article ; Online: Aberrant CREB1 activation in prostate cancer disrupts normal prostate luminal cell differentiation.

Watson, M J / Berger, P L / Banerjee, K / Frank, S B / Tang, L / Ganguly, S S / Hostetter, G / Winn, M / Miranti, C K

Oncogene

2021 Volume 40, Issue 18, Page(s) 3260–3272

Abstract: The molecular mechanisms of luminal cell differentiation are not understood well enough to determine how differentiation goes awry during oncogenesis. Using RNA-Seq analysis, we discovered that CREB1 plays a central role in maintaining new luminal cell ... ...

Abstract	The molecular mechanisms of luminal cell differentiation are not understood well enough to determine how differentiation goes awry during oncogenesis. Using RNA-Seq analysis, we discovered that CREB1 plays a central role in maintaining new luminal cell survival and that oncogenesis dramatically changes the CREB1-induced transcriptome. CREB1 is active in luminal cells, but not basal cells. We identified ING4 and its E3 ligase, JFK, as CREB1 transcriptional targets in luminal cells. During luminal cell differentiation, transient induction of ING4 expression is followed by a peak in CREB1 activity, while JFK increases concomitantly with CREB1 activation. Transient expression of ING4 is required for luminal cell induction; however, failure to properly down-regulate ING4 leads to luminal cell death. Consequently, blocking CREB1 increased ING4 expression, suppressed JFK, and led to luminal cell death. Thus, CREB1 is responsible for the suppression of ING4 required for luminal cell survival and maintenance. Oncogenic transformation by suppressing PTEN resulted in constitutive activation of CREB1. However, the tumor cells could no longer fully differentiate into luminal cells, failed to express ING4, and displayed a unique CREB1 transcriptome. Blocking CREB1 in tumorigenic cells suppressed tumor growth in vivo, rescued ING4 expression, and restored luminal cell formation, but ultimately induced luminal cell death. IHC of primary prostate tumors demonstrated a strong correlation between loss of ING4 and loss of PTEN. This is the first study to define a molecular mechanism whereby oncogenic loss of PTEN, leading to aberrant CREB1 activation, suppresses ING4 expression causing disruption of luminal cell differentiation.
MeSH term(s)	Cell Cycle Proteins ; Cell Differentiation ; Humans ; Male ; PTEN Phosphohydrolase ; Prostate ; Prostatic Neoplasms
Chemical Substances	Cell Cycle Proteins ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67)
Language	English
Publishing date	2021-04-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/s41388-021-01772-y
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Article ; Online: Full Outline of UnResponsiveness score and Glasgow Coma Scale in medical patients with altered sensorium: interrater reliability and relation to outcome.

Gujjar, Arunodaya R / Jacob, Poovathru C / Nandhagopal, R / Ganguly, S S / Obaidy, Ammar / Al-Asmi, Abdullah R

Journal of critical care

2013 Volume 28, Issue 3, Page(s) 316.e1–8

Abstract: Purpose: Full Outline of UnResponsiveness, or FOUR score (FS), is a recently described scoring system for evaluation of altered sensorium. This study examined interrater reliability for FS and Glasgow Coma Scale (GCS) among medical patients with altered ...

Abstract	Purpose: Full Outline of UnResponsiveness, or FOUR score (FS), is a recently described scoring system for evaluation of altered sensorium. This study examined interrater reliability for FS and Glasgow Coma Scale (GCS) among medical patients with altered mental status and compared outcome predictability of GCS, FS, and Sequential Organ Failure Assessment score. Patients and methods: Adult patients with altered mental status due to medical causes were rated by neurology consultants and internal medicine residents on FS and GCS. Interobserver reliability for GCS and FS was assessed using κ score. Relation with outcomes was explored using univariate and multivariate analyses. Main results: Of the 100 patients (age, 62 ± 17 years), 60 had neurologic conditions; 26, metabolic encephalopathy; 9, infections; and 7, others. Thirty-nine patients died at 3 months. κ Scores ranged from 0.71 to 0.85 for GCS and from 0.71 to 0.95 for FS. On multivariate analysis, GCS was predictive of outcome at 3 months; FS was predictive of mortality. Area under the receiver operating characteristic curves suggested equivalent performance of both scoring systems. Conclusions: Interrater reliability and outcome predictability for FS were comparable with those for GCS. This study supports the use of FS for evaluation of altered mental status in the medical wards.
MeSH term(s)	Coma/diagnosis ; Coma/physiopathology ; Female ; Glasgow Coma Scale ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Organ Dysfunction Scores ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; ROC Curve ; Reproducibility of Results
Language	English
Publishing date	2013-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632818-0
ISSN	1557-8615 ; 0883-9441
ISSN (online)	1557-8615
ISSN	0883-9441
DOI	10.1016/j.jcrc.2012.06.009
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Article: Epidemiological transition of some diseases in Oman: a situational analysis.

Ganguly, S S / Al-Lawati, A / Al-Shafaee, M A / Duttagupta, K K

World hospitals and health services : the official journal of the International Hospital Federation

2009 Volume 45, Issue 1, Page(s) 26–31

Abstract: During the past 35 years Oman has undergone a rapid socioeconomic and epidemiological transition leading to a steep reduction in child and adult mortality and morbidity due to the decline of various communicable diseases, including vaccine-preventable ... ...

Abstract	During the past 35 years Oman has undergone a rapid socioeconomic and epidemiological transition leading to a steep reduction in child and adult mortality and morbidity due to the decline of various communicable diseases, including vaccine-preventable diseases. Good governance and planning, together with leadership and commitment by the government, has been a critical factor in this reduction. However, with increasing prosperity, lifestyle-related noncommunicable diseases have emerged as new health challenges to the country, with cardiovascular diseases, diabetes and obesity in the lead among other chronic conditions. Appropriate prevention strategies for reducing the burden of noncommunicable diseases are discussed.
MeSH term(s)	Child Mortality/trends ; Child, Preschool ; Communicable Disease Control/trends ; Humans ; Immunization Programs ; Malaria/epidemiology ; Morbidity/trends ; Oman/epidemiology ; Tuberculosis/epidemiology
Language	English
Publishing date	2009
Publishing country	England
Document type	Journal Article
ZDB-ID	1287212-x
ISSN	1029-0540
ISSN	1029-0540
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Article: Konzeption und Implementierung eines Qualitätsmanagementsystems nach ISO 9001:2000: Qualitäts- und Effizienzsteigerung über 3 Jahre an der Augenklinik der Sultan Qabbos Universität in Oman.

Bialasiewicz, A A / Breidenbach, K / Ganesh, A / Al-Saeidi, R / Ganguly, S S

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft

2006 Volume 103, Issue 10, Page(s) 877–887

Abstract: Background: Oman is a developing country of the Middle East with a University Hospital in a national health system. Problems related to documentation, structure, and procedure prevailing in a multicultural environment result in a lack of productivity. ... ...

Title translation	Conceiving and implementing an ISO 9001:2000 quality management system: quality improvement and efficiency increase over 3 years at the Dept. of Ophthalmology, Sultan Qaboos University in Oman.
Abstract	Background: Oman is a developing country of the Middle East with a University Hospital in a national health system. Problems related to documentation, structure, and procedure prevailing in a multicultural environment result in a lack of productivity. The aim of this study was to test the feasibility of introducing a quality management system according to ISO 9001:2000 into a university department of ophthalmology with special reference to quality and efficiency data over 3 years. Materials and methods: Standardized types of documentation (35 documents, 183 forms and formats, and 453 registers) under a formal roof (booklets for work instructions, quality management, procedures) were conceived in 2001 and implemented, and were evaluated by descriptive statistics over the years 2002-2005 with respect to quality and efficiency. In 2005, the departmental QMS was merged into the QMS of the whole hospital. Results: Establishment of "responsibility clusters" with structured surveillance tasks, procedural improvements, and continuous audits resulted in a significant quality improvement already during the implementation until ISO 9001:2000 certification in 2002, and over the following 3 years. The data were assessed by non-conformities documented monthly (total inpatients: -50%, outpatients: -20%, operating theater: -100%, teaching: -10%; p <0.05) and increased efficiency assessed by the most important performance indicators (before QMS vs a median of 3 years with QMS): major surgery: +459%, inpatient stay: -49.7%, occupancy rate: +63.9%, technical diagnostics: +292.9%, postgraduate teaching total: +740%, research output total: +330% (p <0.05). Conclusions: It is feasible to introduce the quality management system according to ISO 9001:2000 into a developing country in the Middle East. It has an immediate effect on the increase of efficiency (measured by performance indicators) and quality in all systems providing the possibility for regional benchmarking.
MeSH term(s)	Academic Medical Centers/organization & administration ; Delivery of Health Care/standards ; Hospital Departments/standards ; Internationality ; Oman ; Ophthalmology/organization & administration ; Practice Guidelines as Topic ; Quality Assurance, Health Care/organization & administration
Language	German
Publishing date	2006-10
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	1105167-x
ISSN	1433-0423 ; 0941-293X
ISSN (online)	1433-0423
ISSN	0941-293X
DOI	10.1007/s00347-006-1375-y
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Article ; Online: Splenectomy for haematological disorders: a single center study in 150 patients from Oman.

Machado, Norman Oneil / Grant, Christopher S / Alkindi, Salam / Daar, Shahina / Al-Kindy, Nayil / Al Lamki, Zakia / Ganguly, S S

International journal of surgery (London, England)

2009 Volume 7, Issue 5, Page(s) 476–481

Abstract: Background: Haematological disorders, in particular sickle cell disease (SCD) and thalassaemia, are relatively common in Oman. We report our experience of splenectomy for haematological disorders and review the literature on splenectomy role in their ... ...

Abstract	Background: Haematological disorders, in particular sickle cell disease (SCD) and thalassaemia, are relatively common in Oman. We report our experience of splenectomy for haematological disorders and review the literature on splenectomy role in their management. Objectives: To review our experience in the management of 150 patients with haematological disorders undergoing splenectomy with emphasis on indications and outcome. To compare our experience with those reported from outside this region. Methods: The records of 150 patients who underwent splenectomy over a thirteen year period were reviewed retrospectively, analyzing the age and sex of the patients, indication for splenectomy, operative procedures, complications, peri-operative management and outcome. Results: Of the 150 patients, 96 (64%) had SCD and 34 (22.6%) had beta-thalassaemia; the rest comprised patients with refractory idiopathic thrombocytopenic purpura (ITP) n=12, hereditary spherocytosis (HS) n=6, and auto-immune haemolytic anaemia (AHA) n=2. In SCD patients, the main indications for splenectomy were recurrent splenic sequestration (60.4%) and hypersplenism (36.4%), whereas in thalassaemic patients it was increased requirement of packed red blood cells (PRBC) transfusion (mean 310 ml, range 242-372 of PRBC/kg/year). All patients received prophylactic antibiotics and vaccination against pneumococcal infection and when the vaccine was available for Haemophilus influenzae. PRBC and platelet concentrates as well as intravenous fluids were infused preoperatively as per protocol. Concomitant procedures at laparotomy included liver biopsy (14.6%) and cholecystectomy (8.6%). The postoperative morbidity was low (8.6%) and there was no mortality. All patients were maintained on long term penicillin and proguanil, and the mean follow-up was 4.6 years. In SCD patients splenectomy eliminated the risks of life threatening acute splenic sequestration and improved significantly the blood counts of the hypersplenic cases, while in thalassaemic patients it reduced significantly the mean transfusion requirement by 100ml PRBC/kg/year (p<0.0001). Of the patients with refractory ITP, two thirds had a good response to splenectomy (p<0.0001). All HS and AHA patients benefited from splenectomy. Conclusion: The predominant indications for splenectomy were recurrent acute splenic sequestration and hypersplenism in SCD patients, and increased transfusion demand in the thalassaemics. Overall, splenectomy proved beneficial in eliminating the risk of splenic sequestration in SCD patients, in improving the blood counts in SCD with hypersplenism and in reducing transfusion requirement in thalassaemic patients, while in ITP group two thirds of the patients benefited.
MeSH term(s)	Adolescent ; Adult ; Biopsy ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Hematologic Diseases/epidemiology ; Hematologic Diseases/surgery ; Humans ; Incidence ; Male ; Middle Aged ; Oman/epidemiology ; Retrospective Studies ; Spleen/pathology ; Spleen/surgery ; Splenectomy/methods ; Time Factors ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2009-10
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1016/j.ijsu.2009.08.004
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Article: Evaluation of some risk factors for ischaemic heart disease under a matched pairs case-control design.

Ganguly, S S / Dutta, P K / Tilak, V W

The Indian journal of medical research

1997 Volume 105, Page(s) 278–282

Abstract: A pair-wise matched case-control study was carried out in 200 male patients of ischaemic heart disease (IHD). The cases were matched with an equal number of controls in respect of the variables viz., age and socio-economic status. The objective was to ... ...

Abstract	A pair-wise matched case-control study was carried out in 200 male patients of ischaemic heart disease (IHD). The cases were matched with an equal number of controls in respect of the variables viz., age and socio-economic status. The objective was to quantify the risk of developing IHD for some of the leading risk factors under the univariate and multivariate situations. The analysis revealed that of the factors (smoking, overweight, hypertension, diabetes, serum cholesterol and family history) considered, the smoking habit of the individual, presence of family history of the disease and overweight were the significant risk factors responsible for the development of the disease. The estimated odds ratios were found to be 3.29, 2.60 and 2.00 respectively.
MeSH term(s)	Case-Control Studies ; Evaluation Studies as Topic ; Humans ; Male ; Matched-Pair Analysis ; Myocardial Ischemia/etiology ; Risk Factors
Language	English
Publishing date	1997-06
Publishing country	India
Document type	Journal Article
ZDB-ID	390883-5
ISSN	0971-5916 ; 0019-5340
ISSN	0971-5916 ; 0019-5340
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Article: Epidemiological transition of some diseases in Oman: a situational analysis.

Ganguly, S S / Al-Shafaee, M A / Al-Lawati, J A / Dutta, P K / Duttagupta, K K

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit

2009 Volume 15, Issue 1, Page(s) 209–218

Abstract	During the past 35 years Oman has undergone a rapid socioeconomic and epidemiological transition leading to a steep reduction in child and adult mortality and morbidity due to the decline of various communicable diseases, including vaccine-preventable diseases. Good governance and planning, together with leadership and commitment by the government, has been a critical factor in this reduction. However, with increasing prosperity, lifestyle-related noncommunicable diseases have emerged as new health challenges to the country, with cardiovascular diseases, diabetes and obesity in the lead among other chronic conditions. Appropriate prevention strategies for reducing the burden of noncommunicable diseases are discussed.
MeSH term(s)	Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Communicable Disease Control ; Communicable Diseases/epidemiology ; Developing Countries/statistics & numerical data ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/prevention & control ; Health Planning ; Health Status Indicators ; Health Transition ; Humans ; Life Style ; Malaria/epidemiology ; Malaria/prevention & control ; Morbidity/trends ; Needs Assessment ; Obesity/epidemiology ; Obesity/prevention & control ; Oman/epidemiology ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control
Language	English
Publishing date	2009-01
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	1291071-5
ISSN	1687-1634 ; 1020-3397
ISSN (online)	1687-1634
ISSN	1020-3397
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Article: Measurement of circulating levels of VEGF-A, -C, and -D and their receptors, VEGFR-1 and -2 in gastric adenocarcinoma.

Al-Moundhri, Mansour-S / Al-Shukaili, A / Al-Nabhani, M / Al-Bahrani, B / Burney, I-A / Rizivi, A / Ganguly, S-S

World journal of gastroenterology

2008 Volume 14, Issue 24, Page(s) 3879–3883

Abstract: Aim: To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A, -C, and -D, and their receptors, VEGFR-1 and -2 in gastric adenocarcinomas.: Methods: The serum levels of VEGF family members were measured ... ...

Abstract	Aim: To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A, -C, and -D, and their receptors, VEGFR-1 and -2 in gastric adenocarcinomas. Methods: The serum levels of VEGF family members were measured in 76 control subjects and 76 patients with gastric adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements were correlated with clinco-pathological features and survival rates. Results: The serum levels of VEGF-A and its receptor, VEGFR-1, were significantly higher in patients with gastric cancer than in healthy donors (t = 2.3, P = 0.02 and t = 4.2, P < 0.0001, respectively). In contrast, the serum levels of VEGF-D were significantly higher in control subjects than in patients (t = 2.9, P = 0.004). There was no significant difference in serum levels of VEGF-C and VEGFR-2 between patients and controls. VEGF-C was associated with advanced tumor stage and presence of metastasis. VEGFR-1 was associated with metastasis, advanced overall stage, tumor differentiation and survival. VEGFR-2 levels were associated with poor tumor differentiation. There was no significant prognostic value for any of the VEGF family members or their receptors except for VEGFR-1 where high levels were associated with a poor overall survival. Conclusion: Serum VEGF levels vary significantly in the same cohort of patients with variable clinico-pathological features and prognostic values. The simultaneous measurement of VEGF receptors levels in sera may overcome the limitations of a single biomarker assay.
MeSH term(s)	Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/blood ; Case-Control Studies ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Vascular Endothelial Growth Factor A/blood ; Vascular Endothelial Growth Factor C/blood ; Vascular Endothelial Growth Factor D/blood ; Vascular Endothelial Growth Factor Receptor-1/blood ; Vascular Endothelial Growth Factor Receptor-2/blood
Chemical Substances	Biomarkers, Tumor ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor C ; Vascular Endothelial Growth Factor D ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1) ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
Language	English
Publishing date	2008-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.14.3879
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Article: Analysis of ordinal data in a study of endometrial cancer under a matched pairs case-control design.

Ganguly, S S / Naik-Nimbalkar, U V

Statistics in medicine

1995 Volume 14, Issue 14, Page(s) 1545–1552

Abstract: While estimating odds ratios (ORs) in the context of dose levels of conjugated oestrogen exposure and development of endometrial cancer, the categories formed by the levels of the exposure are ordinal in nature. In the literature, the binary logistic ... ...

Abstract	While estimating odds ratios (ORs) in the context of dose levels of conjugated oestrogen exposure and development of endometrial cancer, the categories formed by the levels of the exposure are ordinal in nature. In the literature, the binary logistic model is used for estimating OR for each category relative to the baseline category. We describe the use of two ordinal logistic models, the cumulative logit and continuation-ratio logit models, to estimate the ORs for the matched pairs case-control data set of the Los Angeles endometrial cancer study. A test for equality of the cumulative ORs across the exposure levels is proposed. The test statistic follows asymptotically the chi-square distribution.
MeSH term(s)	Case-Control Studies ; Dose-Response Relationship, Drug ; Endometrial Neoplasms/chemically induced ; Endometrial Neoplasms/epidemiology ; Estrogens, Conjugated (USP)/administration & dosage ; Estrogens, Conjugated (USP)/adverse effects ; Female ; Humans ; Logistic Models ; Matched-Pair Analysis ; Odds Ratio
Chemical Substances	Estrogens, Conjugated (USP)
Language	English
Publishing date	1995-07-30
Publishing country	England
Document type	Journal Article
ZDB-ID	843037-8
ISSN	1097-0258 ; 0277-6715
ISSN (online)	1097-0258
ISSN	0277-6715
DOI	10.1002/sim.4780141405
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