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  1. Article: Effect of transcutaneous electrical acupoint stimulation on postoperative urinary function in elderly patients undergoing total hip arthroplasty.

    Tu, Yuming / Qu, Shanchong / Lin, Shunyan / Gu, Shujing / Gao, Ju

    Zhongguo zhen jiu = Chinese acupuncture & moxibustion

    2024  Volume 44, Issue 4, Page(s) 395–399

    Abstract: Objectives: To observe the effect of transcutaneous electrical acupoint stimulation (TEAS) on postoperative urinary function in elderly patients undergoing total hip arthroplasty (THA).: Methods: One hundred and eighty elderly patients undergoing ... ...

    Title translation 经皮穴位电刺激对老年患者全髋关节置换术后排尿功能的影响.
    Abstract Objectives: To observe the effect of transcutaneous electrical acupoint stimulation (TEAS) on postoperative urinary function in elderly patients undergoing total hip arthroplasty (THA).
    Methods: One hundred and eighty elderly patients undergoing unilateral THA without indwelling urinary catheters were randomly assigned to a TEAS group (90 cases, 3 cases dropped out, 4 cases were eliminated) and a sham TEAS group (90 cases, 1 case dropped out, 4 cases were eliminated). Both groups received fascia iliac block and subarachnoid block anesthesia under ultrasound guidance. The patients in the TEAS group were treated with TEAS at Zhongji (CV 3), Guanyuan (CV 4), and bilateral Huiyang (BL 35), Ciliao (BL 32) 30 minutes before anesthesia initiation, with dissperse-dense wave, frequency of 2 Hz/100 Hz, until 30 minutes after surgery. The patients in the sham TEAS group underwent the same procedure with the device applied at the same acupoints but without electrical stimulation. The incidence of postoperative urinary retention (POUR), time to first void, voiding threshold, urinary adenosine triphosphate (ATP) level, postoperative abnormal voiding status (bladder residual volume, re-catheterization rate, nocturia occurrence), and postoperative incidence of urinary tract infection (UTI) and prosthetic joint infection (PJI) were observed in both groups.
    Results: The incidence of POUR in the TEAS group was lower than that in the sham TEAS group (
    Conclusions: TEAS could effectively reduce the occurrence of postoperative urinary retention and improve the postoperative urinary function in elderly patients undergoing THA, which might be related with increasing the urinary ATP level.
    MeSH term(s) Humans ; Aged ; Acupuncture Points ; Arthroplasty, Replacement, Hip/adverse effects ; Transcutaneous Electric Nerve Stimulation/methods ; Urinary Retention/etiology ; Urinary Retention/therapy ; Nocturia ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Adenosine Triphosphate
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE)
    Language Chinese
    Publishing date 2024-04-15
    Publishing country China
    Document type Randomized Controlled Trial ; Journal Article
    ISSN 0255-2930
    ISSN 0255-2930
    DOI 10.13703/j.0255-2930.20230302-k0005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Anosmia and ageusia after intravenous esketamine and propofol-based general anesthesia.

    Wang, Cunjin / Pan, Yuchen / Guan, Jingjing / Gao, Ju

    Asian journal of surgery

    2023  Volume 46, Issue 11, Page(s) 5219–5221

    MeSH term(s) Humans ; Ageusia ; Propofol ; Anosmia ; Anesthesia, General
    Chemical Substances Propofol (YI7VU623SF) ; Esketamine (50LFG02TXD)
    Language English
    Publishing date 2023-09-19
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: When ankylosing spondylitis coincides with spontaneous cervical fracture: A case report.

    Zhu, Xiangpeng / Zhang, Yang / Ge, Yali / Gao, Ju

    Asian journal of surgery

    2023  Volume 46, Issue 9, Page(s) 4020–4021

    MeSH term(s) Humans ; Spondylitis, Ankylosing/complications ; Spinal Fractures/etiology ; Fractures, Spontaneous ; Neck
    Language English
    Publishing date 2023-05-05
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.04.033
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  4. Article: Effects of melatonin on protecting against lung injury (Review).

    Wang, Weiwei / Gao, Ju

    Experimental and therapeutic medicine

    2021  Volume 21, Issue 3, Page(s) 228

    Abstract: Melatonin (MT; N-acetyl-5-methoxy-tryptamine), which has multiple effects and roles, is secreted from the pineal gland at night according to the daily rhythm. In addition to circadian regulation, MT has anti-inflammatory, antioxidant and anticancer ... ...

    Abstract Melatonin (MT; N-acetyl-5-methoxy-tryptamine), which has multiple effects and roles, is secreted from the pineal gland at night according to the daily rhythm. In addition to circadian regulation, MT has anti-inflammatory, antioxidant and anticancer functions. Recent studies postulated that MT serves a critical role in apoptosis, anti-ischemic reperfusion injury and anti-proliferative effects on various cells. The current review reported on the underlying mechanism behind the protective effect of MT on lung diseases, such as acute lung injury, acute respiratory distress syndrome, chronic obstructive pulmonary disease, lung ischemia-reperfusion injury, sepsis-induced lung injury and ventilator-induced lung injury. MT is considered an adjuvant with therapeutic drugs for preventing inflammation and is responsible for regulating patient sleep cycles in the intensive care unit. The current review described the anti-inflammatory and antioxidant efficiency of MT with a focus on the molecular mechanisms of action in various lung injuries.
    Language English
    Publishing date 2021-01-20
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2021.9659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Genetically supported causality between gut microbiota, immune cells and morphine tolerance: a two-sample Mendelian randomization study.

    Han, Shuai / Gao, Jiapei / Wang, Zi / Xiao, Yinggang / Ge, Yali / Liang, Yongxin / Gao, Ju

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1343763

    Abstract: Background: Previous researches have suggested a significant connection between the gut microbiota/immune cells and morphine tolerance (MT), but there is still uncertainty regarding their causal relationship. Hence, our objective is to inverstigate this ...

    Abstract Background: Previous researches have suggested a significant connection between the gut microbiota/immune cells and morphine tolerance (MT), but there is still uncertainty regarding their causal relationship. Hence, our objective is to inverstigate this causal association and reveal the impact of gut microbiota/immune cells on the risk of developing MT using a two-sample Mendelian randomization (MR) study.
    Methods: We conducted a comprehensive analysis using genome-wide association study (GWAS) summary statistics for gut microbiota, immune cells, and MT. The main approach employed was the inverse variance-weighted (IVW) method in MR. To assess horizontal pleiotropy and remove outlier single-nucleotide polymorphisms (SNPs), we utilized the Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) technique as well as MR-Egger regression. Heterogeneity detection was performed using Cochran's
    Results: We discovered that 6 gut microbial taxa and 16 immune cells were causally related to MT (
    Conclusion: Our research confirm the potential link between gut microbiota and immune cells with MT, shedding light on the mechanism by which gut microbiota and immune cells may contribute to MT. These findings lay the groundwork for future investigations into targeted prevention strategies.
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1343763
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  6. Article: Severe Hypertensive Response to Atropine Therapy for Bradycardia Associated with Dexmedetomidine: Case Report and Literature Review.

    Li, Yong / Gao, Ju / Jiang, Lin / Sun, Canlin / Hong, Hua / Yu, Dapeng

    Clinical pharmacology : advances and applications

    2024  Volume 16, Page(s) 27–31

    Abstract: Dexmedetomidine is a selective and potent ... ...

    Abstract Dexmedetomidine is a selective and potent α
    Language English
    Publishing date 2024-01-11
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2520726-X
    ISSN 1179-1438
    ISSN 1179-1438
    DOI 10.2147/CPAA.S436188
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  7. Article ; Online: A novel missense mutation in the MECOM gene in a Chinese boy with radioulnar synostosis with amegakaryocytic thrombocytopenia.

    Huang, Duowen / Jiang, Mingyan / Zhu, Yiping / Li, Dongjun / Lu, Xiaoxi / Gao, Ju

    BMC pediatrics

    2024  Volume 24, Issue 1, Page(s) 62

    Abstract: Radioulnar synostosis with amegakaryocytic thrombocytopenia (RUSAT) type 2, caused by MDS1 and EVI1 complex locus (MECOM) gene mutations, is a rare inherited bone marrow failure syndrome (IBMFS) with skeletal anomalies, characterized by varying ... ...

    Abstract Radioulnar synostosis with amegakaryocytic thrombocytopenia (RUSAT) type 2, caused by MDS1 and EVI1 complex locus (MECOM) gene mutations, is a rare inherited bone marrow failure syndrome (IBMFS) with skeletal anomalies, characterized by varying presentation of congenital thrombocytopenia (progressing to pancytopenia), bilateral proximal radioulnar synostosis, and other skeletal abnormalities. Due to limited knowledge and heterogenous manifestations, clinical diagnosis of the disease is challenging. Here we reported a novel MECOM mutation in a Chinese boy with typical clinical features for RUSAT-2. Trio-based whole exome sequencing of buccal swab revealed a novel heterozygous missense mutation in exon 11 of the MECOM gene (chr3:168818673; NM_001105078.3:c.2285G > A). The results strongly suggest that the variant was a germline mutation and disease-causing mutation. The patient received matched unrelated donor hematopoetic stem cell transplantation (HSCT). This finding was not only expanded the pathogenic mutation spectrum of MECOM gene, but also provided key information for clinical diagnosis and treatment of RUSAT-2.
    MeSH term(s) Humans ; Male ; China ; MDS1 and EVI1 Complex Locus Protein/genetics ; Mutation ; Mutation, Missense ; Radius/abnormalities ; Synostosis ; Thrombocytopenia/genetics ; Thrombocytopenia/diagnosis ; Transcription Factors/genetics ; Ulna/abnormalities
    Chemical Substances MDS1 and EVI1 Complex Locus Protein ; MECOM protein, human ; Transcription Factors
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/s12887-024-04552-1
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  8. Article ; Online: Effective Treatment of Anlotinib Combined With Chemotherapy in Children With Desmoplastic Small Round Cell Tumor: A Case Series in a Single-center and Literature Review.

    Jing, Xiao-Yu / Shen, Cheng-Qi / He, Guo-Qian / Xu, Rong-Rong / Gao, Ju / Guo, Xia

    Journal of pediatric hematology/oncology

    2024  Volume 46, Issue 3, Page(s) 159–164

    Abstract: Introduction: Desmoplastic small round cell tumor (DSRCT) is a highly aggressive primitive sarcoma with a 5-year survival rate estimated at only 15% to 30%. Although few curative treatment options exist, patients are most often treated with a ... ...

    Abstract Introduction: Desmoplastic small round cell tumor (DSRCT) is a highly aggressive primitive sarcoma with a 5-year survival rate estimated at only 15% to 30%. Although few curative treatment options exist, patients are most often treated with a combination of aggressive chemotherapy, radiation, and surgery. Targeted therapy inhibitors of platelet-derived growth factor A, insulin-like growth factor receptor 1, and vascular endothelial growth factor receptor-2, which are almost uniformly overexpressed in DSRCT, have largely failed in clinical trials. Anlotinib is a multitarget receptor tyrosine kinase inhibitor that inhibits vascular endothelial growth factor receptor 1-3, fibroblast growth factor receptor 1-4, platelet-derived growth factor receptor α/β, c-Kit, and Met. In this study, we presented 3 cases of DSRCT treated effectively with anlotinib combined with chemotherapy.
    Case presentation: Three children DSRCT patients were enrolled from September 2020 to December 2021 and monitored until August 30, 2022. The clinical data were prospectively studied. The peritoneal cancer index classified all 3 patients as stage IV. After surgery, all 3 patients received anlotinib in combination with chemotherapy and reacted to the medication. For all 3 patients, clinical symptoms were substantially eased, and the size of the masses was reduced. Patient 1 and patient 3's progression-free survival had been extended, and anlotinib was continued as a maintenance medication in the 2 patients who were in good health at the end of the follow-up. Patient 2 died of postoperative complications 1 month after second-stage surgery. The main side effects of anlotinib were fatigue and hypertension. However, its toxicity was controllable and tolerable in children patients.
    Conclusions: This is the first report that anlotinib is effective in children with DSRCT. This report may provide an additional option for the treatment of metastatic DSRCT.
    MeSH term(s) Child ; Humans ; Desmoplastic Small Round Cell Tumor/therapy ; Indoles/therapeutic use ; Quinolines ; Treatment Outcome ; Vascular Endothelial Growth Factor A
    Chemical Substances anlotinib ; Indoles ; Quinolines ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000002836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1537: Show issues Location:
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  9. Article ; Online: Piezo2 Contributes to Traumatic Brain Injury by Activating the RhoA/ROCK1 Pathways.

    Xiao, Yinggang / Zhang, Yang / Yuan, Wenjuan / Wang, Cunjin / Ge, Yali / Huang, Tianfeng / Gao, Ju

    Molecular neurobiology

    2024  

    Abstract: Traumatic brain injury (TBI) can lead to short-term and long-term physical and cognitive impairments, which have significant impacts on patients, families, and society. Currently, treatment outcomes for this disease are often unsatisfactory, due at least ...

    Abstract Traumatic brain injury (TBI) can lead to short-term and long-term physical and cognitive impairments, which have significant impacts on patients, families, and society. Currently, treatment outcomes for this disease are often unsatisfactory, due at least in part to the fact that the molecular mechanisms underlying the development of TBI are largely unknown. Here, we observed significant upregulation of Piezo2, a key mechanosensitive ion channel protein, in the injured brain tissue of a mouse model of TBI induced by controlled cortical impact. Pharmacological inhibition and genetic knockdown of Piezo2 after TBI attenuated neuronal death, brain edema, brain tissue necrosis, and deficits in neural function and cognitive function. Mechanistically, the increase in Piezo2 expression contributed to TBI-induced neuronal death and subsequent production of TNF-α and IL-1β, likely through activation of the RhoA/ROCK1 pathways in the central nervous system. Our findings suggest that Piezo2 is a key player in and a potential therapeutic target for TBI.
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-024-04058-y
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  10. Article: Genetically supported causality between gut microbiota and frailty: a two-sample Mendelian randomization study.

    Wang, Zi / Han, Shuai / Xiao, Yinggang / Zhang, Yang / Ge, Yali / Liu, Xin / Gao, Ju

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1324209

    Abstract: Background: A mounting body of evidence suggests a strong connection between gut microbiota and the risk of frailty. However, the question of causality remains unanswered. In this study, we employed a Mendelian randomization (MR) approach to assess ... ...

    Abstract Background: A mounting body of evidence suggests a strong connection between gut microbiota and the risk of frailty. However, the question of causality remains unanswered. In this study, we employed a Mendelian randomization (MR) approach to assess potential causal relationships between gut microbiota and the risk of frailty.
    Materials and methods: Summary statistics for the gut microbiome were obtained from a genome wide association study (GWAS) meta-analysis of the MiBioGen consortium (
    Results: IVW method identified 7 bacterial taxa nominally associated with the risk of FI.
    Conclusion: The MR analysis indicates a causal relationship between specific gut microbiota and FI, offering new insights into the mechanisms underlying FI mediated by gut microbiota.
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1324209
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