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  1. Article ; Online: Spécificité du patient pédiatrique en pré-greffe.

    Garaix, Florentine

    Nephrologie & therapeutique

    2011  Volume 7, Issue 7, Page(s) 587–591

    Abstract: Renal transplantation is the treatment of choice for end-stage renal disease during childhood. In France, access to transplantation is good and even better for children than for adults. Few contraindications, mostly temporary, might delay the ... ...

    Title translation Characteristics of the pediatric patient before transplantation.
    Abstract Renal transplantation is the treatment of choice for end-stage renal disease during childhood. In France, access to transplantation is good and even better for children than for adults. Few contraindications, mostly temporary, might delay the transplantation. The different pathologies leading to end-stage renal disease in children require a specific pre-transplantation examination and a careful choice of the type of donor. Prevalence of disease recurrence is greater in children than in adults. It is one of the most frequent post-transplantation complications and contributes to the increase in patient morbidity and graft failure in our pediatrics cohorts. Kidney donations in North America are for the most part live-donation, which is not the case in France. However, thanks to parent's commitment, the ratio of living donor is currently increasing in France.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; France/epidemiology ; Humans ; Infant ; Infant, Newborn ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/statistics & numerical data ; Living Donors/statistics & numerical data ; Patient Selection ; Preoperative Care ; Prevalence ; Prognosis ; Risk Factors ; Treatment Outcome
    Language French
    Publishing date 2011-12
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2011.11.002
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  2. Article ; Online: A second case of multisystem inflammatory syndrome associated with SARS-CoV-2 in a liver-transplanted child.

    Duvant, Pauline / Roquelaure, Bertrand / Morand, Aurélie / Bosdure, Emmanuelle / Garaix, Florentine / Zandotti, Christine / Fabre, Alexandre

    Pediatric transplantation

    2021  Volume 26, Issue 1, Page(s) e14116

    MeSH term(s) COVID-19/complications ; Child ; Humans ; Intensive Care Units, Pediatric ; Liver ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
    Language English
    Publishing date 2021-08-20
    Publishing country Denmark
    Document type Editorial ; Comment
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.14116
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  3. Article ; Online: Dilatation of the aorta in children with advanced chronic kidney disease.

    Quennelle, Sophie / Ovaert, Caroline / Cailliez, Mathilde / Garaix, Florentine / Tsimaratos, Michel / El Louali, Fedoua

    Pediatric nephrology (Berlin, Germany)

    2021  Volume 36, Issue 7, Page(s) 1825–1831

    Abstract: Background: The peculiarity of the cardiovascular risk profile with increased arterial vulnerability is well known in adults with chronic kidney disease (CKD). It is explained by an increased incidence of traditional cardiovascular risk factors together ...

    Abstract Background: The peculiarity of the cardiovascular risk profile with increased arterial vulnerability is well known in adults with chronic kidney disease (CKD). It is explained by an increased incidence of traditional cardiovascular risk factors together with other comorbidities related to the uremic condition and cardiorenal syndrome (CRS). The present study aimed to determine the cardiovascular impact of the uremic condition in a pediatric population with advanced CKD.
    Methods: From 2016 to 2018, 39 consecutive patients with advanced CKD who underwent echocardiographic evaluation were included. All echocardiographic examinations were performed by the same operator (FE). Demographic, clinical, biological, and echocardiographic data were collected.
    Results: The mean age at echocardiographic exam was 9.7 ± 4.6 years. Twenty-four (61.5%) patients were on hemodialysis; 17 (43.6%) patients were in a peritoneal dialysis program of whom 11 switched at a later stage to hemodialysis. Eight (20.5%) patients had an arteriovenous fistula (AVF). Hypertension was present in 30 (76.9%) patients while left ventricular hypertrophy (LVH) was described in 13 (33.3%) patients. Dilatation of the ascending aorta (Z-score > 2) was found in 15 (38.4%) patients and was statistically (in univariate analysis) related to gender, hypertension, the presence of an AVF, and the use of hemodialysis after peritoneal dialysis (p = 0.024, p = 0.016, p = 0.006, p = 0.009, respectively).
    Conclusion: In addition to classical and predictable abnormalities related to CKD, we found a high prevalence of dilatation of the ascending aorta in children with advanced CKD. Hypertension, AVF, and hemodialysis were associated factors.
    MeSH term(s) Aorta ; Child ; Chronic Disease ; Dilatation ; Humans ; Hypertension ; Hypertrophy, Left Ventricular/diagnostic imaging ; Hypertrophy, Left Ventricular/epidemiology ; Hypertrophy, Left Ventricular/etiology ; Renal Dialysis/adverse effects ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy ; Risk Factors
    Language English
    Publishing date 2021-01-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-020-04887-8
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  4. Article ; Online: Human papillomavirus type 7-associated anal condyloma after renal transplantation in a child.

    Garaix, Florentine / Hery, Geraldine / Tsimaratos, Michel / Colson, Philippe / Tamalet, Catherine

    Pediatric transplantation

    2019  Volume 23, Issue 5, Page(s) e13470

    Abstract: The prevalence, clinical significance, and spectrum of many HPV genotypes are currently largely untapped. We report a case of anal condyloma associated with a rare HPV genotype in a 11-year-old kidney transplant recipient. Eleven months post-graft, ... ...

    Abstract The prevalence, clinical significance, and spectrum of many HPV genotypes are currently largely untapped. We report a case of anal condyloma associated with a rare HPV genotype in a 11-year-old kidney transplant recipient. Eleven months post-graft, rectal bleeding revealed a 5-cm-large anal condyloma for which immuno-histopathology revealed typical papillomatosis. HPV genotyping performed on anal biopsy identified a HPV type 7, for which a single sequence was found in the GenBank sequence database. HPV7 is classically found in hand cutaneous warts, but HPV7-associated condyloma was only described in two patients. Total resection of the anal lesion was performed by electrocoagulation with no recurrence after 6 years. Post-transplant immunosuppression may promote anal condyloma with uncommon HPV types. HPV genotyping in such lesions is useful to get a better understanding of the epidemiology and clinical significance of such unusual HPV types as HPV7.
    MeSH term(s) Anus Diseases/genetics ; Anus Diseases/immunology ; Anus Diseases/virology ; Child ; Condylomata Acuminata/genetics ; Condylomata Acuminata/immunology ; Condylomata Acuminata/virology ; Humans ; Immunosuppression/methods ; Kidney Transplantation ; Male ; Papillomavirus Infections/genetics ; Papillomavirus Infections/immunology ; Papillomavirus Infections/virology
    Language English
    Publishing date 2019-05-12
    Publishing country Denmark
    Document type Case Reports
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.13470
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  5. Article ; Online: Quality of life of transplanted children and their parents: a cross-sectional study.

    Duvant, Pauline / Fillat, Magali / Garaix, Florentine / Roquelaure, Bertrand / Ovaert, Caroline / Fouilloux, Virginie / Tsimaratos, Michel / Auquier, Pascal / Fabre, Alexandre / Baumstarck, Karine

    Orphanet journal of rare diseases

    2021  Volume 16, Issue 1, Page(s) 364

    Abstract: Background: Transplantation is a saving therapeutic that has heavy consequences. The quality of life (QoL) of transplanted children and their parents has been little studied and should help physicians better manage these patients. The objectives of the ... ...

    Abstract Background: Transplantation is a saving therapeutic that has heavy consequences. The quality of life (QoL) of transplanted children and their parents has been little studied and should help physicians better manage these patients. The objectives of the study were to assess: (1) the QoL of transplanted children and parents and compare it with that of children with other chronic conditions associated with long-term consequences, and (2) potential variables modulating the QoL.
    Methods: This cross-sectional study was performed in a multidisciplinary paediatric unit (Timone Hospital, Marseille, France). Children were less than 18 years old; had a liver, kidney or heart transplant; and had a time since transplantation of 1-10 years. Socio-demographics and clinical data were recorded from medical forms. The QoL was assessed using the VSP-A (Vécu et Santé Perçue de l'Adolescent et de l'Enfant) and the WhoQoL self-reported questionnaires.
    Results: Forty-five families were included (response rate: 76%). The transplanted organs were the liver for 20 children, the kidney for 15 children, and the heart for 10 children. The QoL of transplanted children reported by their parents was better than that of children with inborn errors of metabolism and similar to that of childhood leukaemia survivors. The QoL of parents of transplanted children was better than that of parents of children with inborn errors of metabolism and did not differ from French norms. The QoL did not differ according to the nature of the transplanted organ, sex or the main sociodemographic data. The main modulators decreasing QoL were residual treatment level, medications switch and the presence of another regular treatment.
    Conclusion: Transplanted children and their families reported a fairly preserved QoL compared to children with other chronic health conditions. Special attention should be given to QoL modulators related to therapeutic management (medication switches, regular treatments) that might be amenable to improve the QoL. Trial registration Ethics committee of Aix-Marseille University, France (reference number: 2014-08-04-03, 24/4/2015; https://www.univ-amu.fr/fr/public/comite-dethique ).
    MeSH term(s) Adolescent ; Child ; Cross-Sectional Studies ; France ; Humans ; Parents ; Quality of Life ; Surveys and Questionnaires
    Language English
    Publishing date 2021-08-17
    Publishing country England
    Document type Journal Article
    ISSN 1750-1172
    ISSN (online) 1750-1172
    DOI 10.1186/s13023-021-01987-y
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  6. Article ; Online: Atypical severe early-onset nephrotic syndrome: Answers.

    Berthaud, Romain / Heidet, Laurence / Oualha, Mehdi / Brat, Roselyne / Talmud, Déborah / Garaix, Florentine / Rabant, Marion / Frémeaux-Bacchi, Véronique / Antignac, Corinne / Boyer, Olivia / Dorval, Guillaume

    Pediatric nephrology (Berlin, Germany)

    2022  Volume 37, Issue 11, Page(s) 2637–2642

    MeSH term(s) Denys-Drash Syndrome ; Humans ; Mutation ; Nephrotic Syndrome/diagnosis ; WT1 Proteins/genetics
    Chemical Substances WT1 Proteins
    Language English
    Publishing date 2022-05-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-022-05537-x
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  7. Article ; Online: Atypical severe early-onset nephrotic syndrome: Questions.

    Berthaud, Romain / Heidet, Laurence / Oualha, Mehdi / Brat, Roselyne / Talmud, Déborah / Garaix, Florentine / Rabant, Marion / Frémeaux-Bacchi, Véronique / Antignac, Corinne / Boyer, Olivia / Dorval, Guillaume

    Pediatric nephrology (Berlin, Germany)

    2022  Volume 37, Issue 11, Page(s) 2635–2636

    MeSH term(s) Humans ; Kidney ; Nephrotic Syndrome/diagnosis ; Proteinuria
    Language English
    Publishing date 2022-05-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-022-05521-5
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  8. Article: COQ6

    Justine Perrin, R / Rousset-Rouvière, Caroline / Garaix, Florentine / Cano, Aline / Conrath, John / Boyer, Olivia / Tsimaratos, Michel

    JIMD reports

    2020  Volume 54, Issue 1, Page(s) 37–44

    Abstract: Introduction: Primary coenzyme Q10 (CoQ10) deficiencies are a group of mitochondrial disorders that has proven responsiveness to replacement therapy. Mutations in enzymes involved in the biosynthesis of CoQ10 genes are associated with these deficits. ... ...

    Abstract Introduction: Primary coenzyme Q10 (CoQ10) deficiencies are a group of mitochondrial disorders that has proven responsiveness to replacement therapy. Mutations in enzymes involved in the biosynthesis of CoQ10 genes are associated with these deficits. The clinical presentation of this rare autosomal recessive disorder is heterogeneous and depends on the gene involved. Mutations in the
    Case reports: Our study reports the cases of two brothers of Turkish origin with renal failure and sensorineural deafness associated with
    Conclusion/discussion: For the first time,
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2672872-2
    ISSN 2192-8312 ; 2192-8304
    ISSN (online) 2192-8312
    ISSN 2192-8304
    DOI 10.1002/jmd2.12068
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  9. Article ; Online: Tacrolimus Granules for Oral Suspension as Post-Transplant Immunosuppression in Routine Medical Practice in France: The OPTIMOD Study.

    Garaix, Florentine / Stern, Marc / Lamy, François-Xavier / Dubel, Laurence / Kamar, Nassim

    Annals of transplantation

    2018  Volume 23, Page(s) 561–571

    Abstract: BACKGROUND Different pharmaceutical forms of oral tacrolimus allow tailored administration. The granular formulation facilitates accurate dose adjustment of tacrolimus according to patient characteristics, such as weight, or potential concomitant drug ... ...

    Abstract BACKGROUND Different pharmaceutical forms of oral tacrolimus allow tailored administration. The granular formulation facilitates accurate dose adjustment of tacrolimus according to patient characteristics, such as weight, or potential concomitant drug interactions. Currently, there are no data describing the use of tacrolimus granules in transplant recipients in France. MATERIAL AND METHODS OPTIMOD was a 6-month prospective, observational multicenter study that aimed to describe patient characteristics and conditions of use of tacrolimus granules. The 25 participating centers enrolled patients at time of tacrolimus granules initiation and were to collect patient and treatment data at initiation and after 6 months of follow-up. All analyses were descriptive. RESULTS Of 61 patients included, 55.7% were children (mainly kidney graft recipients) and 44.3% were adults (mostly lung graft recipients). Overall, 24.6% of patients (all children) initiated tacrolimus granules immediately post-transplant; the remaining 75.4% converted to tacrolimus granules from ciclosporin or immediate-release tacrolimus hard capsules. The main reasons for initiating tacrolimus granules, irrespective of whether first- or second-line therapy, were to offset potential drug-drug interactions in adults by adjusting dose, and to adapt to the particular needs of children as patients. Most patients (78.7%) underwent ≥1 dose modification during follow-up. Eleven rejection episodes occurred during follow-up, of which none led to graft loss. The adverse-event profile of the tacrolimus granules was similar to that of other tacrolimus formulations and 7 treatment-related adverse events were recorded. CONCLUSIONS Results suggest that tacrolimus granules are well tolerated and effective in preventing transplant rejection when administered in routine practice in France.
    MeSH term(s) Administration, Oral ; Adolescent ; Adult ; Child ; Child, Preschool ; Female ; France ; Humans ; Immunosuppression/methods ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation/methods ; Liver Transplantation/methods ; Lung Transplantation/methods ; Male ; Middle Aged ; Prospective Studies ; Tacrolimus/administration & dosage ; Tacrolimus/therapeutic use ; Treatment Outcome
    Chemical Substances Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2018-08-10
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 1484710-3
    ISSN 2329-0358 ; 1425-9524
    ISSN (online) 2329-0358
    ISSN 1425-9524
    DOI 10.12659/AOT.908522
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    Zs.A 5093: Show issues Location:
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  10. Article ; Online: Technical feasibility and correlations between shear-wave elastography and histology in kidney fibrosis in children.

    Desvignes, Catherine / Dabadie, Alexia / Aschero, Audrey / Ruocco, Alix / Garaix, Florentine / Daniel, Laurent / Ferlicot, Sophie / Villes, Virginie / Loundou, Anderson D / Gorincour, Guillaume / Petit, Philippe

    Pediatric radiology

    2021  Volume 51, Issue 10, Page(s) 1879–1888

    Abstract: Background: Ultrasound elastography has been suggested for assessing organ fibrosis.: Objective: To study the feasibility of shear-wave elastography in children with kidney disease and the correlation between elasticity and kidney fibrosis in order ... ...

    Abstract Background: Ultrasound elastography has been suggested for assessing organ fibrosis.
    Objective: To study the feasibility of shear-wave elastography in children with kidney disease and the correlation between elasticity and kidney fibrosis in order to reduce the indications for kidney biopsy and its complications.
    Materials and methods: Four operators measured kidney elasticity in children with kidney diseases or transplants, all of whom also had a renal biopsy. We assessed the feasibility and the intraobserver variability of the elasticity measurements for each probe used and each kidney explored. Then we tested the correlation between elasticity measurements and the presence of fibrosis.
    Results: Overall, we analyzed 95 children and adolescents, 31 of whom had renal transplant. Measurements with the convex probe were possible in 100% of cases. Linear probe analysis was only possible for 20% of native kidneys and 50% of transplants. Intraobserver variabilities ranged from moderate to high, depending on the probe and kidney studied. Elasticity was higher with the linear probe than with the convex probe (P<0.001 for left kidney and P=0.03 for right kidney). Measurements did not differ from one kidney to another in the same child. Elasticity and fibrosis were both higher in transplant patients (P=0.02 with convex probe; P=0.01 with linear probe; P=0.04 overall). There was no correlation between elasticity and fibrosis.
    Conclusion: Of the devices used in this work, kidney elastography was more accurately analyzed with a convex probe. Our study did not identify any correlation between elasticity and kidney fibrosis.
    MeSH term(s) Adolescent ; Child ; Elasticity Imaging Techniques ; Feasibility Studies ; Fibrosis ; Humans ; Kidney/diagnostic imaging ; Kidney/pathology ; Kidney Diseases/diagnostic imaging ; Kidney Diseases/pathology ; Reproducibility of Results
    Language English
    Publishing date 2021-04-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-021-05068-x
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