Article ; Online: Synthesis, and evaluation of photophysical properties of a potential DPP-derived photosensitizer for photodynamic therapy with D-A-D architecture.
Journal of materials science. Materials in medicine
2024 Volume 35, Issue 1, Page(s) 11
Abstract: The study of a macromolecule derived from DPP and triphenylamine, (DPP-BisTPA) by computational chemistry, its synthesis by direct arylation, optical characterization (UV-Vis and fluorescence) and electrochemistry (cyclic voltammetry), as well as its ... ...
| Abstract | The study of a macromolecule derived from DPP and triphenylamine, (DPP-BisTPA) by computational chemistry, its synthesis by direct arylation, optical characterization (UV-Vis and fluorescence) and electrochemistry (cyclic voltammetry), as well as its evaluation as a generator of reactive oxygen species indirectly, through the degradation of uric acid. The results obtained by DFT using B3LYP/6-31G (d, p) and TD-DFT using CAM-B3LYP/6-31G (d, p) reveal values of energy levels of the first singlet and triplet excited state that indicate a possible intersystem crossover and the possible generation of reactive oxygen species by a type I mechanism. The compound presents an absorption region within the phototherapeutic window. The electrochemical bandgap is 1.64 eV which suggests a behavior as a semiconductor. DPP-BisTPa were processed as hemispherical nanoparticles with a size around 100 nm, and NPOs were evaluated as a photosensitizer with a ROS generation yield of 4% using a photodynamic therapy flashlight as the light source. |
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| MeSH term(s) | Photosensitizing Agents ; Reactive Oxygen Species ; Photochemotherapy ; Amines ; Electrochemistry | |||||
| Chemical Substances | Photosensitizing Agents ; Reactive Oxygen Species ; Amines | |||||
| Language | English | |||||
| Publishing date | 2024-02-01 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1031752-1 | |||||
| ISSN | 1573-4838 ; 0957-4530 | |||||
| ISSN (online) | 1573-4838 | |||||
| ISSN | 0957-4530 | |||||
| DOI | 10.1007/s10856-024-06776-0 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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