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  1. Article ; Online: Travel Distance to Hospital Is Associated With Self-Harm Hospital Presentation But Not Suicide.

    Liang, Ya-Lun / Lin, Chien-Yu / Gao, Yu-Mei / Gunnell, David / Hsu, Chia-Yueh / Chang, Shu-Sen

    Crisis

    2024  

    Language English
    Publishing date 2024-02-14
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 801380-9
    ISSN 2151-2396 ; 0227-5910
    ISSN (online) 2151-2396
    ISSN 0227-5910
    DOI 10.1027/0227-5910/a000945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intentions to Help People at Risk of Suicide and Associated Factors: A National Telephone Survey in Taiwan.

    Hwang, I-Ting / Gao, Yu-Mei / Chang, Shu-Sen / Chi, Ying-Chen / Wu, Kevin Chien-Chang / Chen, Ying-Yeh

    Archives of suicide research : official journal of the International Academy for Suicide Research

    2023  , Page(s) 1–14

    Abstract: Objective: Many people at risk of suicide do not actively seek help. Suicide prevention efforts need to involve the general public to provide appropriate support to those in need. It is important to investigate the intention to help those at risk of ... ...

    Abstract Objective: Many people at risk of suicide do not actively seek help. Suicide prevention efforts need to involve the general public to provide appropriate support to those in need. It is important to investigate the intention to help those at risk of suicide and the factors associated with helping intentions in the general population. We aimed to assess the intention to help people at risk and associated factors using a national representative sample.
    Method: We conducted a national telephone survey of 1,087 Taiwanese adults and collected data regarding participants' socio-demographic characteristics, mental health status, helping intentions, misconceptions about suicide, and attitudes toward suicide and suicide prevention.
    Results: The prevalence of high intentions to help people at risk of suicide was 56.5%. Helping intentions did not differ by sex, educational level, employment status, marital status, or mental health status. Those with high helping intentions were younger, less likely to have misconceptions about suicide or agree that suicide is a personal choice, and more likely to believe that suicide is preventable and support suicide prevention measures.
    Conclusions: Suicide prevention education programs aimed to enhance helping intentions may usefully target debunking misconceptions about suicide and cultivating positive attitudes toward suicide prevention.
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1283671-0
    ISSN 1543-6136 ; 1381-1118
    ISSN (online) 1543-6136
    ISSN 1381-1118
    DOI 10.1080/13811118.2023.2280231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prucalopride inhibits the glioma cells proliferation and induces autophagy via AKT-mTOR pathway.

    Qiao, Hong / Wang, Yong-Bo / Gao, Yu-Mei / Bi, Li-Li

    BMC neurology

    2018  Volume 18, Issue 1, Page(s) 80

    Abstract: Backgrounds: Glioma is the most fatal primary brain glioma in central nervous system mainly attributed to its high invasion. Prucalopride, a Serotonin-4 (5-HT4) receptor agonist, has been reported to regulate neurodevelopment. This study aimed to ... ...

    Abstract Backgrounds: Glioma is the most fatal primary brain glioma in central nervous system mainly attributed to its high invasion. Prucalopride, a Serotonin-4 (5-HT4) receptor agonist, has been reported to regulate neurodevelopment. This study aimed to investigate the influence of the Prucalopride on glioma cells and unveil underlying mechanism.
    Methods: In this study, glioma cells proliferation was evaluated by Cell counting kit-8 (CCK8). Wound healing and transwell assay were used to test cellular migration and invasion. Flow cytometry was utilized to determine cellular apoptosis rate. Apoptosis related markers, autophagy markers, and protein kinase B (AKT)-mammalian target of rapamycin (mTOR) pathway key molecules were detected using western blot assay.
    Results: As a result, the proliferation, migration and invasiveness of glioma cells were impaired by Prucalopride treatment, the apoptosis rate of glioma cells was enhanced by Prucalopride stimulation, accompanied by the increased pro-apoptosis proteins Bax and Cleaved caspase-3 and decreased anti-apoptosis protein Bcl-2. Prucalopride significantly promoted autophagy by increased expression level of Beclin 1 and LC3-II, while decreased expression level of p62. Prucalopride administration resulted in obvious inhibitions of key molecules of AKT-mTOR pathway, including phosphorylated- (p-) AKT, p-mTOR and phosphorylated-ribosomal p70S6 kinase (p-P70S6K).
    Conclusions: Taking together, these results indicate that Prucalopride may be likely to play an anti-tumor role in glioma cells, which suggests potential implications for glioma promising therapy alternation in the further clinics.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Autophagy/drug effects ; Benzofurans/pharmacology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Glioma/pathology ; Humans ; Proto-Oncogene Proteins c-akt/drug effects ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/drug effects
    Chemical Substances Antineoplastic Agents ; Benzofurans ; prucalopride (0A09IUW5TP) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2018-06-04
    Publishing country England
    Document type Journal Article
    ISSN 1471-2377
    ISSN (online) 1471-2377
    DOI 10.1186/s12883-018-1083-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway.

    Wang, Xiao-Ling / Deng, Yu-Xin / Gao, Yu-Mei / Dong, Yang-Ting / Wang, Fan / Guan, Zhi-Zhong / Hong, Wei / Qi, Xiao-Lan

    Aging

    2020  Volume 12, Issue 1, Page(s) 543–570

    Abstract: Ligands of nicotinic acetylcholine receptors (nAChRs) are widely considered as potential therapeutic agents. The present study used primary hippocampus cells and APPswe/PSEN1dE9 double-transgenic mice models to study the possible therapeutic effect and ... ...

    Abstract Ligands of nicotinic acetylcholine receptors (nAChRs) are widely considered as potential therapeutic agents. The present study used primary hippocampus cells and APPswe/PSEN1dE9 double-transgenic mice models to study the possible therapeutic effect and underlying mechanism of the specific activation of α7 nAChR by PNU-282987 in the pathogenesis of Alzheimer's disease. The results indicated that activation of α7 nAChR attenuated the Aβ-induced cell apoptosis, decreased the deposition of Aβ, increased the expression of synaptic-associated proteins, and maintained synaptic morphology. Furthermore, in the APP/PS1_DT mice model, activation of α7 nAChR attenuated Aβ-induced synaptic loss, reduced the deposition of Aβ in the hippocampus, maintained the integral structure of hippocampus-derived synapse, and activated the calmodulin (CaM)-calmodulin-dependent protein kinase II (CaMKII)-cAMP response element-binding protein signaling pathway by upregulation of its key signaling proteins. In addition, activation of α7 nAChR improved the learning and memory abilities of the APP/PS1_DT mice. Collectively, the activation of α7 nAChR by PNU-282987 attenuated the toxic effect of Aβ
    MeSH term(s) Alzheimer Disease/etiology ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Animals ; Apoptosis ; Benzamides/pharmacology ; Bridged Bicyclo Compounds/pharmacology ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Cognition/drug effects ; Cyclic AMP Response Element-Binding Protein/metabolism ; Disease Models, Animal ; Hippocampus/metabolism ; Learning ; Memory ; Neurons/metabolism ; Nicotinic Agonists/pharmacology ; Signal Transduction ; Synapses/metabolism ; Synapses/ultrastructure ; Synaptic Transmission/drug effects ; alpha7 Nicotinic Acetylcholine Receptor/agonists
    Chemical Substances Amyloid beta-Peptides ; Benzamides ; Bridged Bicyclo Compounds ; Cyclic AMP Response Element-Binding Protein ; Nicotinic Agonists ; PNU-282987 ; alpha7 Nicotinic Acetylcholine Receptor ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17)
    Language English
    Publishing date 2020-01-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.102640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cavity QED implementation of non-adiabatic holonomies for universal quantum gates in decoherence-free subspaces with nitrogen-vacancy centers.

    Zhou, Jian / Yu, Wei-Can / Gao, Yu-Mei / Xue, Zheng-Yuan

    Optics express

    2015  Volume 23, Issue 11, Page(s) 14027–14035

    Abstract: A cavity QED implementation of the non-adiabatic holonomic quantum computation in decoherence-free subspaces is proposed with nitrogen-vacancy centers coupled commonly to the whispering-gallery mode of a microsphere cavity, where a universal set of ... ...

    Abstract A cavity QED implementation of the non-adiabatic holonomic quantum computation in decoherence-free subspaces is proposed with nitrogen-vacancy centers coupled commonly to the whispering-gallery mode of a microsphere cavity, where a universal set of quantum gates can be realized on the qubits. In our implementation, with the assistant of the appropriate driving fields, the quantum evolution is insensitive to the cavity field state, which is only virtually excited. The implemented non-adiabatic holonomies, utilizing optical transitions in the Λ type of three-level configuration of the nitrogen-vacancy centers, can be used to construct a universal set of quantum gates on the encoded logical qubits. Therefore, our scheme opens up the possibility of realizing universal holonomic quantum computation with cavity assisted interaction on solid-state spins characterized by long coherence times.
    Language English
    Publishing date 2015-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.23.014027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Derivation and validation of a risk score for contrast-induced nephropathy after cardiac catheterization in Chinese patients.

    Gao, Yu-mei / Li, Di / Cheng, Hong / Chen, Yi-pu

    Clinical and experimental nephrology

    2014  Volume 18, Issue 6, Page(s) 892–898

    Abstract: Background: To derive and validate a risk score for prediction of contrast-induced nephropathy (CIN) in the Chinese patients undergoing cardiac catheterization.: Methods: The hospital medical records of 3945 patients undergoing coronary angiography ... ...

    Abstract Background: To derive and validate a risk score for prediction of contrast-induced nephropathy (CIN) in the Chinese patients undergoing cardiac catheterization.
    Methods: The hospital medical records of 3945 patients undergoing coronary angiography or percutaneous coronary intervention were reviewed. Patients were randomly assigned into two cohorts: one was for derivation of risk score (n = 2764) and another for validation (n = 1181). The CIN was defined as an increase of serum creatinine level ≥44.2 μmol/L or ≥25 % and beyond its upper limit of normal value within 72 h following the procedure. On the basis of the odds ratio obtained from multivariate logistic regression, risk score of CIN was built up. The discrimination of the risk score was assessed using the area under the receiver operating characteristic curve and the calibration was assessed using the Hosmer-Lemeshow goodness-of-fit test.
    Results: The incidences of CIN in the derivation and validation cohorts were 4.6 and 4.2 %, respectively. Independent predictors included age >60 years, hypertension, acute myocardial infarction, heart failure, use of intra-aortic balloon pump, decreased glomerular filtration rate and contrast volume >100 mL. The incidence of CIN was increased with increment of risk score. Both the derivation and validation cohorts showed adequate discrimination (an area under the ROC curve, 0.76 and 0.71, respectively) and good calibration (Hosmer-Lemeshow statistic test, P = 0.50 and P = 0.54, respectively).
    Conclusion: A simple risk score for prediction of CIN development after cardiac catheterization in Chinese patients was built up by this study. Use of this risk score may help clinicians to perform early preventative strategies to minimize the risk of CIN.
    MeSH term(s) Acute Kidney Injury/blood ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/epidemiology ; Aged ; Cardiac Catheterization/adverse effects ; China/epidemiology ; Cohort Studies ; Contrast Media/adverse effects ; Coronary Angiography/adverse effects ; Creatinine/blood ; Female ; Health Status Indicators ; Humans ; Incidence ; Logistic Models ; Male ; Middle Aged ; Percutaneous Coronary Intervention/adverse effects ; ROC Curve ; Random Allocation ; Retrospective Studies ; Risk Factors
    Chemical Substances Contrast Media ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2014-02-11
    Publishing country Japan
    Document type Comparative Study ; Journal Article ; Validation Study
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-014-0942-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Control of organ shape and size by YUAN1 in Arabidopsis thaliana].

    Zhang, Hai-Rui / Xu, Ran / Gao, Yu-Mei / Jin, Wei-Huan / Gao, Gang / Li, Yun-Hai

    Yi chuan = Hereditas

    2014  Volume 35, Issue 9, Page(s) 1106–1116

    Abstract: Control of organ shape and size by cell proliferationandcell expansion is a fundamental process in plant development. However, little is known about the molecular mechanisms that set the shape and size of determinate organs in plants. We have previously ... ...

    Abstract Control of organ shape and size by cell proliferationandcell expansion is a fundamental process in plant development. However, little is known about the molecular mechanisms that set the shape and size of determinate organs in plants. We have previously demonstrated that the Arabidopsis gene DA1 controls the final size of organs by restricting cell proliferation. Through an activation tagging screen for modifiers of da1-1, we have identified a semi-dominant mutant (yuan1-1D) with altered leaf shape and size. The yuan1-1D mutation results in reduced plant height, short and round leaves and short petioles due to defects in cell elongation. YUAN1 encodes a PHD zinc finger domain-containing protein. The GFP-YUAN1 fusion protein is localized to the nucleus. Overexpression of YUAN1 leads to round leaves and short petioles. Genetic analyses show that YUAN1 acts independently of DA1, ROTUNDIFOLIA 3 (ROT3) and ROTUNDIFOLIA4 (ROT4) to influence leaf shape and size. Collectively, our findings show that Arabidopsis YUAN1, a PHD zinc finger domain-containing protein, controls organ shape and size by restricting cell elongation, and give insight into how plants control their organ shape and size.
    MeSH term(s) Arabidopsis/genetics ; Arabidopsis/growth & development ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Gene Expression Regulation, Plant ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; LIM Domain Proteins/genetics ; LIM Domain Proteins/metabolism ; Mutation ; Organ Size ; Plant Leaves/genetics ; Plant Leaves/growth & development ; Plant Leaves/metabolism ; Plant Stems/genetics ; Plant Stems/growth & development ; Plant Stems/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances Arabidopsis Proteins ; DA1 protein, Arabidopsis ; Homeodomain Proteins ; LIM Domain Proteins ; Transcription Factors ; YUAN1 protein, Arabidopsis
    Language Chinese
    Publishing date 2014-01-01
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 0253-9772
    ISSN 0253-9772
    DOI 10.3724/sp.j.1005.2013.01106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Ultra-performance liquid chromatography fingerprinting for quality control of Phragmitis rhizoma (Lugen) produced in Baiyangdian.

    Li, Hong / Gao, Yu-Mei / Zhang, Jing / Wang, Lin / Wang, Xiao-Xin

    Pharmacognosy magazine

    2013  Volume 9, Issue 36, Page(s) 285–289

    Abstract: Objective: To establish an ultra-performance liquid chromatography (UPLC) fingerprinting method for quality control of Phragmitis rhizoma from Baiyangdian.: Materials and methods: Ultrasonic extraction with 70% methanol was performed on 10 samples of ...

    Abstract Objective: To establish an ultra-performance liquid chromatography (UPLC) fingerprinting method for quality control of Phragmitis rhizoma from Baiyangdian.
    Materials and methods: Ultrasonic extraction with 70% methanol was performed on 10 samples of P. rhizoma collected from 10 different villages in Baiyangdian. The sample solutions were analyzed by Waters UPLC equipped with the ACQUITY UPLC BEH C18 column and photodiode array (PDA) detector, and gradient eluted with acetonitrile/water as the mobile phase. The flow rate was set to 0.1 mL/min; the column temperature was set to 25°C; and the detection wavelength was set to 285 nm.
    Results: The chromatograms of the 10 samples showed 27 common peaks, of which one was identified as the ferulic acid standard. The similarity indexes were all above 0.82. Hierarchical cluster analysis showed that the constituents and their quantities differed according to the diameter of the original plant, which is related to its age.
    Conclusion: The UPLC fingerprinting method had the advantages of being fast, accurate, and highly efficient; this indicated that it can be used for quality control of P. rhizoma produced in Baiyangdian. Also, the relation between the quality and diameter/age of the plant needs to be further investigated.
    Language English
    Publishing date 2013-10-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2274976-7
    ISSN 0976-4062 ; 0973-1296
    ISSN (online) 0976-4062
    ISSN 0973-1296
    DOI 10.4103/0973-1296.117810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Epidemiological features of chronic and Alzheimer's diseases in the community-based elderly living in cities and counties in Hebei province].

    Kang, Mei-yu / Gao, Yu-mei / Huo, Hong-qi / Chen, Yu-min / Wang, Jian / Li, Mei-jie / Du, Tao

    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

    2011  Volume 32, Issue 7, Page(s) 672–675

    Abstract: Objective: To understand the epidemiological features of Alzheimer's disease (AD) in the community-based elderly living in cities and counties in Hebei province.: Methods: Under the stratified random sampling method, Mini Mental State Examination ( ... ...

    Abstract Objective: To understand the epidemiological features of Alzheimer's disease (AD) in the community-based elderly living in cities and counties in Hebei province.
    Methods: Under the stratified random sampling method, Mini Mental State Examination (MMSE) was used to evaluate senile dementia and Activity of Daily Living Scale (ADL) and to evaluate the daily lives of the elderly. Related dementia standard on the diagnose of AD and its subtypes was used. Statistically, data was analyzed through SPSS 13.0 software.
    Results: The overall prevalence was 64.84% (2355/3632) on chronic diseases in those elderly who were over 60 years of age while AD appeared to be high and increased with age. The prevalence rate of dementia was 7.24% (263/3632), in which AD accounted for 4.87% (177/3632). Rates for other chronic diseases were as follows:hypertension (32.35%), diabetes (11.37%), chronic obstructive pulmonary disease (9.25%), coronary heart disease (8.84%) and stroke (7.16%). The prevalence of AD increased with age and was related to the low degree of education having.
    Conclusion: Elderly living in the communities of Hebei province showed high prevalent rates of chronic diseases including AD, which had become the major kind of diseases related to old age.
    MeSH term(s) Aged ; Aged, 80 and over ; Aging ; Alzheimer Disease/epidemiology ; China/epidemiology ; Chronic Disease/epidemiology ; Dementia/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Residence Characteristics ; Surveys and Questionnaires
    Language Chinese
    Publishing date 2011-07
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645026-x
    ISSN 0254-6450
    ISSN 0254-6450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: 7-(Hydroxy-meth-yl)-2-(1-hydr-oxy-1-methyl-ethyl)-4-meth-oxy-2,3-dihydro-5H-furo[3,2-g]chromen-5-one methanol hemisolvate.

    Li, Ru / Liu, Pu / Gao, Yu-Mei / Qin, Lin-Lin / Yu, Hua-Ning

    Acta crystallographica. Section E, Structure reports online

    2007  Volume 64, Issue Pt 1, Page(s) o202

    Abstract: The title compound (cimifugin), C(16)H(18)O(6)·0.5CH(3)OH, was isolated from the rhizome of Actaea asiatica Hara. The asymmetric unit contains two independent mol-ecules and a solvent methanol mol-ecule. The five-numbered ring adopts an envelope ... ...

    Abstract The title compound (cimifugin), C(16)H(18)O(6)·0.5CH(3)OH, was isolated from the rhizome of Actaea asiatica Hara. The asymmetric unit contains two independent mol-ecules and a solvent methanol mol-ecule. The five-numbered ring adopts an envelope conformation in each molecule. Intra- and inter-molecular O-H⋯O hydrogen bonds stabilize the crystal structure.
    Language English
    Publishing date 2007-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2041947-8
    ISSN 1600-5368
    ISSN 1600-5368
    DOI 10.1107/S1600536807063763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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