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  1. Article: Microbiota-derived metabolites in regulating the development and physiology of

    Feng, Min / Gao, Baizhen / Garcia, L Rene / Sun, Qing

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1035582

    Abstract: Microbiota consist of microorganisms that provide essential health benefits and contribute to the animal's physiological homeostasis. Microbiota-derived metabolites are crucial mediators in regulating host development, system homeostasis, and overall ... ...

    Abstract Microbiota consist of microorganisms that provide essential health benefits and contribute to the animal's physiological homeostasis. Microbiota-derived metabolites are crucial mediators in regulating host development, system homeostasis, and overall fitness. In this review, by focusing on the animal model
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1035582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Stearoyl-CoA desaturases sustain cholinergic excitation and copulatory robustness in metabolically aging

    Goncalves, Jimmy / Wan, Yufeng / Garcia, L René

    iScience

    2022  Volume 25, Issue 4, Page(s) 104082

    Abstract: Regulated metabolism is required for behaviors as adults age. To understand how lipid usage affects motor coordination, we studied ... ...

    Abstract Regulated metabolism is required for behaviors as adults age. To understand how lipid usage affects motor coordination, we studied male
    Language English
    Publishing date 2022-03-16
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.104082
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  3. Article ; Online: Regulation of sensory motor circuits used in C. elegans male intromission behavior.

    García, L René

    Seminars in cell & developmental biology

    2014  Volume 33, Page(s) 42–49

    Abstract: Intromission of a male's copulatory organ into his mate's genital orifice is a behavioral step that is conserved in most terrestrial mating behaviors. The behavior serves to anchor the male to his mate and aids in the transmission of the male's gametes ... ...

    Abstract Intromission of a male's copulatory organ into his mate's genital orifice is a behavioral step that is conserved in most terrestrial mating behaviors. The behavior serves to anchor the male to his mate and aids in the transmission of the male's gametes into the female. In all animals, the successful execution of intromission likely involves coordinated sensory/motor regulation coupled with constant self-monitoring. The compact male C. elegans reproductive nervous system provides an accessible experimental model for identification and dissection of the molecular and cellular circuit components that promote different motor outputs required for the transfer of the male's genetic material into the self-fertilizing hermaphrodite. The C. elegans male tail contains forty-one sex-specific muscles and 81 sex-specific neurons, which promote different steps of mating behavior. In this review, I will outline the functional contributions of the male-specific sensory-motor neurons and their postsynaptic muscles that control the motions of the male copulatory spicules during the various phases of intromission behavior and ejaculation. In addition, I will summarize the roles of neurotransmitter receptors and ion channels that regulate the outputs of individual circuit components and describe how the intromission circuit uses these molecules to regulate reproductive behavior during male aging and nutritional deprivation.
    MeSH term(s) Aging ; Animals ; Caenorhabditis elegans/physiology ; Dopamine/physiology ; Female ; Fertilization ; Male ; Nerve Net/physiology ; Sexual Behavior, Animal ; Synaptic Transmission
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2014-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2014.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2918: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Intracellular transport and compartmentation of phosphate in plants.

    Versaw, Wayne K / Garcia, L Rene

    Current opinion in plant biology

    2017  Volume 39, Page(s) 25–30

    Abstract: Phosphate (Pi) is an essential macronutrient with structural and metabolic roles within every compartment of the plant cell. Intracellular Pi transporters direct Pi to each organelle and also control its exchange between subcellular compartments thereby ... ...

    Abstract Phosphate (Pi) is an essential macronutrient with structural and metabolic roles within every compartment of the plant cell. Intracellular Pi transporters direct Pi to each organelle and also control its exchange between subcellular compartments thereby providing the means to coordinate compartmented metabolic processes, including glycolysis, photosynthesis, and respiration. In this review we summarize recent advances in the identification and functional analysis of Pi transporters that localize to vacuoles, chloroplasts, non-photosynthetic plastids, mitochondria, and the Golgi apparatus. Electrical potentials across intracellular membranes and the pH of subcellular environments will also be highlighted as key factors influencing the energetics of Pi transport, and therefore pose limits for Pi compartmentation.
    Language English
    Publishing date 2017-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1418472-2
    ISSN 1879-0356 ; 1369-5266
    ISSN (online) 1879-0356
    ISSN 1369-5266
    DOI 10.1016/j.pbi.2017.04.015
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    In stock of ZB MED Bonn / Germany

    Z 2005/717: Show issues

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  5. Article ; Online: EAT-2 attenuates C. elegans development via metabolic remodeling in a chemically defined food environment.

    Cao, Xuwen / Xie, Yusu / Yang, Hanwen / Sun, Peiqi / Xue, Beining / Garcia, L Rene / Zhang, Liusuo

    Cellular and molecular life sciences : CMLS

    2023  Volume 80, Issue 8, Page(s) 205

    Abstract: Dietary intake and nutrient composition regulate animal growth and development; however, the underlying mechanisms remain elusive. Our previous study has shown that either the mammalian deafness homolog gene tmc-1 or its downstream acetylcholine receptor ...

    Abstract Dietary intake and nutrient composition regulate animal growth and development; however, the underlying mechanisms remain elusive. Our previous study has shown that either the mammalian deafness homolog gene tmc-1 or its downstream acetylcholine receptor gene eat-2 attenuates Caenorhabditis elegans development in a chemically defined food CeMM (C. elegans maintenance medium) environment, but the underpinning mechanisms are not well-understood. Here, we found that, in CeMM food environment, for both eat-2 and tmc-1 fast-growing mutants, several fatty acid synthesis and elongation genes were highly expressed, while many fatty acid β-oxidation genes were repressed. Accordingly, dietary supplementation of individual fatty acids, such as monomethyl branch chain fatty acid C17ISO, palmitic acid and stearic acid significantly promoted wild-type animal development on CeMM, and mutations in either C17ISO synthesis gene elo-5 or elo-6 slowed the rapid growth of eat-2 mutant. Tissue-specific rescue experiments showed that elo-6 promoted animal development mainly in the intestine. Furthermore, transcriptome and metabolome analyses revealed that elo-6/C17ISO regulation of C. elegans development may be correlated with up-regulating expression of cuticle synthetic and hedgehog signaling genes, as well as promoting biosynthesis of amino acids, amino acid derivatives and vitamins. Correspondingly, we found that amino acid derivative S-adenosylmethionine and its upstream metabolite methionine sulfoxide significantly promoted C. elegans development on CeMM. This study demonstrated that C17ISO, palmitic acid, stearic acid, S-adenosylmethionine and methionine sulfoxide inhibited or bypassed the TMC-1 and EAT-2-mediated attenuation of development via metabolic remodeling, and allowed the animals to adapt to the new nutritional niche.
    MeSH term(s) Receptors, Nicotinic/genetics ; Receptors, Nicotinic/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/growth & development ; Caenorhabditis elegans/metabolism ; Animals ; Eating ; Nutrients/metabolism ; Pharyngeal Muscles/metabolism ; Fatty Acids/metabolism ; Ion Channels/genetics ; Ion Channels/metabolism
    Chemical Substances Eat-2 protein, C elegans ; Receptors, Nicotinic ; Caenorhabditis elegans Proteins ; Fatty Acids ; TMC-1 protein, C elegans ; Ion Channels
    Language English
    Publishing date 2023-07-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-023-04849-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Neural circuits for sexually dimorphic and sexually divergent behaviors in Caenorhabditis elegans.

    García, L René / Portman, Douglas S

    Current opinion in neurobiology

    2016  Volume 38, Page(s) 46–52

    Abstract: Increasing interest in sex differences in Caenorhabditis elegans neurobiology is resulting from several advances, including the completion of the male tail connectome and the surprising discovery of two 'new' neurons in the male head. In this species, ... ...

    Abstract Increasing interest in sex differences in Caenorhabditis elegans neurobiology is resulting from several advances, including the completion of the male tail connectome and the surprising discovery of two 'new' neurons in the male head. In this species, sex-specific circuits in the hermaphrodite and male control reproductive behaviors such as egg-laying and copulation, respectively. Studies of these systems are revealing interesting similarities and contrasts, particularly in the mechanisms by which nutritional status influences reproductive behaviors. Other studies have highlighted the importance of sexual modulation of shared neurons and circuits in optimizing behavioral strategies. Together, these findings indicate that C. elegans uses intertwined, distributed sex differences in circuit structure and function to implement sex-specific as well as sexually divergent, shared behaviors.
    Language English
    Publishing date 2016-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2016.02.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Sexual Dimorphism and Sex Differences in

    Barr, Maureen M / García, L Rene / Portman, Douglas S

    Genetics

    2018  Volume 208, Issue 3, Page(s) 909–935

    Abstract: As fundamental features of nearly all animal species, sexual dimorphisms and sex differences have particular relevance for the development and function of the nervous system. The unique advantages of the ... ...

    Abstract As fundamental features of nearly all animal species, sexual dimorphisms and sex differences have particular relevance for the development and function of the nervous system. The unique advantages of the nematode
    MeSH term(s) Animals ; Caenorhabditis elegans/anatomy & histology ; Caenorhabditis elegans/physiology ; Cell Differentiation ; Cell Lineage ; Neurogenesis ; Neurons/metabolism ; Organogenesis ; Sex Characteristics ; Sexual Behavior, Animal ; Sexual Development
    Language English
    Publishing date 2018-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1534/genetics.117.300294
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 767: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Spatial Profiles of Phosphate in Roots Indicate Developmental Control of Uptake, Recycling, and Sequestration.

    Sahu, Abira / Banerjee, Swayoma / Raju, Aditi Subramani / Chiou, Tzyy-Jen / Garcia, L Rene / Versaw, Wayne K

    Plant physiology

    2020  Volume 184, Issue 4, Page(s) 2064–2077

    Abstract: The availability of inorganic phosphate (Pi) limits plant growth and crop productivity on much of the world's arable land. To better understand how plants cope with deficient and variable supplies of this essential nutrient, we used Pi imaging to ... ...

    Abstract The availability of inorganic phosphate (Pi) limits plant growth and crop productivity on much of the world's arable land. To better understand how plants cope with deficient and variable supplies of this essential nutrient, we used Pi imaging to spatially resolve and quantify cytosolic Pi concentrations and the respective contributions of Pi uptake, metabolic recycling, and vacuolar sequestration to cytosolic Pi homeostasis in Arabidopsis (
    MeSH term(s) Arabidopsis/chemistry ; Arabidopsis/growth & development ; Biological Transport/physiology ; Cytosol/chemistry ; Phosphates/analysis ; Plant Roots/chemistry ; Plant Roots/growth & development
    Chemical Substances Phosphates
    Language English
    Publishing date 2020-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1104/pp.20.01008
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    In stock of ZB MED Bonn / Germany

    Z 1193: Show issues

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  9. Article ; Online: SIR-2.1 integrates metabolic homeostasis with the reproductive neuromuscular excitability in early aging male Caenorhabditis elegans.

    Guo, Xiaoyan / García, L René

    eLife

    2014  Volume 3, Page(s) e01730

    Abstract: The decline of aging C. elegans male's mating behavior is correlated with the increased excitability of the cholinergic circuitry that executes copulation. In this study, we show that the mating circuits' functional durability depends on the metabolic ... ...

    Abstract The decline of aging C. elegans male's mating behavior is correlated with the increased excitability of the cholinergic circuitry that executes copulation. In this study, we show that the mating circuits' functional durability depends on the metabolic regulator SIR-2.1, a NAD(+)-dependent histone deacetylase. Aging sir-2.1(0) males display accelerated mating behavior decline due to premature hyperexcitability of cholinergic circuits used for intromission and ejaculation. In sir-2.1(0) males, the hypercontraction of the spicule-associated muscles pinch the vas deferens opening, thus blocking sperm release. The hyperexcitability is aggravated by reactive oxygen species (ROS). Our genetic, pharmacological, and behavioral analyses suggest that in sir-2.1(0) and older wild-type males, enhanced catabolic enzymes expression, coupled with the reduced expression of ROS-scavengers contribute to the behavioral decline. However, as a compensatory response to reduce altered catabolism/ROS production, anabolic enzymes expression levels are also increased, resulting in higher gluconeogenesis and lipid synthesis. DOI: http://dx.doi.org/10.7554/eLife.01730.001.
    MeSH term(s) Aging ; Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/metabolism ; Energy Metabolism ; Histone Deacetylases/metabolism ; Homeostasis ; Male ; Sexual Behavior, Animal ; Sirtuins/metabolism
    Chemical Substances Caenorhabditis elegans Proteins ; SIR-2.1 protein, C elegans (EC 3.5.1.-) ; Sirtuins (EC 3.5.1.-) ; Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2014-04-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.01730
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  10. Article ; Online: Caenorhabditis elegans

    LeBoeuf, Brigitte / Garcia, L Rene

    G3 (Bethesda, Md.)

    2017  Volume 7, Issue 2, Page(s) 647–662

    Abstract: Sexual dimorphism can be achieved using a variety of mechanisms, including sex-specific circuits and sex-specific function of shared circuits, though how these work together to produce sexually dimorphic behaviors requires further investigation. Here, we ...

    Abstract Sexual dimorphism can be achieved using a variety of mechanisms, including sex-specific circuits and sex-specific function of shared circuits, though how these work together to produce sexually dimorphic behaviors requires further investigation. Here, we explore how components of the sex-shared defecation circuitry are incorporated into the sex-specific male mating circuitry in
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/physiology ; Calmodulin ; Copulation/physiology ; Defecation/genetics ; Female ; Male ; Neurons/metabolism ; Reproduction/genetics ; Sex Characteristics ; Sexual Behavior, Animal ; Spermatozoa/metabolism
    Chemical Substances Calmodulin
    Language English
    Publishing date 2017-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1534/g3.116.036756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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