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Article ; Online: Non-coding RNA regulation of macrophage function in asthma.

Tian, Chunyan / Gao, Jiawei / Yang, Liuxin / Yuan, Xingxing

2023 Volume 112, Page(s) 110926

Abstract: As a chronic respiratory disease, asthma is related to airway inflammation and remodeling. Macrophages are regarded as main innate immune cells in the airway that exert various functions like antigen recognition and presentation, phagocytosis, and ... ...

Abstract	As a chronic respiratory disease, asthma is related to airway inflammation and remodeling. Macrophages are regarded as main innate immune cells in the airway that exert various functions like antigen recognition and presentation, phagocytosis, and pathogen clearance, playing a crucial role in the pathogeneses of asthma. Non-coding RNAs (ncRNAs), mainly include microRNA, long non-coding RNA and circular RNA, have been extensively investigated on the regulation of pathological process in asthma. Recent studies have indicated that ncRNA-regulated macrophages affect macrophage polarization, airway inflammation, immune regulation and airway remodeling, which suggests that modulating macrophages by ncRNAs may be a promising strategy for the treatment of asthma. This review summarizes the effect of macrophages in asthma and the regulatory mechanisms of ncRNAs, as well as focuses on the role of ncRNAs-regulated macrophages in asthma, for the development of novel therapeutic strategies in this disease.
MeSH term(s)	Humans ; RNA, Untranslated/genetics ; Asthma/genetics ; Asthma/pathology ; MicroRNAs/genetics ; RNA, Long Noncoding/genetics ; Macrophages/pathology ; Inflammation/pathology
Chemical Substances	RNA, Untranslated ; MicroRNAs ; RNA, Long Noncoding
Language	English
Publishing date	2023-10-15
Publishing country	England
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1002702-6
ISSN	1873-3913 ; 0898-6568
ISSN (online)	1873-3913
ISSN	0898-6568
DOI	10.1016/j.cellsig.2023.110926
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Book ; Online: The Computational Complexity of Fire Emblem Series and similar Tactical Role-Playing Games

Gao, Jiawei

2019

Abstract: Fire Emblem (FE) is a popular turn-based tactical role-playing game (TRPG) series on the Nintendo gaming consoles. This paper studies the computational complexity of FE, and proves that: 1. General FE is PSPACE-complete. 2. Poly-round FE is NP-complete, ... ...

Abstract	Fire Emblem (FE) is a popular turn-based tactical role-playing game (TRPG) series on the Nintendo gaming consoles. This paper studies the computational complexity of FE, and proves that: 1. General FE is PSPACE-complete. 2. Poly-round FE is NP-complete, even when the map is cycle-free. Poly-round FE is to decide whether the player can win the game in a certain number of rounds that is polynomial to the map size. A map is called cycle-free if its corresponding planar graph is cycle-free. These hardness results also hold for other similar TRPG series, such as Final Fantasy Tactics, Tactics Ogre and Disgaea.
Keywords	Computer Science - Computational Complexity ; Computer Science - Artificial Intelligence ; Computer Science - Data Structures and Algorithms
Publishing date	2019-09-16
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Machine learning deciphers the significance of mitochondrial regulators on the diagnosis and subtype classification in non-alcoholic fatty liver disease.

Wang, Bingyu / Yu, Hongyang / Gao, Jiawei / Yang, Liuxin / Zhang, Yali / Yuan, Xingxing / Zhang, Yang

Heliyon

2024 Volume 10, Issue 9, Page(s) e29860

Abstract: Background: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent liver disease worldwide and lack of research on the diagnostic utility of mitochondrial regulators in NAFLD. Mitochondrial dysfunction plays a pivotal role in the development ... ...

Abstract	Background: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent liver disease worldwide and lack of research on the diagnostic utility of mitochondrial regulators in NAFLD. Mitochondrial dysfunction plays a pivotal role in the development and progression of NAFLD, especially oxidative stress and acidity β-oxidative overload. Thus, we aimed to identify and validate a panel of mitochondrial gene expression biomarkers for detection of NAFLD. Methods: We selected the GSE89632 dataset and identified key mitochondrial regulators by intersecting DEGs, WGCNA modules, and MRGs. Classification of NAFLD subtypes based on these key mitochondrial regulatory factors was performed, and the pattern of immune system infiltration in different NAFLD subtypes were also investigated. RF, LASSO, and SVM-RFE were employed to identify possible diagnostic biomarkers from key mitochondrial regulatory factors and the predictive power was demonstrated through ROC curves. Finally, we validated these potential diagnostic biomarkers in human peripheral blood samples and a high-fat diet-induced NAFLD mouse model. Results: We identified 25 key regulators of mitochondria and two NAFLD subtypes with different immune infiltration patterns. Four potential diagnostic biomarkers (BCL2L11, NAGS, HDHD3, and RMND1) were screened by three machine learning methods thereby establishing the diagnostic model, which showed favorable predictive power and achieved significant clinical benefit at certain threshold probabilities. Then, through internal and external validation, we identified and confirmed that BCL2L11 was significantly downregulated in NAFLD, while the other three were significantly upregulated. Conclusion: The four MRGs, namely BCL2L11, NAGS, HDHD3, and RMND1, are novel potential biomarkers for diagnosing NAFLD. A diagnostic model constructed using the four MRGs may aid early diagnosis of NAFLD in clinics.
Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e29860
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Article ; Online: [Advances in using adaptive laboratory evolution technology for engineering of photosynthetic cyanobacteria].

Gao, Jiawei / Zhu, Xiaofei / Sun, Tao / Chen, Lei / Zhang, Weiwen

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

2023 Volume 39, Issue 8, Page(s) 3075–3094

Abstract: Cyanobacteria are the only prokaryotes capable of oxygenic photosynthesis, which have potential to serve as "autotrophic cell factories". However, the synthesis of biofuels and chemicals using cyanobacteria as chassis are suffered from poor stress ... ...

Abstract	Cyanobacteria are the only prokaryotes capable of oxygenic photosynthesis, which have potential to serve as "autotrophic cell factories". However, the synthesis of biofuels and chemicals using cyanobacteria as chassis are suffered from poor stress tolerance and low yield, resulting in low economic feasibility for industrial production. Thus, it's urgent to construct new cyanobacterial chassis by means of synthetic biology. In recent years, adaptive laboratory evolution (ALE) has made great achievements in chassis engineering, including optimizing growth rate, increasing tolerance, enhancing substrate utilization and increasing product yield. ALE has also made some progress in improving the tolerance of cyanobacteria to high light intensity, heavy metal ions, high concentrations of salt and organic solvents. However, the engineering efficiency of ALE strategy in cyanobacteria is generally low, and the molecular mechanisms underpinning the tolerance to various stresses have not been fully elucidated. To this end, this review summarizes the ALE-associated technical strategies and their applications in cyanobacteria chassis engineering, following by discussing how to construct larger ALE mutation library, increase mutation frequency of strains and shorten evolution time. Moreover, exploration of the construction principles and strategies for constructing multi-stress tolerant cyanobacteria, and efficient analysis the mutant libraries of evolved strains as well as construction of strains with high yield and strong robustness are discussed, with the aim to facilitate the engineering of cyanobacteria chassis and the application of engineered cyanobacteria in the future.
MeSH term(s)	Technology ; Photosynthesis/genetics ; Cyanobacteria/genetics ; Light ; Biofuels
Chemical Substances	Biofuels
Language	Chinese
Publishing date	2023-08-28
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	1042206-7
ISSN	1872-2075 ; 1042-749X
ISSN (online)	1872-2075
ISSN	1042-749X
DOI	10.13345/j.cjb.230132
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Article: Mendelian randomization analyses support causal relationship between gut microbiota and childhood obesity.

Li, Qi / Gao, Jiawei / Luo, Jiashun / Lin, Dihui / Wu, Xinrui

Frontiers in pediatrics

2023 Volume 11, Page(s) 1229236

Abstract: Background: Childhood obesity (CO) is an increasing public health issue. Mounting evidence has shown that gut microbiota (GM) is closely related to CO. However, the causal association needs to be treated with caution due to confounding factors and ... ...

Abstract	Background: Childhood obesity (CO) is an increasing public health issue. Mounting evidence has shown that gut microbiota (GM) is closely related to CO. However, the causal association needs to be treated with caution due to confounding factors and reverse causation. Methods: Data were obtained from the Microbiome Genome Consortium for GM as well as the Early Growth Genetics Consortium for childhood obesity and childhood body mass index (CBMI). Inverse variance weighted, maximum likelihood, weighted median, and MR.RAPS methods were applied to examine the causal association. Then replication dataset was used to validate the results and reverse Mendelian randomization analysis was performed to confirm the causal direction. Additionally, sensitivity analyses including Cochran's Results: Our study found suggestive causal relationships between eight bacterial genera and the risk of childhood obesity (five for CO and four for CBMI). After validating the results in the replication dataset, we finally identified three childhood obesity-related GM including the genera Conclusions: In this study, we employed the MR approach to investigate the causal relationship between GM and CO, and discovered that the genus
Language	English
Publishing date	2023-08-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1229236
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Article: Study on the Physiological, Cellular, and Morphological Aspects of the Postharvest Development of Cut Lily Flowers

Zhang, Yushan / Zhong, Dexin / Liu, Zhanfei / Gao, Jiawei

Chinese Society for Horticultural Science (CSHS) and Institute of Vegetables and Flowers (IVF), Chinese Academy of Agricultural Sciences (CAAS) Horticultural plant journal. 2021 Mar., v. 7, no. 2

2021

Abstract: It is of great practical significance to study the development process of cut lily for regulating flowering and preservation. In this study, the developmental process of lily cut flower was explored from cellular, morphological, and physiological aspects. ...

Abstract	It is of great practical significance to study the development process of cut lily for regulating flowering and preservation. In this study, the developmental process of lily cut flower was explored from cellular, morphological, and physiological aspects. From a morphological aspect, the tepal edge grows faster than the midrib. The midrib groove of the flowering stage is wider than that of bud stage. The fast-growing edge of the petals results in the midrib bending outward. Moreover, the rapid growth of the stamens and stigmas also contributes to bud cracking. From the cellular aspect, in the bud stage there were more wrinkles in the outer epidermal cell wall of the tepal than those in the inner epidermal cell wall, indicating that asymmetric structural differences exist from the beginning of lily development. From a physiological aspect, from the bud cracking stage to the senescence stage, a variety of substances in the tepal cells gradually decreased, including total nitrogen, total phosphorus, total potassium, total calcium, starch, soluble sugar, and soluble protein, but not malondialdehyde. These results indicate that the asymmetric growth caused by this structural difference is responsible for flowering. The wrinkles in the cell wall can be regarded as indicators of senescent cells and are caused by the degradation of the cell wall and the loss of intracellular turgor pressure. The differences in the epidermal cells between the inner and outer tepal indicated ultrastructural changes in the tepal cells. The bud and flowering stages are maintained by the tepals acting as a sink. After flowering, the tepals gradually change from a sink to a source organ. Senescence of the cut lily flowers was caused by the decomposition of intracellular compounds in the tepals and the remobilization of nutrients from the tepals to the developing organs.
Keywords	calcium ; cell walls ; cut flowers ; flower tepals ; horticultural crops ; malondialdehyde ; potassium ; starch ; sugars ; total nitrogen ; total phosphorus ; turgor
Language	English
Dates of publication	2021-03
Size	p. 149-158.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ISSN	2468-0141
DOI	10.1016/j.hpj.2021.02.005
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: High-sensitivity humidity and temperature sensor by cascading a polyimide coated long period fiber grating and a polydimethylsiloxane wrapped Mach-Zehnder interferometer.

Jiang, Wenbo / Sun, Simei / Song, Jiao / Gao, Jiawei / Hu, Chuanju / Li, Li / Deng, Longfeng / Chen, Fulin

The Review of scientific instruments

2024 Volume 94, Issue 12

Abstract: Two different structures, long period fiber grating (LPFG) and a Mach-Zehnder interferometer (MZI), were cascaded to fabricate a sensor for sensing humidity and temperature simultaneously. Due to the humidity sensitive characteristic of polyimide (PI) ... ...

Abstract	Two different structures, long period fiber grating (LPFG) and a Mach-Zehnder interferometer (MZI), were cascaded to fabricate a sensor for sensing humidity and temperature simultaneously. Due to the humidity sensitive characteristic of polyimide (PI) and the temperature sensitive characteristic of polydimethylsiloxane (PDMS), the LPFG was coated with PI and the MZI was wrapped in PDMS to improve the humidity and temperature sensitivities, respectively. Humidity and temperature experiments and the stability and repeatability of the proposed sensors were performed. The sensor shows humidity and temperature sensitivities of ∼164 pm/%RH and 183 pm/°C in the humidity and temperature increasing experiments, respectively. Combining increasing, decreasing, and repeatable experiments of temperature and humidity, the proposed sensor shows stable performance in humidity sensitivity of ∼159 pm/%RH and temperature sensitivity of ∼175 pm/°C, with good linearity of ∼0.994. The structure of the proposed sensor has the advantages of low implementation cost, easy fabrication, and good stability.
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0163910
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Article: Intraperitoneal hyaline vascular Castleman disease: Three case reports.

Gao, Jia-Wei / Shi, Zhe-Yi / Zhu, Zhao-Bi / Xu, Xiang-Rong / Chen, Wei

World journal of clinical cases

2023 Volume 11, Issue 36, Page(s) 8527–8534

Abstract: Background: Castleman disease (CD) was first reported in 1954. It is a rare non-malignant lymphoproliferative disease with unclear etiology. As the clinical manifestations of CD are different, there are difficulties in its diagnosis and treatment. ... ...

Abstract	Background: Castleman disease (CD) was first reported in 1954. It is a rare non-malignant lymphoproliferative disease with unclear etiology. As the clinical manifestations of CD are different, there are difficulties in its diagnosis and treatment. Therefore, for patients with CD, it is important to establish the diagnosis in order to choose the appropriate treatment. Case summary: In this report, three patients with intraperitoneal CD treated at our center from January 2018 to June 2023 were reviewed, and the clinical and paraclinical examinations, diagnosis, and treatment were analyzed, and all three patients were diagnosed with CD by routine histopathological and immunohistochemical examinations. Conclusion: CD is a complex and rare disease. Because there are no special clinical symptoms and laboratory abnormalities, the diagnosis often depends on routine pathological and immunohistochemical findings.
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i36.8527
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Article: Integration analysis of single-cell and spatial transcriptomics reveal the cellular heterogeneity landscape in glioblastoma and establish a polygenic risk model.

Liu, Yaxuan / Wu, Zhenyu / Feng, Yueyuan / Gao, Jiawei / Wang, Bo / Lian, Changlin / Diao, Bo

Frontiers in oncology

2023 Volume 13, Page(s) 1109037

Abstract: Background: Glioblastoma (GBM) is adults' most common and fatally malignant brain tumor. The heterogeneity is the leading cause of treatment failure. However, the relationship between cellular heterogeneity, tumor microenvironment, and GBM progression ... ...

Abstract	Background: Glioblastoma (GBM) is adults' most common and fatally malignant brain tumor. The heterogeneity is the leading cause of treatment failure. However, the relationship between cellular heterogeneity, tumor microenvironment, and GBM progression is still elusive. Methods: Integrated analysis of single-cell RNA sequencing (scRNA-seq) and spatial transcriptome sequencing (stRNA-seq) of GBM were conducted to analyze the spatial tumor microenvironment. We investigated the subpopulation heterogeneity of malignant cells through gene set enrichment analyses, cell communications analyses, and pseudotime analyses. Significantly changed genes of the pseudotime analysis were screened to create a tumor progress-related gene risk score (TPRGRS) using Cox regression algorithms in the bulkRNA-sequencing(bulkRNA-seq) dataset. We combined the TPRGRS and clinical characteristics to predict the prognosis of patients with GBM. Furthermore, functional analysis was applied to uncover the underlying mechanisms of the TPRGRS. Results: GBM cells were accurately charted to their spatial locations and uncovered their spatial colocalization. The malignant cells were divided into five clusters with transcriptional and functional heterogeneity, including unclassified malignant cells and astrocyte-like, mesenchymal-like, oligodendrocytes-progenitor-like, and neural-progenitor-like malignant cells. Cell-cell communications analysis in scRNA-seq and stRNA-seq identified ligand-receptor pairs of the CXCL, EGF, FGF, and MIF signaling pathways as bridges implying that tumor microenvironment may cause malignant cells' transcriptomic adaptability and disease progression. Pseudotime analysis showed the differentiation trajectory of GBM cells from proneural to mesenchymal transition and identified genes or pathways that affect cell differentiation. TPRGRS could successfully divide patients with GBM in three datasets into high- and low-risk groups, which was proved to be a prognostic factor independent of routine clinicopathological characteristics. Functional analysis revealed the TPRGRS associated with growth factor binding, cytokine activity, signaling receptor activator activity functions, and oncogenic pathways. Further analysis revealed the association of the TPRGRS with gene mutations and immunity in GBM. Finally, the external datasets and qRT-PCR verified high expressions of the TPRGRS mRNAs in GBM cells. Conclusion: Our study provides novel insights into heterogeneity in GBM based on scRNA-seq and stRNA-seq data. Moreover, our study proposed a malignant cell transition-based TPRGRS through integrated analysis of bulkRNA-seq and scRNA-seq data, combined with the routine clinicopathological evaluation of tumors, which may provide more personalized drug regimens for GBM patients.
Language	English
Publishing date	2023-06-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1109037
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Article ; Online: Highly sensitive strain sensor based on tapered few-mode fiber.

Li, Li / Jiang, Chao / Hu, Chuanju / Gao, Jiawei / Deng, Longfeng / Cao, Tingshui / Li, Hong

The Review of scientific instruments

2023 Volume 94, Issue 7

Abstract: A high sensitivity strain sensor using a sandwich structure of "single mode fiber (SMF)-few mode fiber (FMF)-single mode fiber (SMF)" was proposed and experimentally validated. The designed sensor is achieved by splicing a segment of FMF between two ... ...

Abstract	A high sensitivity strain sensor using a sandwich structure of "single mode fiber (SMF)-few mode fiber (FMF)-single mode fiber (SMF)" was proposed and experimentally validated. The designed sensor is achieved by splicing a segment of FMF between two segments of SMFs, and then using a fiber optic fusion tapering machine to double the length of FMF. Introducing tapered optical fibers into the structure to excite more evanescent waves improves the sensitivity of the sensor to the surrounding environment. In addition, due to the fact that the FMF is tapered into a very fine shape, the tensile stress applied to the FMF will increase. Therefore, conical FMF has excellent stress concentration ability, which is easily deformed under stress, thus achieving a high strain sensitivity of -23.9 pm/με. Finally, a cascaded FBG was used to compensate for the temperature cross-sensitivity of the sensor. This strain sensor with an extremely simple structure and high sensitivity has wide application value in the industry.
Language	English
Publishing date	2023-07-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0157555
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