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Book: Special issue: Insecticide toxicology in China

Zhu, Kun Yan / Gao, Xiwu / Han, Zhaojun

(Pesticide biochemistry and physiology ; Volume 132 (September 2016))

2016

Author's details	guest editors: Kun Yan Zhu, Xiwu Gao and Zhaojun Han
Series title	Pesticide biochemistry and physiology ; Volume 132 (September 2016)
Collection
Language	English
Size	131 Seiten, Illustrationen
Publisher	Elsevier
Publishing place	Amsterdam
Publishing country	Netherlands
Document type	Book
HBZ-ID	HT019121495
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Shelf mark	Loan status	Location
Z 3585 (132)	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Clathrin-dependent endocytosis plays a critical role in larval and pupal development, and female oocyte production in the red flour beetle (Tribolium castaneum).

Xiao, Da / Yao, Jianxiu / Gao, Xiwu / Zhu, Kun Yan

Pest management science

2023 Volume 79, Issue 5, Page(s) 1731–1742

Abstract: Background: Clathrin-dependent endocytosis is a vesicular transport process by which cells take macromolecules from the extracellular space to the intracellular space. It plays important roles in various cellular functions, but its biological ... ...

Abstract	Background: Clathrin-dependent endocytosis is a vesicular transport process by which cells take macromolecules from the extracellular space to the intracellular space. It plays important roles in various cellular functions, but its biological significance in insect development and reproduction has not been well studied. Results: We characterized and functionally analyzed four major clathrin-dependent endocytic pathway genes (TcChc, TcAP50, TcVhaSFD, TcRab7) in Tribolium castaneum. RNA interference (RNAi) by injecting double-stranded RNA (dsRNA) targeting each gene at three doses (50, 100, or 200 ng per insect) in 20-day-old larvae led to 100% larval mortality. When the expressions of TcChc, TcVhaSFD, and TcRab7 were suppressed by injecting their respective dsRNAs at each dose in 1-day-old pupae, the adults that emerged from the dsRNA-injected pupae were deformed, with the absence of wing development. The deformed adults died within 2 days after eclosion. When the expression of TcAP50 was suppressed by injecting its dsRNA into 1-day-old pupae, although no apparent deformed adults were observed, all the adults died within 35 days after eclosion. In addition, when the expressions of TcChc and TcVhaSFD were suppressed by injecting their respective dsRNAs at a reduced dose (10 ng per insect) in 5-day-old pupae, the ovarian development and oocyte production in the resultant females were completely inhibited. Conclusion: Our results indicate that clathrin-dependent endocytosis is essential for insect development and reproduction. The results from this study can help researchers identify potential molecular targets for developing novel strategies for insect pest management. © 2023 Society of Chemical Industry.
MeSH term(s)	Animals ; Female ; Coleoptera/genetics ; Tribolium ; Larva ; RNA Interference ; RNA, Double-Stranded/genetics ; RNA, Double-Stranded/metabolism ; Endocytosis ; Clathrin/genetics ; Clathrin/metabolism ; Insect Proteins/genetics ; Insect Proteins/metabolism
Chemical Substances	RNA, Double-Stranded ; Clathrin ; Insect Proteins
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2001705-4
ISSN	1526-4998 ; 1526-498X
ISSN (online)	1526-4998
ISSN	1526-498X
DOI	10.1002/ps.7348
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Transgenerational hormesis effects of nitenpyram on fitness and insecticide tolerance/resistance of Nilaparvata lugens

Gong, Youhui / Cheng, Shiyang / Desneux, Nicolas / Gao, Xiwu / Xiu, Xiaojian / Wang, Fulian / Hou, Maolin

J Pest Sci. 2023 Jan., v. 96, no. 1 p.161-180

2023

Abstract: Brown planthopper (Nilaparvata lugens) (BPH) is a devastating migratory rice pest in tropical, subtropical, and temperate regions. Insecticide-induced population resurgence is a concern for BPH control. Exposure to low/sublethal concentrations of ... ...

Abstract	Brown planthopper (Nilaparvata lugens) (BPH) is a devastating migratory rice pest in tropical, subtropical, and temperate regions. Insecticide-induced population resurgence is a concern for BPH control. Exposure to low/sublethal concentrations of insecticides has resulted in increased reproduction and fitness as well as insecticide tolerance in many insects. Nitenpyram, a neonicotinoid insecticide, has been frequently used in BPH control. In the present study, the transgenerational hormesis effects in terms of fitness-related traits and insecticide tolerance induced by low concentrations of nitenpyram were reported in both susceptible (S) and field-collected strains (F) of BPH, after exposure to their respective LC₂₀ nitenpyram concentrations for six generations. Our findings stressed that chronic, multigenerational preconditioning of BPHs to LC₂₀ nitenpyram not only increased the biological fitness (in terms of life table parameters and estimated population size), but also primed BPHs to be more tolerate/resistant to insecticides nitenpyram, imidacloprid and cycloxaprid. The upregulation of detoxification (CYP6ER1) and fecundity-related (vitellogenin) genes in both the LC₂₀-preconditioned S and F strains (S-Sub₆ and F-Sub₆) might contribute to the increased insecticide tolerance and reproduction hormesis. These results support the hypothesis that BPH population outbreaks following multigenerational exposure to low concentrations of nitenpyram in field crops occur through increased reproduction and resistance development. Moreover, based on our results, sulfoxaflor and triflumezopyrim are proposed to be used in rotation with nitenpyram, imidacloprid or cycloxaprid to delay the development of tolerance/resistance in BPHs in paddy fields.
Keywords	Nilaparvata lugens ; hormesis ; imidacloprid ; life tables ; migratory behavior ; nitenpyram ; paddies ; pests ; population size ; reproduction ; rice ; sulfoxaflor ; vitellogenin
Language	English
Dates of publication	2023-01
Size	p. 161-180.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	2141662-X
ISSN	1612-4766 ; 1439-0280 ; 1612-4758
ISSN (online)	1612-4766 ; 1439-0280
ISSN	1612-4758
DOI	10.1007/s10340-022-01494-4
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: miR-34-5p, a novel molecular target against lepidopteran pests

Li, Linhong / Zhu, Bin / Sun, Xi / Zheng, Kaiwen / Liang, Pei / Gao, Xiwu

J Pest Sci. 2023 Jan., v. 96, no. 1 p.209-224

2023

Abstract: The management of economically important lepidopteran pests has relied heavily on chemical and Bt-bio pesticides since 1940s, which has led to multiple recurring issues in resistance and environment. In this study, to search for a genetic-based control ... ...

Abstract	The management of economically important lepidopteran pests has relied heavily on chemical and Bt-bio pesticides since 1940s, which has led to multiple recurring issues in resistance and environment. In this study, to search for a genetic-based control alternative with a distinctively different mode of action, we carried out a toxicological characterization of miR-34-5p, a highly conserved lepidopteran microRNA targeting EcR. Integrating target site prediction, co-localization of miRNA and EcR by fluorescence in situ hybridization, luciferase reporter assays as well as the gain-of-function and loss-of-function experiments, we comprehensively examined the physiological function and insecticidal properties of miR-34-5p among three representative lepidopteran pests, including Helicoverpa armigera, Spodoptera exigua, and Plutella xylostella. The combined results confirm a conserved role of miR-34-5p in the regulation of EcR in multiple lepidopteran pests. Overexpression or knocking down of miR-34-5p through both injection and feeding leads to insecticidal phenotypes, including high mortality, low fecundity, and developmental defects, suggesting that miRNAs can be considered as novel molecular targets in general, miR-34-5p for lepidopteran pests in particular. These results highlight the importance of miR-34-5p in the regulation of EcR expression in lepidopteran insects and provide a solid foundation for development of miRNA-based green pest control technology.
Keywords	Helicoverpa armigera ; Plutella xylostella ; Spodoptera exigua ; fecundity ; fluorescence ; gain-of-function mutation ; hybridization ; loss-of-function mutation ; luciferase ; mechanism of action ; microRNA ; mortality ; pests ; prediction ; toxicology
Language	English
Dates of publication	2023-01
Size	p. 209-224.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	2141662-X
ISSN	1612-4766 ; 1439-0280 ; 1612-4758
ISSN (online)	1612-4766 ; 1439-0280
ISSN	1612-4758
DOI	10.1007/s10340-022-01488-2
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The variation of a cytochrome P450 gene, CYP6G4, drives the evolution of Musca domestica L. (Diptera: Muscidae) resistance to insecticides in China

You, Chunmei / Zhang, Lulu / Song, Jiajia / Zhang, Lei / Zhen, Congai / Gao, Xiwu

International Journal of Biological Macromolecules. 2023 May, v. 236 p.123399-

2023

Abstract: Long term and excessive insecticide use has resulted in some environmental problems and especially, insecticide resistance evolution in insect pests. The variation of cytochrome P450 monooxygenases (P450s), associated with the metabolic detoxification of ...

Abstract	Long term and excessive insecticide use has resulted in some environmental problems and especially, insecticide resistance evolution in insect pests. The variation of cytochrome P450 monooxygenases (P450s), associated with the metabolic detoxification of toxic xenobiotics, is often involved in insecticide resistance. Here, we found that the variation in a P450 gene, CYP6G4, is the most important driver of carbamates resistance in the house fly (Musca domestica). Deciphering the detailed molecular mechanisms of the insecticide resistance is critical for performing suitable insecticide resistance management strategies. Our research results revealed that the combination of amino acid mutations (110C-330E-360N/S, 110C-330E-360S) of CYP6G4 could improve the resistance to propoxur. The nucleotide variations in the promoter region of CYP6G4 significantly increased the luciferase activity by the reporter gene assays. Additionally, miR-281-1-5p was confirmed to post-transcriptionally down-regulate the expression of CYP6G4. These findings suggest that three independent mechanisms; amino acid mutations of the P450 protein, mutations in the promoter region and low expression of post-trans-regulatory factors, as the powerful strategies for the insect resistance to toxic compounds, play a crucial role in the evolutionary processes of insecticide resistance.
Keywords	Musca domestica ; amino acids ; cytochrome P-450 ; evolution ; insect resistance ; insecticide resistance ; insecticides ; insects ; luciferase ; metabolic detoxification ; promoter regions ; propoxur ; reporter genes ; resistance management ; toxicity ; xenobiotics ; China ; CYP6G4 ; Gene regulation ; Detoxification
Language	English
Dates of publication	2023-05
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.123399
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A novel V263I mutation in the glutamate-gated chloride channel of Plutella xylostella (L.) confers a high level of resistance to abamectin

Sun, Xi / Hua, Wenjuan / Wang, Kunkun / Song, Jiajia / Zhu, Bin / Gao, Xiwu / Liang, Pei

International Journal of Biological Macromolecules. 2023 Mar., v. 230 p.123389-

2023

Abstract: The frequent and extensive use of insecticides leads to the evolution of insecticide resistance, which has become one of the constraints on global agricultural production. Avermectins are microbial-derived insecticides that target a wide number of insect ...

Abstract	The frequent and extensive use of insecticides leads to the evolution of insecticide resistance, which has become one of the constraints on global agricultural production. Avermectins are microbial-derived insecticides that target a wide number of insect pests, including the diamondback moth Plutella xylostella, an important global pest of brassicaceous vegetables. However, field populations of P. xylostella have evolved serious resistance to avermectins, including abamectin, thereby threatening the efficiency of these insecticides. In this study, a novel valine to isoleucine mutation (V263I) was identified in the glutamate-gated chloride channel (GluCl) of field P. xylostella populations, which showed different levels of resistance to abamectin. Electrophysiological analysis revealed that the V263I mutation significantly reduced the sensitivity of PxGluCl to abamectin by 6.9-fold. Genome-modified Drosophila melanogaster carrying the V263I mutation exhibited 27.1-fold resistance to abamectin. Then, a knockin strain (V263I-KI) of P. xylostella expressing the homozygous V263I mutation was successfully constructed using the CRISPR/Cas9. The V263I-KI had high resistance to abamectin (106.3-fold), but significantly reduced fecundity. In this study, the function of V263I mutation in PxGluCl was verified for the first time. These findings provide a more comprehensive understanding of abamectin resistance mechanisms and lay the foundation for providing a new molecular detection method for abamectin resistance monitoring.
Keywords	CRISPR-Cas systems ; Drosophila melanogaster ; Plutella xylostella ; abamectin ; chlorides ; electrophysiology ; evolution ; fecundity ; homozygosity ; insecticide resistance ; insects ; isoleucine ; mutation ; pests ; valine ; Glutamate-gated chloride channel ; CRISPR/Cas9
Language	English
Dates of publication	2023-03
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.123389
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

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Location:
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Article ; Online: CRISPR/Cas9‐mediated D472N substitution in the Rdl1 of Plutella xylostella confers low resistance to abamectin

Sun, Xi / Hua, Wenjuan / Zhu, Bin / Liang, Pei / Gao, Xiwu

Pest Management Science. 2023 Feb., v. 79, no. 2 p.741-747

2023

Abstract: BACKGROUND: Abamectin is one of the main insecticides used for the control of Plutella xylostella, a destructive pest of cruciferous crops. Target‐site mutation plays an important role in insecticide resistance. A point mutation (D472N) has been reported ...

Abstract	BACKGROUND: Abamectin is one of the main insecticides used for the control of Plutella xylostella, a destructive pest of cruciferous crops. Target‐site mutation plays an important role in insecticide resistance. A point mutation (D472N) has been reported in the Rdl1 γ‐aminobutyric acid receptor (GABAR) in P. xylostella, but its roles in insecticide resistance remain unknown. RESULTS: In this study, the D472N mutation of the Rdl1 GABAR was detected in several field populations of P. xylostella and showed a positive correlation with abamectin resistance. A knock‐in homozygous mutation strain (D472N‐KI) of P. xylostella was successfully constructed using CRISPR/Cas9 coupled with homology‐directed repair, and the bioassay results demonstrated that compared with the susceptible strain, the D472N‐KI strain had 11.1‐ and 3.7‐fold increased resistance to abamectin and endosulfan, respectively. There was no difference in resistance to fipronil, broflanilide or isocycloseram, which also target the GABAR. In addition, the total fecundity of the D472N‐KI strain was significantly reduced by 50.0%. CONCLUSION: Our results suggest that the homozygous D472N mutation in Rdl1 confers a low level of resistance to abamectin in P. xylostella but causes significant fecundity disadvantages, which may delay the development of resistance to some extent. These results lay a foundation for further understanding the mechanisms of abamectin resistance in insect pests. © 2022 Society of Chemical Industry.
Keywords	Brassicaceae ; CRISPR-Cas systems ; Plutella xylostella ; abamectin ; bioassays ; endosulfan ; fecundity ; fipronil ; homozygosity ; insecticide resistance ; pests ; point mutation ; site-directed mutagenesis
Language	English
Dates of publication	2023-02
Size	p. 741-747.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2001705-4
ISSN	1526-4998 ; 1526-498X
ISSN (online)	1526-4998
ISSN	1526-498X
DOI	10.1002/ps.7252
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

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Article ; Online: Clathrin‐dependent endocytosis plays a critical role in larval and pupal development, and female oocyte production in the red flour beetle (Tribolium castaneum)

Xiao, Da / Yao, Jianxiu / Gao, Xiwu / Zhu, Kun Yan

Pest Management Science. 2023 May, v. 79, no. 5 p.1731-1742

2023

Abstract: BACKGROUND: Clathrin‐dependent endocytosis is a vesicular transport process by which cells take macromolecules from the extracellular space to the intracellular space. It plays important roles in various cellular functions, but its biological ... ...

Abstract	BACKGROUND: Clathrin‐dependent endocytosis is a vesicular transport process by which cells take macromolecules from the extracellular space to the intracellular space. It plays important roles in various cellular functions, but its biological significance in insect development and reproduction has not been well studied. RESULTS: We characterized and functionally analyzed four major clathrin‐dependent endocytic pathway genes (TcChc, TcAP50, TcVhaSFD, TcRab7) in Tribolium castaneum. RNA interference (RNAi) by injecting double‐stranded RNA (dsRNA) targeting each gene at three doses (50, 100, or 200 ng per insect) in 20‐day‐old larvae led to 100% larval mortality. When the expressions of TcChc, TcVhaSFD, and TcRab7 were suppressed by injecting their respective dsRNAs at each dose in 1‐day‐old pupae, the adults that emerged from the dsRNA‐injected pupae were deformed, with the absence of wing development. The deformed adults died within 2 days after eclosion. When the expression of TcAP50 was suppressed by injecting its dsRNA into 1‐day‐old pupae, although no apparent deformed adults were observed, all the adults died within 35 days after eclosion. In addition, when the expressions of TcChc and TcVhaSFD were suppressed by injecting their respective dsRNAs at a reduced dose (10 ng per insect) in 5‐day‐old pupae, the ovarian development and oocyte production in the resultant females were completely inhibited. CONCLUSION: Our results indicate that clathrin‐dependent endocytosis is essential for insect development and reproduction. The results from this study can help researchers identify potential molecular targets for developing novel strategies for insect pest management. © 2023 Society of Chemical Industry.
Keywords	RNA interference ; Tribolium castaneum ; double-stranded RNA ; eclosion ; endocytosis ; extracellular space ; females ; genes ; insect control ; insects ; intracellular space ; larvae ; mortality ; oocytes ; ovarian development ; pupal development ; reproduction
Language	English
Dates of publication	2023-05
Size	p. 1731-1742.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2001705-4
ISSN	1526-4998 ; 1526-498X
ISSN (online)	1526-4998
ISSN	1526-498X
DOI	10.1002/ps.7348
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

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Article: Time of Day-Specific Changes in Metabolic Detoxification and Insecticide Tolerance in the House Fly,

You, Chunmei / Li, Zelin / Yin, Yuanzhi / Na, Naretuya / Gao, Xiwu

Frontiers in physiology

2022 Volume 12, Page(s) 803682

Abstract: Both insects and mammals all exhibit a daily fluctuation of susceptibility to chemicals at different times of the day. However, this phenomenon has not been further studied in the house fly ( ...

Abstract	Both insects and mammals all exhibit a daily fluctuation of susceptibility to chemicals at different times of the day. However, this phenomenon has not been further studied in the house fly (
Language	English
Publishing date	2022-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.803682
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A General Signal Pathway to Regulate Multiple Detoxification Genes Drives the Evolution of

Zhang, Lei / Lv, Shenglan / Li, Mingjian / Gu, Meng / Gao, Xiwu

International journal of molecular sciences

2022 Volume 23, Issue 24

Abstract: The study of insect adaptation to the defensive metabolites of host plants and various kinds of insecticides in order to acquire resistance is a hot topic in the pest-control field, but the mechanism is still unclear. In our study, we found that a ... ...

Abstract	The study of insect adaptation to the defensive metabolites of host plants and various kinds of insecticides in order to acquire resistance is a hot topic in the pest-control field, but the mechanism is still unclear. In our study, we found that a general signal pathway exists in
Language	English
Publishing date	2022-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232416126
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