Article ; Online: Me31B: a key repressor in germline regulation and beyond.
2024 Volume 44, Issue 5
Abstract: Maternally Expressed at 31B (Me31B), an evolutionarily conserved ATP-dependent RNA helicase, plays an important role in the development of the germline across diverse animal species. Its cellular functionality has been posited as a translational ... ...
Abstract | Maternally Expressed at 31B (Me31B), an evolutionarily conserved ATP-dependent RNA helicase, plays an important role in the development of the germline across diverse animal species. Its cellular functionality has been posited as a translational repressor, participating in various RNA metabolism pathways to intricately regulate the spatiotemporal expression of RNAs. Despite its evident significance, the precise role and mechanistic underpinnings of Me31B remain insufficiently understood. This article endeavors to comprehensively review historic and recent research on Me31B, distill the major findings, discern generalizable patterns in Me31B's functions across different research contexts, and provide insights into its fundamental role and mechanism of action. The primary focus of this article centers on elucidating the role of Drosophila Me31B within the germline, while concurrently delving into pertinent research on its orthologs within other species and cellular systems. |
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MeSH term(s) | Animals ; Germ Cells/metabolism ; Drosophila Proteins/metabolism ; Drosophila Proteins/genetics ; Gene Expression Regulation, Developmental ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Humans ; RNA Helicases/metabolism ; RNA Helicases/genetics ; Drosophila/genetics ; Drosophila/metabolism |
Chemical Substances | Drosophila Proteins ; RNA Helicases (EC 3.6.4.13) |
Language | English |
Publishing date | 2024-04-10 |
Publishing country | England |
Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural |
ZDB-ID | 764946-0 |
ISSN | 1573-4935 ; 0144-8463 |
ISSN (online) | 1573-4935 |
ISSN | 0144-8463 |
DOI | 10.1042/BSR20231769 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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