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  1. Article: A novel ent-pimarane-type diterpenoid from Sigesbeckia glabrescens with anti-inflammatory activity

    Gao, Xiao-Xu / Jiang, Su-Zhen / Wang, Jing / Jia, Jing-Ming / Wang, An-Hua

    Journal of Asian natural products research. 2022 Mar. 4, v. 24, no. 3

    2022  

    Abstract: A novel ent-pimarane-type diterpenoid, sigesbeckia J (1), along with two known diterpenoids, siegesbeckia acid (2) and ent-18-acetoxy-16R,17-dihydroxykauran-19-oic acid (3), were isolated from the aerial parts of Sigesbeckia glabrescens Makino. Their ... ...

    Abstract A novel ent-pimarane-type diterpenoid, sigesbeckia J (1), along with two known diterpenoids, siegesbeckia acid (2) and ent-18-acetoxy-16R,17-dihydroxykauran-19-oic acid (3), were isolated from the aerial parts of Sigesbeckia glabrescens Makino. Their chemical structures were elucidated based on extensive spectroscopic interpretation. The absolute configuration of ent-pimarane-type diterpenoid (1) was determined by comparing experimental and calculated ECD spectra. Compared with the positive control minocycline (IC₅₀ 32.84 μM), compound 1 exhibited moderate cell growth anti-inflammatory activities in vitro by testing their inhibition of LPS-induced NO production in BV2 microglial cells, with IC₅₀ value of 58.74 μM.
    Keywords Sigesbeckia glabrescens ; anti-inflammatory activity ; cell growth ; diterpenoids ; minocycline ; research ; spectral analysis
    Language English
    Dates of publication 2022-0304
    Size p. 296-302.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2021.1915994
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Sophoranone A and B: two new cytotoxic prenylated metabolites and their analogs from the root bark of Sophora flavescens

    Long, Guo-Qing / Hu, Gao-Sheng / Gao, Xiao-Xu / Jia, Jing-Ming / Wang, Anhua

    Natural Product Research. 2022 Mar. 19, v. 36, no. 6 p.1515-1521

    2022  

    Abstract: Sophora flavescens Ait. has been utilized as an anticarcinogen, antibacterial and insecticide. Two new prenylflavonoids, Sophoflavonoid A (1) and Sophoflavonoid B (2), together with four known analogues were isolated from the root bark of S. flavescens. ... ...

    Abstract Sophora flavescens Ait. has been utilized as an anticarcinogen, antibacterial and insecticide. Two new prenylflavonoids, Sophoflavonoid A (1) and Sophoflavonoid B (2), together with four known analogues were isolated from the root bark of S. flavescens. The structures of these compounds were elucidated by the interpretation of spectroscopic data and chemical evidence. Their absolute configurations were determined by ECD analysis. The inhibitory effects of compounds 1–6 against three lung carcinoma cells were determined using the MTT assay. The results revealed that compound 3 displayed strong cytotoxic effect against H460 cell line (IC₅₀, 4.67 μM), while compounds 1, 4–6 exhibited significant inhibitory effects against three tumor cells. Therefore, this study suggests that the isopentenyl flavonoid-rich products of S. flavescens, including the new compounds, could be valuable candidates for the development of pharmaceuticals in the prevention and treatment for tumors.
    Keywords Sophora flavescens ; anticarcinogenic agents ; bark ; cell lines ; cytotoxicity ; insecticides ; lung neoplasms ; metabolites ; research ; spectral analysis ; toxicity testing ; prenylflavonoid ; lung carcinoma
    Language English
    Dates of publication 2022-0319
    Size p. 1515-1521.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.1894562
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: A novel alkaloid from the seeds of Sophora alopecuroides L

    Rong, Zi-Jian / Gao, Xiao-Xu / Hu, Gao-Sheng / Yan, Ting / Jia, Jing-Ming / Wang, An-Hua

    Natural product research. 2022 Apr. 3, v. 36, no. 7

    2022  

    Abstract: A new cytisine-type alkaloid, along with five known alkaloids was obtained from the seeds of Sophora alopecuroides. Their structures were determined to be (−)-N-(2'-hydroxy-3',5'-di-tert-butyl-toluene)-cytisine (1), (−)-lupanine (2), (+)-matrine (3), (+)- ...

    Abstract A new cytisine-type alkaloid, along with five known alkaloids was obtained from the seeds of Sophora alopecuroides. Their structures were determined to be (−)-N-(2'-hydroxy-3',5'-di-tert-butyl-toluene)-cytisine (1), (−)-lupanine (2), (+)-matrine (3), (+)-sophoramine (4), (+)-lehmannine (5) and (−)-sophocarpine (6). Their structures were established by NMR, ECD and HRESIMS data analyses. Their cytotoxicity effects against five human tumor cell lines were tested by MTT assay. Compound 1 has showed a wide range of cytotoxicity activities against varied tumor cells in vitro.
    Keywords Sophora alopecuroides ; alkaloids ; cytotoxicity ; humans ; neoplasm cells ; neoplasms ; research ; toxicity testing
    Language English
    Dates of publication 2022-0403
    Size p. 1864-1869.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2020.1824226
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Two novel polyketones from the leaves and twigs of Clerodendrum trichotomum

    Gao, Yu-Ning / Wei, Jiang-Chun / Qi, Zhuang-Bo / Gao, Xiao-Xu / Wang, An-Hua

    Journal of Asian natural products research. 2022 Mar. 4, v. 24, no. 3

    2022  

    Abstract: Two novel polyketones, along with four known compounds, were isolated from the leaves and twigs of Clerodendrum trichotomum. Their structures were determined to be clerodendruketone A (1), clerodendruketone B (2), ecdysanols E (3), ecdysanols D (4), 5,5′- ...

    Abstract Two novel polyketones, along with four known compounds, were isolated from the leaves and twigs of Clerodendrum trichotomum. Their structures were determined to be clerodendruketone A (1), clerodendruketone B (2), ecdysanols E (3), ecdysanols D (4), 5,5′-dimethoxy-7-oxolariciresinol (5), and (-)-(7′S,8S,8′R)-4,4′-dihydroxy-3,3′,5,5′-tetramethoxy-7′,9-epoxy-lignan-9′-ol-7-one (6) through the methods of NMR, HRESIMS and ECD data analyses. The antioxidant effects against free radical were tested by DPPH assay. The antibacterial activity against Escherichia coli and Staphylococcus aureus were tested by turbidimetry assay. The results demonstrated that compounds 1 and 2 had significative antibacterial activity, and compound 3 had moderate antioxidant activity.
    Keywords Clerodendrum trichotomum ; Escherichia coli ; Staphylococcus aureus ; antibacterial properties ; antioxidant activity ; antioxidants ; free radicals ; research ; turbidimetry
    Language English
    Dates of publication 2022-0304
    Size p. 245-251.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2021.1914598
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Sigesbeckia K and L, two new diterpenoids from Sigesbeckia glabrescens with anti-inflammatory activity

    Hu, GaoSheng / Gao, XiaoXu / Wang, DongDong / Long, GuoQing / Jia, JingMing / Wang, AnHua

    Natural product research. 2022 Mar. 4, v. 36, no. 5

    2022  

    Abstract: A chemical investigation of Sigesbeckia glabrescens Makino identified four compounds. On the basis of spectroscopic data, they were determined to be ent-pimarane-type diterpenoids and their analogues, among which were two previously undescribed compounds, ...

    Abstract A chemical investigation of Sigesbeckia glabrescens Makino identified four compounds. On the basis of spectroscopic data, they were determined to be ent-pimarane-type diterpenoids and their analogues, among which were two previously undescribed compounds, Sigesbeckia K (1) and Sigesbeckia L (2). The anti-inflammatory effects of these compounds were evaluated by testing their inhibition of LPS-induced NO production in BV2 microglial cells, which revealed potential inhibitory effects with IC₅₀ value at 62.56 μM and compared with the positive control minocycline (IC₅₀ 32.84 μM).
    Keywords Sigesbeckia glabrescens ; anti-inflammatory activity ; diterpenoids ; minocycline ; research ; spectral analysis
    Language English
    Dates of publication 2022-0304
    Size p. 1282-1287.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2020.1871342
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Euphorfinoids A and B, a pair of ent-atisane diterpenoid epimers from the roots of Euphorbia fischeriana, and their bioactivities

    Wei, Jiangchun / Gao, Yu-Ning / Huang, Huihui / Zhang, Xiao-Yu / Liu, Xuan-Li / Gao, Xiao-Xu / Li, Na / Zhao, Yue / Wang, Anhua / Jia, Jing-Ming

    Natural Product Research. 2023 Apr. 18, v. 37, no. 8 p.1300-1309

    2023  

    Abstract: Euphorfinoids A and B (1 and 2), a pair of ent-atisane diterpenoid epimers with a vicinal 2,3-diol moiety, together with four known analogues (3–6), were isolated from the roots of wild Euphorbia fischeriana. Their structures were elucidated by ... ...

    Abstract Euphorfinoids A and B (1 and 2), a pair of ent-atisane diterpenoid epimers with a vicinal 2,3-diol moiety, together with four known analogues (3–6), were isolated from the roots of wild Euphorbia fischeriana. Their structures were elucidated by spectroscopic analysis, including extensive NMR, HR-ESIMS, NMR calculations, X-ray diffraction, and comparison with structurally related known analogues. Our bioassays have established that compound 1 displayed moderate anti-proliferative effects on Hcc1806 cell line with IC₅₀ 15.53 ± 0.21 μM, and compound 5 showed remarkable inhibitory effects against AChE with IC₅₀ 32.56 ± 2.74 μM by an in vitro screened experiment.
    Keywords Euphorbia fischeriana ; X-ray diffraction ; cell lines ; diterpenoids ; moieties ; research ; spectral analysis ; ent-atisane ; structure elucidation ; biological activity ; anti-proliferative
    Language English
    Dates of publication 2023-0418
    Size p. 1300-1309.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.2003796
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  7. Article ; Online: A novel

    Gao, Xiao-Xu / Jiang, Su-Zhen / Wang, Jing / Jia, Jing-Ming / Wang, An-Hua

    Journal of Asian natural products research

    2021  Volume 24, Issue 3, Page(s) 296–302

    Abstract: ... A ... ...

    Abstract A novel
    Language English
    Publishing date 2021-04-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2021.1915994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Two novel polyketones from the leaves and twigs of

    Gao, Yu-Ning / Wei, Jiang-Chun / Qi, Zhuang-Bo / Gao, Xiao-Xu / Wang, An-Hua

    Journal of Asian natural products research

    2021  Volume 24, Issue 3, Page(s) 245–251

    Abstract: Two novel polyketones, along with four known compounds, were isolated from the leaves and twigs ... ...

    Abstract Two novel polyketones, along with four known compounds, were isolated from the leaves and twigs of
    Language English
    Publishing date 2021-04-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2021.1914598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Sophoranone A and B: two new cytotoxic prenylated metabolites and their analogs from the root bark of

    Long, Guo-Qing / Hu, Gao-Sheng / Gao, Xiao-Xu / Jia, Jing-Ming / Wang, An-Hua

    Natural product research

    2021  Volume 36, Issue 6, Page(s) 1515–1521

    Abstract: ... Sophora ... ...

    Abstract Sophora flavescens
    MeSH term(s) Antineoplastic Agents/analysis ; Flavonoids/chemistry ; Plant Bark ; Plant Roots/chemistry ; Sophora/chemistry
    Chemical Substances Antineoplastic Agents ; Flavonoids ; sophoranone
    Language English
    Publishing date 2021-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.1894562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Five previously undescribed compounds from

    Wang, Kun-Jun / Bao, Te-Ri-Gen / Yang, Yong-Cheng / Wang, Dong-Dong / Wang, An-Hua / Gao, Xiao-Xu / Yan, Ting / Jia, Jing-Ming

    Natural product research

    2022  Volume 38, Issue 3, Page(s) 503–511

    Abstract: A new biflavone (philonotisflavone-3'''-methyl ether), three diterpenes (lupulin G, lupulin H, lupulin I), a new ecdysteroid (ajugasterone E), and four known compounds were isolated from the whole plant ... ...

    Abstract A new biflavone (philonotisflavone-3'''-methyl ether), three diterpenes (lupulin G, lupulin H, lupulin I), a new ecdysteroid (ajugasterone E), and four known compounds were isolated from the whole plant of
    MeSH term(s) Humans ; Ajuga/chemistry ; Diterpenes/chemistry ; Abietanes/chemistry ; HeLa Cells ; Molecular Structure
    Chemical Substances Diterpenes ; Abietanes
    Language English
    Publishing date 2022-10-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2130305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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