Article ; Online: Emerging roles of non-coding RNAs in psoriasis pathogenesis.
Functional & integrative genomics
2023 Volume 23, Issue 2, Page(s) 129
Abstract: Psoriasis is a complex genetic skin disorder typically manifested by red, scaly, and itchy plaques most commonly over the scalp, trunk, elbows, and knees. Histopathological features include thickening of the epidermal layer due to hyper-proliferation and ...
| Abstract | Psoriasis is a complex genetic skin disorder typically manifested by red, scaly, and itchy plaques most commonly over the scalp, trunk, elbows, and knees. Histopathological features include thickening of the epidermal layer due to hyper-proliferation and abnormal differentiation of epidermal keratinocytes along with infiltration of immune cells in the psoriatic skin. It is a chronic inflammatory relapsing disease, and there is currently no permanent cure for psoriasis. Proper medications can reduce the severity of the disease and improve the quality of life of the patients. While the genetic components of psoriasis pathogenesis are well explored, the full understanding of its epigenetic component remains elusive. Non-coding RNAs (ncRNAs) are documented to regulate various epigenetic processes that lead to the pathogenesis of different diseases including psoriasis. In this review, we have discussed the molecular interplay of different ncRNAs in psoriasis pathogenesis. The roles of microRNAs (miRNAs) in psoriasis are pretty well studied, whereas the roles of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are emerging. This review provides ideas covering some of the latest findings of different modes of functions played by those different ncRNAs documented in the literature. As an ever-evolving topic, some works are still ongoing as well as there are several fields that need rigorous scientific ventures. We have proposed the areas which claim more explorations to better understand the roles played by the ncRNAs in psoriasis pathogenesis. |
|---|---|
| MeSH term(s) | Humans ; Quality of Life ; RNA, Untranslated/genetics ; MicroRNAs/genetics ; Psoriasis/genetics ; Psoriasis/pathology ; Skin/pathology ; RNA, Long Noncoding/genetics |
| Chemical Substances | RNA, Untranslated ; MicroRNAs ; RNA, Long Noncoding |
| Language | English |
| Publishing date | 2023-04-19 |
| Publishing country | Germany |
| Document type | Journal Article ; Review |
| ZDB-ID | 2014670-X |
| ISSN | 1438-7948 ; 1438-793X |
| ISSN (online) | 1438-7948 |
| ISSN | 1438-793X |
| DOI | 10.1007/s10142-023-01057-5 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 5230: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.