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Article ; Online: Effect of RPL27 knockdown on the proliferation and apoptosis of human liver cancer cells.

Suo, Lida / Gao, Mingwei / Ma, Taiheng / Gao, Zhenming

Biochemical and biophysical research communications

2023 Volume 682, Page(s) 156–162

Abstract: RPL27 is linked to the development of various diseases including malignant tumors. RPL27 may play an oncogenic function in hepatocellular carcinoma (HCC), but this is unknown. So, the aim of this study was to investigate how the human liver cancer cell ... ...

Abstract	RPL27 is linked to the development of various diseases including malignant tumors. RPL27 may play an oncogenic function in hepatocellular carcinoma (HCC), but this is unknown. So, the aim of this study was to investigate how the human liver cancer cell lines SNU449 and HepG2 responded to RPL27 knockdown in terms of proliferation and apoptosis. SNU449 and HepG2 were cultured and infected with shCon and shRPL27 lentiviral particles to induce RPL27 knockdown, and then RPL27 expression was detected using qPCR and Western blot. Cell proliferation was measured using CCK8, cell cloning, cell scraping, and transwell migration and invasion, while apoptosis was measured using flow cytometry (FCM). The qPCR revealed that mRNA expression of RPL27 decreased after knocking down RPL27 in cells. The CCK8 and cell cloning assay confirmed that knocking down RPL27 significantly reduced cell viability. The cell scratch assay and transwell assays showed that the proliferation rate decreased after knocking down RPL27. A substantial increase in apoptotic cells was discovered by FCM. According to WB, RPL27 knockdown increased the expression of Bax and Caspase-3 while decreasing the expression of bcl-2. The findings showed that RPL27 knockdown inhibited cell proliferation in SNU449 and HepG2 via inducing apoptosis, proving that RPL27 is a novel gene linked with HCC and is crucial for both proliferation and apoptosis. These outcomes imply that RPL27 may be a potential target for liver cancer diagnosis and therapy.
MeSH term(s)	Humans ; Apoptosis ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Hep G2 Cells ; Liver Neoplasms/pathology
Chemical Substances	RPL27A protein, human
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2023.10.012
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Article ; Online: Risk Factors Related to Early Biliary Complications After Liver Transplantation: a Single-Center Analysis.

Suo, Lida / Liang, Xiangnan / Zhang, Weibin / Ma, Taiheng / Gao, Zhenming

Transplantation proceedings

2023 Volume 55, Issue 1, Page(s) 164–169

Abstract: Background: The aim of this study was to evaluate the risk factors of early biliary complications (EBC) after liver transplantation (LT) and seek effective treatments based on our single-center experience.: Methods: A total of 124 adult patients were ...

Abstract	Background: The aim of this study was to evaluate the risk factors of early biliary complications (EBC) after liver transplantation (LT) and seek effective treatments based on our single-center experience. Methods: A total of 124 adult patients were divided into a non-EBC group and EBC group. EBC usually accounts for biliary leakage, biliary stricture, biliary stones, sphincter of Oddi dysfunction, and transient jaundice within 3 months after LT. Statistical analysis including logistic regression was performed to determine EBC risk factors. All procedures complied with the Helsinki Congress and the Declaration of Istanbul. Results: Non-EBC (n = 95) and EBC (n = 29) were finally compared, which had no difference in their general characteristics. EBC occurred in 29 patients (26.92%): 1 biliary hemorrhage (3.45%), 7 biliary leakage (24.13%), and 16 biliary stricture (55.18%), and 5 others (17.24%). Of all EBC patients, endoscopic retrograde cholangiopancreatography (68.96%) was higher used to deal with complications than conservative treatment (10.35%), percutaneous transhepatic cholangial drainage (17.24%), and surgical treatment (3.45%). On univariate analyses, risk factors for EBC were bilirubin (P = .014), warm ischemia time (WIT) (P = .020), second WIT (P = .042), and operative time (OT) (P = .033). On multivariate analysis, independent risk factors for BC were WIT (P = .011) and OT (P = .049). Conclusions: The presence of WIT and OT were the independent risk factors for the development of EBC. In addition, we also confirmed that endoscopic retrograde cholangiopancreatography was beneficial and safe in the management of EBC after LT.
MeSH term(s)	Adult ; Humans ; Liver Transplantation/methods ; Constriction, Pathologic/etiology ; Retrospective Studies ; Biliary Tract Diseases/etiology ; Cholestasis/etiology ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Risk Factors ; Treatment Outcome ; Postoperative Complications/etiology
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2022.12.007
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Zs.A 835: Show issues

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Article ; Online: A case of primary hepatic extranodal marginal zone B-cell mucosa-associated lymphoid tissue (MALT) lymphoma treated by radiofrequency ablation (RFA), and a literature review.

Xu, Zhe / Pang, Chong / Sui, Jidong / Gao, Zhenming

The Journal of international medical research

2021 Volume 49, Issue 3, Page(s) 300060521999539

Abstract: Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is an extremely rare liver malignancy that usually lacks characteristic imaging findings and which is often misdiagnosed. We report a 63-year-old woman diagnosed with primary hepatic ... ...

Abstract	Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is an extremely rare liver malignancy that usually lacks characteristic imaging findings and which is often misdiagnosed. We report a 63-year-old woman diagnosed with primary hepatic extranodal marginal zone B-cell lymphoma, MALT type. The patient underwent needle biopsy and radiofrequency ablation (RFA), and showed no signs of relapse during the 12-month postoperative follow-up. This case stresses the rarity of primary hepatic MALT-type lymphoma and the unique and effective treatment for this patient. Our patient received RFA, which showed good efficacy and which provides a new option for the treatment of hepatic MALT lymphoma. We also present our findings from a systematic review to improve the current understanding of this disease.
MeSH term(s)	B-Lymphocytes ; Female ; Humans ; Lymphoid Tissue ; Lymphoma, B-Cell, Marginal Zone/diagnostic imaging ; Lymphoma, B-Cell, Marginal Zone/surgery ; Middle Aged ; Mucous Membrane ; Neoplasm Recurrence, Local ; Radiofrequency Ablation
Language	English
Publishing date	2021-03-10
Publishing country	England
Document type	Case Reports ; Journal Article ; Systematic Review
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/0300060521999539
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Zs.A 925: Show issues

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Article ; Online: [Retracted] Alpinetin suppresses proliferation of human hepatoma cells by the activation of MKK7 and elevates sensitization to cis‑diammined dichloridoplatium.

Tang, Bo / Du, Jian / Wang, Jingwen / Tan, Guang / Gao, Zhenming / Wang, Zhongyu / Wang, Liming

Oncology reports

2023 Volume 49, Issue 5

Abstract: Following the publication of the above paper, it was drawn to the Editors' attention by a concerned reader that western blot data shown in Fig. 2B were strikingly similar to data that had appeared in different form in another article. Owing to the fact ... ...

Abstract	Following the publication of the above paper, it was drawn to the Editors' attention by a concerned reader that western blot data shown in Fig. 2B were strikingly similar to data that had appeared in different form in another article. Owing to the fact that the contentious data in the above article were already under consideration for publication elsewhere prior to its submission to Oncology Reports, the Editor has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused. [Oncology Reports 27: 1090‑1096, 2012; DOI: 10.3892/or.2011.1580].
Language	English
Publishing date	2023-03-31
Publishing country	Greece
Document type	Retraction of Publication
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2023.8534
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Article ; Online: Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis.

Fan, Rong / Sui, Jidong / Dong, Xuepeng / Jing, Biao / Gao, Zhenming

Free radical biology & medicine

2021 Volume 173, Page(s) 29–40

Abstract: Acute pancreatitis (AP) is an inflammatory disorder associated with multiple organ failure. Pyroptosis and ferroptosis are two newly recognized cell death, and whether pyroptosis and ferroptosis are involved in AP remain largely elusive. The nature ... ...

Abstract	Acute pancreatitis (AP) is an inflammatory disorder associated with multiple organ failure. Pyroptosis and ferroptosis are two newly recognized cell death, and whether pyroptosis and ferroptosis are involved in AP remain largely elusive. The nature compound Wedelolactone (Wed) exhibits strong anti-inflammatory and antioxidant activities, the present study aims to investigate the effect of Wed on AP and unravel whether Wed could protect against AP and relevant lung injury against pyroptosis and ferroptosis. Our results showed that the pyroptosis inhibitor disulfiram or ferroptosis inhibitor ferrostatin-1 significantly alleviated AP and associated lung injury in the taurocholate or caerulein-induced murine AP model. Administration with Wed ameliorated AP and lung injury as evidenced by improved pathological injuries, reduced serum pancreatic digestive enzymes, and proinflammatory cytokines. The in vivo and in vitro data demonstrated that Wed broadly inhibited caspase1/caspase11 activation, reduced mature interleukin-1β (IL-1β) and N-terminal domain of gasdermin D (GSDMD-N) level. The oxidative stress and lipid peroxidation were also suppressed along with the up-regulation of the ferroptosis antagonism marker glutathione peroxidase-4 (GPX4) in Wed treatment group. Wed promoted the transcriptional activity and the selenium sensitivity of GPX4. Moreover, the protective effects of Wed in caerulein-stimulated pancreatic acinar cells were markedly abrogated by the down-regulation of GPX4. Collectively, our data suggest that pyroptosis and ferroptosis play crucial roles in AP. Wed mitigated AP and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis.
MeSH term(s)	Acute Disease ; Animals ; Coumarins ; Ferroptosis ; Lung Injury/drug therapy ; Mice ; Pancreatitis/chemically induced ; Pancreatitis/drug therapy ; Pyroptosis
Chemical Substances	Coumarins ; wedelolactone (0K6L725GNS)
Language	English
Publishing date	2021-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2021.07.009
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Zs.A 2109: Show issues

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Article ; Online: Integrated Imaging and Proteomic Sensors Resolve Proteome Aggregation in Liver Caused by Non-steroidal Anti-inflammatory Drug Overdose.

Dong, Xuepeng / Zhang, Zhenduo / Wan, Wang / Jing, Biao / Deng, Jintai / Jin, Wenhan / Shen, Di / Gao, Zhenming / Liu, Yu

ACS sensors

2023 Volume 8, Issue 6, Page(s) 2247–2254

Abstract: Given the extreme heterogeneity and the loss of defined protein structures, misfolded and aggregated proteins are technically challenging to visualize and analyze. Herein, we assembled an integrated sensor system to resolve aggregated proteome in live ... ...

Abstract	Given the extreme heterogeneity and the loss of defined protein structures, misfolded and aggregated proteins are technically challenging to visualize and analyze. Herein, we assembled an integrated sensor system to resolve aggregated proteome in live cells and animal liver tissues that are overdosed by non-steroidal anti-inflammatory drugs (NSAIDs). A fluorogenic protein aggregation sensor (AggStain) first discovered the presence of aggregated proteome upon overdosing liver cells with NSAIDs. A solvatochromic protein aggregation sensor (AggRetina) further quantified the compactness (polarity) inside these cellular aggregates. Importantly, we exploited a proteomic sensor (AggLink) to selectively capture aggregated proteins upon NSAID overdose and profile their composition, revealing global collapse of cellular protein homeostasis. Finally, we detected subtle proteome aggregation in mouse liver tissue without obvious acute injury at a low NSAID dosage. Overall, we demonstrated an integrated sensor toolset for proteome aggregation studies and unveiled for the first time that NSAID overdose can cause proteome aggregation in liver cells and tissues.
MeSH term(s)	Animals ; Mice ; Proteome ; Protein Aggregates ; Proteomics ; Anti-Inflammatory Agents, Non-Steroidal/toxicity ; Liver/metabolism ; Drug Overdose/diagnosis
Chemical Substances	Proteome ; Protein Aggregates ; Anti-Inflammatory Agents, Non-Steroidal
Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.3c00216
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Article ; Online: Potential prognostic biomarkers of hepatocellular carcinoma based on 4D label-free quantitative proteomics analysis pilot investigation.

Suo, Lida / Liang, Xiangnan / Zhang, Weibin / Gao, Mingwei / Ma, Taiheng / Hu, Daosheng / Song, Yilin / Gao, Zhenming

The International journal of biological markers

2023 Volume 39, Issue 1, Page(s) 59–69

Abstract: Background: Hepatocellular carcinoma carries a poor prognosis and poses a serious threat to global health. Currently, there are few potential prognostic biomarkers available for the prognosis of hepatocellular carcinoma.: Methods: This pilot study ... ...

Abstract	Background: Hepatocellular carcinoma carries a poor prognosis and poses a serious threat to global health. Currently, there are few potential prognostic biomarkers available for the prognosis of hepatocellular carcinoma. Methods: This pilot study used 4D label-free quantitative proteomics to compare the proteomes of hepatocellular carcinoma and adjacent non-tumor tissue. A total of 66,075 peptides, 6363 identified proteins, and 772 differentially expressed proteins were identified in specimens from three hepatocellular carcinoma patients. Through functional enrichment analysis of differentially expressed proteins by Gene Ontology, KEGG pathway, and protein domain, we identified proteins with similar functions. Results: Twelve differentially expressed proteins (RPL17, RPL27, RPL27A, RPS5, RPS16, RSL1D1, DDX18, RRP12, TARS2, YARS2, MARS2, and NARS1) were selected for identification and validation by parallel reaction monitoring. Subsequent Western blotting confirmed overexpression of RPL27, RPS16, and TARS2 in hepatocellular carcinoma compared to non-tumor tissue in 16 pairs of clinical samples. Analysis of The Cancer Genome Atlas datasets associated the increased expression of these proteins with poor prognosis. Tissue microarray revealed a negative association between high expression of RPL27 and TARS2 and the prognosis of hepatocellular carcinoma patients, although RPS16 was not significant. Conclusions: These data suggest that RPL27 and TARS2 play an important role in hepatocellular carcinoma progression and may be potential prognostic biomarkers of overall survival in hepatocellular carcinoma patients.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Pilot Projects ; Liver Neoplasms/pathology ; Prognosis ; Proteomics ; Biomarkers, Tumor/metabolism ; Gene Expression Regulation, Neoplastic ; Pregnancy Proteins/genetics ; Pregnancy Proteins/metabolism ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism
Chemical Substances	Biomarkers, Tumor ; RSL1D1 protein, human ; Pregnancy Proteins ; Ribosomal Proteins
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	645113-5
ISSN	1724-6008 ; 0393-6155
ISSN (online)	1724-6008
ISSN	0393-6155
DOI	10.1177/03936155231212925
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Zs.A 2491: Show issues

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Article ; Online: Unraveling Intracellular Protein Corona Components of Nanoplastics via Photocatalytic Protein Proximity Labeling.

Zhang, Zhenduo / Dong, Xuepeng / Wan, Wang / Guo, Hengke / Sun, Rui / Feng, Huan / Wang, Mengdie / Wang, Zhiming / Jin, Hao / Sun, Jialu / Xia, Qiuxuan / Zhao, Qi / Shen, Di / Gao, Zhenming / Liu, Yu

Analytical chemistry

2024 Volume 96, Issue 12, Page(s) 4978–4986

Abstract: Bioaccumulation of nanoplastic particles has drawn increasing attention regarding environmental sustainability and biosafety. How nanoplastic particles interact with the cellular milieu still remains elusive. Herein, we exemplify a general approach to ... ...

Abstract	Bioaccumulation of nanoplastic particles has drawn increasing attention regarding environmental sustainability and biosafety. How nanoplastic particles interact with the cellular milieu still remains elusive. Herein, we exemplify a general approach to profile the composition of a "protein corona" interacting with nanoparticles via the photocatalytic protein proximity labeling method. To enable photocatalytic proximity labeling of the proteome interacting with particles, iodine-substituted BODIPY (I-BODIPY) is selected as the photosensitizer and covalently conjugated onto amino-polystyrene nanoparticles as a model system. Next, selective proximity labeling of interacting proteins is demonstrated using I-BODIPY-labeled nanoplastic particles in both
MeSH term(s)	Animals ; Mice ; Protein Corona ; Microplastics ; Proteome ; Proteomics ; Polystyrenes ; Nanoparticles ; Boron Compounds
Chemical Substances	4,4-difluoro-4-bora-3a,4a-diaza-s-indacene ; Protein Corona ; Microplastics ; Proteome ; Polystyrenes ; Boron Compounds
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.4c00050
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Zs.A 4033: Show issues

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Article ; Online: Tailoring the Amphiphilicity of Fluorescent Protein Chromophores to Detect Intracellular Proteome Aggregation in Diverse Biological Samples

Wang, Mengdie / Zhang, Zhenduo / Jing, Biao / Dong, Xuepeng / Guo, Kun / Deng, Jintai / Wang, Zhiming / Wan, Wang / Jin, Wenhan / Gao, Zhenming / Liu, Yu

Analytical Chemistry. 2023 July 28, v. 95, no. 31 p.11751-11760

2023

Abstract: The formation of amorphous misfolded and aggregated proteins is a hallmark of proteome stress in diseased cells. Given its lack of defined targeting sites, the rational design of intracellular proteome aggregation sensors has been challenging. Herein, we ...

Abstract	The formation of amorphous misfolded and aggregated proteins is a hallmark of proteome stress in diseased cells. Given its lack of defined targeting sites, the rational design of intracellular proteome aggregation sensors has been challenging. Herein, we modulate the amphiphilicity of fluorescent protein chromophores to enable selective detection of aggregated proteins in different biological samples, including recombinant proteins, stressed live cells, intoxicated mouse liver tissue, and human hepatocellular carcinoma tissue. By tuning the number of hydroxyl groups, we optimize the selectivity of fluorescent protein chromophores toward aggregated proteins in these biological samples. In recombinant protein applications, the most hydrophobic P0 (cLogP = 5.28) offers the highest fold change (FC = 31.6), sensitivity (LLOD = 0.1 μM), and brightness (Φ = 0.20) upon binding to aggregated proteins. In contrast, P4 of balanced amphiphilicity (cLogP = 2.32) is required for selective detection of proteome stresses in live cells. In mouse and human liver histology tissues, hydrophobic P1 exhibits the best performance in staining the aggregated proteome. Overall, the amphiphilicity of fluorescent chromophores governs the sensor’s performance by matching the diverse nature of different biological samples. Together with common extracellular amyloid sensors (e.g., Thioflavin T), these sensors developed herein for intracellular amorphous aggregation complement the toolbox to study protein aggregation.
Keywords	amyloid ; analytical chemistry ; fluorescent dyes ; fluorescent proteins ; hepatoma ; histology ; humans ; hydrophobicity ; liver ; mice ; proteome ; recombinant proteins
Language	English
Dates of publication	2023-0728
Size	p. 11751-11760.
Publishing place	American Chemical Society
Document type	Article ; Online
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c01903
Database	NAL-Catalogue (AGRICOLA)

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Article: Hepatocellular carcinoma with inferior vena cava and right atrium thrombus: A case report.

Liu, Jin / Zhang, Ri-Xin / Dong, Bing / Guo, Kun / Gao, Zhen-Ming / Wang, Li-Ming

World journal of clinical cases

2021 Volume 9, Issue 26, Page(s) 7893–7900

Abstract: Background: Hepatocellular carcinoma (HCC) with inferior vena cava and right atrium thrombus is rare, accounting for approximately 1.4%-4.9% of cases. These patients are rarely reported, but the condition is being increasingly discovered with advances ... ...

Abstract	Background: Hepatocellular carcinoma (HCC) with inferior vena cava and right atrium thrombus is rare, accounting for approximately 1.4%-4.9% of cases. These patients are rarely reported, but the condition is being increasingly discovered with advances in imaging techniques, and their prognosis is extremely pessimistic with no current effective treatment. This condition is further associated with unexpected sudden death by cardiac arrest and acute large area pulmonary embolism. Case summary: A 34-year-old man with advanced HCC with a hepatic vein thrombus extending into the right atrium had a long-term, disease-free survival following 5-mo sequential treatment combined with transcatheter arterial chemoembolization and curative liver resection. No severe adverse effects were encountered, such as massive hemorrhage or pulmonary embolism. The proper selection of operative method is an important factor. Conclusion: HCC with a tumor thrombus extending into the right atrium has a significant impact on the survival of patients. Thrombectomy combined with adjuvant therapy may be beneficial for these patients.
Language	English
Publishing date	2021-09-21
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v9.i26.7893
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