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  1. Article ; Online: Pioglitazone Protects Tubular Epithelial Cells during Kidney Fibrosis by Attenuating miRNA Dysregulation and Autophagy Dysfunction Induced by TGF-β

    Anna Manzéger / Gantsetseg Garmaa / Miklós M. Mózes / Georg Hansmann / Gábor Kökény

    International Journal of Molecular Sciences, Vol 24, Iss 21, p

    2023  Volume 15520

    Abstract: Excessive renal TGF-β production and pro-fibrotic miRNAs are important drivers of kidney fibrosis that lack any efficient treatment. Dysfunctional autophagy might play an important role in the pathogenesis. We aimed to study the yet unknown effects of ... ...

    Abstract Excessive renal TGF-β production and pro-fibrotic miRNAs are important drivers of kidney fibrosis that lack any efficient treatment. Dysfunctional autophagy might play an important role in the pathogenesis. We aimed to study the yet unknown effects of peroxisome proliferator-activated receptor-γ (PPARγ) agonist pioglitazone (Pio) on renal autophagy and miRNA dysregulation during fibrosis. Mouse primary tubular epithelial cells (PTEC) were isolated, pre-treated with 5 µM pioglitazone, and then stimulated with 10 ng/mL TGF-β1 for 24 h. Male 10-week-old C57Bl6 control (CTL) and TGF-β overexpressing mice were fed with regular chow (TGF) or Pio-containing chow (20 mg/kg/day) for 5 weeks (TGF + Pio). PTEC and kidneys were evaluated for mRNA and protein expression. In PTEC, pioglitazone attenuated ( p < 0.05) the TGF-β-induced up-regulation of Col1a1 (1.4-fold), Tgfb1 (2.2-fold), Ctgf (1.5-fold), Egr2 (2.5-fold) mRNAs, miR-130a (1.6-fold), and miR-199a (1.5-fold), inhibited epithelial-to-mesenchymal transition, and rescued autophagy function. In TGF mice, pioglitazone greatly improved kidney fibrosis and related dysfunctional autophagy (increased LC3-II/I ratio and reduced SQSTM1 protein content ( p < 0.05)). These were accompanied by 5-fold, 3-fold, 12-fold, and 2-fold suppression ( p < 0.05) of renal Ccl2, Il6, C3, and Lgals3 mRNA expression, respectively. Our results implicate that pioglitazone counteracts multiple pro-fibrotic processes in the kidney, including autophagy dysfunction and miRNA dysregulation.
    Keywords TGF-β ; kidney fibrosis ; transcription factors ; PPARγ ; miRNA ; autophagy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 500
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The combination of ulinastatin and somatostatin reduces complication rates in acute pancreatitis

    István László Horváth / Stefania Bunduc / Péter Fehérvári / Szilárd Váncsa / Rita Nagy / Gantsetseg Garmaa / Dénes Kleiner / Péter Hegyi / Bálint Erőss / Dezső Csupor

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    a systematic review and meta-analysis of randomized controlled trials

    2022  Volume 10

    Abstract: Abstract Currently, there is no specific pharmaceutical agent for treating acute pancreatitis (AP). Somatostatin and its analogues have been used to prevent the autolysis of the pancreas in AP, however, their effectiveness has not been confirmed. This ... ...

    Abstract Abstract Currently, there is no specific pharmaceutical agent for treating acute pancreatitis (AP). Somatostatin and its analogues have been used to prevent the autolysis of the pancreas in AP, however, their effectiveness has not been confirmed. This investigation aimed to examine the efficacy of ulinastatin, a protease inhibitor, combined with somatostatin analogues in the treatment of AP. We conducted a systematic database search in 4 databases to identify randomized controlled trials in which the efficacy of ulinastatin in combination with somatostatin analogue was compared to somatostatin analogue alone in patients with AP. Since the patient populations of analysed papers were slightly different, we used random effect models to pool odds ratios (OR) and mean differences (MD) and the corresponding 95% confidence intervals (CI). A total of 9 articles comprising 1037 patients were included in the meta-analysis. The combination therapy significantly reduced the complication rates for acute respiratory distress syndrome, acute kidney injury, and multiple organ dysfunction. Symptoms were relieved threefold with the combination therapy compared to somatostatin alone, and combination therapy significantly shortened the length of hospital stay. The decrease in mortality was not statistically significant.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Changes in Vascular Function from Preconception to Postpartum Among Mongolian Women.

    Enkhmaa, Davaasambuu / Ganmaa, Davaasambuu / Tanz, Lauren J / Rich-Edwards, Janet W / Stuart, Jennifer J / Enkhtur, Shonkhuuz / Gantsetseg, Garmaa / Batkhishig, Bandi / Fitzmaurice, Garrett / Bayalag, Munkhuu / Nasantogtokh, Erdenebileg / Bairey Merz, C Noel / Shufelt, Chrisandra L

    Journal of women's health (2002)

    2022  Volume 31, Issue 11, Page(s) 1655–1663

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Pregnancy ; Female ; Humans ; Pulse Wave Analysis ; Prospective Studies ; Blood Pressure/physiology ; Postpartum Period ; Pre-Eclampsia ; Vascular Stiffness
    Language English
    Publishing date 2022-07-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1139774-3
    ISSN 1931-843X ; 1059-7115 ; 1540-9996
    ISSN (online) 1931-843X
    ISSN 1059-7115 ; 1540-9996
    DOI 10.1089/jwh.2021.0360
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    Zs.A 3584: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Maternal Pregnancy Hormone Concentrations in Countries with Very Low and High Breast Cancer Risk.

    Ganmaa, Davaasambuu / Enkhmaa, Davaasambuu / Baatar, Tsedmaa / Uyanga, Buyanjargal / Gantsetseg, Garmaa / Helde, Thomas T / McElrath, Thomas F / Cantonwine, David E / Bradwin, Gary / Falk, Roni T / Hoover, Robert N / Troisi, Rebecca

    International journal of environmental research and public health

    2020  Volume 17, Issue 3

    Abstract: Background: Breast cancer rates in Asia are much lower than in Europe and North America. Within Asia, rates are lower in Mongolia than in neighboring countries. Variation in pregnancy exposure to endogenous hormone concentrations may explain the ... ...

    Abstract Background: Breast cancer rates in Asia are much lower than in Europe and North America. Within Asia, rates are lower in Mongolia than in neighboring countries. Variation in pregnancy exposure to endogenous hormone concentrations may explain the differences, but data are lacking.
    Methods: We measured maternal serum progesterone, prolactin, estradiol and estrone concentrations in the second half of pregnancy in a cross-sectional study of urban (
    Results: Mean concentrations of prolactin (5722 vs. 4648 uIU/mL;
    Conclusions: Mongolian women had greater concentrations of prolactin and estrogen and lower concentrations of progesterone than U.S. women, while hormone concentrations were similar in rural and urban Mongolian pregnancies.
    Impact: These data do not support the hypothesis that estrogen concentrations in pregnant women are lower in Mongolian compared with Caucasian women.
    MeSH term(s) Adult ; Boston/epidemiology ; Breast Neoplasms/epidemiology ; Cross-Sectional Studies ; Estradiol/blood ; Estrone/blood ; Female ; Humans ; Mongolia/epidemiology ; Pregnancy/blood ; Progesterone/blood ; Prolactin/blood ; Young Adult
    Chemical Substances Estrone (2DI9HA706A) ; Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E) ; Prolactin (9002-62-4)
    Language English
    Publishing date 2020-01-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph17030823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease.

    Ganmaa, Davaasambuu / Uyanga, Buyanjargal / Zhou, Xin / Gantsetseg, Garmaa / Delgerekh, Baigali / Enkhmaa, Davaasambuu / Khulan, Dorjnamjil / Ariunzaya, Saranjav / Sumiya, Erdenebaatar / Bolortuya, Batbileg / Yanjmaa, Jutmaan / Enkhtsetseg, Tserenkhuu / Munkhzaya, Ankhbat / Tunsag, Murneren / Khudyakov, Polyna / Seddon, James A / Marais, Ben J / Batbayar, Ochirbat / Erdenetuya, Ganbaatar /
    Amarsaikhan, Bazarsaikhan / Spiegelman, Donna / Tsolmon, Jadambaa / Martineau, Adrian R

    The New England journal of medicine

    2020  Volume 383, Issue 4, Page(s) 359–368

    Abstract: Background: Vitamin D metabolites support innate immune responses to : Methods: We randomly assigned children who had negative results for : Results: A total of 8851 children underwent randomization: 4418 were assigned to the vitamin D group, and ... ...

    Abstract Background: Vitamin D metabolites support innate immune responses to
    Methods: We randomly assigned children who had negative results for
    Results: A total of 8851 children underwent randomization: 4418 were assigned to the vitamin D group, and 4433 to the placebo group; 95.6% of children had a baseline serum 25(OH)D level of less than 20 ng per milliliter. Among children with a valid QFT result at the end of the trial, the percentage with a positive result was 3.6% (147 of 4074 children) in the vitamin D group and 3.3% (134 of 4043) in the placebo group (adjusted risk ratio, 1.10; 95% confidence interval [CI], 0.87 to 1.38; P = 0.42). The mean 25(OH)D level at the end of the trial was 31.0 ng per milliliter in the vitamin D group and 10.7 ng per milliliter in the placebo group (mean between-group difference, 20.3 ng per milliliter; 95% CI, 19.9 to 20.6). Tuberculosis disease was diagnosed in 21 children in the vitamin D group and in 25 children in the placebo group (adjusted risk ratio, 0.87; 95% CI, 0.49 to 1.55). A total of 29 children in the vitamin D group and 34 in the placebo group were hospitalized for treatment of acute respiratory infection (adjusted risk ratio, 0.86; 95% CI, 0.52 to 1.40). The incidence of adverse events did not differ significantly between the two groups.
    Conclusions: Vitamin D supplementation did not result in a lower risk of tuberculosis infection, tuberculosis disease, or acute respiratory infection than placebo among vitamin D-deficient schoolchildren in Mongolia. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT02276755.).
    MeSH term(s) Child ; Cholecalciferol/adverse effects ; Cholecalciferol/therapeutic use ; Dietary Supplements/adverse effects ; Double-Blind Method ; Female ; Follow-Up Studies ; Humans ; Incidence ; Latent Tuberculosis/epidemiology ; Latent Tuberculosis/prevention & control ; Male ; Mycobacterium tuberculosis/isolation & purification ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/prevention & control ; Treatment Failure ; Tuberculin Test ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamins/adverse effects ; Vitamins/therapeutic use
    Chemical Substances Vitamins ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa1915176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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