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  1. Article ; Online: Research on the Construction of College Students' Mental Health Security System.

    Gao, Hui

    Journal of healthcare engineering

    2022  Volume 2022, Page(s) 4001603

    Abstract: With the development of modern society, people are increasingly pursuing quality of life and paying more attention to mental health education. Mental health education in colleges and universities should also conform to the development of the times, ... ...

    Abstract With the development of modern society, people are increasingly pursuing quality of life and paying more attention to mental health education. Mental health education in colleges and universities should also conform to the development of the times, constantly reform the education mode, and help college students establish a healthy psychological environment, so as to better promote the growth of college students. From the perspective of positive psychology, a new idea of mental health education for college students has gradually emerged, that is, from the traditional negative intervention on college students' psychological problems to positive mental health education. Strengthening the mental health education of college students is an important measure to fully implement the Party's educational policy and implement quality education under the new situation, an important way and means to promote the all-round development of college students, and an important part of moral education in colleges and universities. College students' mental health education should be guided by the theory of positive psychology, start with family, society, school, and other aspects to build a brand-new mental health education guarantee system, and finally achieve the purpose of improving college students' psychological quality.
    MeSH term(s) Health Education ; Humans ; Mental Health ; Quality of Life ; Students ; Universities
    Language English
    Publishing date 2022-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2545054-2
    ISSN 2040-2309 ; 2040-2295
    ISSN (online) 2040-2309
    ISSN 2040-2295
    DOI 10.1155/2022/4001603
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  2. Article: Influencing Factors on the Use of Tetrahydrobiopterin in Patients with Phenylketonuria.

    Gao, Hui

    publication RETRACTED

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 5245200

    Abstract: Objective: To explore and analyze the influencing factors of tetrahydrobiopterin therapy in patients with phenylketonuria.: Methods: 86 children with phenylketonuria (PKU) diagnosed and treated in our hospital from February 2019 to September 2021 ... ...

    Abstract Objective: To explore and analyze the influencing factors of tetrahydrobiopterin therapy in patients with phenylketonuria.
    Methods: 86 children with phenylketonuria (PKU) diagnosed and treated in our hospital from February 2019 to September 2021 were randomly enrolled. All the children underwent coenzyme hydroxybiopterin and urinary pterin spectrum analysis, and the children with deficiency received gene mutation testing.
    Results: The results of urine pterin analysis showed that 82 patients had higher urinary N and B contents than the normal reference values, with the N/B slightly higher than the normal B% within the normal range. 4 patients had extremely high urinary N/B and B% <5% and were diagnosed as BH4 deficiency caused by 6-pyruvoyl-tetrahydropterin synthase (PTPS) deficiency, and a combined stress test was performed. The blood Phe level was (720-1200)
    Conclusion: PKU is caused by the defect of phenylalanine hydroxylase activity in children, which causes phenylalanine metabolism disorder, and tetrahydrobiopterin intervention therapy can affect the activity of phenylalanine hydroxylase, increase the decline rate of blood Phe, significantly reduce the level of phenylalanine in children, and promote intellectual recovery. The dose of tetrahydrobiopterin should be tailored, with small doses for mild phenotypes and long-term treatment using even smaller doses.
    Language English
    Publishing date 2022-07-04
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/5245200
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    Zs.A 5995: Show issues Location:
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  3. Book ; Online: Stochastic Multi-Level Compositional Optimization Algorithms over Networks with Level-Independent Convergence Rate

    Gao, Hongchang

    2023  

    Abstract: Stochastic multi-level compositional optimization problems cover many new machine learning paradigms, e.g., multi-step model-agnostic meta-learning, which require efficient optimization algorithms for large-scale applications. This paper studies the ... ...

    Abstract Stochastic multi-level compositional optimization problems cover many new machine learning paradigms, e.g., multi-step model-agnostic meta-learning, which require efficient optimization algorithms for large-scale applications. This paper studies the decentralized stochastic multi-level optimization algorithm, which is challenging because the multi-level structure and decentralized communication scheme may make the number of levels affect the order of the convergence rate. To this end, we develop two novel decentralized optimization algorithms to deal with the multi-level function and its gradient. Our theoretical results show that both algorithms can achieve the level-independent convergence rate for nonconvex problems under much milder conditions compared with existing single-machine algorithms. To the best of our knowledge, this is the first work that achieves the level-independent convergence rate under the decentralized setting. Moreover, extensive experiments confirm the efficacy of our proposed algorithms.
    Keywords Computer Science - Machine Learning
    Subject code 006 ; 510
    Publishing date 2023-06-05
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online: Mitigating Backdoor Attack Via Prerequisite Transformation

    Gao, Han

    2023  

    Abstract: In recent years, with the successful application of DNN in fields such as NLP and CV, its security has also received widespread attention. (Author) proposed the method of backdoor attack in Badnet. Switch implanted backdoor into the model by poisoning ... ...

    Abstract In recent years, with the successful application of DNN in fields such as NLP and CV, its security has also received widespread attention. (Author) proposed the method of backdoor attack in Badnet. Switch implanted backdoor into the model by poisoning the training samples. The model with backdoor did not exhibit any abnormalities on the normal validation sample set, but in the input with trigger, they were mistakenly classified as the attacker's designated category or randomly classified as a different category from the ground truth, This attack method seriously threatens the normal application of DNN in real life, such as autonomous driving, object detection, etc.This article proposes a new method to combat backdoor attacks. We refer to the features in the area covered by the trigger as trigger features, and the remaining areas as normal features. By introducing prerequisite calculation conditions during the training process, these conditions have little impact on normal features and trigger features, and can complete the training of a standard backdoor model. The model trained under these prerequisite calculation conditions can, In the verification set D'val with the same premise calculation conditions, the performance is consistent with that of the ordinary backdoor model. However, in the verification set Dval without the premise calculation conditions, the verification accuracy decreases very little (7%~12%), while the attack success rate (ASR) decreases from 90% to about 8%.Author call this method Prerequisite Transformation(PT).

    Comment: 7 pages,7 figures,2 tables
    Keywords Computer Science - Cryptography and Security ; Computer Science - Computer Vision and Pattern Recognition
    Publishing date 2023-06-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Antibiotic resistance genes in integrated surface ice, cryoconite, and glacier-fed stream in a mountain glacier in Central Asia.

    Ren, Ze / Gao, Hongkai

    Environment international

    2024  Volume 184, Page(s) 108482

    Abstract: Glacier ice, cryoconite, and glacier-fed streams are interconnected features that have important implications for the dynamics and distribution of abiotic and biotic materials. However, the presence and behavior of antibiotic resistance genes (ARGs) ... ...

    Abstract Glacier ice, cryoconite, and glacier-fed streams are interconnected features that have important implications for the dynamics and distribution of abiotic and biotic materials. However, the presence and behavior of antibiotic resistance genes (ARGs) within these glacial environments remained largely unexplored. Addressing this gap, we hypothesized that ARGs are widely distributed and exhibit distinct yet interconnected patterns of diversity and dynamics in these glacial environments. Here, we investigated ARGs in a mountain glacier in Central Asia. A total of 944 ARGs, spanning 22 antibiotic classes, were identified, with 633 ARGs shared across all three environments. Cryoconite exhibited the highest ARG richness, followed by ice, while stream biofilm displayed the lowest value. Exploring ARG profiles, we observed a consistent pattern in terms of antibiotic class and resistance mechanism across all three environments. Beta-lactam resistance genes exhibited the highest diversity, followed by multidrug, glycopeptide, and MLS. The predominant mechanisms were antibiotic inactivation, antibiotic efflux, and target alteration. The most prevalent ARG is cls, followed by mdfA, ropB, fabI, and macB. The similarity in ARG profiles between surface ice and cryoconite samples was more pronounced than their resemblance to stream biofilm samples. The variations of ARG profiles between any pair of environments were largely contributed by turnover component. Further insights into microbial interactions revealed 2328 significant associations between 80 OTUs and 356 ARGs, indicating complex relationships. Certain OTUs, including those from the genera Polaromonas, Ferruginibacter, Hymenobacter, Phormidesmis, Novosphingobium, and Polymorphobacter, were speculated as potential hosts for a variety of ARGs. Our findings underscore the intricate dynamics of antibiotic resistance in glacial ecosystems, emphasizing the need for a holistic understanding of ARG distribution, diversity, and associations across diverse environmental compartments. This research contributes valuable insights into the potential ecological implications of antibiotic resistance dissemination in cold environments, particularly as influenced by increasing climate change.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Ecosystem ; Ice Cover ; Rivers ; Genes, Bacterial ; Drug Resistance, Microbial/genetics ; Asia
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2024.108482
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    Zs.A 3131: Show issues Location:
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  6. Article ; Online: Corneal Plug Keratoplasty for the Treatment of Small Corneal Perforation.

    Qi, Xiaolin / Gao, Hua

    JAMA ophthalmology

    2024  Volume 142, Issue 3, Page(s) e234805

    MeSH term(s) Humans ; Corneal Perforation/surgery ; Cornea ; Corneal Transplantation
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2023.4805
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  7. Article: [Analysis of prognostic factors in patients with COVID-19 infection].

    Gao, H B / Zhang, J

    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

    2024  Volume 47, Issue 3, Page(s) 296–300

    Abstract: The peak of COVID-19 infections in China has just passed, and symptomatic manifestations in patients vary widely, with a minority experiencing severe morbidity and mortality. Early detection of adverse outcomes remains critical for clinical governance ... ...

    Abstract The peak of COVID-19 infections in China has just passed, and symptomatic manifestations in patients vary widely, with a minority experiencing severe morbidity and mortality. Early detection of adverse outcomes remains critical for clinical governance and prognosis in COVID-19. This review synthesized both national and international studies relevant to the prognostic evaluation of COVID-19 and summarized the prognostic implications of demographics (age and gender), specific laboratory parameters, adjunctive examination results, complications, and comorbidities in COVID-19 patients. Pertinent laboratory parameters chiefly included markers of inflammation, coagulation function, and electrolytic balance. Adjunctive examinations included thoracic CT and electrocardiographic evaluations. Major complications and comorbid conditions included thrombotic episodes, co-infections, secondary infections, chronic pulmonary disorders, cardiovascular diseases, acute and chronic renal diseases, diabetes mellitus, and cerebrovascular accidents. Moreover, this article discussed how these elements affected the prognosis of patients with COVID-19. By summarizing the information, it aimed to inform preventive and therapeutic strategies against COVID-19 infections in the forthcoming period.
    MeSH term(s) Humans ; Prognosis ; COVID-19 ; Cardiovascular Diseases ; China ; Coinfection
    Language Chinese
    Publishing date 2024-03-06
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 1027965-9
    ISSN 1001-0939
    ISSN 1001-0939
    DOI 10.3760/cma.j.cn112147-20230822-00096
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    Zs.B 2465: Show issues Location:
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  8. Article ; Online: Physiological and transcriptomic analysis of tomato in response to sub-optimal temperature stress.

    Gao, Huan / Wu, Fengzhi

    Plant signaling & behavior

    2024  Volume 19, Issue 1, Page(s) 2332018

    Abstract: Tomato ( ...

    Abstract Tomato (
    MeSH term(s) Temperature ; Solanum lycopersicum/genetics ; Chlorophyll/metabolism ; Proline/metabolism ; Gene Expression Profiling ; Sugars ; Stress, Physiological/genetics ; Photosynthesis
    Chemical Substances Chlorophyll (1406-65-1) ; Proline (9DLQ4CIU6V) ; Sugars
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ISSN 1559-2324
    ISSN (online) 1559-2324
    DOI 10.1080/15592324.2024.2332018
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  9. Article: Severe Infection Mimicking AML due to Bone Marrow Suppression: a Diagnostic Challenge.

    Liao, Shasha / Gao, Huijie

    Clinical laboratory

    2024  Volume 70, Issue 4

    Abstract: Background: Infection may lead to agranulocytosis due to bone marrow suppression. However, a rare case with infection presented with morphological features of acute myeloid leukemia (AML).: Methods: We report a case of extreme agranulocytosis due to ... ...

    Abstract Background: Infection may lead to agranulocytosis due to bone marrow suppression. However, a rare case with infection presented with morphological features of acute myeloid leukemia (AML).
    Methods: We report a case of extreme agranulocytosis due to severe infection mimicking acute myeloid leukemia. The case was definitively diagnosed by subsequent morphology, flow cytometry, and bone marrow biopsy, and subsequent successful anti-infective treatment confirmed the diagnosis.
    Conclusions: To date, no case of a patient diagnosed with severe infection mimicking AML has been reported. The case emphasizes the importance of an integrated diagnostic work-up, especially careful clinical observation and differential diagnosis.
    MeSH term(s) Humans ; Bone Marrow/pathology ; Leukemia, Myeloid, Acute/complications ; Leukemia, Myeloid, Acute/diagnosis ; Diagnosis, Differential ; Flow Cytometry ; Agranulocytosis/diagnosis ; Agranulocytosis/pathology
    Language English
    Publishing date 2024-04-16
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 1307629-2
    ISSN 1433-6510 ; 0941-2131
    ISSN 1433-6510 ; 0941-2131
    DOI 10.7754/Clin.Lab.2023.231002
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  10. Article ; Online: Synthesis of Linear Polymers in High Molecular Weights via Reaction-Enhanced Reactivity of Intermediates Using Friedel-Crafts Polycondensation.

    Gao, Haifeng

    ACS omega

    2021  Volume 6, Issue 7, Page(s) 4527–4533

    Abstract: Linear polymers for many materials applications are popularly produced via step-growth polymerizations of different pairs of ... ...

    Abstract Linear polymers for many materials applications are popularly produced via step-growth polymerizations of different pairs of A
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.0c06085
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