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Article ; Online: Advanced methods to mechanically isolate stromal vascular fraction: A concise review.

You, Xin / Gao, JianHua / Yao, Yao

2024 Volume 27, Page(s) 120–125

Abstract: Adipose tissue is a highly attractive reservoir of stem cells due to its accessibility and abundance, and the SVF within it holds great promise for stem cell-based therapies. The use of mechanical methods for SVF isolation from adipose tissue is ... ...

Abstract	Adipose tissue is a highly attractive reservoir of stem cells due to its accessibility and abundance, and the SVF within it holds great promise for stem cell-based therapies. The use of mechanical methods for SVF isolation from adipose tissue is preferred over enzymatic methods, as it can be readily applied in clinical settings without additional processing steps. However, there is a lack of consensus on the optimal approach for mechanically isolating SVF. This comprehensive review aims to present and compare the latest mechanical isolation methods for SVF from adipose tissue, including centrifugation, filtration/washing, emulsification, vibration, and mincing/adiponizing. Each of these methods possesses unique advantages and limitations, and yet, no conclusive evidence has emerged demonstrating the superiority of one approach over the others, primarily due to the dearth of well-controlled prospective studies in this field.
Language	English
Publishing date	2024-03-25
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2835333-X
ISSN	2352-3204 ; 2352-3204
ISSN (online)	2352-3204
ISSN	2352-3204
DOI	10.1016/j.reth.2024.03.020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inflammation-mediated metabolic regulation in adipose tissue.

Xu, Shujie / Lu, Feng / Gao, Jianhua / Yuan, Yi

Obesity reviews : an official journal of the International Association for the Study of Obesity

2024 , Page(s) e13724

Abstract: Chronic inflammation of adipose tissue is a prominent characteristic of many metabolic diseases. Lipid metabolism in adipose tissue is consistently dysregulated during inflammation, which is characterized by substantial infiltration by proinflammatory ... ...

Abstract	Chronic inflammation of adipose tissue is a prominent characteristic of many metabolic diseases. Lipid metabolism in adipose tissue is consistently dysregulated during inflammation, which is characterized by substantial infiltration by proinflammatory cells and high cytokine concentrations. Adipose tissue inflammation is caused by a variety of endogenous factors, such as mitochondrial dysfunction, reactive oxygen species (ROS) production, endoplasmic reticulum (ER) stress, cellular senescence, ceramides biosynthesis and mediators of lipopolysaccharides (LPS) signaling. Additionally, the gut microbiota also plays a crucial role in regulating adipose tissue inflammation. Essentially, adipose tissue inflammation arises from an imbalance in adipocyte metabolism and the regulation of immune cells. Specific inflammatory signals, including nuclear factor-κB (NF-κB) signaling, inflammasome signaling and inflammation-mediated autophagy, have been shown to be involved in the metabolic regulation. The pathogenesis of metabolic diseases characterized by chronic inflammation (obesity, insulin resistance, atherosclerosis and nonalcoholic fatty liver disease [NAFLD]) and recent research regarding potential therapeutic targets for these conditions are also discussed in this review.
Language	English
Publishing date	2024-02-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2147980-X
ISSN	1467-789X ; 1467-7881
ISSN (online)	1467-789X
ISSN	1467-7881
DOI	10.1111/obr.13724
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Article ; Online: Adipose-derived stem cells in immune-related skin disease: a review of current research and underlying mechanisms.

Sun, Tianyi / Zhou, Cheng / Lu, Feng / Dong, Ziqing / Gao, Jianhua / Li, Bin

Stem cell research & therapy

2024 Volume 15, Issue 1, Page(s) 37

Abstract: Adipose-derived stem cells (ASCs) are a critical adult stem cell subpopulation and are widely utilized in the fields of regenerative medicine and stem cell research due to their abundance, ease of harvest, and low immunogenicity. ASCs, which are ... ...

Abstract	Adipose-derived stem cells (ASCs) are a critical adult stem cell subpopulation and are widely utilized in the fields of regenerative medicine and stem cell research due to their abundance, ease of harvest, and low immunogenicity. ASCs, which are homologous with skin by nature, can treat immune-related skin diseases by promoting skin regeneration and conferring immunosuppressive effects, with the latter being the most important therapeutic mechanism. ASCs regulate the immune response by direct cell-cell communication with immune cells, such as T cells, macrophages, and B cells. In addition to cell-cell interactions, ASCs modulate the immune response indirectly by secreting cytokines, interleukins, growth factors, and extracellular vesicles. The immunomodulatory effects of ASCs have been exploited to treat many immune-related skin diseases with good therapeutic outcomes. This article reviews the mechanisms underlying the immunomodulatory effects of ASCs, as well as progress in research on immune-related skin diseases.
MeSH term(s)	Adult ; Humans ; Adipose Tissue ; Mesenchymal Stem Cells/metabolism ; Adipocytes ; Skin ; Skin Diseases/therapy ; Skin Diseases/metabolism
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-023-03561-8
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Article: Challenges and opportunities in obesity: the role of adipocytes during tissue fibrosis.

Zhang, Qian / Lu, Chongxuan / Lu, Feng / Liao, Yunjun / Cai, Junrong / Gao, Jianhua

Frontiers in endocrinology

2024 Volume 15, Page(s) 1365156

Abstract: Obesity is a chronic disease that affects the energy balance of the whole body. In addition to increasing fat mass, tissue fibrosis occurred in white adipose tissue in obese condition. Fibrosis is the over-activation of fibroblasts leading to excessive ... ...

Abstract	Obesity is a chronic disease that affects the energy balance of the whole body. In addition to increasing fat mass, tissue fibrosis occurred in white adipose tissue in obese condition. Fibrosis is the over-activation of fibroblasts leading to excessive accumulation of extracellular matrix, which could be caused by various factors, including the status of adipocytes. The morphology of adipocytes responds rapidly and dynamically to nutrient fluctuations. Adaptive hypertrophy of normal adipocytes protects peripheral organs from damage from lipotoxicity. However, the biological behavior of hypertrophic adipocytes in chronic obesity is abnormally altered. Adipocytes lead to fibrotic remodeling of the extracellular matrix by inducing unresolved chronic inflammation, persistent hypoxia, and increasing myofibroblast numbers. Moreover, adipocyte-induced fibrosis not only restricts the flexible expansion and contraction of adipose tissue but also initiates the development of various diseases through cellular autonomic and paracrine effects. Regarding anti-fibrotic therapy, dysregulated intracellular signaling and epigenetic changes represent potential candidate targets. Thus, modulation of adipocytes may provide potential therapeutic avenues for reversing pathological fibrosis in adipose tissue and achieving the anti-obesity purpose.
MeSH term(s)	Humans ; Fibrosis ; Obesity/pathology ; Obesity/metabolism ; Adipocytes/pathology ; Adipocytes/metabolism ; Animals ; Adipose Tissue/pathology ; Adipose Tissue/metabolism
Language	English
Publishing date	2024-04-15
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2024.1365156
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Article ; Online: Sustained Release Microneedles: Materials and Applications in Facial Rejuvenation.

Huang, Xiaoqi / Chang, Qiang / Gao, Jian-Hua / Lu, Feng

Tissue engineering. Part B, Reviews

2023 Volume 29, Issue 3, Page(s) 190–202

Abstract: Wrinkled and loose skin resulting from collagen degradation along with fibers decreasing reflects the youth diminishing. Microneedles (MNs) have opened up new avenues for the development of painless and noninvasive transdermal drug delivery systems for ... ...

Abstract	Wrinkled and loose skin resulting from collagen degradation along with fibers decreasing reflects the youth diminishing. Microneedles (MNs) have opened up new avenues for the development of painless and noninvasive transdermal drug delivery systems for facial rejuvenation. Encapsulated drugs or molecules are transmitted to targeted tissues via percutaneous microchannels, which eliminate potential gastric stimulation or first-pass metabolic effects, as well as boost patient compliance. Although MNs are considered effective and feasible therapeutic alternatives to metals, silicon, and polymers, traditional procedures with reduction processes continue to encounter methodological limitations. In recent years, promising additive manufacturing processes such as three-dimensional printing and two-photon polymerization manufacturing have been developed with the aim of overcoming the limitations by traditional processes to facilitate an efficient and economic production mode. This review summarizes the design, material selection, and manufacturing method for recently advanced MN systems. Furthermore, we also highlight specific polymeric or natural microneedle products, like hyaluronan, plant derivates, and vitamins, for esthetic applications in this review. Impact Statement In this review, the materials and manufactural routes of microneedles (MNs) are detailed. Moreover, similar to the diagnostic or therapeutic MNs, the feature of dispensation with training and ready-to-use is perfect for beautification and anti-aging, which necessitate repeated and long-term usage. Furthermore, the specific polymeric or natural products for esthetic applications of MNs are highlighted in this review.
MeSH term(s)	Humans ; Adolescent ; Skin/metabolism ; Drug Delivery Systems/methods ; Delayed-Action Preparations/metabolism ; Delayed-Action Preparations/pharmacology ; Rejuvenation ; Microinjections/methods ; Polymers
Chemical Substances	Delayed-Action Preparations ; Polymers
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2420584-9
ISSN	1937-3376 ; 1937-3368
ISSN (online)	1937-3376
ISSN	1937-3368
DOI	10.1089/ten.TEB.2022.0131
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Article ; Online: Corynebacterium bovis

You, Xin / Yao, Yao / Gao, JianHua / Liao, YunJun

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1265872

Abstract: In this report, we present a case study of a rare human bacterium, ...

Abstract	In this report, we present a case study of a rare human bacterium,
MeSH term(s)	Humans ; Adipose Tissue ; Transplantation, Autologous/adverse effects ; Transplantation, Autologous/methods ; Mammaplasty/methods ; Retrospective Studies
Language	English
Publishing date	2023-12-08
Publishing country	Switzerland
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1265872
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Article ; Online: CandiHap: a haplotype analysis toolkit for natural variation study.

Li, Xukai / Shi, Zhiyong / Gao, Jianhua / Wang, Xingchun / Guo, Kai

Molecular breeding : new strategies in plant improvement

2023 Volume 43, Issue 3, Page(s) 21

Abstract: Haplotype blocks greatly assist association-based mapping of casual candidate genes by significantly reducing genotyping effort. The gene haplotype could be used to evaluate variants of affected traits captured from the gene region. While there is a ... ...

Abstract	Haplotype blocks greatly assist association-based mapping of casual candidate genes by significantly reducing genotyping effort. The gene haplotype could be used to evaluate variants of affected traits captured from the gene region. While there is a rising interest in gene haplotypes, much of the corresponding analysis was carried out manually. CandiHap allows rapid and robust haplotype analysis and candidate identification preselection of candidate causal single-nucleotide polymorphisms and InDels from Sanger or next-generation sequencing data. Investigators can use CandiHap to specify a gene or linkage sites based on genome-wide association studies and explore favorable haplotypes of candidate genes for target traits. CandiHap can be run on computers with Windows, Mac, or UNIX platforms in a graphical user interface or command line, and applied to any species, such as plant, animal, and microbial. The CandiHap software, user manual, and example datasets are freely available at BioCode (https://ngdc.cncb.ac.cn/biocode/tools/BT007080) or GitHub (https://github.com/xukaili/CandiHap). Supplementary information: The online version contains supplementary material available at 10.1007/s11032-023-01366-4.
Language	English
Publishing date	2023-03-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1230924-2
ISSN	1572-9788 ; 1380-3743
ISSN (online)	1572-9788
ISSN	1380-3743
DOI	10.1007/s11032-023-01366-4
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Article ; Online: New development of sensitivity improvement for compensated neutron porosity tool in gas-filled boreholes.

Zhang, Qiong / Wang, Xinyang / Zhang, Qinzhong / Gao, Jianhua

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

2022 Volume 185, Page(s) 110216

Abstract: Porosity is one of the most important indicators used for hydrocarbon reservoir evaluation and extraction. However, obtain accurate formation porosity measurements in gas-filled boreholes can be challenging, this is because gas cannot slow down neutrons ... ...

Abstract	Porosity is one of the most important indicators used for hydrocarbon reservoir evaluation and extraction. However, obtain accurate formation porosity measurements in gas-filled boreholes can be challenging, this is because gas cannot slow down neutrons as effectively as water due to its lower hydrogen index, which results in measurement sensitivity reduction and consequently impacts the obtained porosity. One way to address this issue is loading water into the borehole which is commonly referred to as water loading. However, this process significantly increases operational time and cost, as well as shielding perforated gas zones. Therefore, a new strategy is proposed to improve the sensitivity of porosity measurement in gas or air-filled boreholes without the need for water loading. The key to this strategy is to incorporate a sleeve design outside the tool to enhance its performance in gas-filled intervals. The sleeve is composed of a downhole applicable material whose neutron slowing down ability is close to water. The optimized deployment orientation of the sleeve could then be determined through simulation. In this work, three potential sleeve materials are identified and compared based on an existing neutron porosity tool. The impacts of different tool-sleeve-borehole orientations are analyzed to determine the most effective design strategy. A series of test pit experiments is conducted to validate the feasibility of the design.
Language	English
Publishing date	2022-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1142596-9
ISSN	1872-9800 ; 0883-2889 ; 0969-8043
ISSN (online)	1872-9800
ISSN	0883-2889 ; 0969-8043
DOI	10.1016/j.apradiso.2022.110216
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Article: Spatial responses of vegetation-soil system to complex factors in a sandy-rocky island chain

Chi, Yuan / Gao, Jianhua / Wang, Jing / Wang, Enkang

Global ecology and conservation. 2022 Oct., v. 38

2022

Abstract: Vegetation-soil systems vary spatially across sandy and rocky islands due to the complex interaction of natural and anthropogenic factors. Revealing the spatial responses of vegetation-soil system to these factors is important for island conservation and ...

Abstract	Vegetation-soil systems vary spatially across sandy and rocky islands due to the complex interaction of natural and anthropogenic factors. Revealing the spatial responses of vegetation-soil system to these factors is important for island conservation and the understanding of island ecology. An island chain in China, which is characterized by the coexistence of sandy and rocky islands connected by bridges, was selected for the study. The vegetation-soil system was represented using the vegetation health index (VHI), soil health index (SHI), and vegetation-soil system health index (VSSHI). A total of 20 factors were identified in aspects of island basic factors (e.g., area, shape, and isolation), landscape pattern (i.e., composition and configuration), terrain condition (e.g., altitude, slope, and distance to the shoreline), and ecological indices (vegetation, salinity, heat, humidity, and aridity indices). The spatial responses were analyzed at the island (10 islands) and site (111 sites) scales. The results indicated that the vegetation-soil system presented distinctly better conditions on the rocky islands than on the sandy island. The spatial responses showed similar and different characteristics across the dual scales. The similarity was represented by the higher sensitivities of VHI and VSSHI than that of SHI at the two scales, and the difference mainly lay in the decrease in the influences of landscape pattern along the scales from island to site. The factors related to macro aspects (i.e., island area, sea reclamation scale, land use intensity, and vegetation coverage) were the main influencing factors at the island scale. Islands with small area and sea reclamation scale, low land use intensity, and high vegetation coverage presented a high VSSHI. The detailed land surface characteristics that refer to the factors in micro aspects, including aridity degree, soil salinity, vegetation quality, and altitude, became the main influencing factors at the site scale. The VSSHI generally decreased and increased with the increase in the former and latter two factors, respectively. Across different types of islands, anthropogenic activities dominated the vegetation-soil system on the sandy island through intensive sea reclamation and land uses, and natural and anthropogenic factors jointly determined the system on the rocky islands.
Keywords	altitude ; dry environmental conditions ; ecology ; heat ; humidity ; land use ; landscapes ; salinity ; shorelines ; soil quality ; soil salinity ; vegetation ; China
Language	English
Dates of publication	2022-10
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2814786-8
ISSN	2351-9894
ISSN	2351-9894
DOI	10.1016/j.gecco.2022.e02249
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Article ; Online: CandiHap: a haplotype analysis toolkit for natural variation study

Li, Xukai / Shi, Zhiyong / Gao, Jianhua / Wang, Xingchun / Guo, Kai

Mol Breeding. 2023 Mar., v. 43, no. 3 p.21-21

2023

Abstract	Haplotype blocks greatly assist association-based mapping of casual candidate genes by significantly reducing genotyping effort. The gene haplotype could be used to evaluate variants of affected traits captured from the gene region. While there is a rising interest in gene haplotypes, much of the corresponding analysis was carried out manually. CandiHap allows rapid and robust haplotype analysis and candidate identification preselection of candidate causal single-nucleotide polymorphisms and InDels from Sanger or next-generation sequencing data. Investigators can use CandiHap to specify a gene or linkage sites based on genome-wide association studies and explore favorable haplotypes of candidate genes for target traits. CandiHap can be run on computers with Windows, Mac, or UNIX platforms in a graphical user interface or command line, and applied to any species, such as plant, animal, and microbial. The CandiHap software, user manual, and example datasets are freely available at BioCode (https://ngdc.cncb.ac.cn/biocode/tools/BT007080) or GitHub (https://github.com/xukaili/CandiHap).
Keywords	animals ; computer software ; genes ; genotyping ; haplotypes ; user interface
Language	English
Dates of publication	2023-03
Size	p. 21.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	1230924-2
ISSN	1572-9788 ; 1380-3743
ISSN (online)	1572-9788
ISSN	1380-3743
DOI	10.1007/s11032-023-01366-4
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