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Article: Tannic acid/Mg²⁺-based versatile coating to manipulate the osteoimmunomodulation of implants

He, Min / Gao, Xinhui / Fan, Yadi / Xie, Li / Yang, Mo / Tian, Weidong

Journal of materials chemistry B. 2021 Feb. 4, v. 9, no. 4

2021

Abstract: Instead of directly stimulating osteogenesis, endowing an implant surface with a favourable osteoimmunomodulatory (OIM) function has emerged as a new effective strategy to enhance osteointegration. Though metal-phenolic coatings have demonstrated to ... ...

Abstract	Instead of directly stimulating osteogenesis, endowing an implant surface with a favourable osteoimmunomodulatory (OIM) function has emerged as a new effective strategy to enhance osteointegration. Though metal-phenolic coatings have demonstrated to possess an immunomodulatory function, their potential application in manipulating an osteoimmune response has not been well explored. Herein, in order to develop a simple, rapid and universal coating method to impart excellent OIM to hard tissue implants, tannic acid (TA) and Mg²⁺ were selected to form a coating on Ti plate based on metal-phenolic chemistry. Besides its virtues of simplicity, ultrafastness, low-cost, and versatility, another merit for the coating method is that it can easily combine the unique functions of metal ions and phenolic ligands. The chelated Mg²⁺ can not only activate macrophage polarization towards the anti-inflammatory phenotype but also directly stimulate the osteogenic differentiation of bone marrow-derived stem cells (BMSCs). TA motifs rendered the coating with an excellent reactive oxygen species (ROS) scavenging capacity. TA and Mg²⁺ showed synergistic effects on regulating macrophage biological behaviour, suppressing its polarization towards the M1 phenotype, and promoting its polarization towards the M2 phenotype. In vivo histological analysis also demonstrated that the TA/Mg²⁺ coating could effectively inhibit the host response. Finally, the formed osteoimmune environment obviously enhanced the osteogenic differentiation of BMSCs. The above results demonstrated that the designed TA/Mg²⁺ coating not only possessed the function of directly stimulating osteogenesis but also the function of manipulating OIM to a desired one. Hence, it has great potential to be applied on advanced hard tissue implants to enhance osteointegration.
Keywords	bone formation ; histology ; immunomodulators ; ligands ; macrophages ; phenotype ; reactive oxygen species ; tannins
Language	English
Dates of publication	2021-0204
Size	p. 1096-1106.
Publishing place	The Royal Society of Chemistry
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d0tb01577f
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Tannic acid/Mg

He, Min / Gao, Xinhui / Fan, Yadi / Xie, Li / Yang, Mo / Tian, Weidong

Journal of materials chemistry. B

2021 Volume 9, Issue 4, Page(s) 1096–1106

Abstract	Instead of directly stimulating osteogenesis, endowing an implant surface with a favourable osteoimmunomodulatory (OIM) function has emerged as a new effective strategy to enhance osteointegration. Though metal-phenolic coatings have demonstrated to possess an immunomodulatory function, their potential application in manipulating an osteoimmune response has not been well explored. Herein, in order to develop a simple, rapid and universal coating method to impart excellent OIM to hard tissue implants, tannic acid (TA) and Mg
MeSH term(s)	Animals ; Cells, Cultured ; Coated Materials, Biocompatible/chemical synthesis ; Coated Materials, Biocompatible/chemistry ; Coated Materials, Biocompatible/pharmacology ; Immunomodulation/drug effects ; Magnesium/chemistry ; Magnesium/pharmacology ; Mice ; Osteogenesis/drug effects ; Particle Size ; Prostheses and Implants ; RAW 264.7 Cells ; Surface Properties ; Tannins/chemistry ; Tannins/pharmacology
Chemical Substances	Coated Materials, Biocompatible ; Tannins ; Magnesium (I38ZP9992A)
Language	English
Publishing date	2021-01-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d0tb01577f
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Integrated analyses of miRNA and mRNA profiles in leukocytes and serums in traditional Chinese medicine (TCM)-defined Pi-qi-deficiency syndrome and Pi-wei damp-heat syndrome resulting from chronic atrophic gastritis.

You, Leiming / Zhang, Shen / Li, Ting'an / Sang, Xiaopu / Li, Kunyu / Wang, Wei / Gao, Xinhui / Wu, Jiarui / Huang, Guangrui / Wang, Ting / Xu, Anlong

Chinese medicine

2021 Volume 16, Issue 1, Page(s) 4

Abstract: Background: To investigate the microRNA (miRNA)-gene interactions underlying leukocyte functions and characteristics, especially the potential serum biomarkers, implicated in the traditional Chinese medicine (TCM)-defined Pi-qi-deficiency syndrome (PQDS) ...

Abstract	Background: To investigate the microRNA (miRNA)-gene interactions underlying leukocyte functions and characteristics, especially the potential serum biomarkers, implicated in the traditional Chinese medicine (TCM)-defined Pi-qi-deficiency syndrome (PQDS) and Pi-wei damp-heat syndrome (PDHS) resulting from chronic atrophic gastritis (CAG). Methods: Using RNA/miRNA-sequencing approach, compared with healthy control population, we identified the PDHS- or PQDS-specific miRNAs and genes in leukocytes or serums, especially the Zheng (syndrome)-specific miRNA-gene interactions, and further decoded their functions and pathways. Results: Despite being the TCM-defined Zhengs resulting from the same disease of CAG, the Zheng-specific genes and miRNAs were not same. The PDHS-specific leukocyte genes were mainly involved in defense and immune responses, including NOD-like receptor signaling and several synapses-related pathways. The expression upregulation of PDHS-specific genes enriched in the neutrophil degranulation pathway, indicated the enhanced leukocyte degranulation activation. The PQDS-specific genes in leukocytes were implicated in inflammatory response, extracellular matrix (ECM) organization and collagen catabolism. They could be enriched in MAPK and IL17 signaling and helper T cell differentiation pathways, especially the pathways associated with cell-to-cell adhesion/junction and communication such as cell adhesion molecules, ECM organization and ECM-receptor interaction, probably contributing to the characteristics and functions of leukocytes. Also, the experimentally-supported miRNA-gene interactions, concerned with COL4A2, COL26A1, SPP1 and PROCR, were implicated in the regulation of pathways related to cell-to-cell adhesion/junction and communication, suggesting the potential roles of the PQDS-specific miRNA-gene interactions for the characteristic and functional changes of leukocytes. Interestingly, the PQDS-specific miRNAs in the serums and the corresponding leukocytes, seemed to have the common roles in contributing to the characteristics and functions of leukocytes. Importantly, the hsa-miR-122-5p could be a potential biomarker, capable of being contained and carried in plasma exosomes and much higher expression in both the leukocytes and corresponding serums in the CAG patients with PQDS rather than PDHS. Conclusions: These results may provide new insights into the characteristic and functional changes of leukocytes in the two Zhengs, PDHS and PQDS, especially the miRNA-mediated gene regulation underlying leukocyte characteristics and functions, with potential leukocyte and serum biomarkers for future application in integrative medicine. Trial registration ClinicalTrials.gov, NCT02915393. Registered on September 17, 2016.
Language	English
Publishing date	2021-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-020-00416-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Serum protein profiles suggest a possible link between qi deficiency constitution and Pi-qi-deficiency syndrome of chronic superficial gastritis

Gao, Xinhui / You, Leiming / Liu, Aijie / Sang, Xiaopu / Li, Ting’an / Zhang, Shen / Li, Kunyu / Huang, Guangrui / Wang, Ting / Xu, Anlong

Beijing University of Chinese Medicine Journal of traditional Chinese medical sciences. 2019 Oct., v. 6, no. 4

2019

Abstract: To identify potential serum protein candidates involved in linking the traditional Chinese medicine (TCM)-defined qi deficiency constitution (QDC) to Pi-qi-deficiency syndrome (PQDS) of chronic superficial gastritis (CSG).Using participants with the TCM- ... ...

Abstract	To identify potential serum protein candidates involved in linking the traditional Chinese medicine (TCM)-defined qi deficiency constitution (QDC) to Pi-qi-deficiency syndrome (PQDS) of chronic superficial gastritis (CSG).Using participants with the TCM-defined balanced constitution as a control population, label-free quantitative proteomics was adopted to identify differentially expressed proteins (DEPs) in serum samples from two case populations: case population 1 (participants with QDC) and case population 2 (patients with PQDS of CSG). The DEPs discovered in both case populations were analyzed to identify common DEPs as potential candidates for proteins involved in the link between QDC and PQDS. Based on Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) and Gene Ontology (GO) enrichment analysis and analysis of protein–protein interaction networks, we evaluated the possible functions of these potential serum candidates.We discovered 24 and 28 proteins that were differentially expressed in case populations 1 and 2, respectively, compared with the control population. Hierarchical clustering analysis showed that the expression profile of DEPs of individuals from the same population clustered well, while those from different populations were segregated. Furthermore, GO analysis revealed the 10 DEPs that were common to both case populations to be mainly associated with negative regulation of cellular metabolic and immune system processes while KEGG analysis indicated these proteins to be associated with complement and coagulation cascades and peroxisome proliferator-activated receptor signaling. Notably, serum levels of C4b-binding protein beta chain, glycosylphosphatidylinositol-specific phospholipase D1 and MS-F1 light chain variable region proteins were notably higher in the two case populations compared with the control, particularly in the case of CSG with PQDS.The results presented here provide new insights into the molecular mechanisms underlying development of PQDS of CSG from QDC, and suggest candidate serum biomarkers for future application in integrative medicine.
Keywords	Oriental traditional medicine ; biomarkers ; blood proteins ; blood serum ; coagulation ; complement ; gastritis ; gene expression regulation ; gene ontology ; immune system ; peroxisome proliferator-activated receptors ; phospholipases ; protein-protein interactions ; proteomics
Language	English
Dates of publication	2019-10
Size	p. 308-314.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2834228-8
ISSN	2095-7548 ; 2589-0395
ISSN	2095-7548 ; 2589-0395
DOI	10.1016/j.jtcms.2019.11.004
Database	NAL-Catalogue (AGRICOLA)

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Article: Integrated Analyses of lncRNA and mRNA Profiles Reveal Characteristic and Functional Changes of Leukocytes in Qi-Deficiency Constitution and Pi-Qi-Deficiency Syndrome of Chronic Superficial Gastritis.

You, Leiming / Liu, Aijie / Sang, Xiaopu / Gao, Xinhui / Li, Ting'An / Zhang, Shen / Li, Kunyu / Wang, Wei / Huang, Guangrui / Wang, Ting / Xu, Anlong

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 8518053

Abstract: Methods: We adopted RNA-sequencing approach to identify differential lncRNAs and genes in leukocytes, clustered expression profiles, and analyzed biological functions and pathways of differential genes to decode their potential roles in contributing to ... ...

Abstract	Methods: We adopted RNA-sequencing approach to identify differential lncRNAs and genes in leukocytes, clustered expression profiles, and analyzed biological functions and pathways of differential genes to decode their potential roles in contributing to characteristics and functions of leukocytes. In addition, interaction networks were created to detail the interactions between differential genes. In particular, we explored differential lncRNAs-mediated regulation of differential genes and predicted the subcellular location of lncRNAs to reveal their potential roles. Results: Compared with TCM-defined balanced constitution (BC), 183 and 93 genes as well as 749 and 651 lncRNAs were differentially expressed ( Conclusions: These results may provide new insights into the characteristic and functional changes of leukocytes in QDC and PQDS, especially the mechanism underlying the linkage of QDC to PQDS, with potential leukocytes biomarkers for future application in integrative medicine.
Keywords	covid19
Language	English
Publishing date	2020-07-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/8518053
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Screening for blood leukocyte microRNA biomarkers responsible for association between qi deficiency constitution and Pi-qi-deficiency syndrome of chronic superficial gastritis

Sheng, Honghao / You, Leiming / Sang, Xiaopu / Gao, Xinhui / Liu, Aijie / Li, Ting'an / Li, Kunyu / Zhang, Shen / Huang, Guangrui / Wang, Ting / Xu, Anlong

Beijing University of Chinese Medicine Journal of traditional Chinese medical sciences. 2018 Oct., v. 5, no. 4

2018

Abstract: To screen for blood leukocyte microRNA (miRNA) biomarkers responsible for the association between the traditional Chinese medicine (TCM) qi deficiency constitution (QDC) and the Pi-qi-deficiency syndrome (PQDS) of chronic superficial gastritis (CSG) ... ...

Abstract	To screen for blood leukocyte microRNA (miRNA) biomarkers responsible for the association between the traditional Chinese medicine (TCM) qi deficiency constitution (QDC) and the Pi-qi-deficiency syndrome (PQDS) of chronic superficial gastritis (CSG).Peripheral blood leukocytes were separated from people of two TCM constitutions (balance and qi deficiency) and from CSG patients with PQDS. Total RNA was isolated from the leukocytes and subjected to subsequent high-throughput miRNA sequencing to identify the miRNAs that are specifically and highly expressed in persons of QDC and CSG patients with PQDS. In addition, the target genes of the associated miRNAs were predicted. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway-based enrichment analyses of these target genes were performed to further evaluate the associated miRNA candidates as potential biomarkers responsible for the association between QDC and PQDS of CSG.Compared with the control group with a balance constitution (P < .05, fold change >1.5 or <0.5), 31 and 38 differentially expressed miRNAs were found in persons of QDC and CSG patients with PQDS, respectively. In particular, hsa-miR-145-5p and hsa-miR-146a-3p were highly expressed in both the persons of QDC and CSG patients with PQDS. GO analysis of the target genes of the two common miRNAs showed that they were mainly associated with functions related to synthesis and metabolism, such as cellular nitrogen compound metabolic processes, biosynthetic processes, cellular protein modification processes, and cellular component assembly. KEGG analysis identified the common pathways enriched among the target genes, including the Hippo signaling pathway and the transcriptional misregulation pathway. The common target genes of the two miRNAs seemed to be associated with the spliceosome pathway and the RNA degradation pathway.Hsa-miR-145-5p and hsa-miR-146a-3p may serve as candidate biomarkers responsible for the association between QDC and PQDS of CSG.
Keywords	Oriental traditional medicine ; biomarkers ; biosynthesis ; gastritis ; gene ontology ; leukocytes ; microRNA ; nitrogen compounds ; people ; spliceosomes ; transcription (genetics)
Language	English
Dates of publication	2018-10
Size	p. 335-343.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2834228-8
ISSN	2095-7548 ; 2589-0395
ISSN	2095-7548 ; 2589-0395
DOI	10.1016/j.jtcms.2018.11.003
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: LanceletDB: an integrated genome database for lancelet, comparing domain types and combination in orthologues among lancelet and other species.

You, Leiming / Chi, Jiaqi / Huang, Shengfeng / Yu, Ting / Huang, Guangrui / Feng, Yuchao / Sang, Xiaopu / Gao, Xinhui / Li, Ting'an / Yue, Zirui / Liu, Aijie / Chen, Shangwu / Xu, Anlong

Database : the journal of biological databases and curation

2019 Volume 2019

Abstract: Lancelet (amphioxus) represents the most basally divergent extant chordate (cephalochordates) that diverged from the other two chordate lineages (urochordates and vertebrates) more than half a billion years ago. As it occupies a key position in evolution, ...

Abstract	Lancelet (amphioxus) represents the most basally divergent extant chordate (cephalochordates) that diverged from the other two chordate lineages (urochordates and vertebrates) more than half a billion years ago. As it occupies a key position in evolution, it is considered as one of the best proxies for understanding the chordate ancestral state. Thus, the construction of a database with multiple lancelet genomes and gene annotation data, including protein domains, is urgently needed to investigate the loss and gain of domains in orthologues among species, especially ancient domain types (non-vertebrate-specific domains) and novel domain combination, which is helpful for providing new insight into the chordate ancestral state and vertebrate evolution. Here, we present an integrated genome database for lancelet, LanceletDB, which provides reference haploid genome sequence and annotation data for lancelet (Branchiostoma belcheri), including gene models and annotation, protein domain types, gene expression pattern in embryogenesis, different expression sequence tag sets and alternative polyadenylation (APA) sites profiled by the sequencing APA sites method. Especially, LanceletDB allows comparison of domain types and combination in orthologues among type species so as to decode the ancient domain types and novel domain combination during evolution. We also integrated the released diploid lancelet genome annotation data (Branchiostoma floridae) to expand LanceletDB and extend its usefulness. These data are available through the search and analysis page, basic local alignment search tool page and genome browser to provide an integrated display.
MeSH term(s)	Animals ; Databases, Genetic ; Genome ; Lancelets/genetics ; Lancelets/metabolism ; Molecular Sequence Annotation
Language	English
Publishing date	2019-05-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2496706-3
ISSN	1758-0463 ; 1758-0463
ISSN (online)	1758-0463
ISSN	1758-0463
DOI	10.1093/database/baz056
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Integrated Analyses of lncRNA and mRNA Profiles Reveal Characteristic and Functional Changes of Leukocytes in Qi-Deficiency Constitution and Pi-Qi-Deficiency Syndrome of Chronic Superficial Gastritis

You, Leiming / Liu, Aijie / Sang, Xiaopu / Gao, Xinhui / Li, Ting039 / An, / Zhang, Shen / Li, Kunyu / Wang, Wei / Huang, Guangrui / Wang, Ting / Xu, Anlong

Evid Based Complement Alternat Med

Abstract	Methods: We adopted RNA-sequencing approach to identify differential lncRNAs and genes in leukocytes, clustered expression profiles, and analyzed biological functions and pathways of differential genes to decode their potential roles in contributing to characteristics and functions of leukocytes. In addition, interaction networks were created to detail the interactions between differential genes. In particular, we explored differential lncRNAs-mediated regulation of differential genes and predicted the subcellular location of lncRNAs to reveal their potential roles. Results: Compared with TCM-defined balanced constitution (BC), 183 and 93 genes as well as 749 and 651 lncRNAs were differentially expressed (P < 0.05 and \|log2 (fold change)\| ≥1) in leukocytes of individuals from case populations 1 (QDC) and 2 (PQDS), respectively. Of them, 12 genes and 111 lncRNAs were common to each case population. Several networks were created to detail the interactions among case-specific genes, especially case-specific lncRNAs-mediated regulation of case-specific genes. Also, interaction networks were created for the common lncRNAs and genes. HCL analyses showed that differential genes and lncRNAs, especially the common genes and lncRNAs, kept similar expression patterns in both case populations. Furthermore, function enrichment analyses just indicated the common biological processes, namely, extracellular matrix organization and cell adhesion via plasma membrane adhesion molecules. In addition, most common genes underwent very tight and complex regulation of many trans- and cis-acting lncRNAs. In particular, of them, ADAMTSL5, COL26A1, COL27A1, MSH5, and LOC390937 could be regulated by multiple case-specific and common lncRNAs, including the means that directs binding of the common lncRNAs to their coded proteins. The common changes in the extracellular matrix and integral components of plasma membrane related to cell-cell adhesion/junction and communication may implicate the linkage between QDC and PQDS, contributing to alterations in characteristics and functions of leukocytes. Conclusions: These results may provide new insights into the characteristic and functional changes of leukocytes in QDC and PQDS, especially the mechanism underlying the linkage of QDC to PQDS, with potential leukocytes biomarkers for future application in integrative medicine.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32724329
Database	COVID19

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Article: Tannic acid/Mg²⁺-based versatile coating to manipulate the osteoimmunomodulation of implants

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Article ; Online: Tannic acid/Mg

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Article: Integrated analyses of miRNA and mRNA profiles in leukocytes and serums in traditional Chinese medicine (TCM)-defined Pi-qi-deficiency syndrome and Pi-wei damp-heat syndrome resulting from chronic atrophic gastritis.

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Article: Serum protein profiles suggest a possible link between qi deficiency constitution and Pi-qi-deficiency syndrome of chronic superficial gastritis

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Article: Integrated Analyses of lncRNA and mRNA Profiles Reveal Characteristic and Functional Changes of Leukocytes in Qi-Deficiency Constitution and Pi-Qi-Deficiency Syndrome of Chronic Superficial Gastritis.

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Article: Screening for blood leukocyte microRNA biomarkers responsible for association between qi deficiency constitution and Pi-qi-deficiency syndrome of chronic superficial gastritis

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Article ; Online: LanceletDB: an integrated genome database for lancelet, comparing domain types and combination in orthologues among lancelet and other species.

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Article: Integrated Analyses of lncRNA and mRNA Profiles Reveal Characteristic and Functional Changes of Leukocytes in Qi-Deficiency Constitution and Pi-Qi-Deficiency Syndrome of Chronic Superficial Gastritis

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