LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 43

Search options

  1. Book: Visual guide to musculoskeletal tumors

    Wodajo, Felasfa M. / Gannon, Francis H. / Murphey, Mark D.

    a clinical, radiologic, histologic approach

    2010  

    Author's details Felasfa M. Wodajo ; Francis H. Gannon ; Mark D. Murphey
    Keywords Bone Neoplasms / diagnosis ; Bone Neoplasms / pathology ; Soft Tissue Neoplasms / pathology ; Soft Tissue Neoplasms / diagnosis
    Language English
    Size XI, 226 S. : überw. Ill., 28 cm
    Publisher Saunders Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT016443489
    ISBN 978-1-4377-0303-0 ; 1-4377-0303-8
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 3665 order for loan Magazin
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Early Resveratrol Treatment Mitigates Joint Degeneration and Dampens Pain in a Mouse Model of Pseudoachondroplasia (PSACH).

    Hecht, Jacqueline T / Veerisetty, Alka C / Patra, Debabrata / Hossain, Mohammad G / Chiu, Frankie / Mobed, Claire / Gannon, Francis H / Posey, Karen L

    Biomolecules

    2023  Volume 13, Issue 10

    Abstract: Pseudoachondroplasia (PSACH), a severe dwarfing condition associated with early-onset joint degeneration and lifelong joint pain, is caused by mutations in cartilage oligomeric matrix protein (COMP). The mechanisms underlying the mutant-COMP pathology ... ...

    Abstract Pseudoachondroplasia (PSACH), a severe dwarfing condition associated with early-onset joint degeneration and lifelong joint pain, is caused by mutations in cartilage oligomeric matrix protein (COMP). The mechanisms underlying the mutant-COMP pathology have been defined using the MT-COMP mouse model of PSACH that has the common D469del mutation. Mutant-COMP protein does not fold properly, and it is retained in the rough endoplasmic reticulum (rER) of chondrocytes rather than being exported to the extracellular matrix (ECM), driving ER stress that stimulates oxidative stress and inflammation, driving a self-perpetuating cycle. CHOP (ER stress signaling protein) and TNFα inflammation drive high levels of mTORC1 signaling, shutting down autophagy and blocking ER clearance, resulting in premature loss of chondrocytes that negatively impacts linear growth and causes early joint degeneration in MT-COMP mice and PSACH. Previously, we have shown that resveratrol treatment from birth to 20 weeks prevents joint degeneration and decreases the pathological processes in articular chondrocytes. Resveratrol's therapeutic mechanism of action in the mutant-COMP pathology was shown to act by primarily stimulating autophagy and reducing inflammation. Importantly, we demonstrated that MT-COMP mice experience pain consistent with PSACH joint pain. Here, we show, in the MT-COMP mouse, that resveratrol treatment must begin within 4 weeks to preserve joint health and reduce pain. Resveratrol treatment started at 6 or 8 weeks (to 20 weeks) was not effective in preventing joint degeneration. Collectively, our findings in MT-COMP mice show that there is a postnatal resveratrol treatment window wherein the inevitable mutant-COMP joint degeneration and pain can be prevented.
    MeSH term(s) Mice ; Animals ; Resveratrol/pharmacology ; Resveratrol/therapeutic use ; Mutation ; Inflammation ; Osteoarthritis ; Pain ; Arthralgia
    Chemical Substances Resveratrol (Q369O8926L)
    Language English
    Publishing date 2023-10-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13101553
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: miRNA-34c

    Bae, Yangjin / Zeng, Huan-Chang / Chen, Yi-Ting / Ketkar, Shamika / Munivez, Elda / Yu, Zhiyin / Gannon, Francis H / Lee, Brendan H

    JBMR plus

    2022  Volume 6, Issue 5, Page(s) e10623

    Abstract: The expression of microRNAs (miRNAs) is dysregulated in many types of cancers including osteosarcoma (OS) due to genetic and epigenetic alterations. Among these, ...

    Abstract The expression of microRNAs (miRNAs) is dysregulated in many types of cancers including osteosarcoma (OS) due to genetic and epigenetic alterations. Among these,
    Language English
    Publishing date 2022-04-09
    Publishing country England
    Document type Journal Article
    ISSN 2473-4039
    ISSN (online) 2473-4039
    DOI 10.1002/jbm4.10623
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Primary Osteoarthritis Early Joint Degeneration Induced by Endoplasmic Reticulum Stress Is Mitigated by Resveratrol.

    Hecht, Jacqueline T / Veerisetty, Alka C / Wu, Juliana / Coustry, Francoise / Hossain, Mohammad G / Chiu, Frankie / Gannon, Francis H / Posey, Karen L

    The American journal of pathology

    2021  Volume 191, Issue 9, Page(s) 1624–1637

    Abstract: Increasing numbers of people are living with osteoarthritis (OA) due to aging and obesity, creating an urgent need for effective treatment and preventions. Two top risk factors for OA, age and obesity, are associated with endoplasmic reticulum (ER) ... ...

    Abstract Increasing numbers of people are living with osteoarthritis (OA) due to aging and obesity, creating an urgent need for effective treatment and preventions. Two top risk factors for OA, age and obesity, are associated with endoplasmic reticulum (ER) stress. The I-ERS mouse, an ER stress-driven model of primary OA, was developed to study the role of ER stress in primary OA susceptibility. The I-ERS mouse has the unique ability to induce ER stress in healthy adult articular chondrocytes and cartilage, driving joint degeneration that mimics early primary OA. In this study, ER stress-induced damage occurred gradually and stimulated joint degeneration with OA characteristics including increased matrix metalloproteinase activity, inflammation, senescence, chondrocyte death, decreased proteoglycans, autophagy block, and gait dysfunction. Consistent with human OA, intense exercise hastened and increased the level of ER stress-induced joint damage. Notably, loss of a critical ER stress response protein (CHOP) largely ameliorated ER stress-stimulated OA outcomes including preserving proteoglycan content, reducing inflammation, and relieving autophagy block. Resveratrol diminished ER stress-induced joint degeneration by decreasing CHOP, TNFα, IL-1β, MMP-13, pS6, number of TUNEL-positive chondrocytes, and senescence marker p16 INK4a. The finding, that a dietary supplement can prevent ER stressed-induced joint degeneration in mice, provides a preclinical foundation to potentially develop a prevention strategy for those at high risk to develop OA.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Cartilage, Articular/drug effects ; Cartilage, Articular/pathology ; Endoplasmic Reticulum Stress/physiology ; Male ; Mice ; Osteoarthritis/etiology ; Osteoarthritis/pathology ; Resveratrol/pharmacology
    Chemical Substances Antioxidants ; Resveratrol (Q369O8926L)
    Language English
    Publishing date 2021-06-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2021.05.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.76: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Bilateral adrenal histoplasmosis in an immunocompetent man from Texas.

    Rog, Colin J / Rosen, Daniel G / Gannon, Francis H

    Medical mycology case reports

    2016  Volume 14, Page(s) 4–7

    Abstract: Disseminated histoplasmosis affecting the adrenal gland(s) of immunocompetent adults is a very rare infection. Here, we present a case of bilateral adrenal histoplasmosis in an immunocompetent, 62-year-old gentleman from Texas along with a brief review ... ...

    Abstract Disseminated histoplasmosis affecting the adrenal gland(s) of immunocompetent adults is a very rare infection. Here, we present a case of bilateral adrenal histoplasmosis in an immunocompetent, 62-year-old gentleman from Texas along with a brief review of the published literature. Given the risk of patient decompensation secondary to adrenal insufficiency and the wide availability of effective treatments, adrenal histoplasmosis must be considered even in immunocompetent adults who acquire adrenal masses.
    Language English
    Publishing date 2016-11-29
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2211-7539
    ISSN 2211-7539
    DOI 10.1016/j.mmcr.2016.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: Bilateral adrenal histoplasmosis in an immunocompetent man from Texas

    Rog, Colin J / Rosen, Daniel G / Gannon, Francis H

    Medical mycology case reports. 2016 Dec., v. 14

    2016  

    Abstract: Disseminated histoplasmosis affecting the adrenal gland(s) of immunocompetent adults is a very rare infection. Here, we present a case of bilateral adrenal histoplasmosis in an immunocompetent, 62-year-old gentleman from Texas along with a brief review ... ...

    Abstract Disseminated histoplasmosis affecting the adrenal gland(s) of immunocompetent adults is a very rare infection. Here, we present a case of bilateral adrenal histoplasmosis in an immunocompetent, 62-year-old gentleman from Texas along with a brief review of the published literature. Given the risk of patient decompensation secondary to adrenal insufficiency and the wide availability of effective treatments, adrenal histoplasmosis must be considered even in immunocompetent adults who acquire adrenal masses.
    Keywords adrenal glands ; adults ; case studies ; histoplasmosis ; mycology ; patients ; risk ; Texas
    Language English
    Dates of publication 2016-12
    Size p. 4-7.
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2211-7539
    DOI 10.1016/j.mmcr.2016.11.006
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Traumatic fracture callus.

    Gannon, Francis H / Thompson, Lester

    Ear, nose, & throat journal

    2007  Volume 86, Issue 4, Page(s) 200

    MeSH term(s) Bony Callus/pathology ; Facial Bones/injuries ; Facial Bones/pathology ; Facial Injuries/pathology ; Fracture Healing/physiology ; Humans ; Skull/pathology ; Skull Fractures/pathology
    Language English
    Publishing date 2007-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Targeting TGF-β for treatment of osteogenesis imperfecta.

    Song, I-Wen / Nagamani, Sandesh Cs / Nguyen, Dianne / Grafe, Ingo / Sutton, Vernon Reid / Gannon, Francis H / Munivez, Elda / Jiang, Ming-Ming / Tran, Alyssa / Wallace, Maegen / Esposito, Paul / Musaad, Salma / Strudthoff, Elizabeth / McGuire, Sharon / Thornton, Michele / Shenava, Vinitha / Rosenfeld, Scott / Huang, Shixia / Shypailo, Roman /
    Orwoll, Eric / Lee, Brendan

    The Journal of clinical investigation

    2022  Volume 132, Issue 7

    Abstract: BACKGROUNDCurrently, there is no disease-specific therapy for osteogenesis imperfecta (OI). Preclinical studies demonstrate that excessive TGF-β signaling is a pathogenic mechanism in OI. Here, we evaluated TGF-β signaling in children with OI and ... ...

    Abstract BACKGROUNDCurrently, there is no disease-specific therapy for osteogenesis imperfecta (OI). Preclinical studies demonstrate that excessive TGF-β signaling is a pathogenic mechanism in OI. Here, we evaluated TGF-β signaling in children with OI and conducted a phase I clinical trial of TGF-β inhibition in adults with OI.METHODSHistology and RNA-Seq were performed on bones obtained from children. Gene Ontology (GO) enrichment assay, gene set enrichment analysis (GSEA), and Ingenuity Pathway Analysis (IPA) were used to identify dysregulated pathways. Reverse-phase protein array, Western blot, and IHC were performed to evaluate protein expression. A phase I study of fresolimumab, a TGF-β neutralizing antibody, was conducted in 8 adults with OI. Safety and effects on bone remodeling markers and lumbar spine areal bone mineral density (LS aBMD) were assessed.RESULTSOI bone demonstrated woven structure, increased osteocytes, high turnover, and reduced maturation. SMAD phosphorylation was the most significantly upregulated GO molecular event. GSEA identified the TGF-β pathway as the top activated signaling pathway, and IPA showed that TGF-β1 was the most significant activated upstream regulator mediating the global changes identified in OI bone. Treatment with fresolimumab was well-tolerated and associated with increases in LS aBMD in participants with OI type IV, whereas participants with OI type III and VIII had unchanged or decreased LS aBMD.CONCLUSIONIncreased TGF-β signaling is a driver pathogenic mechanism in OI. Anti-TGF-β therapy could be a potential disease-specific therapy, with dose-dependent effects on bone mass and turnover.TRIAL REGISTRATIONClinicalTrials.gov NCT03064074.FUNDINGBrittle Bone Disorders Consortium (U54AR068069), Clinical Translational Core of Baylor College of Medicine Intellectual and Developmental Disabilities Research Center (P50HD103555) from National Institute of Child Health and Human Development, USDA/ARS (cooperative agreement 58-6250-6-001), and Sanofi Genzyme.
    MeSH term(s) Adult ; Bone Density ; Bone and Bones/metabolism ; Child ; Humans ; Lumbar Vertebrae/metabolism ; Osteogenesis Imperfecta/drug therapy ; Osteogenesis Imperfecta/genetics ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism
    Chemical Substances Transforming Growth Factor beta
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Clinical Trial, Phase I ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI152571
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Ossifying fibroma of the jaw.

    Gannon, Francis H / Thompson, Lester

    Ear, nose, & throat journal

    2004  Volume 83, Issue 7, Page(s) 458

    MeSH term(s) Fibroma, Ossifying/diagnosis ; Humans ; Jaw Neoplasms/diagnosis
    Language English
    Publishing date 2004-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Book: Visual guide to musculoskeletal tumors

    Wodajo, Felasfa M / Gannon, Francis H / Murphey, Mark D

    a clinical, radiologic, histologic approach

    2010  

    Author's details Felasfa M. Wodajo, Francis H. Gannon, Mark D. Murphey
    MeSH term(s) Bone Neoplasms/diagnosis ; Bone Neoplasms/pathology ; Soft Tissue Neoplasms/pathology ; Soft Tissue Neoplasms/diagnosis
    Language English
    Size xi, 226 p. :, ill.
    Publisher Saunders/Elsevier
    Publishing place Philadelphia
    Document type Book
    Note Includes index.
    ISBN 9781437703030 ; 1437703038
    Database Catalogue of the US National Library of Medicine (NLM)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top