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Article ; Online: Machine Learning Applications in Optical Fiber Sensing: A Research Agenda.

Reyes-Vera, Erick / Valencia-Arias, Alejandro / García-Pineda, Vanessa / Aurora-Vigo, Edward Florencio / Alvarez Vásquez, Halyn / Sánchez, Gustavo

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 7

Abstract: The constant monitoring and control of various health, infrastructure, and natural factors have led to the design and development of technological devices in a wide range of fields. This has resulted in the creation of different types of sensors that can ...

Abstract	The constant monitoring and control of various health, infrastructure, and natural factors have led to the design and development of technological devices in a wide range of fields. This has resulted in the creation of different types of sensors that can be used to monitor and control different environments, such as fire, water, temperature, and movement, among others. These sensors detect anomalies in the input data to the system, allowing alerts to be generated for early risk detection. The advancement of artificial intelligence has led to improved sensor systems and networks, resulting in devices with better performance and more precise results by incorporating various features. The aim of this work is to conduct a bibliometric analysis using the PRISMA 2020 set to identify research trends in the development of machine learning applications in fiber optic sensors. This methodology facilitates the analysis of a dataset comprised of documents obtained from Scopus and Web of Science databases. It enables the evaluation of both the quantity and quality of publications in the study area based on specific criteria, such as trends, key concepts, and advances in concepts over time. The study found that deep learning techniques and fiber Bragg gratings have been extensively researched in infrastructure, with a focus on using fiber optic sensors for structural health monitoring in future research. One of the main limitations is the lack of research on the use of novel materials, such as graphite, for designing fiber optic sensors. One of the main limitations is the lack of research on the use of novel materials, such as graphite, for designing fiber optic sensors. This presents an opportunity for future studies.
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24072200
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Sentinel Lymph Node Impact on the Quality of Life of Patients with Endometrial Cancer.

García-Pineda, Virginia / Hernández, Alicia / Garrido-Mallach, Sonia / Rodríguez-González, Elena / Alonso-Espías, María / Gracia, Myriam / Arnedo, Rocío / Zapardiel, Ignacio

Journal of personalized medicine

2023 Volume 13, Issue 5

Abstract: Objective: Given the improvement in the surgical treatment of endometrial cancer with the inclusion of sentinel lymph node biopsy (SLNB), our aim was to evaluate the impact of this minimally invasive and tailored nodal assessment on patients' quality of ...

Abstract	Objective: Given the improvement in the surgical treatment of endometrial cancer with the inclusion of sentinel lymph node biopsy (SLNB), our aim was to evaluate the impact of this minimally invasive and tailored nodal assessment on patients' quality of life (QoL). Methods: This was a cross-sectional study conducted in a single-centre, tertiary-level hospital. Patients diagnosed with preoperative early-stage endometrial cancer, who underwent primary surgical treatment between August 2015 and November 2021, were included. The enrolled patients were divided into two cohorts according to the nodal staging performed: the first group underwent only SLNB (SLNB group); the second group underwent pelvic and/or para-aortic lymphadenectomy (LND group). We evaluated the overall QoL using the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life core 30-item questionnaire (EORTC QLQ-C30) and a sexual health questionnaire (EORTC SHQ-C20). The scores were compared between the groups. Results: Ninety patients were enrolled in the study: 61 (67.8%) in the SLNB group and 29 (32.2%) in the LND group. In the LND group, 24 (82.7%) patients underwent pelvic and para-aortic LND, while 5 (17.3%) patients underwent pelvic LND. The assessment of the functional scales showed better results for the SLNB group than for the LND group, with a significantly lower impact on physical status (8.2% vs. 25%, respectively; Conclusions: The implementation of a surgical technique with SLNB improved patients' overall QoL by increasing their well-being in the functional and symptom spheres.
Language	English
Publishing date	2023-05-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13050847
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Article: Role of Adjuvant Radiotherapy in Patients with Cervical Cancer Undergoing Radical Hysterectomy.

Alonso-Espías, María / Gorostidi, Mikel / Gracia, Myriam / García-Pineda, Virginia / Diestro, María Dolores / Siegrist, Jaime / Hernández, Alicia / Zapardiel, Ignacio

Journal of personalized medicine

2023 Volume 13, Issue 10

Abstract: The benefit of adjuvant radiotherapy (RT) after radical hysterectomy in patients with cervical cancer remains controversial. The aim of this study was to determine adjuvant RT's impact on survival in accordance with Sedlis criteria. Patients with early- ... ...

Abstract	The benefit of adjuvant radiotherapy (RT) after radical hysterectomy in patients with cervical cancer remains controversial. The aim of this study was to determine adjuvant RT's impact on survival in accordance with Sedlis criteria. Patients with early-stage cervical cancer undergoing radical hysterectomy between 2005 and 2022 at a single tertiary care institution were included. A multivariate analysis was performed to determinate if RT was an independent prognostic factor for recurrence or death. We also analysed whether there was a statistically significant difference in overall survival (OS) between patients who met only one or two Sedlis criteria, depending on whether they received adjuvant RT or not. 121 patients were included in this retrospective study, of whom 48 (39.7%) received adjuvant RT due to the presence of unfavourable pathological findings. In multivariate analysis, RT was not found to be a statistically significant prognostic factor for OS (
Language	English
Publishing date	2023-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13101486
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Article: Survival Analysis in Endometrial Carcinomas by Type of Surgical Approach: A Matched-Pair Study.

Coronado, Pluvio J / Rychlik, Agnieszka / Baquedano, Laura / García-Pineda, Virginia / Martínez-Maestre, Maria A / Querleu, Denis / Zapardiel, Ignacio

Cancers

2022 Volume 14, Issue 4

Abstract: 1) Background: This study aimed to analyze the impact of surgical approach on survival rates in women diagnosed with endometrial cancer. (2) Methods: A retrospective multicenter cohort of 1382 women diagnosed with EC was performed. A total of 684 (49.5%) ...

Abstract	(1) Background: This study aimed to analyze the impact of surgical approach on survival rates in women diagnosed with endometrial cancer. (2) Methods: A retrospective multicenter cohort of 1382 women diagnosed with EC was performed. A total of 684 (49.5%) women underwent minimally invasive surgery, 233 (34%) underwent robotic-assisted laparoscopy (RAL), 451 (66%) underwent conventional laparoscopy (LPS), and 698 (50.5%) underwent open surgery (OP). Sociodemographic features, tumor characteristics, and survival rates were analyzed in the whole sample and in a matched-pair model. (3) Results: Women operated on by OP were significantly older, presented more comorbidities, and had more aggressive tumors. Disease-free (DFS), overall (OS), and specific survival related to EC (SS) amounts were significantly higher for MIS compared to OP (
Language	English
Publishing date	2022-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14041081
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Article ; Online: Tertiary cytoreductive surgery by laparoscopy in granulosa cell tumor recurrence.

García Pineda, Virginia / Hernández, Alicia / Cabanes, María / Siegrist, Jaime / Gracia, Myriam / Zapardiel, Ignacio

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2020 Volume 30, Issue 11, Page(s) 1844–1845

MeSH term(s)	Cytoreduction Surgical Procedures/methods ; Female ; Granulosa Cell Tumor/surgery ; Humans ; Laparoscopy/methods ; Neoplasm Recurrence, Local/surgery ; Ovarian Neoplasms/surgery
Language	English
Publishing date	2020-07-01
Publishing country	England
Document type	Journal Article ; Video-Audio Media
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2019-001079
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Article: Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study.

Cristóbal Quevedo, Ignacio / Cristóbal García, Ignacio / Gracia, Myriam / Garcia-Pineda, Virginia / Alonso-Espias, Maria / Siegrist, Jaime / Diestro, Maria Dolores / Hernández, Alicia / Zapardiel, Ignacio

Journal of personalized medicine

2023 Volume 13, Issue 2

Abstract: The main objective was to analyze the rate of bilateral sentinel lymph node (SLN) detection in endometrial cancer using indocyanine green (ICG) as a unique tracer compared to Technetium99 + ICG. As secondary objectives, we analyzed the drainage pattern ... ...

Abstract	The main objective was to analyze the rate of bilateral sentinel lymph node (SLN) detection in endometrial cancer using indocyanine green (ICG) as a unique tracer compared to Technetium99 + ICG. As secondary objectives, we analyzed the drainage pattern and factors that might affect the oncological outcomes. A case-control ambispective study was carried out on consecutive patients at our center. Data on the SLN biopsy with ICG collected prospectively were compared to retrospective data on the use of a double-tracer technique including Technetium99 + ICG. In total, 194 patients were enrolled and assigned to both groups, in which the group with both tracers (controls) included 107 (54.9%) patients and the ICG-alone group (cases) included 87 (45.1%) patients. The rate of bilateral drainage was significantly higher in the ICG group (98.9% vs. 89.7%;
Language	English
Publishing date	2023-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13020170
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Article: Molecular Signature of Endometrial Cancer with Coexistent Adenomyosis: A Multicentric Exploratory Analysis.

Raimondo, Diego / Raffone, Antonio / Virgilio, Agnese / Ferla, Stefano / Maletta, Manuela / Neola, Daniele / Travaglino, Antonio / Paradisi, Roberto / Hernández, Alicia / Spagnolo, Emanuela / García-Pineda, Virginia / Lenzi, Jacopo / Guida, Maurizio / Casadio, Paolo / Seracchioli, Renato

Cancers

2023 Volume 15, Issue 21

Abstract: Adenomyosis has been associated with better survival outcomes in women with endometrial cancer. However, although the endometrial cancer patients' risk stratification has been revolutionized by molecular findings, the impact of the molecular signature on ...

Abstract	Adenomyosis has been associated with better survival outcomes in women with endometrial cancer. However, although the endometrial cancer patients' risk stratification has been revolutionized by molecular findings, the impact of the molecular signature on the favorable prognosis of endometrial cancer patients with coexistent adenomyosis is unknown. The aim of our study was to compare the prevalence of molecular groups at poor and intermediate prognosis between endometrial cancer patients with and without coexistent adenomyosis. A multicentric, observational, retrospective, cohort study was performed to assess the differences in the prevalence of p53-abnormal expression (p53-abn) and mismatch repair protein-deficient expression (MMR-d) signatures between endometrial cancer patients with and without coexistent adenomyosis. A total of 147 endometrial cancer patients were included in the study: 38 in the adenomyosis group and 109 in the no adenomyosis group. A total of 37 patients showed the MMR-d signature (12 in the adenomyosis group and 25 in the no adenomyosis group), while 12 showed the p53-abn signature (3 in the adenomyosis group and 9 in the no adenomyosis group). No significant difference was found in the prevalence of p53-abn (
Language	English
Publishing date	2023-10-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15215208
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Article ; Online: Utility of indocyanine green as a single tracer for sentinel node biopsy in endometrial cancer.

Cabezas Palacios, María Nieves / García Pineda, Virginia / Gracia Segovia, Myriam / Diestro Tejeda, María Dolores / Hernández Gutiérrez, Alicia / Zapardiel Gutiérrez, Ignacio

The journal of obstetrics and gynaecology research

2021 Volume 48, Issue 1, Page(s) 222–229

Abstract: Aim: Our study aims to investigate the safety and effectiveness of sentinel lymph node biopsy using indocyanine green (ICG) for the surgical staging of early-stage endometrial cancer in comparison to technetium-99 m use.: Methods: We conducted an ... ...

Abstract	Aim: Our study aims to investigate the safety and effectiveness of sentinel lymph node biopsy using indocyanine green (ICG) for the surgical staging of early-stage endometrial cancer in comparison to technetium-99 m use. Methods: We conducted an observational retrospective study with patients diagnosed of endometrial cancer and FIGO stages I-II. All participants were injected technetium-99m the day prior to the surgery and underwent lymphoscintigraphy along with single-photon emission computed tomography. In addition, all patients were administered intraoperatively ICG injection to detect sentinel lymph node biopsy. The surgical staging was then completed according to the European Society for Medical Oncology preoperative risk category. Data obtained from the analysis of technetium-99m detection was compared to ICG detection. Results: A total of 53 women with endometrial cancer were included in the study, 49 (92.5%) of them showed drainage preoperatively in the single-photon emission computed tomography and/or lymphoscintigraphy. The intraoperative bilateral detection rate for technetium-99 m was 26 (49.1%) patients compared to 40 (75.5%) patients with ICG (p = 0.013). We observed a 42.5% increase in the mean number of lymph nodes retrieved by ICG compared to technetium-99m (2.85 vs 2,0 nodes; p = 0.002). We intraoperatively identified 164 lymph nodes, 104 (63.4%) located in both obturator areas and external iliac vessels. Conclusion: The use of ICG for the performance of sentinel node biopsy in patients with endometrial cancer seems safe and could be superior to technetium-99 m, since it offers a higher bilateral detection rate and nodal retrieval, resulting in the possibility to perform safely less full staging lymphadenectomies.
MeSH term(s)	Coloring Agents ; Endometrial Neoplasms/diagnostic imaging ; Endometrial Neoplasms/surgery ; Female ; Humans ; Indocyanine Green ; Lymph Node Excision ; Lymph Nodes ; Radiopharmaceuticals ; Retrospective Studies ; Sentinel Lymph Node Biopsy
Chemical Substances	Coloring Agents ; Radiopharmaceuticals ; Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2021-10-26
Publishing country	Australia
Document type	Journal Article ; Observational Study
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.15071
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Article ; Online: Oncological outcomes of intraperitoneal chemotherapy in advanced ovarian cancer: BRCA mutation role.

Padilla-Iserte, Pablo / Iváñez, Maria / Muruzabal, Juan Carlos / Navarro, Rafael / Díaz-Feijoo, Berta / Iacoponi, Sara / García-Pineda, Virginia / Díaz, Cristina / Utrilla-Layna, Jesús / Gil-Moreno, Antonio / Serra, Anna / Gilabert-Estellés, Juan / Martínez Canto, Cristina / Tejerizo, Álvaro / Lago, Víctor / Cárdenas-Rebollo, José Miguel / Domingo, Santiago

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2024 Volume 50, Issue 4, Page(s) 108263

Abstract: Introduction: The knowledge of BRCA status offers a chance to evaluate the role of the intraperitoneal route in patients selected by biomolecular profiles after primary cytoreduction surgery in advanced ovarian cancer.: Materials and methods: We ... ...

Abstract	Introduction: The knowledge of BRCA status offers a chance to evaluate the role of the intraperitoneal route in patients selected by biomolecular profiles after primary cytoreduction surgery in advanced ovarian cancer. Materials and methods: We performed a retrospective, multicenter study to assess oncological outcomes depending on adjuvant treatment (intraperitoneal [IP] vs intravenous [IV]) and BRCA status (BRCA1/2 mutated vs. BRCA wild type [WT]). The primary endpoint was to determine progression-free survival. The secondary objectives were overall survival and toxicity. Results: A total of 288 women from eight centers were included: 177 in the IP arm and 111 in the IV arm, grouped into four arms according to BRCA1/2 status. Significantly better PFS was observed in BRCA1/2-mutated patients with IP chemotherapy (HR: 0.35; 95% CI, 0.16-0.75, p = 0.007), which was not present in BRCA1/2-mutated patients with IV chemotherapy (HR: 0.65; 95% CI, 0.37-1.12, p = 0.14). Significantly better OS was also observed in IP chemotherapy (HR: 0.17; 95% CI, 0.06-043, p < 0.0001), but was not present in IV chemotherapy in relation with BRCA mutation (HR: 0.52; 95% CI, 0.22-1.27, p = 0.15). For BRCA WT patients, worse survival was observed regardless of the adjuvant route used. The IP route was more toxic compared to the IV route, but toxicity was equivalent at the long-term follow-up. Conclusion: This retrospective study suggests that BRCA status can help to offer an individualized, systematic treatment after optimal primary surgery for advanced ovarian cancer, but is limited by the small sample size. Prospective trials are essential to confirm these results.
MeSH term(s)	Humans ; Female ; BRCA1 Protein/genetics ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/surgery ; Retrospective Studies ; Prospective Studies ; BRCA2 Protein/genetics ; Carcinoma, Ovarian Epithelial ; Mutation
Chemical Substances	BRCA1 protein, human ; BRCA1 Protein ; BRCA2 protein, human ; BRCA2 Protein
Language	English
Publishing date	2024-03-09
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2024.108263
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 549: Show issues

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Article: Low-Volume Nodal Metastasis in Endometrial Cancer: Risk Factors and Prognostic Significance.

García Pineda, Virginia / Hernández Gutiérrez, Alicia / Gracia Segovia, Myriam / Siegrist Ridruejo, Jaime / Diestro Tejeda, María Dolores / Zapardiel, Ignacio

Journal of clinical medicine

2020 Volume 9, Issue 6

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2020-06-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9061999
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