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  1. Article: [Progress in the clinical cure of the population of inactive hepatitis B surface antigen carriers].

    Mo, Z S / Gao, Z L

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2024  Volume 31, Issue 12, Page(s) 1336–1339

    Abstract: The population of inactive HBsAg carriers (IHCs) is enormous, and it is often overlooked because of the insidious progression and mild severity of the disease. With the continuous enrichment and consolidation of research evidence, the population of IHC ... ...

    Abstract The population of inactive HBsAg carriers (IHCs) is enormous, and it is often overlooked because of the insidious progression and mild severity of the disease. With the continuous enrichment and consolidation of research evidence, the population of IHC has obtained a high clinical cure rate through a treatment strategy based on pegylated interferon α and a stronger treatment intention. This article reviews the definition and treatment recommendations of IHCs in current domestic and international guidelines, as well as the disease progression and clinical cure research progress, so as to provide a reference and basis for scientific management and rational therapeutics.
    MeSH term(s) Hepatitis B Surface Antigens ; Interferon-alpha
    Chemical Substances Hepatitis B Surface Antigens ; Interferon-alpha
    Language Chinese
    Publishing date 2024-01-22
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20231116-00201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Exploring the ALT threshold from the ALT level of patients with chronic hepatitis B for clinical cure in China (Mount Everest Engineering Project)].

    Gao, Z L

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2021  Volume 29, Issue 10, Page(s) 1020–1021

    MeSH term(s) Alanine Transaminase ; China ; DNA, Viral ; Hepatitis B e Antigens ; Hepatitis B, Chronic/drug therapy ; Humans
    Chemical Substances DNA, Viral ; Hepatitis B e Antigens ; Alanine Transaminase (EC 2.6.1.2)
    Language Chinese
    Publishing date 2021-11-23
    Publishing country China
    Document type Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20210823-00422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Predictive factors for HBsAg-negative seroconversion in chronic hepatitis B after antiviral therapy].

    Wu, L L / Gao, Z L

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2023  Volume 32, Issue 2, Page(s) 186–192

    Abstract: Hepatitis B surface antigen (HBsAg) negative seroconversion (HBsAg < 0.05 IU/ml) is research hotspot in the field of hepatitis at this stage, and patients who achieve HBsAg negative seroconversion have significantly fewer liver-related complications. ... ...

    Abstract Hepatitis B surface antigen (HBsAg) negative seroconversion (HBsAg < 0.05 IU/ml) is research hotspot in the field of hepatitis at this stage, and patients who achieve HBsAg negative seroconversion have significantly fewer liver-related complications. Presently, there are many studies with regard to HBsAg-negative seroconversion, but there are still relatively few indicators used in clinical practice to predict HBsAg-negative seroconversion. Low baseline HBsAg quantification and dynamic decline during treatment are currently recognized as the best indicators for predicting HBsAg-negative seroconversion. However, other factors such as viral genotype, elevated transaminases during treatment course, immune cell function and cytokine levels, and host factors can all influence HBsAg-negative seroconversion. This article reviews the relevant indicators and potential predictive factors for HBsAg-negative seroconversion.
    MeSH term(s) Humans ; Hepatitis B Surface Antigens ; Hepatitis B, Chronic/drug therapy ; Antiviral Agents/therapeutic use ; Interferon-alpha/therapeutic use ; Hepatitis B e Antigens ; Seroconversion ; Treatment Outcome ; DNA, Viral ; Hepatitis B virus/genetics
    Chemical Substances Hepatitis B Surface Antigens ; Antiviral Agents ; Interferon-alpha ; Hepatitis B e Antigens ; DNA, Viral
    Language Chinese
    Publishing date 2023-08-03
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20231213-00278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Research advances in the treatment of liver failure with mesenchymal stem cell-derived exosomes].

    Luo, Q M / Zhu, S / Peng, L / Gao, Z L

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2022  Volume 30, Issue 3, Page(s) 249–252

    Abstract: Liver failure is a serious clinical syndrome in which multiple pathogenic factors exceed the liver's self-repair capability, resulting massive hepatocellular necrosis, rapid disease progression and high mortality. Liver transplantation is the most ... ...

    Abstract Liver failure is a serious clinical syndrome in which multiple pathogenic factors exceed the liver's self-repair capability, resulting massive hepatocellular necrosis, rapid disease progression and high mortality. Liver transplantation is the most effective method for the treatment of liver failure, but it has disadvantages, such as insufficient liver donor and high cost. The clinical efficacy of mesenchymal stem cells in liver failure have been validated, but its application has been limited to certain extent. Cell-free-based therapies, especially mesenchymal stem cell-derived exosomes, has become a research hotspot in recent years. This paper reviews the research advances in the treatment of liver failure with the use of mesenchymal stem cell-derived exosomes.
    MeSH term(s) Cell- and Tissue-Based Therapy ; Exosomes ; Hepatic Insufficiency ; Humans ; Liver Failure/therapy ; Liver Failure, Acute/therapy ; Mesenchymal Stem Cells
    Language Chinese
    Publishing date 2022-04-24
    Publishing country China
    Document type Journal Article ; Review
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn51113-20220406-00171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Analysis of clinical characteristics of persistent HBeAg positivity in patients with chronic hepatitis B treated with nucleos(t)ide analogues].

    Peng, L P / Gan, W Q / Zheng, Y B / Chen, Y M / Liu, J / Wu, Z B / Gao, Z L

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2024  Volume 32, Issue 3, Page(s) 193–200

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Female ; Humans ; Hepatitis B, Chronic/drug therapy ; Hepatitis B e Antigens ; Antiviral Agents/therapeutic use ; Hepatitis B Surface Antigens ; Retrospective Studies ; DNA, Viral ; Neoplasm Recurrence, Local/drug therapy ; Hepatitis B/drug therapy ; Liver Cirrhosis/drug therapy ; Hepatitis B virus/genetics ; Treatment Outcome
    Chemical Substances Hepatitis B e Antigens ; Antiviral Agents ; Hepatitis B Surface Antigens ; DNA, Viral
    Language Chinese
    Publishing date 2024-01-23
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20230822-00065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Multi-omics combined test performance effectiveness on opportunistic screening of high-risk liver cancer population].

    Xie, C / Lin, B L / Deng, H / Zhang, X H / Zhao, Q Y / Gao, Z L

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2023  Volume 32, Issue 2, Page(s) 140–147

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Liver Neoplasms/diagnosis ; alpha-Fetoproteins ; Carcinoma, Hepatocellular/diagnosis ; Multiomics ; Early Detection of Cancer ; Biomarkers ; Precancerous Conditions ; Biomarkers, Tumor
    Chemical Substances alpha-Fetoproteins ; Biomarkers ; Biomarkers, Tumor
    Language Chinese
    Publishing date 2023-08-03
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20231125-00235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Impression of direct-acting antiviral agents in the treatment of recurrent hepatocellular carcinoma related to chronic hepatitis C].

    Zhang, X H / Gao, Z L

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2018  Volume 26, Issue 3, Page(s) 179–183

    Abstract: The treatment of chronic hepatitis C has gradually entered into the era of direct-acting antiviral agents (DAAs) from the era of pegylated interferon-α combined with ribavirin, which has a high curative effect, good tolerability, and complete patient- ... ...

    Abstract The treatment of chronic hepatitis C has gradually entered into the era of direct-acting antiviral agents (DAAs) from the era of pegylated interferon-α combined with ribavirin, which has a high curative effect, good tolerability, and complete patient-friendly oral form of administration. Sustained virologic response (SVR) acquired by pegylated interferon-α plus ribavirin therapy has been widely recognized by scholars in reducing the recurrence of primary liver cancer and liver cancer, especially in cirrhotic patients. The clinical application time of DAAs is short and its report is inconsistent with the increase or decrease of primary liver cancer and liver cancer recurrence. Simultaneously, the effect of SVR in people with hepatocellular carcinoma on DAAs seems to be different from those in patients without hepatocellular carcinoma. This article reviews some of the existing reports in order to increase the understanding of DAAs and liver cancer and serve the long-term benefit of clinical treatment.
    MeSH term(s) Adult ; Antiviral Agents/therapeutic use ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/virology ; Drug Therapy, Combination ; Hepacivirus ; Hepatitis C, Chronic/complications ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Liver Neoplasms/virology ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology
    Chemical Substances Antiviral Agents
    Language Chinese
    Publishing date 2018-05-27
    Publishing country China
    Document type Journal Article ; Review
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.issn.1007-3418.2018.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Advances in the study of mesenchymal stem cells for end-stage liver disease].

    Zheng, Y Y / Zhu, S / Peng, L / Gao, Z L

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2021  Volume 29, Issue 7, Page(s) 618–621

    Abstract: End-stage liver disease refers to the advanced stage of liver disease caused by various chronic liver damage. Orthotopic liver transplantation is the most important final treatment option, but liver transplantation is still limited by many factors at ... ...

    Abstract End-stage liver disease refers to the advanced stage of liver disease caused by various chronic liver damage. Orthotopic liver transplantation is the most important final treatment option, but liver transplantation is still limited by many factors at present. Stem cell transplantation therapy has attracted widespread attention as a potential treatment for end-stage liver disease. This article reviews the research progress of mesenchymal stem cell therapy in end-stage liver disease.
    MeSH term(s) End Stage Liver Disease/surgery ; Humans ; Liver Diseases ; Liver Transplantation ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells
    Language Chinese
    Publishing date 2021-08-09
    Publishing country China
    Document type Journal Article ; Review
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20210610-00270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [A cross-sectional study of renal dysfunction in chronic hepatitis B outpatients treated with nucleos(t)ide drugs in China].

    Liu, J / Xiao, G M / Lyu, F F / Gao, Z L

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2021  Volume 29, Issue 5, Page(s) 409–414

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Antiviral Agents/adverse effects ; China/epidemiology ; Cross-Sectional Studies ; Female ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/epidemiology ; Humans ; Male ; Middle Aged ; Nucleosides/therapeutic use ; Outpatients ; Pharmaceutical Preparations
    Chemical Substances Antiviral Agents ; Nucleosides ; Pharmaceutical Preparations
    Language Chinese
    Publishing date 2021-06-09
    Publishing country China
    Document type Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20200526-00273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Efficacy analysis of selective genicular artery embolization in the treatment of knee pain secondary to osteoarthritis].

    Sun, C H / Gao, Z L / Lin, K / Yang, H / Zhao, C Y / Lu, R / Wu, L Y / Chen, Y

    Zhonghua yi xue za zhi

    2022  Volume 102, Issue 11, Page(s) 795–800

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Aged ; Arteries ; Female ; Humans ; Knee Joint ; Male ; Middle Aged ; Osteoarthritis, Knee/therapy ; Pain/etiology ; Treatment Outcome
    Language Chinese
    Publishing date 2022-03-09
    Publishing country China
    Document type Journal Article
    ZDB-ID 132513-9
    ISSN 0376-2491
    ISSN 0376-2491
    DOI 10.3760/cma.j.cn112137-20210926-02166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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