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  1. Article ; Online: HPLC and LC-MS/MS-Based Quantitative Characterization of Related Substances Associated with Sotalol Hydrochloride.

    Zhu, Pengyan / Shen, Xiaojing / Wang, Xinting / Liu, Xinlan / Zhang, Yingshuang / Wang, Ke / Gao, Wenfen / Wang, Xuanjun / Yuan, Wenjuan

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 3

    Abstract: In total, three related substances (RS) associated with sotalol hydrochloride (STHCl) were herein identified with a novel gradient high-performance liquid chromatography (HPLC) protocol. Further characterization of these substances was then performed via ...

    Abstract In total, three related substances (RS) associated with sotalol hydrochloride (STHCl) were herein identified with a novel gradient high-performance liquid chromatography (HPLC) protocol. Further characterization of these substances was then performed via liquid chromatography-mass spectroscopy (LC-MS/MS) and nuclear magnetic resonance (NMR) approaches. For these analyses, commercial STHCl samples were used for quantitative HPLC studies and the degradation of STHCl under acidic (1M HCl), alkaline (1M NaOH), oxidative (30% H
    MeSH term(s) Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid/methods ; Sotalol/pharmacology ; Tandem Mass Spectrometry/methods ; Hydrogen Peroxide ; Liquid Chromatography-Mass Spectrometry ; Drug Stability ; Hydrolysis ; Oxidation-Reduction ; Photolysis
    Chemical Substances Sotalol (A6D97U294I) ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29030588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  2. Article: Two new steroidal alkaloids with cytotoxic activities from the roots of Veratrum grandiflorum Loes

    Yuan, Wen-Juan / Zhu, Peng-Yan / Qiao, Miao / Gao, Wen-Fen / Li, Guo-Dong / Wang, Xuan-Jun / Sheng, Jun

    Phytochemistry letters. 2021 Dec., v. 46

    2021  

    Abstract: Two new steroidal alkaloids, Grandivine A and B (1 and 3), together with eight known related compounds were obtained from the roots of Veratrum grandiflorum Loes. The structures of the compounds were elucidated though extensive spectroscopic techniques. ... ...

    Abstract Two new steroidal alkaloids, Grandivine A and B (1 and 3), together with eight known related compounds were obtained from the roots of Veratrum grandiflorum Loes. The structures of the compounds were elucidated though extensive spectroscopic techniques. Compounds 3 and 4 exhibited moderate cytotoxic effects against four cancer cell lines.
    Keywords Veratrum ; cytotoxicity ; neoplasm cells ; plant biochemistry ; spectroscopy
    Language English
    Dates of publication 2021-12
    Size p. 56-60.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2021.08.012
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Diterpenes with potential treatment of vitiligo from the aerials parts of Euphorbia antiquorum L.

    Yuan, Wen-Juan / Gao, Wen-Fen / Zhao, Jiang-Yu / Zhang, Yu / Chen, Duo-Zhi / Li, Shun-Lin / Di, Ying-Tong / Hao, Xiao-Jiang

    Fitoterapia

    2020  Volume 144, Page(s) 104583

    Abstract: Six new diterpenes Euphonoids A-F including one ingenol (1), three lathyrane (2-5), one ent-abietane (6) and fifteen known derivatives (7-21) were isolated from the aerial parts of Euphorbia antiquorum L. Their structures were elucidated by physical data ...

    Abstract Six new diterpenes Euphonoids A-F including one ingenol (1), three lathyrane (2-5), one ent-abietane (6) and fifteen known derivatives (7-21) were isolated from the aerial parts of Euphorbia antiquorum L. Their structures were elucidated by physical data analysis. Compounds 1, 12, and 16 improve the melanogenesis in B16 cells in vitro.
    MeSH term(s) Animals ; Cell Line, Tumor ; China ; Diterpenes/isolation & purification ; Diterpenes/pharmacology ; Euphorbia/chemistry ; Melanins/analysis ; Melanoma, Experimental/drug therapy ; Mice ; Molecular Structure ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Components, Aerial/chemistry ; Vitiligo/metabolism
    Chemical Substances Diterpenes ; Melanins ; Phytochemicals
    Language English
    Publishing date 2020-03-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 412385-2
    ISSN 1873-6971 ; 0367-326X
    ISSN (online) 1873-6971
    ISSN 0367-326X
    DOI 10.1016/j.fitote.2020.104583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1873: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Preparation and characterization of genipin-cross-linked silk fibroin/chitosan sustained-release microspheres.

    Zeng, Shuguang / Ye, Manwen / Qiu, Junqi / Fang, Wei / Rong, Mingdeng / Guo, Zehong / Gao, Wenfen

    Drug design, development and therapy

    2015  Volume 9, Page(s) 2501–2514

    Abstract: We report the effects of distinct concentrations of genipin and silk fibroin (SF):chitosan (CS) ratios on the formation of SF-CS composite microspheres. We selected microspheres featuring an SF:CS ratio of 1:1, encapsulated various concentrations of ... ...

    Abstract We report the effects of distinct concentrations of genipin and silk fibroin (SF):chitosan (CS) ratios on the formation of SF-CS composite microspheres. We selected microspheres featuring an SF:CS ratio of 1:1, encapsulated various concentrations of bovine serum albumin (BSA), and then compared their encapsulation efficiency and sustained-release rate with those of pure CS microspheres. We determined that the following five groups of microspheres were highly spherical and featured particle sizes ranging from 70 μm to 147 μm: mass ratio of CS:SF =1:0.5, 0.1 g or 0.5 g genipin; CS:SF =1:1, 0.05 g or 1 g genipin; and CS:SF =1:2, 0.5 g genipin. The microspheres prepared using 1:1 CS:SF ratio and 0.05 g genipin in the presence of 10 mg, 20 mg, and 50 mg of BSA exhibited encapsulation efficiencies of 50.16%±4.32%, 56.58%±3.58%, and 42.19%±7.47%, respectively. Fourier-transform infrared spectroscopy (FTIR) results showed that SF and CS were cross-linked and that the α-helices and random coils of SF were converted into β-sheets. BSA did not chemically react with CS or SF. Moreover, thermal gravimetric analysis (TGA) results showed that the melting point of BSA did not change, which confirmed the FTIR results, and X-ray diffraction results showed that BSA was entrapped in microspheres in a noncrystalline form, which further verified the TGA and FTIR data. The sustained-release microspheres prepared in the presence of 10 mg, 20 mg, and 50 mg of BSA burst release 30.79%±3.43%, 34.41%±4.46%, and 41.75%±0.96% of the entrapped BSA on the 1st day and cumulatively released 75.20%±2.52%, 79.16%±4.31%, and 89.04%±4.68% in 21 days, respectively. The pure CS microspheres prepared in the presence of 10 mg of BSA burst release 39.53%±1.76% of BSA on the 1st day and cumulatively released 83.57%±2.33% of the total encapsulated BSA in 21 days. The SF-CS composite microspheres exhibited higher sustained release than did the pure CS microspheres, and thus these composite microspheres might function as a superior drug carrier.
    MeSH term(s) Chitosan/chemistry ; Cross-Linking Reagents ; Delayed-Action Preparations ; Drug Compounding ; Fibroins/chemistry ; Iridoids/chemistry ; Microspheres ; Particle Size ; Serum Albumin, Bovine/chemistry ; Silk/chemistry ; Solubility ; Surface Properties ; Thermogravimetry ; Water/analysis ; X-Ray Diffraction
    Chemical Substances Cross-Linking Reagents ; Delayed-Action Preparations ; Iridoids ; Silk ; Water (059QF0KO0R) ; Serum Albumin, Bovine (27432CM55Q) ; Fibroins (9007-76-5) ; Chitosan (9012-76-4) ; genipin (A3V2NE52YG)
    Language English
    Publishing date 2015
    Publishing country New Zealand
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S78402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: (±)-Perforison A, A Pair of New Chromone Enantiomers from Harrisonia perforata.

    Yuan, Wen-Juan / Gao, Wen-Fen / Zhang, Jia-Hui / Cao, Pei / Zhang, Yu / Chen, Duo-Zhi / Li, Shun-Lin / Di, Ying-Tong / Hao, Xiao-Jiang

    Natural product communications

    2018  Volume 12, Issue 1, Page(s) 63–65

    Abstract: Perforison A and (-)-perforison A, a new pair of chromone enantiomers, along with four known compounds, were isolated from the leaves and stems of Harrisonia perforata. Their structures and absolute configurations were determined on the basis of ... ...

    Abstract (+)-Perforison A and (-)-perforison A, a new pair of chromone enantiomers, along with four known compounds, were isolated from the leaves and stems of Harrisonia perforata. Their structures and absolute configurations were determined on the basis of extensive analysis of spectroscopic data and electronic circular dichroism (ECD) calculations. The cytotoxic activities in vitro of these compounds were evaluated, but none showed significant activity.
    MeSH term(s) Antineoplastic Agents, Phytogenic/pharmacology ; Cell Line, Tumor ; Chromones/chemistry ; Circular Dichroism ; Drug Screening Assays, Antitumor ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Negative Results ; Plant Leaves/chemistry ; Plant Stems/chemistry ; Simaroubaceae/chemistry ; Stereoisomerism
    Chemical Substances Antineoplastic Agents, Phytogenic ; Chromones
    Language English
    Publishing date 2018-11-22
    Publishing country United States
    Document type Journal Article
    ISSN 1934-578X
    ISSN 1934-578X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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