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Article ; Online: A metabolomic and proteomic study to elucidate the molecular mechanisms of immunotherapy resistance in patients with oesophageal squamous cell carcinoma.

Gao, Lijuan / Chen, Yongshun

2023 Volume 18, Issue 5, Page(s) 36

Abstract: Systemic chemotherapy, the standard first-line treatment option for patients with advanced oesophageal squamous cell carcinoma (OSCC), results in a median survival of ~1 year. Immune checkpoint inhibitors are a breakthrough oncology treatment option; ... ...

Abstract	Systemic chemotherapy, the standard first-line treatment option for patients with advanced oesophageal squamous cell carcinoma (OSCC), results in a median survival of ~1 year. Immune checkpoint inhibitors are a breakthrough oncology treatment option; however, most patients with advanced OSCC develop primary and acquired resistance to programmed death receptor-1 (PD-1) monoclonal antibody, severely affecting their prognosis. Therefore, there is an urgent need to investigate the molecular mechanism underlying resistance to treatment. The present study aimed to explore the mechanism of resistance to PD-1 monoclonal antibody. Plasma samples were collected from patients with OSCC treated with immunotherapy, who achieved pathological response/partial response (CR/PR) or stable disease/progressive disease (SD/PD) after the fourth treatment cycle. TM-widely targeted metabolomics, widely targeted lipidomics, and DIA proteomics assays were performed. Differential metabolites were screened based on fold change (FC) ≥1.5 or ≤0.67 and a VIP ≥1; differential proteins were screened based on FC >1.5 or <0.67 and P<0.05. The identified metabolites were annotated and mapped using the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway databases. The differential proteins were annotated to the Gene Ontology and KEGG pathway databases. A correlation network diagram was drawn using differential expressed proteins and metabolites with (Pearson correlation coefficient) r>0.80 and P<0.05. Finally, 197 and 113 differential metabolites and proteins were screened, respectively, in patients with CR/PR and SD/PD groups. The KEGG enrichment analysis revealed that all of these metabolites and proteins were enriched in cholesterol metabolism and in the NF-κB and phospholipase D signalling pathways. The present study is the first to demonstrate that PD-1 inhibitor resistance may be attributed to cholesterol metabolism or NF-κB and phospholipase D signalling pathway activation. This finding suggests that targeting these signalling pathways may be a promising novel therapeutic approach in OSCC which may improve prognosis in patients undergoing immunotherapy.
Language	English
Publishing date	2023-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2763624-0
ISSN	2049-9442 ; 2049-9434
ISSN (online)	2049-9442
ISSN	2049-9434
DOI	10.3892/br.2023.1619
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The regulation of intestinal microbiota and the intervention of Chinese herbal medicine in the treatment of ulcerative colitis

Wang Haiou / Li Jinyou / Huang Wenkang / Ye Yiping / Gao Lijuan

Pharmacological Research - Modern Chinese Medicine, Vol 10, Iss , Pp 100356- (2024)

2024

Abstract: Background: The incidence of Ulcerative colitis (UC), a key form of inflammatory bowel disease (IBD) affecting the rectum and colon, is increasing globally. The advancement in microbiome and metabolomics research has revealed the crucial involvement of ... ...

Abstract	Background: The incidence of Ulcerative colitis (UC), a key form of inflammatory bowel disease (IBD) affecting the rectum and colon, is increasing globally. The advancement in microbiome and metabolomics research has revealed the crucial involvement of the intestinal microbiota in the pathogenesis and progression of UC. Chinese herbal medicines, characterized by structural diversity and multiple pharmacological activities, consistently serve as vital sources for developing anti-UC drugs. Methods: In this review, we searched and focused on several online databases, including the Web of Science, Science Direct, PubMed, and Google Scholar, using three keywords: “ulcerative colitis”, “intestinal microbiota”, and “Chinese herbal medicine” from 2013 to 2023. This review aims to uncover the mechanism of action of intestinal microbiota in the occurrence and development of UC and to explore the potential of Chinese herbal medicine in preventing and treating UC within the context of intestinal microbiota regulation. Results: This review summarizes the critical role of the intestinal microbiota in maintaining intestinal homeostasis by facilitating the repair of the intestinal epithelial cell barrier, modulating the immune system, and regulating pivotal metabolisms, including bile acids, amino acids, and short-chain fatty acids. Specifically, Chinese herbal medicines, comprising active ingredients such as polysaccharides, polyphenols, alkaloids, flavonoids, and terpenoids, as well as single Chinese herbal medicines and their extracts (extracts from Pulsatilla chinensis (Bunge) Regelcan, Ceandntella asiatica (L.) Urb., Heritiera littoralis fruit., and so on), and several combination preparations (for example, Ganluyin, Jiawei Gegen Qinlian Decoction, Baitouweng Tang), are capable of preventing and treating UC by regulating the gut flora. This, in turn, contributes to the repair of the intestinal epithelial barrier, modulation of the immune system, and regulation of those metabolisms. Conclusion: Overall, our study presents a ...
Keywords	Ulcerative colitis ; Intestinal microbiota ; Homeostasis ; Chinese herbal medicine ; Active ingredients ; Other systems of medicine ; RZ201-999 ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2024-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Autophagy controls programmed death-ligand 1 expression on cancer cells (Review).

Gao, Lijuan / Chen, Yongshun

Biomedical reports

2021 Volume 15, Issue 4, Page(s) 84

Abstract: Programmed death-ligand 1 (PD-L1) is a transmembrane protein mainly located on cancer cells, including renal cell carcinoma, breast, colorectal, gastric and non-small cell lung cancer. PD-L1 binds to the PD-1 receptor expressed on T lymphocytes to ... ...

Abstract	Programmed death-ligand 1 (PD-L1) is a transmembrane protein mainly located on cancer cells, including renal cell carcinoma, breast, colorectal, gastric and non-small cell lung cancer. PD-L1 binds to the PD-1 receptor expressed on T lymphocytes to inhibit the activation of T lymphocytes, thus allowing tumour cells to escape immune surveillance, leading to tumour growth and the poor prognosis of patients with cancer. Inhibitors targeting the programmed death-1/PD-L1 axis have been widely used in the clinical treatment of a variety of solid tumours in recent years. However, the clinical efficacy of these inhibitors varies. Studies have demonstrated that the effect of the targeted drug is positively associated with the expression of PD-L1 on the tumour membrane. Hence, exploring the mechanism of PD-L1 expression is very important for the treatment of tumours. Autophagy is a physiological process that maintains the stability of the internal environment. Autophagy degrades aging organelles and long-lived proteins and produces nutrients for cell recycling. To the best of our knowledge, the present review is the first to summarize the research that has been conducted on autophagy-regulated PD-L1 expression, which may provide new avenues for tumour immunotherapy.
Language	English
Publishing date	2021-08-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2763624-0
ISSN	2049-9442 ; 2049-9434
ISSN (online)	2049-9442
ISSN	2049-9434
DOI	10.3892/br.2021.1460
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Article ; Online: Programmable Potentials Choreograph Defects in a Colloidal Crystal Shell.

Zhu, Guolong / Gao, Lijuan / Wang, Yuming / Tlusty, Tsvi / Yan, Li-Tang

Physical review letters

2024 Volume 132, Issue 4, Page(s) 48201

Abstract: Crystallization on spherical surfaces is obliged by topology to induce lattice defects. But controlling the organization of such defects remains a great challenge due to the long-range constraints of the curved geometry. Here, we report on DNA-coated ... ...

Abstract	Crystallization on spherical surfaces is obliged by topology to induce lattice defects. But controlling the organization of such defects remains a great challenge due to the long-range constraints of the curved geometry. Here, we report on DNA-coated colloids whose programmable interaction potentials can be used to regulate the arrangement of defects and even achieve perfect icosahedral order on a sphere. Combined simulations and theoretical analysis show how the potential can be tuned by changing the temperature, thereby controlling the number of defects. An explicit expression for the effective potential is derived, allowing us to distinguish the effects of entropic repulsion and enthalpic attraction. Altogether, the present findings provide insights into the physics of crystallization on curved spaces and may be used for designing desired crystal geometries.
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.132.048201
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Article ; Online: Effect of long-term in-row branch covering on soil microorganisms in pear orchards.

Ji, Minghui / Xu, Jintao / Gao, Lijuan / Li, Longfei / Liu, Huan / Hao, Baofeng

Open life sciences

2024 Volume 19, Issue 1, Page(s) 20220807

Abstract: Branches covering (BC) is a way to reuse the pruned branches and save the cost of ground cloth. This study investigated the effects of BC and ground-cloth covering on the soil microcosm environment by measuring the chemical properties and microbial ... ...

Abstract	Branches covering (BC) is a way to reuse the pruned branches and save the cost of ground cloth. This study investigated the effects of BC and ground-cloth covering on the soil microcosm environment by measuring the chemical properties and microbial communities at different soil depths for 6 years. The results revealed that BC significantly improved soil chemical properties, increased the abundance of bacterial microbial communities and the diversity and homogeneity of bacteria and fungi, while decreased the abundance of fungal microbial communities. There was a threshold value for the regulation of microbial communities by BC, which decreased the high-abundance communities (
Language	English
Publishing date	2024-01-29
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2817958-4
ISSN	2391-5412 ; 2391-5412
ISSN (online)	2391-5412
ISSN	2391-5412
DOI	10.1515/biol-2022-0807
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Article ; Online: Non-equilibrium structural and dynamic behaviors of active polymers in complex and crowded environments.

Zhu, Guolong / Gao, Lijuan / Sun, Yihang / Wei, Wenjie / Yan, Li-Tang

Reports on progress in physics. Physical Society (Great Britain)

2024 Volume 87, Issue 5

Abstract: Active matter systems, which convert internal chemical energy or energy from the environment into directed motion, are ubiquitous in nature and exhibit a range of emerging non-equilibrium behaviors. However, most of the current works on active matter ... ...

Abstract	Active matter systems, which convert internal chemical energy or energy from the environment into directed motion, are ubiquitous in nature and exhibit a range of emerging non-equilibrium behaviors. However, most of the current works on active matter have been devoted to particles, and the study of active polymers has only recently come into the spotlight due to their prevalence within living organisms. The intricate interplay between activity and conformational degrees of freedom gives rise to novel structural and dynamical behaviors of active polymers. Research in active polymers remarkably broadens diverse concepts of polymer physics, such as molecular architecture, dynamics, scaling and so on, which is of significant importance for the development of new polymer materials with unique performance. Furthermore, active polymers are often found in strongly interacting and crowded systems and in complex environments, so that the understanding of this behavior is essential for future developments of novel polymer-based biomaterials. This review thereby focuses on the study of active polymers in complex and crowded environments, and aims to provide insights into the fundamental physics underlying the adaptive and collective behaviors far from equilibrium, as well as the open challenges that the field is currently facing.
Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	205657-4
ISSN	1361-6633 ; 0034-4885
ISSN (online)	1361-6633
ISSN	0034-4885
DOI	10.1088/1361-6633/ad3e11
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Article ; Online: CBC-1 as a Cynanbungeigenin C derivative inhibits the growth of colorectal cancer through targeting Hedgehog pathway component GLI 1.

Chen, Jinwen / Chen, Wei / Li, Xiaoyu / Ye, Yiping / Huang, Wenkang / Gao, Lijuan / Zhang, Meng

Steroids

2024 Volume 206, Page(s) 109421

Abstract: Colorectal cancer (CRC) is one of the most common gastrointestinal cancers that results in death in worldwide. The Hedgehog (HH) signalling pathway regulates the initiation and progression of CRC. Inhibiting the HH pathway has been presented as a ... ...

Abstract	Colorectal cancer (CRC) is one of the most common gastrointestinal cancers that results in death in worldwide. The Hedgehog (HH) signalling pathway regulates the initiation and progression of CRC. Inhibiting the HH pathway has been presented as a potential treatment strategy in recent years. Cynanbungeigenin C (CBC) is a new type of C
MeSH term(s)	Humans ; Zinc Finger Protein GLI1/metabolism ; Zinc Finger Protein GLI1/antagonists & inhibitors ; Zinc Finger Protein GLI1/genetics ; Cell Proliferation/drug effects ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/metabolism ; Hedgehog Proteins/metabolism ; Hedgehog Proteins/antagonists & inhibitors ; Animals ; Apoptosis/drug effects ; Signal Transduction/drug effects ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Mice ; Cell Line, Tumor ; Mice, Nude ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Mice, Inbred BALB C
Chemical Substances	Zinc Finger Protein GLI1 ; Hedgehog Proteins ; GLI1 protein, human ; Antineoplastic Agents
Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80312-1
ISSN	1878-5867 ; 0039-128X
ISSN (online)	1878-5867
ISSN	0039-128X
DOI	10.1016/j.steroids.2024.109421
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Article ; Online: Serum irisin correlates to the severity of acute myocardial infarction and predicts the postoperative major adverse cardiovascular events.

Chai, Qiaoying / Zhang, Wei / Gao, Lijuan / Yang, Yingtao / Xin, Shuanli

Biomolecules & biomedicine

2023 Volume 23, Issue 5, Page(s) 785–791

Abstract: Irisin is a myogenic cytokine which plays an important role in the cardiovascular system. The aim of this study was to investigate the correlation between serum irisin levels and major adverse cardiovascular events (MACE) in patients with acute ... ...

Abstract	Irisin is a myogenic cytokine which plays an important role in the cardiovascular system. The aim of this study was to investigate the correlation between serum irisin levels and major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). A total of 207 patients with AMI who underwent PCI were selected as research subjects. Serum irisin levels at admission were measured, and patients were stratified according to the receiver operating characteristic curve to assess differences in MACE within one year after PCI. After one year of follow-up, 207 patients were divided into two groups, 86 with MACE and 121 without MACE. There were significant differences in age, Killip grade, left ventricular ejection fraction, cardiac troponin I, creatine kinase-muscle/brain, and serum irisin between the two groups. Serum irisin level at admission in AMI patients significantly correlated with the occurrence of MACE after PCI, and could be used as an effective marker for predicting the occurrence of MACE in AMI patients after PCI.
MeSH term(s)	Humans ; Fibronectins ; Stroke Volume ; Percutaneous Coronary Intervention/adverse effects ; Ventricular Function, Left ; Myocardial Infarction ; Heart
Chemical Substances	Fibronectins
Language	English
Publishing date	2023-09-04
Publishing country	Bosnia and Herzegovina
Document type	Journal Article
ISSN	2831-090X
ISSN (online)	2831-090X
DOI	10.17305/bb.2023.8888
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Article ; Online: Application of B-ultrasound for localization and its impact on first-attempt success rates of nasogastric tube insertion in critically ill patients.

Gao, Lijuan / Luo, Xiajuan / Deng, Huijie / Shi, Ni / Wen, Xiaohua

Medicine

2023 Volume 102, Issue 50, Page(s) e36452

Abstract: The objective of this study is to explore the application effect of B-ultrasound positioning in assisting nasointestinal tube implantation in critically ill patients. This study is a retrospective study. In this study, 90 cases of severe patients with ... ...

Abstract	The objective of this study is to explore the application effect of B-ultrasound positioning in assisting nasointestinal tube implantation in critically ill patients. This study is a retrospective study. In this study, 90 cases of severe patients with nasointestinal tube implantation were included. According to the different ways of nasointestinal tube insertion received by patients, 61 patients with conventional blind insertion methods were included in the blind insertion group, and 29 patients with conventional methods and B-ultrasound assisted positioning were included in the B-ultrasound positioning group. The general clinical data, success rate of catheterization, catheterization time, pyloric passage rate, and target nutritional value time of the 2 groups were compared. The changes of the 2 groups after catheterization were compared by SOFA and APACHE II. The contents of albumin and lymphocyte count were compared between the 2 groups before and after catheterization. The time of target nutritional value of the patients of the B-ultrasound positioning group was markedly decreased comparing with the patients of the blind insertion group. The index of catheterization time of the patients between the blind insertion group and B-ultrasound positioning group had no obvious contrast. The APACHE II score and SOFA score of the patients of the B-ultrasound positioning group were obviously lower than the blind insertion group. The contents of lymphocyte count of the patients of the B-ultrasound positioning group were markedly increased comparing with the patients of the blind insertion group after catheterization, but the contents of albumin content had no obvious change. The scores of respiratory system, circulatory system, nervous system, and urinary system in the B-ultrasound positioning group were significantly higher than those in the blind insertion group, while the COPT scores were significantly lower than those in the blind insertion group. B-ultrasound assisted nasointestinal tube implantation is well tolerated in critically ill patients, and can effectively ameliorate the nutritional status and of the ill patients.
MeSH term(s)	Humans ; Critical Illness/therapy ; Retrospective Studies ; Intubation, Gastrointestinal/methods ; Enteral Nutrition ; Albumins
Chemical Substances	Albumins
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000036452
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Article: Identifying Active Compounds and Mechanisms of

Chen, Shiyi / Huang, Wenkang / Li, Xiaoyu / Gao, Lijuan / Ye, Yiping

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 2156157

Abstract: Purpose: The ripe fruits of : Methods: The prominent compounds of QFA were acquired from TCMSP database. Their targets were retrieved from SwissTargetPrediction database, and target genes associated with URTIs were collected from DisGeNET and ... ...

Abstract	Purpose: The ripe fruits of Methods: The prominent compounds of QFA were acquired from TCMSP database. Their targets were retrieved from SwissTargetPrediction database, and target genes associated with URTIs were collected from DisGeNET and GeneCards databases. The target protein-protein interaction (PPI) network was constructed by using STRING database and Cytoscape. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were enriched. Visual compound-target-pathway network was established with Cytoscape. The effects of compounds were verified on the inhibitory activities against phosphoinositide 3-kinases (PI3Ks). Finally, the molecular docking was carried out to confirm the binding affinity of the bioactive compounds and target proteins. Results: Five important active compounds, naringenin (NAR), tangeretin (TAN), luteolin (LUT), hesperetin (HES), and auraptene (AUR), were obtained. The enrichment analysis demonstrated that the pathways associated with inflammation mainly contained PI3K/Akt signalling pathway, TNF signalling pathway, and so on. The most important targets covering inflammation-related proteins might be PI3Ks. Conclusion: The results revealed that QFA could treat URTIs through a multi-compound, multi-target, multi-pathway network, in which TAN, LUT, and AUR acted as PI3K
Language	English
Publishing date	2022-07-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/2156157
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