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  1. Article: Recurrent Ureterosciatic Herniation Causing Right Obstructive Uropathy.

    García-Rico, Eduardo / Ortega-Polledo, Luis Enrique / Carrion, Diego M / Quiroga-Valcarcel, Ana / Fernández Hernández, Laura

    Cureus

    2024  Volume 16, Issue 3, Page(s) e57128

    Abstract: Sciatic hernias are unusual, challenging to diagnose, and can present some treatment dilemmas. Sciatic hernias containing the ureter are even less common. Symptoms are variable from renal fossa pain, mild or severe pelvic pain, neuropathic pain, or ... ...

    Abstract Sciatic hernias are unusual, challenging to diagnose, and can present some treatment dilemmas. Sciatic hernias containing the ureter are even less common. Symptoms are variable from renal fossa pain, mild or severe pelvic pain, neuropathic pain, or dysesthesias. Although stenting alone can be a treatment option for this condition, in cases where symptoms or ureteral obstruction relapse after initial treatment, sciatic hernioplasty must be considered as the definitive treatment. This article presents the case of a female patient who presented with a history of nonspecific abdominal pain and was diagnosed with a right-sided ureterosciatic hernia. This was managed with a ureteral stent for reduction of herniated ureteral content, but after recurrence, laparoscopic sciatic hernioplasty was performed. The patient was pain-free and without obstructive uropathy at the one-year follow-up.
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.57128
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  2. Article: Surface-Enhanced Raman Scattering (SERS) Spectroscopy for Sensing and Characterization of Exosomes in Cancer Diagnosis.

    Guerrini, Luca / Garcia-Rico, Eduardo / O'Loghlen, Ana / Giannini, Vincenzo / Alvarez-Puebla, Ramon A

    Cancers

    2021  Volume 13, Issue 9

    Abstract: Exosomes are emerging as one of the most intriguing cancer biomarkers in modern oncology for early cancer diagnosis, prognosis and treatment monitoring. Concurrently, several nanoplasmonic methods have been applied and developed to tackle the challenging ...

    Abstract Exosomes are emerging as one of the most intriguing cancer biomarkers in modern oncology for early cancer diagnosis, prognosis and treatment monitoring. Concurrently, several nanoplasmonic methods have been applied and developed to tackle the challenging task of enabling the rapid, sensitive, affordable analysis of exosomes. In this review, we specifically focus our attention on the application of plasmonic devices exploiting surface-enhanced Raman spectroscopy (SERS) as the optosensing technique for the structural interrogation and characterization of the heterogeneous nature of exosomes. We summarized the current state-of-art of this field while illustrating the main strategic approaches and discuss their advantages and limitations.
    Language English
    Publishing date 2021-04-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13092179
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  3. Article ; Online: Direct surface-enhanced Raman scattering (SERS) spectroscopy of nucleic acids: from fundamental studies to real-life applications.

    Garcia-Rico, Eduardo / Alvarez-Puebla, Ramon A / Guerrini, Luca

    Chemical Society reviews

    2018  Volume 47, Issue 13, Page(s) 4909–4923

    Abstract: Plasmonic optical biosensors for the analysis of nucleic acids have drawn a great deal of interest in nanomedicine because of their capability to overcome major limitations of conventional methods. Within this realm, surface-enhanced Raman scattering ( ... ...

    Abstract Plasmonic optical biosensors for the analysis of nucleic acids have drawn a great deal of interest in nanomedicine because of their capability to overcome major limitations of conventional methods. Within this realm, surface-enhanced Raman scattering (SERS)-based sensing is progressively emerging as a powerful analytical tool beyond the basic grounds of academia to viable commercial products. SERS benefits from the synergistic combination between the intrinsic structural specificity and experimental flexibility of Raman spectroscopy, the extremely high sensitivity provided by plasmonic nanomaterials, and the tremendous advances in nanofabrication techniques and spectroscopic instrumentation. SERS application to nucleic acids analysis has been largely restricted to indirect sensing approaches, where a SERS reporter and oligonucleotide ligands are typically combined onto the nanomaterials to enable extrinsic detection of the target sequences. On the other hand, the acquisition of the intrinsic SERS vibrational fingerprint of nucleic acids (direct sensing) has traditionally suffered from major limitations. However, recent years have witnessed a burst of interest in this area, largely driven by the efforts to address key reproducibility and sensitivity issues. In this tutorial review, we summarize and discuss the most recent cutting-edge research in the field of direct SERS sensing of nucleic acids by coherently organising the diverse data reported in the literature in a structurally logical fashion.
    MeSH term(s) Nucleic Acids/analysis ; Spectrum Analysis, Raman/methods ; Surface Properties
    Chemical Substances Nucleic Acids
    Language English
    Publishing date 2018-07-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/c7cs00809k
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  4. Article ; Online: Endourological panorama and current state of training in endourology among European teaching hospitals.

    Ortega Polledo, Luis E / Mantica, Guglielmo / Carrión, Diego M / Khelif, Adrian / Subiela Henríquez, José D / González Padilla, Daniel A / Sanchís Bonet, Ángeles / Tamayo Ruiz, Juan C / García Rico, Eduardo / Alonso Gregorio, Sergio / Gómez Rivas, Juan / Esperto, Francesco / Scoffone, Cesare M / Cracco, Cecilia M / Checcucci, Enrico

    Minerva urology and nephrology

    2023  Volume 76, Issue 1, Page(s) 5–8

    Language English
    Publishing date 2023-12-13
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062840-4
    ISSN 2724-6442
    ISSN (online) 2724-6442
    DOI 10.23736/S2724-6051.23.05646-X
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: SERS Quantification and Characterization of Proteins and Other Biomolecules.

    Feliu, Neus / Hassan, Moustapha / Garcia Rico, Eduardo / Cui, Daxiang / Parak, Wolfgang / Alvarez-Puebla, Ramon

    Langmuir : the ACS journal of surfaces and colloids

    2017  Volume 33, Issue 38, Page(s) 9711–9730

    Abstract: Changes in protein expression levels and protein structure may indicate genomic mutations and may be related to some diseases. Therefore, the precise quantification and characterization of proteins can be used for disease diagnosis. Compared with several ...

    Abstract Changes in protein expression levels and protein structure may indicate genomic mutations and may be related to some diseases. Therefore, the precise quantification and characterization of proteins can be used for disease diagnosis. Compared with several other alternative methods, surface-enhanced Raman scattering (SERS) spectroscopy is regarded as an excellent choice for the quantification and structural characterization of proteins. Herein, we review the main advance of using plasmonic nanostructures as SERS sensing platform for this purpose. Three design approaches, including direct SERS, indirect SERS, and SERS-encoded nanoparticles, are discussed in the direction of developing new precise approaches of quantification and characterization of proteins. While this Review is focused on proteins, in order to highlight concepts of SERS-based sensors also detection of other biomolecules will be discussed.
    MeSH term(s) Nanoparticles ; Nanostructures ; Proteins/chemistry ; Spectrum Analysis, Raman
    Chemical Substances Proteins
    Language English
    Publishing date 2017-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.7b01567
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  6. Article ; Online: Smelling, Seeing, Tasting-Old Senses for New Sensing.

    Guerrini, Luca / Garcia-Rico, Eduardo / Pazos-Perez, Nicolas / Alvarez-Puebla, Ramon A

    ACS nano

    2017  Volume 11, Issue 6, Page(s) 5217–5222

    Abstract: The senses are the physiological mechanisms of perception that enable an organism to interact with the surrounding media. For centuries, humans have utilized these senses in science; vision and olfaction have been used the most extensively in ... ...

    Abstract The senses are the physiological mechanisms of perception that enable an organism to interact with the surrounding media. For centuries, humans have utilized these senses in science; vision and olfaction have been used the most extensively in laboratories followed by gustation and somatosensation, whereas audition has only rarely been employed. Most of these applications of senses were developed spontaneously based on the natural behavior of the chemistry of the reactants producing changes in scent, taste, or color. In recent years, by exploiting the outstanding properties of nanoparticles, many groups have demonstrated alternative sensing scenarios where the detection limits are remarkably improved, enabling the recognition of hazardous substances by mere sight, smell, or taste. Such alternative sensing approaches can be divided into two main groups: (i) methods that identify a single analyte by engineering a reaction that promotes a change in color or the generation of a characteristic scent, and (ii) methods that emulate or even improve mammalian senses, especially those related to taste and smell. In this Perspective, we discuss the context of each technology, present prominent examples, and evaluate the complexities, potential pitfalls, and opportunities presented by different re-engineering strategies.
    MeSH term(s) Animals ; Biosensing Techniques/instrumentation ; Biosensing Techniques/methods ; Colorimetry/instrumentation ; Colorimetry/methods ; Escherichia coli/isolation & purification ; Escherichia coli Infections/microbiology ; Humans ; Mercury/analysis ; Nanoparticles/chemistry ; Smell ; Taste ; Vision, Ocular
    Chemical Substances Mercury (FXS1BY2PGL)
    Language English
    Publishing date 2017-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.7b03176
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  7. Article: COVID-19 impact and predictive factors for mortality in cancer patients

    Sanz Garcia, E. / Peinado, P. / Moreno, I. / Dorta, M. / Alvarez, B. / Alvarez Gallego, R. / Madurga, R. / Rodriguez Pascual, J. / Ugidos, L. / Muñoz, C. / Garcia-Rico, E. / Cubillo, A.

    Annals of Oncology

    Abstract: Background: SARS-CoV-2 is a novel coronavirus that has been responsible for the largest pandemic in the last century: COVID-19 This disease has widely affected Spain with a high lethality in ancient patients (pts) and with comorbidities Oncological pts ... ...

    Abstract Background: SARS-CoV-2 is a novel coronavirus that has been responsible for the largest pandemic in the last century: COVID-19 This disease has widely affected Spain with a high lethality in ancient patients (pts) and with comorbidities Oncological pts were not an exception Methods: We evaluated the association between COVID-19 mortality and clinical/laboratory/radiological parameters in cancer pts from March to April 2020 at our institution Past medical history and COVID-19-related parameters (symptoms, laboratory/x-ray findings and treatments) were retrospectively collected Univariate analysis (UA) has been done using Fisher exact and U-Mann-Withney test for qualitative and quantitative variables, respectively Multivariant analysis (MA) has been done using logistic regression Results: Forty three hospitalized pts were diagnosed with COVID-19;30 pts (69 8%) were symptomatic on admission and 13 pts (30 2%) were hospital-acquired cases Median age was 68 8 ± 7 8 years Most part of the pts had gastrointestinal (GI) (13;30 2%), thoracic (Tx) (12;27 9%) and breast (6;14%) cancer A higher prevalence of Tx tumours compared to our new pts prevalence is observed (9%) Fever was the most common symptom (27;62 8%) and bilateral pneumonia was observed in 24 pts (55 8%) SARS-Co-V-2 PCR was positive in 34 pts (79 1%) Hydroxychloroquine was administered in 35 pts (81 4%), steroids and antiretrovirals in 19 pts (44 1%) and tocilizumab in 12 pts (27 9%) Mortality rate due to COVID-19 was 30 23% (13 pts) and 8 pts could resume oncological treatment Hypertension (HTA) and previous daily steroids given during last month before admission;as well as performance status, fever, Curb-65, SOFA score and D-Dimer (DD) at admission were associated with COVID-19 mortality in UA Similarly, high flow oxygen requirements during hospitalization and DD at 72 hours are predictors of mortality HTA [OR: 8 3 (1-5-70 1)], steroids [OR: 10 7 (1 3 – 143 8)] and fever [OR: 0 09 (0 01 – 0 55)]were also associated in MA Conclusions: COVID-19 showed a relative higher incidence in pts with Tx and GI tumours Some clinical and laboratory parameters were found to be predictive factors for mortality as previously reported in non-cancer pts Further investigations with larger number of pts are needed Legal entity responsible for the study: HM Hospitales Funding: Has not received any funding Disclosure: All authors have declared no conflicts of interest
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #806039
    Database COVID19

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  8. Article ; Online: 1760P COVID-19 severe pneumonia in cancer patients

    Peinado, P. / Sanz Garcia, E. / Moreno, I. / Dorta, M. / Alvarez, B. / Alvarez Gallego, R. / Madurga, R. / Ugidos, L. / Rodriguez Pascual, J. / Muñoz, C. / Garcia-Rico, E. / Cubillo, A.

    Annals of Oncology

    Impact and predictive factors

    2020  Volume 31, Page(s) S1024

    Keywords Oncology ; Hematology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1016/j.annonc.2020.08.1824
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2862: Show issues Location:
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  9. Article ; Online: 1749P COVID-19 impact and predictive factors for mortality in cancer patients

    Sanz Garcia, E. / Peinado, P. / Moreno, I. / Dorta, M. / Alvarez, B. / Alvarez Gallego, R. / Madurga, R. / Rodriguez Pascual, J. / Ugidos, L. / Muñoz, C. / Garcia-Rico, E. / Cubillo, A.

    Annals of Oncology

    2020  Volume 31, Page(s) S1021

    Keywords Oncology ; Hematology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1016/j.annonc.2020.08.1813
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2862: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Conformational SERS Classification of K-Ras Point Mutations for Cancer Diagnostics.

    Morla-Folch, Judit / Gisbert-Quilis, Patricia / Masetti, Matteo / Garcia-Rico, Eduardo / Alvarez-Puebla, Ramon A / Guerrini, Luca

    Angewandte Chemie (International ed. in English)

    2017  Volume 56, Issue 9, Page(s) 2381–2385

    Abstract: Point mutations in Ras oncogenes are routinely screened for diagnostics and treatment of tumors (especially in colorectal cancer). Here, we develop an optical approach based on direct SERS coupled with chemometrics for the study of the specific ... ...

    Abstract Point mutations in Ras oncogenes are routinely screened for diagnostics and treatment of tumors (especially in colorectal cancer). Here, we develop an optical approach based on direct SERS coupled with chemometrics for the study of the specific conformations that single-point mutations impose on a relatively large fragment of the K-Ras gene (141 nucleobases). Results obtained offer the unambiguous classification of different mutations providing a potentially useful insight for diagnostics and treatment of cancer in a sensitive, fast, direct and inexpensive manner.
    MeSH term(s) DNA/genetics ; DNA Mutational Analysis/methods ; Genes, ras ; Humans ; Neoplasms/diagnosis ; Neoplasms/genetics ; Point Mutation ; Spectrum Analysis, Raman/methods
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2017-01-12
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201611243
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