Artikel ; Online: Chronic neutrophilic leukemia complicated with monoclonal gammopathy of undetermined significance: A case report and literature review.
Journal of clinical laboratory analysis
2022 Band 36, Heft 4, Seite(n) e24287
Abstract: Background: Study of the molecular biological characteristics of chronic neutrophilic leukemia complicated with plasma cell disorder (CNL-PCD) and lymphocytic proliferative disease (CNL-LPD).: Methods: The clinical data of a patient with chronic ... ...
| Abstract | Background: Study of the molecular biological characteristics of chronic neutrophilic leukemia complicated with plasma cell disorder (CNL-PCD) and lymphocytic proliferative disease (CNL-LPD). Methods: The clinical data of a patient with chronic neutrophilic leukemia complicated with monoclonal gammopathy of undetermined significance (CNL-MGUS) in our hospital were reviewed, and the Chinese and/or English literature about CNL-PCD and CNL-LPD in PubMed and the Chinese database CNKI in the past 10 years was searched to analyze the molecular biological characteristics of this disease. Results: A 73-year-old male had persistent leukocytosis for 18 months. The white blood cell count was 46.77 × 109/L and primarily composed of mature neutrophils; hemoglobin: 77 g/L; platelet count: 189 × 109/L. Serum immunofixation electrophoresis showed IgG-λ monoclonal M protein. A CT scan showed splenomegaly. Next-generation sequencing (NGS) showed that CSF3R T618I, ASXL1 and RUNX1 mutations were positive. It was diagnosed as CNL-MGUS. We summarized 10 cases of CNL-PCD and 1 case of CNL-LPD who underwent genetic mutation detection reported in the literature. The CSF3R mutational frequency (7/11, 63.6%) was lower than that of isolated CNL. The ASXL1 mutations were all positive (3/3), which may represent a poor prognostic factor. The SETBP1 mutation may promote the progression of CNL-PCD. We also found JAK2, RUNX1, NRAS, etc. in CNL-PCD. Conclusions: Chronic neutrophilic leukemia may be more inclined to coexist with plasma cell disorder. The CSF3R mutation in CNL-PCD is still the most common mutated gene compared with isolated CNL. Mutations in SETBP1 and ASXL1 may be poor prognostic factors for CNL-PCD. |
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| Mesh-Begriff(e) | Aged ; Core Binding Factor Alpha 2 Subunit/genetics ; Humans ; Leukemia, Neutrophilic, Chronic/complications ; Leukemia, Neutrophilic, Chronic/diagnosis ; Leukemia, Neutrophilic, Chronic/genetics ; Male ; Monoclonal Gammopathy of Undetermined Significance/complications ; Monoclonal Gammopathy of Undetermined Significance/genetics ; Mutation/genetics ; Paraproteinemias/complications ; Paraproteinemias/genetics | |||||
| Chemische Substanzen | Core Binding Factor Alpha 2 Subunit | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2022-02-16 | |||||
| Erscheinungsland | United States | |||||
| Dokumenttyp | Case Reports ; Journal Article ; Review | |||||
| ZDB-ID | 645095-7 | |||||
| ISSN | 1098-2825 ; 0887-8013 | |||||
| ISSN (online) | 1098-2825 | |||||
| ISSN | 0887-8013 | |||||
| DOI | 10.1002/jcla.24287 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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