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  1. Book ; Online: Multi-Sensor Information Fusion

    Jin, Xue-Bo / Gao, Yuan

    2020  

    Abstract: This book includes papers from the section "Multisensor Information Fusion", from Sensors between 2018 to 2019. It focuses on the latest research results of current multi-sensor fusion technologies and represents the latest research trends, including ... ...

    Abstract This book includes papers from the section "Multisensor Information Fusion", from Sensors between 2018 to 2019. It focuses on the latest research results of current multi-sensor fusion technologies and represents the latest research trends, including traditional information fusion technologies, estimation and filtering, and the latest research, artificial intelligence involving deep learning
    Keywords Technology (General) ; Engineering (General). Civil engineering (General)
    Size 1 electronic resource (602 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020480966
    ISBN 9783039283026 ; 9783039283033 ; 3039283022 ; 3039283030
    DOI 10.3390/books978-3-03928-303-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Using Human iPSC-Derived Peripheral Nervous System Disease Models for Drug Discovery.

    Gao, Yuan

    Handbook of experimental pharmacology

    2023  Volume 281, Page(s) 191–205

    Abstract: Induced pluripotent stem cells (IPSCs), with their remarkable ability to differentiate into various cell types, including peripheral nervous system cells such as neurons and glial cells, offer an excellent platform for in vitro disease modeling. These ... ...

    Abstract Induced pluripotent stem cells (IPSCs), with their remarkable ability to differentiate into various cell types, including peripheral nervous system cells such as neurons and glial cells, offer an excellent platform for in vitro disease modeling. These iPSC-derived disease models have proven valuable in drug discovery, as they provide more precise simulations of a patient's disease state and allow for the assessment of potential therapeutic effectiveness and safety.
    MeSH term(s) Humans ; Induced Pluripotent Stem Cells ; Neurons ; Peripheral Nervous System Diseases/drug therapy ; Peripheral Nervous System Diseases/metabolism ; Drug Discovery ; Cell Differentiation
    Language English
    Publishing date 2023-11-25
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2023_690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  3. Article: Overcoming mental health stigma through student's awareness and project-based inclusive pedagogy in English teaching colleges: Moderating role of institutional support in China.

    Gao, Yuan

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 992904

    Abstract: Mental health stigma undermines collaborative work and creates communication breakdowns for students to face real-world challenges. Moreover, project-based English learning in East-Asian nations is a significant challenge for advancing students' ... ...

    Abstract Mental health stigma undermines collaborative work and creates communication breakdowns for students to face real-world challenges. Moreover, project-based English learning in East-Asian nations is a significant challenge for advancing students' effective learning, while students lack mental health self-awareness. Unawareness causes distractions and results in learning inefficiencies. Furthermore, without institutional support (IS) achieving effective learning could never be possible. Therefore, this study investigates the relationships between project-based learning (PBL) and mental health awareness (MHA) with effective English language teaching among university students in China. We also tested the moderation effect of IS in the relationships between PBL and MHA with effective English language learning (EEL). Using the purposive sampling technique, we collected valid responses from 713 students studying English as a foreign language in universities and colleges in Harbin, China. The findings interestingly supported the direct hypotheses between PBL and EEL, as well as MHA and EEL. Moreover, the moderating role of IS established a significant effect on both PBL and EEL, as well as MHA and EEL, respectively. Policymakers, practitioners, and academicians should understand that integrating PBL as an inclusive pedagogy method with proper IS may enhance effective learning; however, it will consume more time.
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.992904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: An Investigation Into the Role of English as a Foreign Language Teachers' Self-Efficacy in Their Organizational Commitment.

    Gao, Yuan

    Frontiers in psychology

    2022  Volume 13, Page(s) 894333

    Abstract: The way EFL students experience the process of learning has always been of utmost importance since it tremendously affects the amount of learning and received pleasure throughout this process for both teachers and students. From this aspect, both self- ... ...

    Abstract The way EFL students experience the process of learning has always been of utmost importance since it tremendously affects the amount of learning and received pleasure throughout this process for both teachers and students. From this aspect, both self-efficacious and committed teachers make a contribution to their organization's success. Even though many studies have been conducted about teachers' self-efficacy and their organizational commitment, a few of which concentrate their attention on the link between these two variables. To fill this gap, this review paper provides a glimpse at the underlying roles of teacher self-efficacy and their organizational commitment. Furthermore, it presents the definitions and applications of each construct. Finally, some implications and future recommendations are put forward to avid scholars.
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.894333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Research on R&D Investment, Corporate Leverage and Firm Performance

    Gao Yuan

    E3S Web of Conferences, Vol 292, p

    Based on Chinese Manufacturing Industry

    2021  Volume 02046

    Abstract: With the development of science and technology, Chinese manufacturing industry is facing transformation and upgrading, and innovation is an important driving force to promote industrial transformation and upgrading. Therefore, based on the background of ... ...

    Abstract With the development of science and technology, Chinese manufacturing industry is facing transformation and upgrading, and innovation is an important driving force to promote industrial transformation and upgrading. Therefore, based on the background of Chinese manufacturing transformation and upgrading, this paper uses fixed effect model to study the relationship between R & D investment and corporate performance, and the moderating effect of corporate leverage. The study finds that the greater the R & D investment of enterprises is, the better the performance of enterprises is. Meanwhile, the leverage of enterprises has a negative moderating effect on the relationship between R & D investment and enterprise performance. Therefore, enterprises should pay attention to their own R & D, reduce their debt levels, and promote the transformation and upgrading of enterprises. At the same time, the government should introduce corresponding preferential policies to encourage enterprises to carry out R & D and deleverage, in order to promote the healthy development of industrial economy.
    Keywords Environmental sciences ; GE1-350
    Subject code 650
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: miR-889-3p targeting BMPR2 promotes the development of retinoblastoma via JNK/MAPK/ERK signaling.

    Gao, Yuan / Du, Pei

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7277

    Abstract: MicroRNAs (miRNAs) are vital regulators of tumor pathogenesis, including that of retinoblastoma (Rb). This study investigated the functions and mechanisms of action of miR-889-3p in Rb. BMPR2 and miR-889-3p levels were assessed by quantitative reverse ... ...

    Abstract MicroRNAs (miRNAs) are vital regulators of tumor pathogenesis, including that of retinoblastoma (Rb). This study investigated the functions and mechanisms of action of miR-889-3p in Rb. BMPR2 and miR-889-3p levels were assessed by quantitative reverse transcription PCR (qRT-PCR) or western blotting. Through several cell function tests, the effects of miR-889-3p and BMPR2 on cell proliferation, migration, and JNK/MAPK/ERK signaling were evaluated. The interaction between miR-889-3p and BMPR2 was investigated using a luciferase reporter assay. In vivo tumor development was investigated using a xenograft test. The association between miR-889-3p and BMPR2 expression was identified using Pearson's correlation analysis. miR-889-3p was increased in Rb cells, and miR-889-3p knockdown inhibited Rb cell proliferation, migration, and phosphorylation of c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and ERK1/2 in vitro, as well as tumor growth in vivo. Further, they were inversely associated in Rb tissues and miR-889-3p may directly attached to the 3'-UTR of BMPR2 mRNA. Finally, the inhibition of BMPR2 inverted the negative effects of the miR-889-3p inhibitor on migration, proliferation, and activation of JNK, p38 MAPK, and ERK1/2 in Rb cells. Our results indicate that miR-889-3p, which targets BMPR2 and promotes Rb growth by controlling the JNK/MAPK/ERK pathway, is an oncogene in Rb. These results suggested that the miR-889-3p/BMPR2 axis may be a new therapeutic target for Rb.
    MeSH term(s) Humans ; Retinoblastoma/pathology ; JNK Mitogen-Activated Protein Kinases/metabolism ; MicroRNAs/metabolism ; Signal Transduction ; Cell Proliferation/genetics ; Retinal Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Gene Expression Regulation, Neoplastic ; Apoptosis/genetics ; Bone Morphogenetic Protein Receptors, Type II/genetics ; Bone Morphogenetic Protein Receptors, Type II/metabolism
    Chemical Substances JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; MicroRNAs ; BMPR2 protein, human (EC 2.7.11.30) ; Bone Morphogenetic Protein Receptors, Type II (EC 2.7.11.30)
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-49994-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Therapeutic index of targeting select chromatin complexes in human cancer patients.

    Gao, Yuan / Vakoc, Christopher R

    Current opinion in genetics & development

    2024  Volume 85, Page(s) 102162

    Abstract: Aberrant chromatin regulation can promote the initiation and progression of human cancer. An improved understanding of such mechanisms has resulted in the identification of cancers with an enhanced dependency on specific chromatin regulatory proteins ... ...

    Abstract Aberrant chromatin regulation can promote the initiation and progression of human cancer. An improved understanding of such mechanisms has resulted in the identification of cancers with an enhanced dependency on specific chromatin regulatory proteins relative to nonmalignant cell types. Hence, targeting of such complexes with small molecules has significant therapeutic potential in oncology. In recent years, several drugs have been developed and evaluated in human cancer patients, which can influence tumor biology by reprogramming of chromatin structure. In this review, we summarize several of the known mechanisms that endow cancer cells with a powerful dependency on chromatin regulation that exceeds the requirements for normal tissue homeostasis. We also summarize the remarkable small-molecule inhibitors that exploit chromatin regulator dependencies with a clear therapeutic benefit in human cancer patients.
    MeSH term(s) Humans ; Chromatin/genetics ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Transcription Factors/genetics ; Chromatin Assembly and Disassembly ; Therapeutic Index
    Chemical Substances Chromatin ; Transcription Factors
    Language English
    Publishing date 2024-02-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2024.102162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Colonoscopy in the diagnosis and management of appendiceal disease.

    Gao, Yuan / Hu, Bing

    World journal of gastrointestinal endoscopy

    2024  Volume 16, Issue 4, Page(s) 187–192

    Abstract: In this editorial, we comment on the article published in the recent issue of ... ...

    Abstract In this editorial, we comment on the article published in the recent issue of the
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Editorial
    ZDB-ID 2573698-X
    ISSN 1948-5190
    ISSN 1948-5190
    DOI 10.4253/wjge.v16.i4.187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Correlation between ER, PR, P53, Ki67 expression, and high-risk HPV infection in patients with different levels of cervical intraepithelial neoplasia

    Gao Yuan

    European Journal of Inflammation, Vol

    2020  Volume 18

    Abstract: This study was designed to investigate the correlation between high-risk human papillomavirus (HPV) infection and the expression of IHC markers (ER, PR, p53, Ki67) in patients with different grades of cervical intraepithelial neoplasia (CIN). It was a ... ...

    Abstract This study was designed to investigate the correlation between high-risk human papillomavirus (HPV) infection and the expression of IHC markers (ER, PR, p53, Ki67) in patients with different grades of cervical intraepithelial neoplasia (CIN). It was a retrospective study, which was conducted from June 2016 to June 2018. 140 specimens of CIN were collected from the pathology department of a certain hospital that included 40 specimens of CIN1, 50 specimens of CIN2 and 50 specimens of CIN3. The expression of ER, PR, P53 and Ki67 were determined by immunohistochemistry. The high-risk HPV infections were detected by PCR fluorescence quantification and were given the correlation analysis. In the 140 specimens, the positive rates of HPV16 and HPV18 in CIN1 specimens were 27.5% and 25.0% respectively, and in CIN2 specimens were 64.0% and 60.0% respectively, and in CIN3 specimens were 90.0% and 92.0% respectively, the difference were statistically significant (p<0.05). There were no significant correlation (p<0.05) between HPV16 and HPV18 positive rate and patient age, tissue differentiation, and tumor size. With the increased of CIN grade, the positive rate of ER, PR, P53 and Ki67 expression in specimen were also increased significantly, and the difference were statistically significant (p<0.05). Pearson correlation analysis showed there were positive correlation (p<0.05) between the positive rates of HPV16 and HPV18 and the positive rates of ER, PR, P53 and Ki67. With the increase of CIN level, the positive rates of high-risk HPV infection as well as ER, PR, P53 and Ki67 are increased, and they have positive correlation.
    Keywords Medicine ; R
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Significant correlation between glucose metabolism status and acute radiation enteritis resulting from concurrent chemoradiotherapy in rectal cancer.

    Gao, Yuan / Meng, Lingjun

    American journal of translational research

    2023  Volume 15, Issue 6, Page(s) 4228–4236

    Abstract: Objective: To explore the relationship between glucose metabolism and acute radiation enteritis from chemoradiotherapy for rectal cancer.: Methods: In this retrospective study, the clinical data of 75 rectal cancer patients who received concurrent ... ...

    Abstract Objective: To explore the relationship between glucose metabolism and acute radiation enteritis from chemoradiotherapy for rectal cancer.
    Methods: In this retrospective study, the clinical data of 75 rectal cancer patients who received concurrent chemoradiotherapy in Binzhou Second People's Hospital from February 2019 to February 2022 were collected and analyzed. According to the Radiation Therapy Oncology Group (RTOG)/European Organization for Research on Treatment of Cancer (EORTC) radiation response grading criteria, the patients were classified into four groups with different glucose metabolism statuses: NGR (normal glucose regulation) group, IFG (impaired fasting glucose) group, IGT (impaired glucose tolerance) group, and DM (diabetes mellitus) group. Two-factor logistic regression was used to analyze whether IFG, IGT, or DM were risk factors for acute radiation enteritis.
    Results: (1) The fasting plasma glucose (FPG, F=20.550,
    Conclusions: DM was significantly correlated with acute radiation enteritis induced by concurrent chemoradiotherapy for rectal cancer, while IFG and IGT were not.
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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