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  1. Article: Triacylglycerol, fatty acid, and phytochemical profiles in a new red sorghum variety (Ji Liang No. 1) and its antioxidant and anti‐inflammatory properties

    Gao, Boyan

    Food Science & Nutrition, 7(3):949-958

    2019  

    Abstract: In this study, a new red sorghum variety (Ji Liang No. 1) was investigated for its triacylglycerol (TAG) and fatty acid profiles, carotenoid and tocopherol compositions, total phenolic, total flavonoid and phenolic acid contents, and antioxidant and anti‐ ...

    Abstract In this study, a new red sorghum variety (Ji Liang No. 1) was investigated for its triacylglycerol (TAG) and fatty acid profiles, carotenoid and tocopherol compositions, total phenolic, total flavonoid and phenolic acid contents, and antioxidant and anti‐inflammatory properties. A total of 17 TAGs were identified in the red sorghum oil. Linoleic and oleic acids were the primary fatty acids, contributing more than 80% of the total fatty acids. β‐Carotene was the primary carotenoid at a level of 26.14 μg/g. α‐, γ‐, and δ‐tocopherols were at levels of 0.19, 4.08, and 0.10 μg/g, respectively. Moreover, acetone–water (60:40, v/v) extract of the red sorghum exhibited the greatest total phenolic content of 2.77 mg GAE/g and total flavonoid content of 5.44 mg RE/g. The extract had scavenging capacities against DPPH, ABTS+, and peroxyl radicals and suppressed LPS stimulated IL‐1β, IL‐6, and COX‐2 mRNA expressions in a dose‐dependent manner. Ferulic, p‐coumaric, isoferulic, and p‐hydroxybenzoic acids were found in the red sorghum, with ferulic acid as the predominant phenolic acid and mostly in an insoluble bound form. These data indicated a potential utilization of the red sorghum in health‐promoting functional food or supplemental products.
    Keywords antioxidant ; anti‐inflammation ; phenolic ; red sorghum ; triacylglycerol
    Language English
    Document type Article
    Database Repository for Life Sciences

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  2. Book ; Online: Alternative Splicing

    Gao, Bei / Chen, Moxian / Oliver, Melvin J

    From Abiotic Stress Tolerance to Evolutionary Genomics

    2023  

    Keywords Research & information: general ; Biology, life sciences ; rice ; grain size ; QTL ; BSA-seq ; splicing ; additive effects ; alternative splicing ; GWAS ; proteogenomics ; Zea mays L. ; plant genotype ; plant-microbe interaction ; microbiome assembly ; post-transcriptional regulation ; alkaloids ; ascorbate ; phytohormones ; lipids ; metabolism ; phenylpropanoids ; plants ; starch ; terpenoids ; FtHDACs ; genome-wide ; low-temperature responses ; Tartary buckwheat ; microRNA ; moderate soil drying ; inferior spikelets ; MACP2 ; membrane attack complex/perforin-like protein ; pathogen infection ; salicylic acid signaling ; indole glucosinolates ; PpRNH1A ; heat stress (HS) ; lipid droplets ; Physcomitrium (Physcomitrella) patens ; Brassica napus ; transcription factors ; nutrient stress ; transcriptomic analysis ; miRNA ; galanthamine ; Lycoris ; SWATH-MS ; n/a
    Language English
    Size 1 electronic resource (188 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030376735
    ISBN 9783036574561 ; 3036574565
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: A near-death experience.

    Gao, Bruce

    Canadian Urological Association journal = Journal de l'Association des urologues du Canada

    2023  Volume 17, Issue 8, Page(s) S164

    Language English
    Publishing date 2023-08-10
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2431403-1
    ISSN 1911-6470
    ISSN 1911-6470
    DOI 10.5489/cuaj.8497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Understanding smart education continuance intention in a delayed benefit context: An integration of sensory stimuli, UTAUT, and flow theory.

    Gao, Biao

    Acta psychologica

    2023  Volume 234, Page(s) 103856

    Abstract: Smart education is a combination of AI and education, and its benefits are delayed. Existing research lacks an understanding of smart education continuance intention in the context of this delayed benefit. Thus, this study aimed to examine users' ... ...

    Abstract Smart education is a combination of AI and education, and its benefits are delayed. Existing research lacks an understanding of smart education continuance intention in the context of this delayed benefit. Thus, this study aimed to examine users' continuance intention in a delayed benefit context by integrating sensory stimulus, the extended UTAUT, and flow theory. The study focused on a mobile-based smart education (MBSE) system (Liulishuo) and collected data on 494 MBSE users. The PLS-SEM analysis suggested that the model is largely supported. Identifying MBSE's technical attributes as sensory stimuli, the extended UTAUT as primary information processing, flow as secondary information processing, and continuance intention as a decision, this study verifies the relationships between various constructs and their influence on MBSE continuance intention. The results also indicate that a user's flow state plays a crucial role in strengthening continuance intention and realizing the delayed benefits of smart education. Thus, this study provides a deeper understanding of continuous usage mechanisms as they relate to smart education.
    MeSH term(s) Humans ; Intention ; Educational Status ; Cognition ; Data Collection
    Language English
    Publishing date 2023-02-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1480049-4
    ISSN 1873-6297 ; 0001-6918
    ISSN (online) 1873-6297
    ISSN 0001-6918
    DOI 10.1016/j.actpsy.2023.103856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pulmonary Artery Stenosis in Tetralogy of Fallot.

    Gao, Botao

    Cardiology in review

    2023  

    Abstract: Tetralogy of Fallot (TOF) is the most common cyanotic congenital cardiac defect. The survival rate after primary complete repair is high (98-100%); however, pulmonary artery stenosis (PAS) is not uncommon after TOF repair, and severe PAS aggravates ... ...

    Abstract Tetralogy of Fallot (TOF) is the most common cyanotic congenital cardiac defect. The survival rate after primary complete repair is high (98-100%); however, pulmonary artery stenosis (PAS) is not uncommon after TOF repair, and severe PAS aggravates pulmonary regurgitation, resulting in right ventricle dilation, ventricular arrhythmia, and possibly death. PAS in TOF can be congenital due to hypoplasia or coarctation or can be acquired secondary to a surgical procedure. The latter may be caused by an exogenous conduit implant, compression from the adjacent enlarged ascending aorta, or outflow tract dilation after transannular patch repair. PAS can also be caused by the pulmonary artery plasty strategy itself. Here, the intrinsic mechanisms underlying PAS and pulmonary artery plasty techniques and strategies are reviewed to provide guidance for surgeons.
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1294965-6
    ISSN 1538-4683 ; 1061-5377
    ISSN (online) 1538-4683
    ISSN 1061-5377
    DOI 10.1097/CRD.0000000000000627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4491: Show issues Location:
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  6. Thesis ; Online: Predictive profiling of SARS-CoV-2 variants by deep mutational learning

    Gao, Beichen

    2023  

    Keywords Antibody ; Antibody engineering ; SARS-CoV-2 ; Machine learning ; Deep Learning ; info:eu-repo/classification/ddc/610 ; Medical sciences ; medicine
    Language English
    Publisher ETH Zurich
    Publishing country ch
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Exploration of cardiac rehabilitation nursing for elderly patients with myocardial infarction based on individualized cardiac rehabilitation.

    Liu, Hua-Ning / Gao, Bo

    World journal of clinical cases

    2024  Volume 12, Issue 2, Page(s) 256–266

    Abstract: Background: Myocardial infarction is a high-risk condition prevalent among the elderly population, often leading to adverse clinical manifestations such as reduced cardiopulmonary function, anxiety, and depression post-surgery. Consequently, cardiac ... ...

    Abstract Background: Myocardial infarction is a high-risk condition prevalent among the elderly population, often leading to adverse clinical manifestations such as reduced cardiopulmonary function, anxiety, and depression post-surgery. Consequently, cardiac rehabilitation holds immense importance in mitigating these complications.
    Aim: To evaluate the effect of individualized cardiac rehabilitation on blood pressure variability (BPV) and baroreflex sensitivity (BRS) in elderly patients with myocardial infarction.
    Methods: A cohort of 74 elderly patients diagnosed with myocardial infarction and admitted to our hospital between January 2021 and January 2022 were subjected to random selection. Subsequently, all patients were divided into two groups, namely the research group (
    Results: Of 24 h diastolic BPV, 24 h systolic BPV, carbon dioxide ventilation equivalent slope of the research group were lower than those of the control group at T1 and T2, BRS, peak heart rate and systolic blood pressure product, 1 min heart rate recovery were higher than those of the control group, and the incidence of adverse events in the research group was lower than that of the control group, the difference was statistically significant (
    Conclusion: In this study, we found that after individualized cardiac rehabilitation in elderly patients with myocardial infarction, BPV and BRS can be effectively improved, cardiac function is significantly enhanced, and a better prognosis is obtained.
    Language English
    Publishing date 2024-02-03
    Publishing country United States
    Document type Journal Article
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v12.i2.256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: MESuSiE enables scalable and powerful multi-ancestry fine-mapping of causal variants in genome-wide association studies.

    Gao, Boran / Zhou, Xiang

    Nature genetics

    2024  Volume 56, Issue 1, Page(s) 170–179

    Abstract: Fine-mapping in genome-wide association studies attempts to identify causal SNPs from a set of candidate SNPs in a local genomic region of interest and is commonly performed in one genetic ancestry at a time. Here, we present multi-ancestry sum of the ... ...

    Abstract Fine-mapping in genome-wide association studies attempts to identify causal SNPs from a set of candidate SNPs in a local genomic region of interest and is commonly performed in one genetic ancestry at a time. Here, we present multi-ancestry sum of the single effects model (MESuSiE), a probabilistic multi-ancestry fine-mapping method, to improve the accuracy and resolution of fine-mapping by leveraging association information across ancestries. MESuSiE uses summary statistics as input, accounts for the diverse linkage disequilibrium pattern observed in different ancestries, explicitly models both shared and ancestry-specific causal SNPs, and relies on a variational inference algorithm for scalable computation. We evaluated the performance of MESuSiE through comprehensive simulations and multi-ancestry fine-mapping of four lipid traits with both European and African samples. In the real data, MESuSiE improves fine-mapping resolution by 19.0% to 72.0% compared to existing approaches, is an order of magnitude faster, and captures and categorizes shared and ancestry-specific causal signals with enhanced functional enrichment.
    MeSH term(s) Humans ; Algorithms ; Black People ; Genome-Wide Association Study/methods ; Genomics ; Linkage Disequilibrium ; Polymorphism, Single Nucleotide/genetics ; European People
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-023-01604-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3613: Show issues Location:
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    Zs.MG 46: Show issues

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  9. Article ; Online: Exosomes for neurodegenerative diseases: diagnosis and targeted therapy.

    Tao, Hui / Gao, Bo

    Journal of neurology

    2024  

    Abstract: Purpose of review: Neurodegenerative diseases are still challenging clinical issues, with no curative interventions available and early, accurate diagnosis remaining difficult. Finding solutions to them is of great importance. In this review, we discuss ...

    Abstract Purpose of review: Neurodegenerative diseases are still challenging clinical issues, with no curative interventions available and early, accurate diagnosis remaining difficult. Finding solutions to them is of great importance. In this review, we discuss possible exosomal diagnostic biomarkers and explore current explorations in exosome-targeted therapy for some common neurodegenerative diseases, offering insights into the clinical transformation of exosomes in this field.
    Recent findings: The burgeoning research on exosomes has shed light on their potential applications in disease diagnosis and treatment. As a type of extracellular vesicles, exosomes are capable of crossing the blood - brain barrier and exist in various body fluids, whose components can reflect pathophysiological changes in the brain. In addition, they can deliver specific drugs to brain tissue, and even possess certain therapeutic effects themselves. And the recent advancements in engineering modification technology have further enabled exosomes to selectively target specific sites, facilitating the possibility of targeted therapy for neurodegenerative diseases. The unique properties of exosomes give them great potential in the diagnosis and treatment of neurodegenerative diseases, and provide novel ideas for dealing with such diseases.
    Language English
    Publishing date 2024-04-12
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-024-12329-w
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    Ui II Zs.40: Show issues Location:
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  10. Article: Meta-analysis of the clinical efficacy of the Gamma3 nail

    Wu, Xuan / Gao, Bo

    World journal of orthopedics

    2024  Volume 15, Issue 3, Page(s) 285–292

    Abstract: Background: The traditional Gamma3 nail is a mainstream treatment for femoral intertrochanteric fractures. Literature reports that the Gamma3U-blade system can increase the stability of the Gamma3 nail and reduce complication incidence. However, ... ...

    Abstract Background: The traditional Gamma3 nail is a mainstream treatment for femoral intertrochanteric fractures. Literature reports that the Gamma3U-blade system can increase the stability of the Gamma3 nail and reduce complication incidence. However, comparative studies between the Gamma3U-blade and Gamma3 systems are limited; hence, this meta-analysis was performed to explore the clinical efficacy of these two surgical methods.
    Aim: To investigate the clinical efficacy of Gamma3 and Gamma3 U-blade for intertrochanteric fractures.
    Methods: A computerized search for Chinese and English literature published from 2010 to 2022 was conducted in PubMed, Cochrane, CNKI, Wanfang, and VIP databases. The search keywords were gamma 3, gamma 3 U blade, and intertrochanteric fracture. Additionally, literature tracking was performed on the references of published literature. The data were analyzed using Revman 5.3 software. Two individuals checked the inputs for accuracy. Continuous variables were described using mean difference and standard deviation, and outcome effect sizes were expressed using ratio OR and 95% confidence interval (CI). High heterogeneity was considered at (
    Results: Following a comprehensive literature search, review, and analysis, six articles were selected for inclusion in this study. This selection comprised five articles in English and one in Chinese, with publication years spanning from 2016 to 2022. The study with the largest sample size, conducted by Seungbae in 2021, included a total of 304 cases. Statistical analysis: A total of 1063 patients were included in this meta-analysis. The main outcome indicators were: Surgical time: The Gamma3U blade system had a longer surgical time compared to Gamma3 nails (
    Conclusion: Our study indicated that the Gamma3 system reduces operative time compared to the Gamma3 U-blade system in treating intertrochanteric fractures. Both surgical methods proved to be safe and effective for this patient group. These findings may offer valuable insights and guidance for future surgical protocols in hip fracture patients.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649712-8
    ISSN 2218-5836
    ISSN 2218-5836
    DOI 10.5312/wjo.v15.i3.285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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