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  1. Artikel ; Online: The mechanism of μ-opioid receptor (MOR)-TRPV1 crosstalk in TRPV1 activation involves morphine anti-nociception, tolerance and dependence.

    Bao, Yanju / Gao, Yebo / Yang, Liping / Kong, Xiangying / Yu, Jing / Hou, Wei / Hua, Baojin

    Channels (Austin, Tex.)

    2015  Band 9, Heft 5, Seite(n) 235–243

    Abstract: Initiated by the activation of various nociceptors, pain is a reaction to specific stimulus modalities. The μ-opioid receptor (MOR) agonists, including morphine, remain the most potent analgesics to treat patients with moderate to severe pain. However, ... ...

    Abstract Initiated by the activation of various nociceptors, pain is a reaction to specific stimulus modalities. The μ-opioid receptor (MOR) agonists, including morphine, remain the most potent analgesics to treat patients with moderate to severe pain. However, the utility of MOR agonists is limited by the adverse effects associated with the use of these drugs, including analgesic tolerance and physical dependence. A strong connection has been suggested between the expression of the transient receptor potential vanilloid type 1 (TRPV1) ion channel and the development of inflammatory hyperalgesia. TRPV1 is important for thermal nociception induction, and is mainly expressed on sensory neurons. Recent reports suggest that opioid or TRPV1 receptor agonist exposure has contrasting consequences for anti-nociception, tolerance and dependence. Chronic morphine exposure modulates TRPV1 activation and induces the anti-nociception effects of morphine. The regulation of many downstream targets of TRPV1 plays a critical role in this process, including calcitonin gene-related peptide (CGRP) and substance P (SP). Additional factors also include capsaicin treatment blocking the anti-nociception effects of morphine in rats, as well as opioid modulation of TRPV1 responses through the cAMP-dependent PKA pathway and MAPK signaling pathways. Here, we review new insights concerning the mechanism underlying MOR-TRPV1 crosstalk and signaling pathways and discuss the potential mechanisms of morphine-induced anti-nociception, tolerance and dependence associated with the TRPV1 signaling pathway and highlight how understanding these mechanisms might help find therapeutic targets for the treatment of morphine induced antinociception, tolerance and dependence.
    Mesh-Begriff(e) Analgesics, Opioid/pharmacology ; Animals ; Humans ; Morphine/pharmacology ; Morphine Dependence/metabolism ; Nociception ; Receptors, Opioid, mu/genetics ; Receptors, Opioid, mu/metabolism ; Signal Transduction ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism
    Chemische Substanzen Analgesics, Opioid ; Receptors, Opioid, mu ; TRPV Cation Channels ; Morphine (76I7G6D29C)
    Sprache Englisch
    Erscheinungsdatum 2015
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1933-6969
    ISSN (online) 1933-6969
    DOI 10.1080/19336950.2015.1069450
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: New insights into protease-activated receptor 4 signaling pathways in the pathogenesis of inflammation and neuropathic pain: a literature review.

    Bao, Yanju / Gao, Yebo / Yang, Liping / Kong, Xiangying / Zheng, Honggang / Hou, Wei / Hua, Baojin

    Channels (Austin, Tex.)

    2015  Band 9, Heft 1, Seite(n) 5–13

    Abstract: Pain is an unpleasant sensory and emotional experience that is commonly associated with actual or potential tissue damage. Despite decades of pain research, many patients continue to suffer from chronic pain that is refractory to current treatments. ... ...

    Abstract Pain is an unpleasant sensory and emotional experience that is commonly associated with actual or potential tissue damage. Despite decades of pain research, many patients continue to suffer from chronic pain that is refractory to current treatments. Accumulating evidence has indicated an important role of protease-activated receptor 4 (PAR4) in the pathogenesis of inflammation and neuropathic pain. Here we reviewed PAR4 expression and activation via intracellular signaling pathways and the role of PAR4 signaling pathways in the development and maintenance of pain. Understanding PAR4 and its corresponding signaling pathways will provide insight to further explore the molecular basis of pain, which will also help to identify new targets for pharmacological intervention for pain relief.
    Mesh-Begriff(e) Animals ; Humans ; Inflammation/metabolism ; Neuralgia/metabolism ; Receptors, Thrombin/metabolism ; Signal Transduction
    Chemische Substanzen Receptors, Thrombin ; protease-activated receptor 4
    Sprache Englisch
    Erscheinungsdatum 2015
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1933-6969
    ISSN (online) 1933-6969
    DOI 10.4161/19336950.2014.995001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: New insights of nociceptor sensitization in bone cancer pain.

    Hua, Baojin / Gao, Yebo / Kong, Xiangying / Yang, Liping / Hou, Wei / Bao, Yanju

    Expert opinion on therapeutic targets

    2015  Band 19, Heft 2, Seite(n) 227–243

    Abstract: Introduction: Numerous studies have shown that an intact CNS is required for the conscious perception of cancer-induced bone pain (CIBP) and that changes in the CNS are clearly evident. Accordingly, the blockage of nociceptive stimulus into the CNS can ... ...

    Abstract Introduction: Numerous studies have shown that an intact CNS is required for the conscious perception of cancer-induced bone pain (CIBP) and that changes in the CNS are clearly evident. Accordingly, the blockage of nociceptive stimulus into the CNS can effectively relieve or markedly attenuate CIBP, revealing the clinical implication of the blockage of ongoing peripheral inputs for the control of CIBP.
    Areas covered: In this review, the heterogeneity and excitability of nociceptors in bone are covered. Furthermore, their role in initiating and maintaining CIBP is also described.
    Expert opinion: Developing mechanistic therapies to treat CIBP is a challenge, but they have the potential to fundamentally change our ability to effectively block/relieve CIBP and increase the functional status and quality of life of patients with bone metastasis. Further studies are desperately needed at both the preclinical and clinical levels to determine whether the targets as mentioned in this review are viable and feasible for patient populations.
    Mesh-Begriff(e) Animals ; Bone Neoplasms/complications ; Drug Design ; Humans ; Nociceptors/metabolism ; Pain/drug therapy ; Pain/etiology ; Pain/pathology ; Quality of Life
    Sprache Englisch
    Erscheinungsdatum 2015-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1517/14728222.2014.980815
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Chinese patent medicine Fei-Liu-Ping ointment as an adjunctive treatment for non-small cell lung cancer: protocol for a systematic review.

    Zheng, Honggang / He, Shulin / Liu, Rui / Xu, Xinyao / Xu, Tao / Chen, Shuntai / Guo, Qiujun / Gao, Yebo / Hua, Baojin

    BMJ open

    2017  Band 7, Heft 1, Seite(n) e015045

    Abstract: Introduction: Fei-Liu-Ping ointment has been widely applied as adjunctive drug in the treatment of non-small cell lung cancer (NSCLC). However, there has been no systematic review of research findings regarding the efficacy of this treatment. Here, we ... ...

    Abstract Introduction: Fei-Liu-Ping ointment has been widely applied as adjunctive drug in the treatment of non-small cell lung cancer (NSCLC). However, there has been no systematic review of research findings regarding the efficacy of this treatment. Here, we provide a protocol for assessing the effectiveness and safety of Fei-Liu-Ping ointment in the treatment of NSCLC.
    Methods and analysis: The electronic databases to be searched will include MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, Excerpt Medica Database (EMBASE), China National Knowledge Infrastructure (CNKI), China Scientific Journal Database (VIP), Wanfang Database and Chinese Biomedical Literature Database (CBM). Papers in English or Chinese published from inception to 2016 will be included without any restrictions. We will conduct a meta-analysis of randomised controlled trial if possible. The therapeutic effects according to the standard for treatment of solid tumours by the WHO and the quality of life as evaluated by Karnofsky score and weight will be applied as the primary outcomes. We will also evaluate the data synthesis and risk of bias using Review Manager 5.3 software.
    Dissemination: The results of this review will offer implications for the use of Fei-Liu-Ping ointment as an adjunctive treatment for NSCLC. This knowledge will inform recommendations by surgeons and researchers who are interested in the treatment of NSCLC. The results of this systematic review will be disseminated through presentation at a conference and publication of the data in a peer-reviewed journal.
    Trial registration number: PROSPERO CRD42016036911.
    Mesh-Begriff(e) Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/therapy ; Combined Modality Therapy ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/therapy ; Nonprescription Drugs/therapeutic use ; Ointments ; Systematic Reviews as Topic ; Treatment Outcome
    Chemische Substanzen Drugs, Chinese Herbal ; Nonprescription Drugs ; Ointments ; fei-liu-ping
    Sprache Englisch
    Erscheinungsdatum 2017-01-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2747269-3
    ISSN 2044-6055 ; 2044-6055 ; 2053-3624
    ISSN (online) 2044-6055
    ISSN 2044-6055 ; 2053-3624
    DOI 10.1136/bmjopen-2016-015045
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Norcantharidin inhibits IL-6-induced epithelial‑mesenchymal transition via the JAK2/STAT3/TWIST signaling pathway in hepatocellular carcinoma cells.

    Gao, Yebo / Li, Weidong / Liu, Rui / Guo, Qiujun / Li, Jie / Bao, Yanju / Zheng, Honggang / Jiang, Shulong / Hua, Baojin

    Oncology reports

    2017  Band 38, Heft 2, Seite(n) 1224–1232

    Abstract: Epithelial-mesenchymal transition (EMT), plays a vital role in hepatocellular carcinoma (HCC) development and metastasis. Norcantharidin (NCTD; 7-oxabicyclo (2.2.1) heptane-2,3-dicarboxylic anhydride) plays anticancer roles in the regulation of tumor ... ...

    Abstract Epithelial-mesenchymal transition (EMT), plays a vital role in hepatocellular carcinoma (HCC) development and metastasis. Norcantharidin (NCTD; 7-oxabicyclo (2.2.1) heptane-2,3-dicarboxylic anhydride) plays anticancer roles in the regulation of tumor cell proliferation, apoptosis and migration. However, the molecular mechanism of HCC EMT and the effects of NCTD in the HCC EMT process have been either poorly elucidated or not studied. In this study, HCC EMT was induced by the treatment of IL-6 and various concentrations of NCTD (0, 30, 60 and 120 µM) were treated with HCC cell lines, HCCLM3 and SMMC-7721. We investigated the effect of NCTD on the invasion of HCC cells by using Transwell assay. Immunofluorescence staining, western blot analysis and quantitative RT-PCR were performed to evaluate the protein and mRNA expression levels of HCC cells. Here, using cell line models, our data demonstrated that interleukin 6 (IL-6) induced EMT through the JAK/STAT3/TWIST pathway in HCC. Moreover, our studies revealed that NCTD markedly inhibited IL-6-induced EMT and cell invasiveness. Signaling studies revealed that NCTD sufficiently suppressed JAK/STAT3/TWIST signaling to reverse the IL-6-promoting effects. Collectively, these data provide evidence for the use of NCTD as a potential anticancer drug in HCC metastatic patients.
    Mesh-Begriff(e) Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Biomarkers, Tumor ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Humans ; Interleukin-6/pharmacology ; Janus Kinase 2/antagonists & inhibitors ; Janus Kinase 2/metabolism ; Liver Neoplasms/drug therapy ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Neoplasm Invasiveness ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/metabolism ; Tumor Cells, Cultured ; Twist-Related Protein 1/antagonists & inhibitors ; Twist-Related Protein 1/metabolism
    Chemische Substanzen Antineoplastic Agents ; Biomarkers, Tumor ; Bridged Bicyclo Compounds, Heterocyclic ; IL6 protein, human ; Interleukin-6 ; STAT3 Transcription Factor ; Twist-Related Protein 1 ; norcantharidin (8452E71EO7) ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
    Sprache Englisch
    Erscheinungsdatum 2017-08
    Erscheinungsland Greece
    Dokumenttyp Journal Article
    ZDB-ID 1222484-4
    ISSN 1791-2431 ; 1021-335X
    ISSN (online) 1791-2431
    ISSN 1021-335X
    DOI 10.3892/or.2017.5775
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4213: Hefte anzeigen Standort:
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  6. Artikel ; Online: Protease-activated receptor 4: a critical participator in inflammatory response.

    Fu, Qiang / Cheng, Jing / Gao, Yebo / Zhang, Yonglei / Chen, Xiaobing / Xie, Jianguo

    Inflammation

    2014  Band 38, Heft 2, Seite(n) 886–895

    Abstract: Protease-activated receptors (PARs) are G protein-coupled receptors of which four members PAR1, PAR2, PAR3, and PAR4 have been identified, characterized by a typical mechanism of activation involving various related proteases. The amino-terminal sequence ...

    Abstract Protease-activated receptors (PARs) are G protein-coupled receptors of which four members PAR1, PAR2, PAR3, and PAR4 have been identified, characterized by a typical mechanism of activation involving various related proteases. The amino-terminal sequence of PARs is cleaved by a broad array of proteases, leading to specific proteolytic cleavage which forms endogenous tethered ligands to induce agonist-biased PAR activation. The biological effect of PARs activated by coagulation proteases to regulate hemostasis and thrombosis plays an enormous role in the cardiovascular system, while PAR4 can also be activated by trypsin, cathepsin G, the activated factor X of the coagulation cascade, and trypsin IV. Irrespective of its role in thrombin-induced platelet aggregation, PAR4 activation is believed to be involved in inflammatory lesions, as show by investigations that have unmasked the effects of PAR4 on neutrophil recruitment, the regulation of edema, and plasma extravasation. This review summarizes the roles of PAR4 in coagulation and other extracellular protease pathways, which activate PAR4 to participate in normal regulation and disease.
    Mesh-Begriff(e) Animals ; Blood Coagulation/physiology ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Peptide Hydrolases/immunology ; Peptide Hydrolases/metabolism ; Receptors, G-Protein-Coupled/immunology ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Thrombin/immunology ; Receptors, Thrombin/metabolism ; Signal Transduction/physiology
    Chemische Substanzen Receptors, G-Protein-Coupled ; Receptors, Thrombin ; Peptide Hydrolases (EC 3.4.-) ; protease-activated receptor 4 (JWE1M73YZN)
    Sprache Englisch
    Erscheinungsdatum 2014-08-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 434408-x
    ISSN 1573-2576 ; 0360-3997
    ISSN (online) 1573-2576
    ISSN 0360-3997
    DOI 10.1007/s10753-014-9999-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1401: Hefte anzeigen Standort:
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  7. Artikel: Sinomenine inhibits A549 human lung cancer cell invasion by mediating the STAT3 signaling pathway.

    Jiang, Shulong / Gao, Yebo / Hou, Wei / Liu, Rui / Qi, Xin / Xu, Xia / Li, Jie / Bao, Yanju / Zheng, Honggang / Hua, Baojin

    Oncology letters

    2016  Band 12, Heft 2, Seite(n) 1380–1386

    Abstract: Increasing evidence suggests that the failure of lung cancer treatment may occur as a result of tumor invasion and metastasis. Signal transducer and activator of transcription 3 (STAT3), an epithelial-mesenchymal transition-inducing transcription factor, ...

    Abstract Increasing evidence suggests that the failure of lung cancer treatment may occur as a result of tumor invasion and metastasis. Signal transducer and activator of transcription 3 (STAT3), an epithelial-mesenchymal transition-inducing transcription factor, is a key signaling molecule involved in the proliferation, apoptosis, invasion and metastasis of tumor cells. Sinomenine is an alkaloid compound with an antineoplastic potential against a variety of cancer cells. The aim of the present study was to assess the antitumor mechanisms of sinomenine in the A549 human lung cancer cell line. The results demonstrated that sinomenine manifested dose-dependent cytotoxicity and induced apoptosis in A549 cells. The protein expression of Janus kinase 2, STAT3, phosphorylated-STAT3, Snail, N-cadherin and vimentin decreased in sinomenine-treated cells, while E-cadherin protein expression increased. The regulation of STAT3, N-cadherin and E-cadherin by sinomenine was further confirmed by reverse transcription-quantitative polymerase chain reaction and immunofluorescent staining. It was demonstrated that sinomenine exerts inhibitory effects on A549 human lung cancer cell invasion, possibly through the inhibition of STAT3 signaling. These results provide a novel insight into the role of sinomenine in the treatment of non-small cell lung cancer.
    Sprache Englisch
    Erscheinungsdatum 2016-06-23
    Erscheinungsland Greece
    Dokumenttyp Journal Article
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2016.4768
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Association between Tumor Vasculogenic Mimicry and the Poor Prognosis of Gastric Cancer in China: An Updated Systematic Review and Meta-Analysis.

    Guo, Qiujun / Yuan, Yuan / Jin, Zhichao / Xu, Tao / Gao, Yebo / Wei, Huamin / Li, Conghuang / Hou, Wei / Hua, Baojin

    BioMed research international

    2016  Band 2016, Seite(n) 2408645

    Abstract: ... ...

    Abstract Background
    Mesh-Begriff(e) China/epidemiology ; Disease-Free Survival ; Female ; Humans ; Male ; Neoplasm Metastasis ; Neovascularization, Pathologic/mortality ; Neovascularization, Pathologic/pathology ; Stomach Neoplasms/blood supply ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Survival Rate
    Sprache Englisch
    Erscheinungsdatum 2016
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2016/2408645
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: [Prognostic analysis of 42 patients with gastric neuroendocrine carcinoma].

    Kou, Yu / Gao, Ye-bo / Ma, Jie / Yang, Ke / Fu, Qiang / Xie, Jian-guo

    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

    2013  Band 16, Heft 6, Seite(n) 570–573

    Abstract: Objective: To investigate the clinicopathological characteristics and prognosis of gastric neuroendocrine carcinoma (NEC).: Methods: Clinical data of 42 patients with gastric neuroendocrine carcinoma admitted in the Cancer Hospital of Zhengzhou ... ...

    Abstract Objective: To investigate the clinicopathological characteristics and prognosis of gastric neuroendocrine carcinoma (NEC).
    Methods: Clinical data of 42 patients with gastric neuroendocrine carcinoma admitted in the Cancer Hospital of Zhengzhou University between May 2006 and July 2011 were analyzed retrospectively. The prognostic factors were determined by Log-rank test.
    Results: Gastric NEC was found in 42 (0.83%) of 5046 patients with gastric cancer during the same period, including 37 males and 5 females. The average age of the patients was 63 years old at the diagnosis. Forty patients underwent R0 resection and 2 patients R1 resection. Forty patients received routine adjuvant chemotherapy with fluorouracil plus oxaliplatin. The median follow-up duration was 26.0 months (range 4-70 months). The median survival was 25.0 months, and the overall 1-, 3-, 5-year survival rates were 71.4%, 26.2% and 11.9%, respectively. Univariate analysis revealed that maximum tumor diameter, tumor invasion depth, lymph node metastasis, lymphatic invasion, stage, and curability were associated with survival (all P<0.05).
    Conclusions: Gastric NEC is rare. Curative operation is essential for improving the prognosis, while the choice of comprehensive treatment after surgery should be optimized.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Carcinoma, Neuroendocrine/pathology ; Carcinoma, Neuroendocrine/surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery
    Sprache Chinesisch
    Erscheinungsdatum 2013-06
    Erscheinungsland China
    Dokumenttyp English Abstract ; Journal Article
    ISSN 1671-0274
    ISSN 1671-0274
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Protease-activated receptor 2 antagonist potentiates analgesic effects of systemic morphine in a rat model of bone cancer pain.

    Bao, Yanju / Hou, Wei / Yang, Liping / Kong, Xiangying / Du, Maobo / Zheng, Honggang / Gao, Yebo / Hua, Baojin

    Regional anesthesia and pain medicine

    2015  Band 40, Heft 2, Seite(n) 158–165

    Abstract: Background and objectives: Bone cancer pain affects the quality of life of cancer patients. This study was aimed at investigating the analgesic effects of combined therapies with an antagonist of proteinase-activated receptor (PAR) 2 and morphine on ... ...

    Abstract Background and objectives: Bone cancer pain affects the quality of life of cancer patients. This study was aimed at investigating the analgesic effects of combined therapies with an antagonist of proteinase-activated receptor (PAR) 2 and morphine on pain-related behaviors in a rat model of bone cancer pain.
    Methods: Female Wistar rats were inoculated intramedullarily with Walker 256 cells into their tibias. The analgesic effects of intraperitoneal treatment with morphine and/or intrathecal with the PAR2 antagonist, FSLLRY-NH2, on bone cancer pain-related behaviors in rats were examined.
    Results: Treatment with morphine at 3 or 10 mg/kg significantly improved limb-use and weight-bearing scores and reduced the number of spontaneous flinches in rats. Treatment with FSLLRY-NH2 at 10 mmol/L also significantly improved limb use and weight bearing scores, and reduced the number of spontaneous flinches in rats. Combination a sub-analgesic dose of FSLLRY-NH2 (0.1 mmol/L) and morphine further elevated limb-use and weight-bearing scores and reduced the number of flinches compared with the effects of morphine alone in rats.
    Conclusions: Our data indicate that the combination of morphine and FSLLRY-NH2 has potent analgesic effects on bone cancer pain and our findings may aid in design of new strategies for the treatment of bone cancer pain.
    Mesh-Begriff(e) Analgesics, Opioid/pharmacology ; Animals ; Bone Neoplasms/complications ; Carcinoma 256, Walker ; Drug Synergism ; Female ; Injections, Intraperitoneal ; Morphine/pharmacology ; Neoplasm Transplantation ; Oligopeptides/therapeutic use ; Pain Measurement ; Pain, Intractable/drug therapy ; Rats ; Rats, Wistar ; Receptor, PAR-2/antagonists & inhibitors
    Chemische Substanzen Analgesics, Opioid ; H-Phe-Ser-Leu-Leu-Arg-Tyr-NH2 ; Oligopeptides ; Receptor, PAR-2 ; Morphine (76I7G6D29C)
    Sprache Englisch
    Erscheinungsdatum 2015-02-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1425299-5
    ISSN 1532-8651 ; 1098-7339 ; 0146-521X
    ISSN (online) 1532-8651
    ISSN 1098-7339 ; 0146-521X
    DOI 10.1097/AAP.0000000000000211
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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