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  1. Article ; Online: Preparation of copper nanoparticles fluorescent probes and detection of hydrogen peroxide and glucose.

    Shi, Lin / Gao, Wuyang / Ma, Tianfeng / Xu, Xiaohua / Wang, Huan / Lu, Yongchang

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2024  Volume 311, Page(s) 123980

    Abstract: Fluorescent copper nanoparticles (CuNPs) was synthesized by one-step chemical reduction method using ascorbic acid (AA) and copper sulfate ( ... ...

    Abstract Fluorescent copper nanoparticles (CuNPs) was synthesized by one-step chemical reduction method using ascorbic acid (AA) and copper sulfate (CuSO
    MeSH term(s) Humans ; Glucose/analysis ; Hydrogen Peroxide/analysis ; Copper/chemistry ; Fluorescent Dyes/chemistry ; Glucose Oxidase ; Nanoparticles ; Limit of Detection
    Chemical Substances Glucose (IY9XDZ35W2) ; Hydrogen Peroxide (BBX060AN9V) ; Copper (789U1901C5) ; Fluorescent Dyes ; Glucose Oxidase (EC 1.1.3.4)
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2024.123980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  2. Article ; Online: Collagen Tubular Airway-on-Chip for Extended Epithelial Culture and Investigation of Ventilation Dynamics.

    Gao, Wuyang / Kanagarajah, Kayshani R / Graham, Emma / Soon, Kayla / Veres, Teodor / Moraes, Theo J / Bear, Christine E / Veldhuizen, Ruud A / Wong, Amy P / Günther, Axel

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2309270

    Abstract: The lower respiratory tract is a hierarchical network of compliant tubular structures that are made from extracellular matrix proteins with a wall lined by an epithelium. While microfluidic airway-on-a-chip models incorporate the effects of shear and ... ...

    Abstract The lower respiratory tract is a hierarchical network of compliant tubular structures that are made from extracellular matrix proteins with a wall lined by an epithelium. While microfluidic airway-on-a-chip models incorporate the effects of shear and stretch on the epithelium, week-long air-liquid-interface culture at physiological shear stresses, the circular cross-section, and compliance of native airway walls have yet to be recapitulated. To overcome these limitations, a collagen tube-based airway model is presented. The lumen is lined with a confluent epithelium during two-week continuous perfusion with warm, humid air while presenting culture medium from the outside and compensating for evaporation. The model recapitulates human small airways in extracellular matrix composition and mechanical microenvironment, allowing for the first time dynamic studies of elastocapillary phenomena associated with regular breathing and mechanical ventilation, as well as their impacts on the epithelium. A case study reveales increasing damage to the epithelium during repetitive collapse and reopening cycles as opposed to overdistension, suggesting expiratory flow resistance to reduce atelectasis. The model is expected to promote systematic comparisons between different clinically used ventilation strategies and, more broadly, to enhance human organ-on-a-chip platforms for a variety of tubular tissues.
    Language English
    Publishing date 2024-03-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202309270
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  3. Article ; Online: One-Step Formation of Protein-Based Tubular Structures for Functional Devices and Tissues.

    Gao, Wuyang / Vaezzadeh, Nima / Chow, Kelvin / Chen, Haotian / Lavender, Patricia / Jeronimo, Mark D / McAllister, Arianna / Laselva, Onofrio / Jiang, Jia-Xin / Gage, Blair K / Ogawa, Shinichiro / Ramchandran, Arun / Bear, Christine E / Keller, Gordon M / Günther, Axel

    Advanced healthcare materials

    2021  Volume 10, Issue 8, Page(s) e2001746

    Abstract: Tubular biological structures consisting of extracellular matrix (ECM) proteins and cells are basic functional units of all organs in animals and humans. ECM protein solutions at low concentrations (5-10 milligrams per milliliter) are abundantly used in ... ...

    Abstract Tubular biological structures consisting of extracellular matrix (ECM) proteins and cells are basic functional units of all organs in animals and humans. ECM protein solutions at low concentrations (5-10 milligrams per milliliter) are abundantly used in 3D cell culture. However, their poor "printability" and minute-long gelation time have made the direct extrusion of tubular structures in bioprinting applications challenging. Here, this limitation is overcome and the continuous, template-free conversion of low-concentration collagen, elastin, and fibrinogen solutions into tubular structures of tailored size and radial, circumferential and axial organization is demonstrated. The approach is enabled by a microfabricated printhead for the consistent circumferential distribution of ECM protein solutions and lends itself to scalable manufacture. The attached confinement accommodates minute-long residence times for pH, temperature, light, ionic and enzymatic gelation. Chip hosted ECM tubular structures are amenable to perfusion with aqueous solutions and air, and cyclic stretching. Predictive collapse and reopening in a crossed-tube configuration promote all-ECM valves and pumps. Tissue level function is demonstrated by factors secreted from cells embedded within the tube wall, as well as endothelial or epithelial barriers lining the lumen. The described approaches are anticipated to find applications in ECM-based organ-on-chip and biohybrid structures, hydraulic actuators, and soft machines.
    MeSH term(s) Animals ; Bioprinting ; Collagen ; Elastin ; Extracellular Matrix ; Humans ; Tissue Engineering
    Chemical Substances Collagen (9007-34-5) ; Elastin (9007-58-3)
    Language English
    Publishing date 2021-03-10
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202001746
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6966: Show issues Location:
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  4. Article: [Expression of survivin protein in prostatic carcinoma tissues and its correlation with apoptosis of cancer cells].

    Gao, Wuyang / Hu, Chuanyi / Yi, Muhua

    Zhonghua nan ke xue = National journal of andrology

    2004  Volume 10, Issue 1, Page(s) 12–14

    Abstract: Objective: To investigate the expression of survivin protein in the tissues of prostatic carcinoma and its correlation with apoptosis of cancer cells.: Methods: Expression of survivin protein and apoptosis index(AI) were detected by ... ...

    Abstract Objective: To investigate the expression of survivin protein in the tissues of prostatic carcinoma and its correlation with apoptosis of cancer cells.
    Methods: Expression of survivin protein and apoptosis index(AI) were detected by immunohistochemical and terminal deoxynucleotidyl transterase-mediated dUTP biotin nich end labeling(TUNEL) technique in the tissues of 42 cases of prostatic carcinima (PCa) and 10 cases of normal prostate (NP).
    Results: Survivin prosteins were expressed in 34 of the 42 (80.59%) cases of PCa. The positive rate of survivin was strongly associated with pathological grades, clinical stages and lymphmetastasis in PCa(P < 0.05). In contrast, NP did not express survivin. Survivin protein expression was negatively correlated with AI in PCa(r = -0.679, P < 0.001).
    Conclusions: Apoptosis inhibition by survivin may participate in the onset and progression of PCa, and the detection of survivin protein and AI in PCa may help to evaluate the degree of cell differentiation, decide therapeutic strategies and estimate prognosis.
    MeSH term(s) Aged ; Apoptosis ; Humans ; Immunohistochemistry ; Inhibitor of Apoptosis Proteins ; Male ; Microtubule-Associated Proteins/analysis ; Middle Aged ; Neoplasm Proteins ; Prostatic Neoplasms/chemistry ; Prostatic Neoplasms/pathology
    Chemical Substances BIRC5 protein, human ; Inhibitor of Apoptosis Proteins ; Microtubule-Associated Proteins ; Neoplasm Proteins
    Language Chinese
    Publishing date 2004-01
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6577: Show issues Location:
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  5. Article: [Experimental study of vasoligation in the treatment and prevention of benign prostatic hyperplasia].

    Guo, Xian-Kun / Bian, Jiang / Nie, Yong / Zhang, Zhao-Xiang / Li, Wen-Li / Zhang, Yan / Gao, Wu-Yang / Feng, Yong-Ju / Cheng, Shi-Ping / Xiang, Yan-Jiu

    Zhonghua nan ke xue = National journal of andrology

    2003  Volume 9, Issue 1, Page(s) 20–23

    Abstract: Objectives: To investigate the possibility and efficacy of vasoligation and deferent vein ligation in treating and preventing benign prostatic hyperplasia(BPH).: Methods: 40 male pooches were divided into A, B, C and D groups randomly. Each group has ...

    Abstract Objectives: To investigate the possibility and efficacy of vasoligation and deferent vein ligation in treating and preventing benign prostatic hyperplasia(BPH).
    Methods: 40 male pooches were divided into A, B, C and D groups randomly. Each group has 10 pooches group A and B were made into the model of BPH. Two years later, the pooches in group A and C accepted the operation of vasoligation and deferent vein ligation on both sides. Group B and D only accepted the operation of dissection and relieving its deferent duct. Then continuing to feed the 40 pooches after the operation, they were killed another two years later. After taking out their prostates and calculating their volume and weight, the sections of the prostates were checked by microscope to observe their histology and pathology changes.
    Results: There were significant differences of weight and volume as well as the changes of histology and pathology between group A and group C (P < 0.01). It was the same with group B and D (hyperplasia changes).
    Conclusions: Vasoligation and deferent vein ligation before benign prostatic hyperplasia at pooches grow-up stage can reduce the extent of BPH at old age, and treatment after benign prostatic hyperplasia can make prostatic tissue appear different degrees of atrophy.
    MeSH term(s) Animals ; Disease Models, Animal ; Dogs ; Ligation ; Male ; Prostatic Hyperplasia/prevention & control ; Prostatic Hyperplasia/therapy ; Vasectomy
    Language Chinese
    Publishing date 2003-02
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6577: Show issues Location:
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  6. Article: [A survey of the long-term incidence rate of benign prostate hyperplasia after vasectomy].

    Nie, Yong / Guo, Xian-kun / Gao, Wu-yang / Zhang, Yan / Li, Wen-li / Cheng, Qi-xiu / Bian, Jiang / Wang, Yi / Zhou, Cheng-gui / Cheng, Shi-ping

    Zhonghua yi xue za zhi

    2003  Volume 83, Issue 15, Page(s) 1303–1305

    Abstract: Objective: To study the relationship of the long-term incidence rate of benign prostate hyperplasia (BPH) after vasectomy to age and time after operation.: Method: Questionnaire survey, physical examination, and ultrasonography were conducted among ... ...

    Abstract Objective: To study the relationship of the long-term incidence rate of benign prostate hyperplasia (BPH) after vasectomy to age and time after operation.
    Method: Questionnaire survey, physical examination, and ultrasonography were conducted among 850 healthy males, aged 55 - 76 who underwent vasectomy more than 20 years before and 390 healthy males, aged 53 - 75, who had not undergone vasectomy in Yichang, Hubei province, selected by randomized cluster sampling. The data such as international prostate symptom scoring (IPSS), quality of life (QOL) index, maximum urine flow rate (MFR), and average flow rate (AFR), digital rectal examination (DRE), volume of prostate gland (V), and residual urine (R) were analyzed.
    Results: The general BPH incidence rate of the vasectomy group was 10.8%, significantly lower than that of the control group (40.8%, P < 0.01). The age-specific BPH incidence rates in the vasetomy group were all significantly lower than those of the control group, especially that of the subjects aged over 70 (10.8% vs. 56.5%, P < 0.001). The BPH incidence rate of those who had undergone vasectomy 25 years or over before was 7.8%, significantly lower than that of those who had undergone vasectomy 20 years before (13.2%, P < 0.05), but not significantly difference from that of those who had undergone vasectomy 30 years or over before (5.5%, P > 0.05). The volumes of prostate gland in all age subgroups were significantly smaller in the vasectomy group than in the control group.
    Conclusion: Vasectomy reduces the incidence rate of BPH significantly.
    MeSH term(s) Age Factors ; Aged ; Humans ; Incidence ; Male ; Middle Aged ; Prostatic Hyperplasia/epidemiology ; Time Factors ; Vasectomy
    Language Chinese
    Publishing date 2003-08-10
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 132513-9
    ISSN 0376-2491
    ISSN 0376-2491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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