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  1. Article ; Online: A novel HLA-A null allele, HLA-A*31:188N, identified by next-generation sequencing in a Chinese individual.

    Gao, Su-Qing

    HLA

    2022  Volume 100, Issue 1, Page(s) 70–71

    Abstract: The HLA-A*31:188N allele differs from A*31:01:02:01 by a single nucleotide deletion in exon 3. ...

    Abstract The HLA-A*31:188N allele differs from A*31:01:02:01 by a single nucleotide deletion in exon 3.
    MeSH term(s) Alleles ; Asians/genetics ; China ; HLA-A Antigens/genetics ; High-Throughput Nucleotide Sequencing ; Humans
    Chemical Substances HLA-A Antigens
    Language English
    Publishing date 2022-03-21
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.14596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Full-length sequence of the novel allele, HLA-B*58:01:40, identified in a Chinese individual.

    Yang, Fan / Peng, Long / Gao, Su-Qing

    HLA

    2024  Volume 103, Issue 3, Page(s) e15378

    Abstract: HLA-B*58:01:40 differs from HLA-B*58:01:01 by a single nucleotide change in exon 3, 507 C- > T (codon 145.3 CGC- > CGT). ...

    Abstract HLA-B*58:01:40 differs from HLA-B*58:01:01 by a single nucleotide change in exon 3, 507 C- > T (codon 145.3 CGC- > CGT).
    MeSH term(s) Humans ; Alleles ; Genes, MHC Class I ; Asian People/genetics ; HLA-B Antigens/genetics ; China
    Chemical Substances HLA-B Antigens
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.15378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Using Next-Generation Sequencing Technology to Confirm the HLA Rare Alleles Detected by PCR-SSOP].

    Zhong, Xian-Xin / Wu, Wang-Da / Quan, Zhan-Rou / Gao, Su-Qing

    Zhongguo shi yan xue ye xue za zhi

    2023  Volume 31, Issue 1, Page(s) 203–208

    Abstract: Objective: To confirm the HLA genotypes of the samples including 4 cases of magnetic bead probe HLA genotyping result pattern abnormality and 3 cases of ambiguous result detected by PCR sequence-specific oligonudeotide probe (SSOP) method.: Methods: ... ...

    Abstract Objective: To confirm the HLA genotypes of the samples including 4 cases of magnetic bead probe HLA genotyping result pattern abnormality and 3 cases of ambiguous result detected by PCR sequence-specific oligonudeotide probe (SSOP) method.
    Methods: All samples derived from HLA high-resolution typing laboratory were detected by PCR-SSOP. A total of 4 samples of magnetic bead probe HLA genotyping result pattern abnormality and 3 samples of ambiguous result were further confirmed by PCR sequence-based typing (SBT) technology and next-generation sequencing (NGS) technology.
    Results: A total of 4 samples of magnetic bead probe HLA genotyping result pattern abnormality were detected by PCR-SSOP method. The results of SBT and NGS showed that the
    Conclusion: The abnormal pattern of HLA genotyping results of magnetic probe by PCR-SSOP method suggests that it may be a rare allele or a novel allele, which needs to be verified by sequencing.
    MeSH term(s) Humans ; Alleles ; Polymerase Chain Reaction ; Genotype ; High-Throughput Nucleotide Sequencing ; Histocompatibility Testing/methods ; Technology
    Language Chinese
    Publishing date 2023-02-10
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2404306-0
    ISSN 1009-2137
    ISSN 1009-2137
    DOI 10.19746/j.cnki.issn.1009-2137.2023.01.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A novel HLA-C null allele, HLA-C*08:236N, identified by next-generation sequencing in a Chinese individual.

    Gao, Su-Qing / Zhong, Yan-Ping / Zhang, Yin-Ming

    HLA

    2022  Volume 101, Issue 2, Page(s) 184–185

    Abstract: HLA-C*08:236N differs from C*08:01:01 by a single nucleotide exchange in exon 5 at position 1991. ...

    Abstract HLA-C*08:236N differs from C*08:01:01 by a single nucleotide exchange in exon 5 at position 1991.
    MeSH term(s) Humans ; HLA-C Antigens/genetics ; Alleles ; East Asian People ; Asian People/genetics ; High-Throughput Nucleotide Sequencing
    Chemical Substances HLA-C Antigens
    Language English
    Publishing date 2022-11-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.14861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Discovery of the HLA-C*08:99 allele in a Chinese individual.

    Gao, Su-Qing / Zhong, Yan-Ping / Pen, Long / Ye, Xian-Lin

    HLA

    2022  Volume 100, Issue 3, Page(s) 278–280

    Abstract: HLA-C*08:99 differs by one non-synonymous nucleotide from C*08:01:01 in exon 5, codon 288 GTT>ATT. ...

    Abstract HLA-C*08:99 differs by one non-synonymous nucleotide from C*08:01:01 in exon 5, codon 288 GTT>ATT.
    MeSH term(s) Alleles ; Asians/genetics ; China ; Exons/genetics ; HLA-C Antigens/genetics ; High-Throughput Nucleotide Sequencing ; Humans
    Chemical Substances HLA-C Antigens
    Language English
    Publishing date 2022-06-13
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.14686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Discovery of the novel HLA-A*11:452N allele by next-generation sequencing in a Chinese individual.

    Gao, Su-Qing / Xu, Yun-Ping / Li, Da-Cheng / Zhang, Hao / Peng, Long

    HLA

    2023  Volume 103, Issue 1, Page(s) e15247

    Abstract: HLA-A*11:452N differs from A*11:01:01:01 by a single nucleotide exchange in exon 1. ...

    Abstract HLA-A*11:452N differs from A*11:01:01:01 by a single nucleotide exchange in exon 1.
    MeSH term(s) Humans ; Alleles ; China ; High-Throughput Nucleotide Sequencing ; HLA-A Antigens/genetics ; East Asian People/genetics
    Chemical Substances HLA-A Antigens
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.15247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 661: Show issues Location:
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  7. Article ; Online: Genomic sequence of the novel HLA-A*26:206:02N allele, identified in a patient with hepatitis B infection.

    Gao, Su-Qing / Li, Da-Cheng / Peng, Long / Zhang, Hao / Xu, Yun-Ping

    HLA

    2023  Volume 102, Issue 6, Page(s) 750–752

    Abstract: HLA-A*26:206:02N differs from A*26:01:01:01 by a single nucleotide exchange in exon 3. ...

    Abstract HLA-A*26:206:02N differs from A*26:01:01:01 by a single nucleotide exchange in exon 3.
    MeSH term(s) Humans ; Alleles ; Exons/genetics ; Genomics ; HLA-A Antigens/genetics ; Hepatitis B/genetics ; High-Throughput Nucleotide Sequencing
    Chemical Substances HLA-A Antigens
    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.15232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Establish a Graded Method to Avoid HLA Class I Antibodies Corresponding Antigen and Combining HLAMatchmaker Application in Improving the CCI Value after Platelet Transfusion for Patients with IPTR].

    Gao, Su-Qing / Xu, Yun-Ping / Luo, Chang-Ru / Li, Da-Cheng / Pen, Long / Liu, Tong / Zou, Qiong-Cai

    Zhongguo shi yan xue ye xue za zhi

    2024  Volume 32, Issue 1, Page(s) 242–249

    Abstract: Objective: To establish a graded method to avoid mean fluorescence intensity (MFI) threshold of HLA Class I antibodies corresponding antigen, and the HLAMatchmaker program has been used to select the minimum mismatch value of donor-patient epitopes. ... ...

    Abstract Objective: To establish a graded method to avoid mean fluorescence intensity (MFI) threshold of HLA Class I antibodies corresponding antigen, and the HLAMatchmaker program has been used to select the minimum mismatch value of donor-patient epitopes. Evaluate the application value of combining both methods in selecting HLA compatible platelets (PTL) for patients with immune platelet transfusion failure (IPTR) in improving platelet the corrected count increment (CCI).
    Methods: A total 7 807 PLT cross-matching compatible were performed by the solid-phase red cell adherence (SPRCA) method for 51 IPTR patients. The Luminex single antigen flow cytometry was used to detect HLA Class I antibodies in patients, and detected the MFI value for different specificity antigens of HLA Class I antibodies, was graded into strong positive group (MFI>4 000, level 1), medium positive group (1 000< MFI≤4 000, 2), weak positive group (500< MFI≤1 000, 3), and one negative control group (MFI≤500). The results of 7 807 SPRCA their negative/positive reaction wells were enrolled and statistically analyzed in different grades and the four groups, the statistical differences between the four groups were compared. Multiple applications for the select HLA Class I compatible donor events were made for patients in two cases, and HLAMatchmaker program was used to calculate the number of HLA Class I epitopes mismatches between the donors and patients. The donor with the minimum number of epitopes mismatches was selected, while avoiding the corresponding antigens of HLA Class I antibodies in levels 1 and 2, the provision of HLA compatible platelets for IPTR. After the transfusions, the CCI value of the platelet transfusion efficacy evaluation index was calculated, and the clinical evaluation of the transfusion effect was obtained through statistical analysis.
    Results: There were statistically significant differences in the positive results of SPRCA immunoassay among the strong positive group, medium positive group, and weak positive group of 51 IPTR patients with different specific of HLA -I class antibodies and corresponding antigens(all
    Conclusion: When selecting HLA Class I compatible donors for IPTR patients, the grading avoids HLA Class I antibodies corresponding to donor antigens, and the donor selection strategy with the minimum scores of HLAMatchmaker program is comprehensively selected. The negative result confirmed by platelet cross-matching experiments has certain practical application value for improving platelet count in IPTR patients.
    MeSH term(s) Humans ; Blood Platelets ; Blood Transfusion ; Epitopes ; Histocompatibility Antigens Class I ; Histocompatibility Testing ; HLA Antigens ; Isoantibodies ; Platelet Transfusion ; Blood Grouping and Crossmatching
    Chemical Substances Epitopes ; Histocompatibility Antigens Class I ; HLA Antigens ; Isoantibodies
    Language Chinese
    Publishing date 2024-02-20
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2404306-0
    ISSN 1009-2137
    ISSN 1009-2137
    DOI 10.19746/j.cnki.issn.1009-2137.2024.01.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [The Polymorphism Analysis of HLA Class II Alleles Based on Next-Generation Sequencing and Prevention Strategy for Allele Dropout].

    Gao, Su-Qing / Quan, Zhan-Rou / Zhong, Yan-Ping / Chen, Hao / He, Liu-Mei / Zou, Hong-Yan / Deng, Zhi-Hui

    Zhongguo shi yan xue ye xue za zhi

    2024  Volume 32, Issue 2, Page(s) 603–609

    Abstract: Objective: To investigate the accuracy of next-generation sequencing technology (NGS) in detecting the polymorphisms of : Methods: NGS-based HLA class II genotyping was performed on 1 012 samples using the MiSeqDx: Results: A total of 139 alleles ... ...

    Abstract Objective: To investigate the accuracy of next-generation sequencing technology (NGS) in detecting the polymorphisms of
    Methods: NGS-based HLA class II genotyping was performed on 1 012 samples using the MiSeqDx
    Results: A total of 139 alleles were detected, including
    Conclusion: The HLA genotyping results based on NGS showed a significantly lower ambiguity rate. The HLA class II alleles exhibit genetic polymorphism in the Han population of unrelated healthy individuals in Shenzhen. The independent method based on NGS in clinical histocompatibility testing has limitations and requires internal quality control strategies to avoid allele-dropout events.
    MeSH term(s) Humans ; Alleles ; Gene Frequency ; Genotype ; High-Throughput Nucleotide Sequencing ; Polymorphism, Genetic ; East Asian People/genetics ; Histocompatibility Antigens Class II/genetics
    Chemical Substances Histocompatibility Antigens Class II
    Language Chinese
    Publishing date 2024-04-15
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2404306-0
    ISSN 1009-2137
    ISSN 1009-2137
    DOI 10.19746/j.cnki.issn.1009-2137.2024.02.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Identification of the novel HLA-DRB3*02:02:19 allele.

    Li, Da-Cheng / Zhong, Yan-Ping / Quan, Zhan-Rou / Chen, Hao / Gao, Su-Qing

    HLA

    2021  Volume 98, Issue 5, Page(s) 488–490

    Abstract: The HLA-DRB3*02:02:19 allele differs from DRB3*02:02:01:02 by a single nucleotide change in exon 2. ...

    Abstract The HLA-DRB3*02:02:19 allele differs from DRB3*02:02:01:02 by a single nucleotide change in exon 2.
    MeSH term(s) Alleles ; Exons/genetics ; HLA-DRB1 Chains/genetics ; HLA-DRB3 Chains/genetics ; Histocompatibility Testing ; Humans ; Nucleotides
    Chemical Substances HLA-DRB1 Chains ; HLA-DRB3 Chains ; Nucleotides
    Language English
    Publishing date 2021-08-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.14404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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