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  1. Book: Humic substances and natural organic matter

    Bates, Laurence / Calderín García, Andrés

    (Environmental research advances)

    2016  

    Author's details Laurence Bates, ed. Contributors Andrés Calderín García
    Series title Environmental research advances
    Language English
    Size XI, 157 S. : Ill., graph. Darst., 26 cm
    Publisher Nova Science Publ
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT019228246
    ISBN 978-1-63483-387-5 ; 1-63483-387-2
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    174/18 available for loan (reading room) Freihandmagazin (U1)

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  2. Article ; Online: Encapsulation and immune protection for type 1 diabetes cell therapy.

    Kioulaphides, Sophia / García, Andrés J

    Advanced drug delivery reviews

    2024  Volume 207, Page(s) 115205

    Abstract: Type 1 Diabetes (T1D) involves the autoimmune destruction of insulin-producing β-cells in the pancreas. Exogenous insulin injections are the current therapy but are user-dependent and cannot fully recapitulate physiological insulin secretion dynamics. ... ...

    Abstract Type 1 Diabetes (T1D) involves the autoimmune destruction of insulin-producing β-cells in the pancreas. Exogenous insulin injections are the current therapy but are user-dependent and cannot fully recapitulate physiological insulin secretion dynamics. Since the emergence of allogeneic cell therapy for T1D, the Edmonton Protocol has been the most promising immunosuppression protocol for cadaveric islet transplantation, but the lack of donor islets, poor cell engraftment, and required chronic immunosuppression have limited its application as a therapy for T1D. Encapsulation in biomaterials on the nano-, micro-, and macro-scale offers the potential to integrate islets with the host and protect them from immune responses. This method can be applied to different cell types, including cadaveric, porcine, and stem cell-derived islets, mitigating the issue of a lack of donor cells. This review covers progress in the efforts to integrate insulin-producing cells from multiple sources to T1D patients as a form of cell therapy.
    MeSH term(s) Humans ; Animals ; Swine ; Diabetes Mellitus, Type 1/therapy ; Islets of Langerhans ; Islets of Langerhans Transplantation/methods ; Insulin ; Cadaver
    Chemical Substances Insulin
    Language English
    Publishing date 2024-02-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2024.115205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2241: Show issues Location:
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  3. Article ; Online: Biomaterial therapeutic strategies for treatment of bacterial lung infections.

    Chee, Eunice / García, Andrés J

    Biofilm

    2023  Volume 5, Page(s) 100111

    Abstract: Bacterial infections of the lung frequently occur as a secondary infection to many respiratory viral infections and conditions, including influenza, COVID-19, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF). Currently, clinical ... ...

    Abstract Bacterial infections of the lung frequently occur as a secondary infection to many respiratory viral infections and conditions, including influenza, COVID-19, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF). Currently, clinical standard treats bacterial infections of the lung with antibiotic drugs. However, the use of broad-spectrum antibiotics can disrupt host microbiomes, lead to patient discomfort, and current clinical settings face the constantly increasing threat of drug-resistant bacteria. Biofilms further obstruct effective treatment due to their protective matrix layer, which shields bacteria from both the host immune system and antimicrobial drugs and subsequently promotes drug resistance. Alternative antimicrobial agents, including bacteriophages and antimicrobial peptides, have been utilized to treat drug-resistant bacteria. However, these antimicrobial agents have significant limitations pertaining to their ability to arrive at infection sites without compromised function and ability to persist over an extended period to fully treat infections. Enhanced delivery strategies present great promise in addressing these issues by using micro/nanoparticle carriers that shield antimicrobial agents in transit and result in sustained release, enhancing subsequent therapeutic effect and can even be modulated to be multi-functional to further improve recovery following bacterial infection.
    Language English
    Publishing date 2023-03-01
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-2075
    ISSN (online) 2590-2075
    DOI 10.1016/j.bioflm.2023.100111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Looks are deceiving: a cladistic analysis, three new species, and a new diagnosis of Paravima Caporiacco, 1951 (Opiliones: Agoristenidae)

    García, Andrés F. / Villarreal, Osvaldo

    Arthropod Systematics & Phylogeny. 2023 Apr. 20, v. 81 p.409-437

    2023  

    Abstract: A morphological cladistic analysis, consisting of 45 terminals and 58 characters was performed to evaluate the monophyly of the genus Paravima Caporiacco, 1951, and its relationship to other Leiosteninae. The analysis resulted in two most parsimonious ... ...

    Abstract A morphological cladistic analysis, consisting of 45 terminals and 58 characters was performed to evaluate the monophyly of the genus Paravima Caporiacco, 1951, and its relationship to other Leiosteninae. The analysis resulted in two most parsimonious trees, all recovering Paravima as monophyletic with the inclusion of two species formerly described in Avima Roewer, 1949, therefore, the following nomenclatural acts are herein proposed: Paravima plana (Goodnight & Goodnight, 1949) comb. nov., and Paravima quirozi (González-Sponga, 1981) comb. nov., Avima vigirima (Villarreal-M & Rodríguez-Manzanilla, 2003) is here considered as a junior subjective synonym of P. quirozi (González-Sponga, 1981) comb. nov., Paravima acanthoconus Villarreal-Manzanilla & DoNascimiento, 2005 is here considered as a junior subjective synonym of Paravima propespelunca González-Sponga, 1987, and Paravima flumencaurimarensis González-Sponga, 1987 is here considered as a junior subjective synonym of Paravima goodnightorum Caporiacco, 1951. Additionally, three new species are described: P. lokura sp. nov. (Tamá National Natural Park, Norte de Santander department) and P. magistri sp. nov. (Los Tunos Natural Reserve, Cundinamarca department), both from Colombia; and P. totoro sp. nov. (Henri Pittier National Park, Aragua state) from Venezuela. Finally, an emended generic diagnosis, a key for all the species, and a distributional map are presented.
    Keywords Opiliones ; arthropods ; monophyly ; national parks ; new species ; Colombia ; Venezuela ; Cordillera de la Costa ; harvestmen ; phylogeny
    Language English
    Dates of publication 2023-0420
    Size p. 409-437.
    Publishing place Senckenberg Gesellschaft für Naturforschung
    Document type Article ; Online
    ZDB-ID 2299371-X
    ISSN 1864-8312 ; 1863-7221
    ISSN (online) 1864-8312
    ISSN 1863-7221
    DOI 10.3897/asp.81.e85571
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Locomotion Score and Postpartum Conception in Jersey Cows Raised under Hot-Humid Tropical Conditions: A Prospective Study.

    Vilés, Karina / García, Andrés / Rugel, Octavio / Jorgge, Nahim

    Veterinary sciences

    2024  Volume 11, Issue 3

    Abstract: Reproductive physiology is one of the first systems which is altered when an animal suffers from an imbalance. This is crucial in tropical dairy farming, where maintaining homeostasis and production is particularly demanding. Lameness is a disorder ... ...

    Abstract Reproductive physiology is one of the first systems which is altered when an animal suffers from an imbalance. This is crucial in tropical dairy farming, where maintaining homeostasis and production is particularly demanding. Lameness is a disorder commonly identified by impaired walking, but its early diagnosis could reduce the negative repercussions on production, welfare, and postpartum conception. To evaluate the effect of lameness on postpartum conception, a prospective observational cohort study with a cross-sectional design was developed. Fifty-two Jersey milking cows raised under hot-humid tropical conditions were scored using a five-point locomotion scoring (LS) system (1-non-lame, 2-slightly lame, 3-moderately lame, 4-lame, and 5-severely lame), considering scores ≥ 3 to indicate clinical lameness. Inseminations per conception and days open (CCI) were registered. Inseminations were similar in animals scoring 1, 2, 3, and 5, while they increased in cows with a score of 4, which also increased their CCI along with animals that scored 5. Positive correlations were observed between LS and reproductive variables. The herd's conception rate was reduced from 45% to 21.8% in the presence of clinical lameness (score ≥ 3). Applying the LS system should be essential as part of routine medical examinations used to monitor dairy herds, and it becomes even more crucial under hot-humid tropical environments, where adverse conditions could rapidly aggravate the early stages of lameness and not only increase the costs of hoof care, but also delay fertility in cattle.
    Language English
    Publishing date 2024-02-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci11030102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The influence of COVID-19 on health seeking behaviors among students attending a minority-serving institution in the U.S.

    Malik, Neal / Harding, Kassandra L / Garcia, Andres

    Journal of American college health : J of ACH

    2024  , Page(s) 1–7

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604907-2
    ISSN 1940-3208 ; 0744-8481
    ISSN (online) 1940-3208
    ISSN 0744-8481
    DOI 10.1080/07448481.2024.2334076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 427: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Perichondritis and auricular cellulitis related to piercings as first manifestation of monkeypox.

    Antúnez-Estudillo, Encarnación / Riera Tur, Laura / Caballero García, Andrés

    Acta otorrinolaringologica espanola

    2024  Volume 75, Issue 2, Page(s) 129–132

    Abstract: Introduction: Pinna infections are usually due to Staphylococcus aureus infection. It is common for the patient to have had an earring in the area of infection. Monkeypox infection has gone from being an endemic infection to a worldwide health emergency. ...

    Abstract Introduction: Pinna infections are usually due to Staphylococcus aureus infection. It is common for the patient to have had an earring in the area of infection. Monkeypox infection has gone from being an endemic infection to a worldwide health emergency.
    Case summary: In this article we present five cases of monkeypox earring infection of the pinna and what common features we have seen that differentiate them from Staphylococcus aureus infection.
    Discussion: Symptoms of monkeypox include general malaise, fever with uni- or bilateral lymphadenopathy, and then the appearance within one or two days of skin lesions, we want to alert he otolaryngologist and the medical society to the possibility the diagnostic possibility of monkeypox in patients with an auricular perichondritis.
    MeSH term(s) Male ; Humans ; Cellulitis/etiology ; Mpox (monkeypox) ; Ear, External ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/etiology ; Cartilage Diseases/diagnosis
    Language English
    Publishing date 2024-01-12
    Publishing country Spain
    Document type Case Reports
    ISSN 2173-5735
    ISSN (online) 2173-5735
    DOI 10.1016/j.otoeng.2024.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Controlled release of therapeutic antibody using hydrolytically degradable microgels.

    Mora-Boza, Ana / Ahmedin, Zakir / García, Andrés J

    Journal of biomedical materials research. Part A

    2023  

    Abstract: Monoclonal antibodies have gained significant interest as potential therapeutics for treating various diseases. However, these therapies are not always effective due to poor treatment compliance associated with multiple administrations and drug ... ...

    Abstract Monoclonal antibodies have gained significant interest as potential therapeutics for treating various diseases. However, these therapies are not always effective due to poor treatment compliance associated with multiple administrations and drug resistance. Thus, there is a growing interest in developing advanced monoclonal antibody delivery systems that can customize pharmacokinetics to enhance therapeutic outcomes. This work aimed to engineer hydrolytic 4-arm PEG maleimide (PEG-4MAL) microgels for the controlled delivery of therapeutic antibodies, specifically anti-angiogenic bevacizumab, to overcome the limitations of current monoclonal antibody therapies. Through a PEGylation reaction with a thiol-terminated PEG linker, the antibody was covalently conjugated to the macromer backbone before microgel synthesis. The PEGylation reaction was simple, effective, and did not affect antibody bioactivity. Antibody release kinetics was tuned by changing the concentration of the hydrolytic linker (0-2 mM) and/or PEG-4MAL:protein molar ratio (1000:1, 2000:1, and 5000:1) in the macromer precursor solution during microgel fabrication. The bioactivity of the released antibody was assessed on human umbilical endothelial vascular cells (HUVEC), demonstrating that extracts from hydrolytic microgels reduced cell proliferation over time. Collectively, this study demonstrates the development of highly tunable delivery platform based on degradable PEG-4MAL microgels that can be adapted for therapeutic antibody-controlled release.
    Language English
    Publishing date 2023-11-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2099989-6
    ISSN 1552-4965 ; 1549-3296 ; 0021-9304
    ISSN (online) 1552-4965
    ISSN 1549-3296 ; 0021-9304
    DOI 10.1002/jbm.a.37637
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6195: Show issues Location:
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  9. Article ; Online: Engineered Synthetic Matrices for Human Intestinal Organoid Culture and Therapeutic Delivery.

    Mulero-Russe, Adriana / García, Andrés J

    Advanced materials (Deerfield Beach, Fla.)

    2023  Volume 36, Issue 9, Page(s) e2307678

    Abstract: Human intestinal organoids (HIOs) derived from pluripotent stem cells or adult stem cell biopsies represent a powerful platform to study human development, drug testing, and disease modeling in vitro, and serve as a cell source for tissue regeneration ... ...

    Abstract Human intestinal organoids (HIOs) derived from pluripotent stem cells or adult stem cell biopsies represent a powerful platform to study human development, drug testing, and disease modeling in vitro, and serve as a cell source for tissue regeneration and therapeutic advances in vivo. Synthetic hydrogels can be engineered to serve as analogs of the extracellular matrix to support HIO growth and differentiation. These hydrogels allow for tuning the mechanical and biochemical properties of the matrix, offering an advantage over biologically derived hydrogels such as Matrigel. Human intestinal organoids have been used for repopulating transplantable intestinal grafts and for in vivo delivery to an injured intestinal site. The use of synthetic hydrogels for in vitro culture and for in vivo delivery is expected to significantly increase the relevance of human intestinal organoids for drug screening, disease modeling, and therapeutic applications.
    MeSH term(s) Humans ; Intestines ; Organoids ; Pluripotent Stem Cells ; Extracellular Matrix ; Hydrogels/chemistry
    Chemical Substances Hydrogels
    Language English
    Publishing date 2023-12-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202307678
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  10. Article: Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing.

    García-García, Andrés / Martin, Ivan

    Molecular & cellular oncology

    2021  Volume 8, Issue 6, Page(s) 2007030

    Abstract: We propose ... ...

    Abstract We propose an
    Language English
    Publishing date 2021-12-06
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2021.2007030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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