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Article ; Online: Pharmacogenetics of ABCB1, CDA, DCK, GSTT1, GSTM1 and outcomes in a cohort of pediatric acute myeloid leukemia patients from Colombia.

Yunis, Luz K / Linares-Ballesteros, Adriana / Aponte, Nelson / Barros, Gisela / García, Johnny / Niño, Laura / Uribe, Gloria / Quintero, Edna / Yunis, Juan J

Cancer reports (Hoboken, N.J.)

2022 Volume 6, Issue 3, Page(s) e1744

Abstract: Background and aim: Different studies have shown pharmacogenetic variants related to drug toxicity in acute myeloid leukemia (AML) patients. Our aim was to identify the association between ABCB1, CDA, DCK, GSTT1, and GSTM1 variants with clinical ... ...

Abstract	Background and aim: Different studies have shown pharmacogenetic variants related to drug toxicity in acute myeloid leukemia (AML) patients. Our aim was to identify the association between ABCB1, CDA, DCK, GSTT1, and GSTM1 variants with clinical outcomes and toxicity in pediatric patients with AML. Methods: Fifty-one confirmed de novo AML pediatric patients were included. A SNaPshot™ assay and conventional PCR were used to evaluate ABCB1, CDA, DCK, GSTT1, and GSTM1 variants. Clinical outcomes and toxicity associations were evaluated using odds ratios and Chi-square analysis. Results: Patients carrying ABCB1 (1236C > T, rs1128503) GG genotype in had a 6.8 OR (CI 95% 1.08-42.73, p = .044) for cardiotoxicity as compared to patients carrying either AA or GA genotypes 0.14 OR (CI 95% 0.023-0.92, p = .044). For ABCB1 (1236G > A rs1128503/2677C > A/T rs2032582/3435G > A rs1045642) AA/AA/AA combined genotypes had a strong association with death after HSTC OR 13.73 (CI 95% 1.94-97.17, p = .009). Combined genotypes GG/CC/GG with CDA (79A > C, rs2072671) CA genotype or CDA (-451G > A, rs532545) CT genotype, had a 4.11 OR (CI 95% 2.32-725, p = .007) and 3.8 OR (CI 95% 2.23-6.47, p = .027) with MRD >0.1% after first chemotherapy cycle, respectively. Conclusion: Our results highlight the importance of pharmacogenetic analysis in pediatric AML, particularly in populations with a high degree of admixture, and might be useful as a future tool for patient stratification for treatment.
MeSH term(s)	Humans ; Child ; Pharmacogenetics ; Colombia/epidemiology ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Genotype ; ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/therapeutic use
Chemical Substances	ABCB1 protein, human ; ATP Binding Cassette Transporter, Subfamily B
Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2573-8348
ISSN (online)	2573-8348
DOI	10.1002/cnr2.1744
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Article ; Online: Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer.

Alsaiari, Shahad K / Nadeef, Seba / Daristotle, John L / Rothwell, William / Du, Bujie / Garcia, Johnny / Zhang, Linzixuan / Sarmadi, Morteza / Forster, Timothy A / Menon, Nandita / Lin, Stacey Qiaohui / Tostanoski, Lisa H / Hachmann, Nicole / Wang, Erika Yan / Ventura, John D / Barouch, Dan H / Langer, Robert / Jaklenec, Ana

Science advances

2024 Volume 10, Issue 10, Page(s) eadj6380

Abstract: Nanomaterials offer unique opportunities to engineer immunomodulatory activity. In this work, we report the Toll-like receptor agonist activity of a nanoscale adjuvant zeolitic imidazolate framework-8 (ZIF-8). The accumulation of ZIF-8 in endosomes and ... ...

Abstract	Nanomaterials offer unique opportunities to engineer immunomodulatory activity. In this work, we report the Toll-like receptor agonist activity of a nanoscale adjuvant zeolitic imidazolate framework-8 (ZIF-8). The accumulation of ZIF-8 in endosomes and the pH-responsive release of its subunits enable selective engagement with endosomal Toll-like receptors, minimizing the risk of off-target activation. The intrinsic adjuvant properties of ZIF-8, along with the efficient delivery and biomimetic presentation of a severe acute respiratory syndrome coronavirus 2 spike protein receptor-binding domain trimer, primed rapid humoral and cell-mediated immunity in a dose-sparing manner. Our study offers insights for next-generation adjuvants that can potentially impact future vaccine development.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Adjuvants, Immunologic ; Endosomes ; Toll-Like Receptors ; Zeolites/pharmacology
Chemical Substances	spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Adjuvants, Immunologic ; Toll-Like Receptors ; Zeolites (1318-02-1)
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adj6380
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Article ; Online: Genomic alterations in a cohort of pediatric acute myeloid leukemia patients at two cancer centers in Colombia.

Yunis, Luz K / Linares-Ballesteros, Adriana / Barros, Gisela / Garcia, Johnny / Aponte, Nelson / Niño, Laura / Uribe, Gloria / Quintero, Edna / Perez, Jaime / Martinez, Leila / Yunis, Juan J

International journal of hematology

2022 Volume 117, Issue 2, Page(s) 269–277

Abstract: Few studies identifying genomic aspects in pediatric acute myeloid leukemia patients in Latin American countries have been reported. The aim of this study was to identify genomic alterations, clinical characteristics and outcomes in a cohort of pediatric ...

Abstract	Few studies identifying genomic aspects in pediatric acute myeloid leukemia patients in Latin American countries have been reported. The aim of this study was to identify genomic alterations, clinical characteristics and outcomes in a cohort of pediatric AML patients. This descriptive observational cohort study included patients with confirmed de novo acute myeloid leukemia up to 18 years of age. Cytogenetics and conventional FISH analysis, next-generation sequencing and PCR testing were performed. The correlation of genomic data with treatment response and outcomes were analyzed. Of the 51 patients analyzed, 67.4% had a cytogenetic abnormality and 74.5% had a genetic variant. FLT3 variants (ITD or TKD D835) were found in 27.4%, followed by NRAS (21.6%), KRAS (13.7%) and WT1 and KIT (11.8%). Patients were stratified by risk (66.6% high-risk) after the end of induction. FLT3-ITD was associated with relapse (OR 11.25; CI 1.89-66.72, p 0.006) and NRAS with death during induction (OR 16.71; CI 1.51-184.59, p 0.022). Our study highlights the importance of rapid incorporation of genetic testing in pediatric AML in Colombia, as it directly affects treatment decisions and outcomes. Incorporation of targeted therapies with conventional chemotherapy is an increasingly urgent need in pediatric patients.
MeSH term(s)	Humans ; Colombia/epidemiology ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/drug therapy ; Chromosome Aberrations ; Recurrence ; Genomics ; Mutation ; Prognosis ; fms-Like Tyrosine Kinase 3/genetics
Chemical Substances	fms-Like Tyrosine Kinase 3 (EC 2.7.10.1)
Language	English
Publishing date	2022-10-24
Publishing country	Japan
Document type	Observational Study ; Journal Article
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-022-03475-w
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Article ; Online: Philadelphia-like acute lymphoblastic leukemia: Characterization in a pediatric cohort in a referral center in Colombia.

Linares Ballesteros, Adriana / Yunis, Luz Karime / García, Johnny / Aponte, Nelson / Flechas, Jessica / Martinez, Cindy / Uribe, Gloria / Quintero, Edna / Díaz, Angela / Pardo, Carlos / Sarmiento, Isabel Cristina / Contreras, Agustin / Yunis, Juan Jose

Cancer reports (Hoboken, N.J.)

2021 Volume 5, Issue 5, Page(s) e1587

Abstract: Background: Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a subtype of pediatric leukemia with high risk factors and poor outcome. There are few reports of its prevalence in Latin America.: Aim: This study evaluated the frequency ... ...

Abstract	Background: Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a subtype of pediatric leukemia with high risk factors and poor outcome. There are few reports of its prevalence in Latin America. Aim: This study evaluated the frequency and clinical and biological characteristics of Ph-like ALL in a pediatric cancer center in Colombia. Methods: The Ph-like genetic profile was analyzed by a low-density array (LDA). Samples from patients with Ph-like ALL were analyzed by fluorescent in situ hybridization for cytokine receptor like factor 2 (CRLF2) and ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1) rearrangements. Copy number variations were assessed by multiplex ligation probe amplification. Results: Data from 121 patients were analyzed. Fifteen patients (12.4%) had Ph-like ALL, and these patients had significantly higher leukocyte counts at diagnosis and higher levels of minimal residual disease on days 15 and 33 of induction than patients without the Ph-like subtype. There were no significant differences in sex, age, or response to prednisone at day 8 between the two groups. CRLF2 rearrangements were identified in eight patients, and ABL1 rearrangements were identified in two patients. Other genetic alterations alone or in combination were identified in 77% of patients, including deletions in cyclin dependent kinase inhibitor 2 A/B (46.2%), IKAROS family zinc finger 1 (38.3%), and paired box 5 (30.8%). Conclusions: Ph-like ALL had a 12.4% prevalence in our cohort of patients with pediatric ALL. The identification of this group of patients has importance for risk stratification and future targeted therapy.
MeSH term(s)	Child ; Colombia/epidemiology ; DNA Copy Number Variations ; Humans ; Ikaros Transcription Factor/genetics ; In Situ Hybridization, Fluorescence ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology ; Referral and Consultation
Chemical Substances	Ikaros Transcription Factor (148971-36-2)
Language	English
Publishing date	2021-11-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2573-8348
ISSN (online)	2573-8348
DOI	10.1002/cnr2.1587
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Article ; Online: A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines.

Vander Straeten, Aurélien / Sarmadi, Morteza / Daristotle, John L / Kanelli, Maria / Tostanoski, Lisa H / Collins, Joe / Pardeshi, Apurva / Han, Jooli / Varshney, Dhruv / Eshaghi, Behnaz / Garcia, Johnny / Forster, Timothy A / Li, Gary / Menon, Nandita / Pyon, Sydney L / Zhang, Linzixuan / Jacob-Dolan, Catherine / Powers, Olivia C / Hall, Kevin /

Alsaiari, Shahad K / Wolf, Morris / Tibbitt, Mark W / Farra, Robert / Barouch, Dan H / Langer, Robert / Jaklenec, Ana

Nature biotechnology

2023 Volume 42, Issue 3, Page(s) 510–517

Abstract: Decentralized manufacture of thermostable mRNA vaccines in a microneedle patch (MNP) format could enhance vaccine access in low-resource communities by eliminating the need for a cold chain and trained healthcare personnel. Here we describe an automated ... ...

Abstract	Decentralized manufacture of thermostable mRNA vaccines in a microneedle patch (MNP) format could enhance vaccine access in low-resource communities by eliminating the need for a cold chain and trained healthcare personnel. Here we describe an automated process for printing MNP Coronavirus Disease 2019 (COVID-19) mRNA vaccines in a standalone device. The vaccine ink is composed of lipid nanoparticles loaded with mRNA and a dissolvable polymer blend that was optimized for high bioactivity by screening formulations in vitro. We demonstrate that the resulting MNPs are shelf stable for at least 6 months at room temperature when assessed using a model mRNA construct. Vaccine loading efficiency and microneedle dissolution suggest that efficacious, microgram-scale doses of mRNA encapsulated in lipid nanoparticles could be delivered with a single patch. Immunizations in mice using manually produced MNPs with mRNA encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein receptor-binding domain stimulate long-term immune responses similar to those of intramuscular administration.
MeSH term(s)	Humans ; Animals ; Mice ; COVID-19 Vaccines/genetics ; mRNA Vaccines ; RNA, Messenger/genetics ; SARS-CoV-2/genetics ; COVID-19/prevention & control ; Vaccines
Chemical Substances	COVID-19 Vaccines ; mRNA Vaccines ; RNA, Messenger ; Vaccines
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1311932-1
ISSN	1546-1696 ; 1087-0156
ISSN (online)	1546-1696
ISSN	1087-0156
DOI	10.1038/s41587-023-01774-z
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Article: A survey of particulate matter on california dairy farms.

Garcia, Johnny / Bennett, Deborah H / Tancredi, Daniel / Schenker, Marc B / Mitchell, Diane / Mitloehner, Frank M

Journal of environmental quality

2013 Volume 42, Issue 1, Page(s) 40–47

Abstract: Over the past 30 yr, individual California dairy operations have grown in size; however, little is known about the distribution and determinants of particulate matter (PM) concentrations on these dairies. Elevated exposure to PM is associated with ... ...

Abstract	Over the past 30 yr, individual California dairy operations have grown in size; however, little is known about the distribution and determinants of particulate matter (PM) concentrations on these dairies. Elevated exposure to PM is associated with respiratory and cardiovascular health effects, particularly in occupational settings. The purpose of this study was to quantify the concentrations of PM and all inhalable PM (0-100 µm) on California dairies. Samplers were placed at various locations (e.g., milking parlor, grain storage area, drylot corral, and freestall barns) on 13 different dairies to collect PM and all inhalable PM during the 2008 summer months. The PM and all inhalable PM concentrations varied between different areas on a dairy and from dairy to dairy. Geometric mean concentrations for PM and inhalable PM were 24 µg m (range, 2-116 µg m) and 332 μg m (range, 74-1690 µg m). A key variable for explaining variation in PM concentrations with a mixed effects model was regional background ambient concentrations of PM No significant differences were observed in mean concentrations between upwind and downwind fence line concentrations (adjusted geometric mean ratio [AGMR] = 0.7; 95% CI, 0.4-1.3), although significant differences were found between upwind and central location mean values (AGMR = 0.5; 95% CI, 0.3-0.8; < 0.01). These results indicate dairy PM sources and, thus, elevated occupational exposure. Covariates, such as the age of the dairy and number of cows in the freestall barn and drylot corral, were important variables in explaining PM concentration variability. Levels of PM were lower compared with dairies in other U.S. states and other countries.
MeSH term(s)	Agriculture ; Air Pollutants ; Animals ; California ; Environmental Monitoring ; Particulate Matter ; Surveys and Questionnaires
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2013-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	120525-0
ISSN	1537-2537 ; 0047-2425
ISSN (online)	1537-2537
ISSN	0047-2425
DOI	10.2134/jeq2012.0169
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Article: A Survey of Particulate Matter on California Dairy Farms

Garcia, Johnny / Bennett, Deborah H / Mitchell, Diane / Mitloehner, Frank M / Schenker, Marc B / Tancredi, Daniel

Journal of environmental quality. 2013 Jan., v. 42, no. 1

2013

Abstract	Over the past 30 yr, individual California dairy operations have grown in size; however, little is known about the distribution and determinants of particulate matter (PM) concentrations on these dairies. Elevated exposure to PM is associated with respiratory and cardiovascular health effects, particularly in occupational settings. The purpose of this study was to quantify the concentrations of PM2.5 and all inhalable PM (0–100 μm) on California dairies. Samplers were placed at various locations (e.g., milking parlor, grain storage area, drylot corral, and freestall barns) on 13 different dairies to collect PM2.5 and all inhalable PM during the 2008 summer months. The PM2.5 and all inhalable PM concentrations varied between different areas on a dairy and from dairy to dairy. Geometric mean concentrations for PM2.5 and inhalable PM were 24 μg m−3 (range, 2–116 μg m−3) and 332 μg m−3 (range, 74–1690 μg m−3). A key variable for explaining variation in PM2.5 concentrations with a mixed effects model was regional background ambient concentrations of PM2.5. No significant differences were observed in mean concentrations between upwind and downwind fence line concentrations (adjusted geometric mean ratio [AGMR] = 0.7; 95% CI, 0.4–1.3), although significant differences were found between upwind and central location mean values (AGMR = 0.5; 95% CI, 0.3–0.8; p < 0.01). These results indicate dairy PM sources and, thus, elevated occupational exposure. Covariates, such as the age of the dairy and number of cows in the freestall barn and drylot corral, were important variables in explaining PM concentration variability. Levels of PM were lower compared with dairies in other U.S. states and other countries.
Keywords	barns ; cows ; dairies ; dairy farming ; free stalls ; health effects assessments ; milking ; milking parlors ; models ; occupational exposure ; particulates ; samplers ; summer ; surveys ; California
Language	English
Dates of publication	2013-01
Size	p. 40-47.
Publishing place	The American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.
Document type	Article
Note	epub
ZDB-ID	120525-0
ISSN	1537-2537 ; 0047-2425
ISSN (online)	1537-2537
ISSN	0047-2425
DOI	10.2134/jeq2012.0169
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Occupational exposure to particulate matter and endotoxin for California dairy workers.

Garcia, Johnny / Bennett, Deborah H / Tancredi, Daniel / Schenker, Marc B / Mitchell, Diane / Reynolds, Stephen J / Mitloehner, Frank M

International journal of hygiene and environmental health

2013 Volume 216, Issue 1, Page(s) 56–62

Abstract: Occupational exposure of dairy workers to particulate matter (PM) and endotoxin has been considered by some to be of potential concern. This paper reports personal exposure concentrations of PM (μg/m3) and endotoxin (EU/m3) for 226 workers from 13 ... ...

Abstract	Occupational exposure of dairy workers to particulate matter (PM) and endotoxin has been considered by some to be of potential concern. This paper reports personal exposure concentrations of PM (μg/m3) and endotoxin (EU/m3) for 226 workers from 13 California dairies. Arithmetic mean personal concentrations for PM2.5, inhalable PM and endotoxin were 48 μg/m3 (N = 222), 987 μg/m3 (N = 225) and 453 EU/m3 (N = 225), respectively. Using mixed effects models, time spent re-bedding of freestall barns versus any other job conducted on a dairy led to the highest exposure for PM2.5, inhalable PM, and endotoxin. Personal exposure concentrations were found to be greater than those reported for ambient area based concentrations at the same dairies. A pseudo R-square approach revealed that one area based measure combined with time spent performing tasks explained a significant portion of variation in personal exposure concentrations.
MeSH term(s)	Animals ; California ; Cattle ; Cross-Sectional Studies ; Dairying ; Endotoxins/analysis ; Environmental Monitoring ; Humans ; Occupational Exposure/analysis ; Particulate Matter/analysis ; Regression Analysis
Chemical Substances	Endotoxins ; Particulate Matter
Language	English
Publishing date	2013-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2009176-X
ISSN	1618-131X ; 1438-4639
ISSN (online)	1618-131X
ISSN	1438-4639
DOI	10.1016/j.ijheh.2012.04.001
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Article ; Online: Screening for addictive disorders within a workers' compensation clinic: an exploratory study.

Parhami, Iman / Hyman, Mark / Siani, Aaron / Lin, Stephanie / Collard, Michael / Garcia, Johnny / Casaus, Laurie / Tsuang, John / Fong, Timothy W

Substance use & misuse

2011 Volume 47, Issue 1, Page(s) 99–107

Abstract: We conducted a cross-sectional study investigating the extent of addictive disorders within a workers' compensation (WC) clinic. We also examined the feasibility of substance abuse screening within the same clinic. In 2009 , 100 patients were asked to ... ...

Abstract	We conducted a cross-sectional study investigating the extent of addictive disorders within a workers' compensation (WC) clinic. We also examined the feasibility of substance abuse screening within the same clinic. In 2009 , 100 patients were asked to complete the World Health Organization's Alcohol, Smoking, Substance Involvement Screening Test (WHO-ASSIST) and the Current Opioid Misuse Measure (COMM). According to the WHO-ASSIST, we found that 46% of WC patients required intervention for at least one substance-related disorder (25% tobacco, 23% sedatives, 8% opioids), and according to the COMM, 46% screened positive for prescription opioid misuse. Importantly, the addition of this screening was brief, economical, and well accepted by patients. Further research should analyze the costs and benefits of detection and intervention of substance-related disorders in this setting.
MeSH term(s)	Ambulatory Care Facilities ; Analgesics, Opioid/therapeutic use ; Cross-Sectional Studies ; Female ; Humans ; Male ; Opioid-Related Disorders/diagnosis ; Opioid-Related Disorders/epidemiology ; Pain/drug therapy ; Substance Abuse Detection/methods ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/therapy ; Surveys and Questionnaires ; Tobacco Use Disorder/diagnosis ; Tobacco Use Disorder/epidemiology ; Workers' Compensation
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2011-11-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1310358-1
ISSN	1532-2491 ; 1082-6084
ISSN (online)	1532-2491
ISSN	1082-6084
DOI	10.3109/10826084.2011.629705
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Article ; Online: Activation of inflammatory responses in human U937 macrophages by particulate matter collected from dairy farms

A Vogel Christoph F / Garcia Johnny / Wu Dalei / Mitchell Diane C / Zhang Yanhong / Kado Norman Y / Wong Patrick / Trujillo Danitza / Lollies Anna / Bennet Deborah / Schenker Marc B / Mitloehner Frank M

Environmental Health, Vol 11, Iss 1, p

an in vitro expression analysis of pro-inflammatory markers

2012 Volume 17

Abstract: Abstract Background The purpose of the present study was to investigate activation of inflammatory markers in human macrophages derived from the U937 cell line after exposure to particulate matter (PM) collected on dairy farms in California and to ... ...

Abstract	Abstract Background The purpose of the present study was to investigate activation of inflammatory markers in human macrophages derived from the U937 cell line after exposure to particulate matter (PM) collected on dairy farms in California and to identify the most potent components of the PM. Methods PM from different dairies were collected and tested to induce an inflammatory response determined by the expression of various pro-inflammatory genes, such as Interleukin (IL)-8, in U937 derived macrophages. Gel shift and luciferase reporter assays were performed to examine the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and Toll-like-receptor 4 (TLR4). Results Macrophage exposure to PM derived from dairy farms significantly activated expression of pro-inflammatory genes, including IL-8, cyclooxygenase 2 and Tumor necrosis factor-alpha, which are hallmarks of inflammation. Acute phase proteins, such as serum amyloid A and IL-6, were also significantly upregulated in macrophages treated with PM from dairies. Coarse PM fractions demonstrated more pro-inflammatory activity on an equal-dose basis than fine PM. Urban PM collected from the same region as the dairy farms was associated with a lower concentration of endotoxin and produced significantly less IL-8 expression compared to PM collected on the dairy farms. Conclusion The present study provides evidence that the endotoxin components of the particles collected on dairies play a major role in mediating an inflammatory response through activation of TLR4 and NF-κB signaling.
Keywords	AhR ; IL-8 ; LPS ; NF-κB ; PM ; TLR ; Dairy Farms ; Inflammation ; Industrial medicine. Industrial hygiene ; RC963-969 ; Public aspects of medicine ; RA1-1270
Subject code	616
Language	English
Publishing date	2012-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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